{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T08:35:03Z","timestamp":1773131703252,"version":"3.50.1"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Posterior cortical atrophy (PCA) and semantic dementia (SD) are focal syndromes involving different cerebral regions. This study aimed to demonstrate the existence of abnormal functional connectivity (FC) with an affected network in PCA and SD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 10 patients with PCA, 12 patients with SD, and 11 controls were recruited to undergo a detailed clinical history interview and physical examination, neuropsychological assessments, and PET\/MRI scan. Seed-based FC analyses were conducted to construct FC in language network, visual network, and salience network. The two-sample <jats:italic>t<\/jats:italic>-test was performed to reveal distinct FC patterns in PCA and SD, and we further related the FC difference to cognition. Meanwhile, the uptake value of fluorodeoxyglucose in regions with FC alteration was also extracted for comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a global cognitive impairment in patients with PCA and SD. The results of FC analyses showed that patients with PCA present decreased FC in left precentral gyrus to left V1 and increased FC in right inferior frontal gyrus to right V1 in the visual network, right medial frontal gyrus and left fusiform to left anterior temporal lobe and post-superior temporal gyrus in the language network, and left superior temporal gyrus to left anterior insula in the salience network, which were related to cognitive function. Patients with SD had decreased FC from right superior frontal gyrus, right middle frontal gyrus and right superior frontal gyrus to left anterior temporal lobe, or post-superior temporal gyrus in the language network, as well as left superior frontal gyrus to right anterior insula in the salience network, positively relating to cognitive function, but increased FC in the right superior temporal gyrus to left anterior temporal lobe in the language network, and right insula and left anterior cingulum to right anterior insula in the salience network, negatively relating to cognitive function. Most of the regions with FC change in patients with PCA and SD had abnormal metabolism simultaneously.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Abnormal connectivity spread over the cortex involving language and salience networks was common in patients with PCA and SD, whereas FC change involving the visual network was unique to patients with PCA. The FC changes were matched for cognitive deficits.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2022.850977","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T06:41:55Z","timestamp":1651214515000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Characterizing Differences in Functional Connectivity Between Posterior Cortical Atrophy and Semantic Dementia by Seed-Based Approach"],"prefix":"10.3389","volume":"14","author":[{"given":"Yi","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingze","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lumi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaicheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoping","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.nicl.2018.06.013","article-title":"Functional and structural brain networks in posterior cortical atrophy: a two-centre multiparametric MRI study.","volume":"19","author":"Agosta","year":"2018","journal-title":"Neuroimage Clin."},{"key":"B2","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","article-title":"A fast diffeomorphic image registration algorithm.","volume":"38","author":"Ashburner","year":"2007","journal-title":"Neuroimage"},{"key":"B3","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.neuroimage.2005.02.018","article-title":"Unified segmentation.","volume":"26","author":"Ashburner","year":"2005","journal-title":"Neuroimage"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1093\/cercor\/bhy069","article-title":"Distinct interplay between atrophy and hypometabolism in alzheimer\u2019s versus semantic dementia.","volume":"29","author":"Bejanin","year":"2019","journal-title":"Cereb. Cortex."},{"key":"B5","doi-asserted-by":"publisher","first-page":"819","DOI":"10.2174\/1381612822666151209150954","article-title":"Neuroimmune crosstalk in CNS disorders: the histamine connection.","volume":"22","author":"Cacabelos","year":"2016","journal-title":"Curr. Pharm Des."},{"key":"B6","doi-asserted-by":"publisher","first-page":"5331","DOI":"10.1002\/hbm.23737","article-title":"The impact of T1 versus EPI spatial normalization templates for fMRI data analyses.","volume":"38","author":"Calhoun","year":"2017","journal-title":"Hum. Brain Mapp."},{"key":"B7","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1093\/brain\/aww313","article-title":"Focal temporal pole atrophy and network degeneration in semantic variant primary progressive aphasia.","volume":"140","author":"Collins","year":"2017","journal-title":"Brain"},{"key":"B8","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1136\/jnnp-2012-303309","article-title":"The language profile of posterior cortical atrophy.","volume":"84","author":"Crutch","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B9","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.jalz.2017.01.014","article-title":"Consensus classification of posterior cortical atrophy.","volume":"13","author":"Crutch","year":"2017","journal-title":"Alzheimer\u2019s Dementia"},{"key":"B10","article-title":"Salience network resting-state activity: Prediction of frontotemporal dementia progression.","volume":"70","author":"Day","year":"2013","journal-title":"JAMA Neurol."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16089-9","article-title":"A unified neurocognitive model of semantics language social behaviour and face recognition in semantic dementia.","volume":"11","author":"Ding","year":"2020","journal-title":"Nat. Commun."},{"key":"B12","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1053\/j.semnuclmed.2020.12.002","article-title":"Molecular and anatomical imaging of dementia with lewy bodies and frontotemporal lobar degeneration.","volume":"51","author":"Duignan","year":"2021","journal-title":"Semin. Nucl. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1093\/brain\/awz136","article-title":"Longitudinal neuroanatomical and cognitive progression of posterior cortical atrophy.","volume":"142","author":"Firth","year":"2019","journal-title":"Brain"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.101628","article-title":"Intrinsic connectivity networks in posterior cortical atrophy: a role for the pulvinar? Neuroimage.","volume":"21","author":"Fredericks","year":"2019","journal-title":"Clinical"},{"key":"B15","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1002\/hbm.460030303","article-title":"Spatial registration and normalization of images.","volume":"3","author":"Friston","year":"1995","journal-title":"Hum. Brain Mapp."},{"key":"B16","doi-asserted-by":"publisher","first-page":"S67","DOI":"10.4103\/aian.AIAN_715_20","article-title":"Language breakdown in primary progressive aphasias.","volume":"23","author":"Ghosh","year":"2020","journal-title":"Ann. Indian Acad Neurol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1007\/s11682-018-9952-7","article-title":"The impact of localized grey matter damage on neighboring connectivity: posterior cortical atrophy and the visual network.","volume":"13","author":"Glick-Shames","year":"2019","journal-title":"Brain Imaging Behav."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of primary progressive aphasia and its variants.","volume":"76","author":"Gorno-Tempini","year":"2011","journal-title":"Neurology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.1093\/brain\/awt222","article-title":"Anterior temporal lobe degeneration produces widespread network-driven dysfunction.","volume":"136","author":"Guo","year":"2013","journal-title":"Brain"},{"key":"B20","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1093\/brain\/awp248","article-title":"Semantic dementia: demography, familial factors and survival in a consecutive series of 100 cases.","volume":"133","author":"Hodges","year":"2010","journal-title":"Brain"},{"key":"B21","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1097\/WCO.0000000000000767","article-title":"Update on posterior cortical atrophy.","volume":"33","author":"Holden","year":"2020","journal-title":"Curr. Opin. Neurol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1162\/jocn_a_00722","article-title":"Asymmetric connectivity between the anterior temporal lobe and the language network.","volume":"27","author":"Hurley","year":"2015","journal-title":"J. Cogn. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt155","article-title":"Clinical, imaging, and pathological heterogeneity of the alzheimer\u2019s disease syndrome.","volume":"5","author":"Lam","year":"2013","journal-title":"Alzheimers Res. Ther."},{"key":"B24","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.neurobiolaging.2015.10.017","article-title":"Distinctive pathological mechanisms involved in primary progressive aphasias.","volume":"38","author":"Leyton","year":"2016","journal-title":"Neurobiol. Aging."},{"key":"B25","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1089\/brain.2014.0253","article-title":"DynamicBC : a matlab toolbox for dynamic brain connectome analysis.","volume":"4","author":"Liao","year":"2014","journal-title":"Brain Connect."},{"key":"B26","doi-asserted-by":"publisher","first-page":"9754","DOI":"10.1523\/JNEUROSCI.3464-13.2014","article-title":"Frontal white matter tracts sustaining speech production in primary progressive aphasia.","volume":"34","author":"Mandelli","year":"2014","journal-title":"J. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1007\/s00415-018-8762-6","article-title":"Primary progressive aphasia: a clinical approach.","volume":"265","author":"Marshall","year":"2018","journal-title":"J. Neurol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.3233\/JAD-150934","article-title":"Functional connectivity of ventral and dorsal visual streams in posterior cortical atrophy.","volume":"51","author":"Migliaccio","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1001\/jamaneurol.2018.0395","article-title":"Prevalence of mathematical and visuospatial learning disabilities in patients with posterior cortical atrophy.","volume":"75","author":"Miller","year":"2018","journal-title":"JAMA Neurol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1016\/j.nicl.2018.10.010","article-title":"Atrophy, metabolism and cognition in the posterior cortical atrophy spectrum based on alzheimer\u2019s disease cerebrospinal fluid biomarkers.","volume":"20","author":"Montembeault","year":"2018","journal-title":"NeuroImage Clin."},{"key":"B31","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.cortex.2019.03.018","article-title":"Differential language network functional connectivity alterations in alzheimer\u2019s disease and the semantic variant of primary progressive aphasia.","volume":"117","author":"Montembeault","year":"2019","journal-title":"Cortex"},{"key":"B32","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ajp.2019.07.001","article-title":"Clinical utility of 18F-FDG-PET\/MRI brain in dementia: Preliminary experience from a geriatric clinic in South India.","volume":"44","author":"Mukku","year":"2019","journal-title":"Asian J. Psychiat."},{"key":"B33","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/jcbfm.1992.81","article-title":"Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects.","volume":"12","author":"Muller-Gartner","year":"1992","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B34","doi-asserted-by":"publisher","first-page":"4421","DOI":"10.1002\/hbm.22927","article-title":"Atrophy patterns in early clinical stages across distinct phenotypes of alzheimer\u2019s disease.","volume":"36","author":"Ossenkoppele","year":"2015","journal-title":"Hum. Brain Mapp."},{"key":"B35","doi-asserted-by":"publisher","first-page":"5387","DOI":"10.1093\/cercor\/bhaa119","article-title":"Salience network atrophy links neuron type-specific pathobiology to loss of empathy in frontotemporal dementia.","volume":"30","author":"Pasquini","year":"2020","journal-title":"Cereb. Cortex."},{"key":"B36","doi-asserted-by":"publisher","first-page":"7218","DOI":"10.1523\/JNEUROSCI.2574-18.2019","article-title":"Neuroinflammation and functional connectivity in alzheimer\u2019s disease: Interactive influences on cognitive performance.","volume":"39","author":"Passamonti","year":"2019","journal-title":"J. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101482","article-title":"Breakdown of specific functional brain networks in clinical variants of alzheimer\u2019s disease.","volume":"72","author":"Pini","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1162\/jocn.2009.21339","article-title":"The word processing deficit in semantic dementia: all categories are equal, but some categories are more equal than others.","volume":"22","author":"Pulvermuller","year":"2010","journal-title":"J. Cogn. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1093\/brain\/awx217","article-title":"Distinct spatiotemporal patterns of neuronal functional connectivity in primary progressive aphasia variants.","volume":"140","author":"Ranasinghe","year":"2017","journal-title":"Brain"},{"key":"B40","first-page":"904","article-title":"Correction for partial volume effects in PET: Principle and validation.","volume":"39","author":"Rousset","year":"1998","journal-title":"J. Nucl. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neuron.2009.03.024","article-title":"Neurodegenerative diseases target large-scale human brain networks.","volume":"62","author":"Seeley","year":"2009","journal-title":"Neuron"},{"key":"B42","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.cortex.2017.04.016","article-title":"Semantic word category processing in semantic dementia and posterior cortical atrophy.","volume":"93","author":"Shebani","year":"2017","journal-title":"Cortex"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1093\/brain\/awz122","article-title":"Neuropathological correlates of structural and functional imaging biomarkers in 4-repeat tauopathies.","volume":"142","author":"Spina","year":"2019","journal-title":"Brain"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101729","article-title":"Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.","volume":"22","author":"Toller","year":"2019","journal-title":"Neuroimage Clin."},{"key":"B45","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.tins.2013.06.007","article-title":"Molecular nexopathies: a new paradigm of neurodegenerative disease.","volume":"36","author":"Warren","year":"2013","journal-title":"Trends Neurosci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1162\/jocn_a_00550","article-title":"What role does the anterior temporal lobe play in sentence-level processing? Neural correlates of syntactic processing in semantic variant primary progressive aphasia.","volume":"26","author":"Wilson","year":"2014","journal-title":"J. Cogn. Neurosci."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068910","article-title":"BrainNet Viewer: A network visualization tool for human brain connectomics","volume":"8","author":"Xia","year":"2013","journal-title":"PLoS One"},{"key":"B48","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s12021-016-9299-4","article-title":"DPABI: Data processing & analysis for (Resting-State) brain imaging.","volume":"14","author":"Yan","year":"2016","journal-title":"Neuroinformatics"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1016\/j.neuron.2012.03.004","article-title":"Predicting regional neurodegeneration from the healthy brain functional connectome.","volume":"73","author":"Zhou","year":"2012","journal-title":"Neuron"}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2022.850977\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T06:42:02Z","timestamp":1651214522000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2022.850977\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,29]]},"references-count":49,"alternative-id":["10.3389\/fnagi.2022.850977"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2022.850977","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,29]]},"article-number":"850977"}}