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Aging Neurosci."],"abstract":"<jats:p>Cerebral amyloid-\u03b2 (A\u03b2) depositions in depression in old age are controversial. A substantial proportion of individuals with late-life major depressive disorder (MDD) could be classified as having suspected non-Alzheimer\u2019s disease pathophysiology (SNAP) by a negative test for the biomarker amyloid-\u03b2 (A\u03b2\u2212) but positive neurodegeneration (ND+). This study aimed to evaluate subthreshold A\u03b2 loads in amyloid-negative MDD, particularly in SNAP MDD patients. This study included 46 amyloid-negative MDD patients: 23 SNAP (A\u03b2\u2212\/ND+) MDD and 23 A\u03b2\u2212\/ND\u2212 MDD, and 22 A\u03b2\u2212\/ND\u2212 control subjects. All subjects underwent <jats:sup>18<\/jats:sup>F-florbetapir PET, FDG-PET, and MRI. Regions of interest (ROIs) and voxel-wise group comparisons were performed with adjustment for age, gender, and level of education. The SNAP MDD patients exhibited significantly deceased <jats:sup>18<\/jats:sup>F-florbetapir uptakes in most cortical regions but not the parietal and precuneus cortex, as compared with the A\u03b2\u2212\/ND\u2212 MDD and control subjects (FDR correction, <jats:italic>p<\/jats:italic> &amp;lt; 0.05). No correlations of neuropsychological tests or depression characteristics with global cortical uptakes, but significant positive correlations between cognitive functions and adjusted hippocampal volumes among different groups were observed. The reduced A\u03b2 depositions in the amyloid-negative MDD patients might be attributed mainly to the SNAP MDD patients. Our results indicated that meaningfully low amounts of subclinical A\u03b2 might contain critical information on the non-amyloid-mediated pathogenesis.<\/jats:p>","DOI":"10.3389\/fnagi.2022.857940","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T10:26:04Z","timestamp":1654251964000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Decreased Cerebral Amyloid-\u03b2 Depositions in Patients With a Lifetime History of Major Depression With Suspected Non-Alzheimer Pathophysiology"],"prefix":"10.3389","volume":"14","author":[{"given":"Kuan-Yi","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Ju","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Hsiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yih","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Sheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Chen","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ing-Tsung","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"B1","year":"2013","journal-title":"Diagnostic and Statistical Manual of Mental Disorders."},{"key":"B2","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1212\/WNL.0000000000007747","article-title":"Subthreshold amyloid and its biological and clinical meaning: Long way ahead.","volume":"93","author":"Bischof","year":"2019","journal-title":"Neurology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/S1474-4422(16)30125-9","article-title":"Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer\u2019s disease pathophysiology (SNAP) or Alzheimer\u2019s disease pathology: a longitudinal study.","volume":"15","author":"Burnham","year":"2016","journal-title":"Lancet Neurol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1097\/WAD.0b013e31816c92bf","article-title":"Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B.","volume":"22","author":"Butters","year":"2008","journal-title":"Alzheimer. 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