{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:54:28Z","timestamp":1788656068478,"version":"build-2803163510"},"reference-count":116,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00e0\u00ad Cesk\u00e9 Republiky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Spatial navigation impairment is a promising cognitive marker of Alzheimer\u2019s disease (AD) that can reflect the underlying pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We assessed spatial navigation performance in AD biomarker positive older adults with amnestic mild cognitive impairment (AD aMCI) vs. those AD biomarker negative (non-AD aMCI), and examined associations between navigation performance, MRI measures of brain atrophy, and cerebrospinal fluid (CSF) biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 122 participants with AD aMCI (\n                      <jats:italic>n<\/jats:italic>\n                      = 33), non-AD aMCI (\n                      <jats:italic>n<\/jats:italic>\n                      = 31), mild AD dementia (\n                      <jats:italic>n<\/jats:italic>\n                      = 28), and 30 cognitively normal older adults (CN) underwent cognitive assessment, brain MRI (\n                      <jats:italic>n<\/jats:italic>\n                      = 100 had high-quality images for volumetric analysis) and three virtual navigation tasks focused on route learning (body-centered navigation), wayfinding (world-centered navigation) and perspective taking\/wayfinding. Cognitively impaired participants underwent CSF biomarker assessment [amyloid-\u03b2\n                      <jats:sub>1\u201342<\/jats:sub>\n                      , total tau, and phosphorylated tau\n                      <jats:sub>181<\/jats:sub>\n                      (p-tau\n                      <jats:sub>181<\/jats:sub>\n                      )] and amyloid PET imaging (\n                      <jats:italic>n<\/jats:italic>\n                      = 47 and\n                      <jats:italic>n<\/jats:italic>\n                      = 45, respectively), with a subset having both (\n                      <jats:italic>n<\/jats:italic>\n                      = 19).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In route learning, AD aMCI performed worse than non-AD aMCI (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001), who performed similarly to CN. In wayfinding, aMCI participants performed worse than CN (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2264 0.009) and AD aMCI performed worse than non-AD aMCI in the second task session (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.032). In perspective taking\/wayfinding, aMCI participants performed worse than CN (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2264 0.001). AD aMCI and non-AD aMCI did not differ in conventional cognitive tests. Route learning was associated with parietal thickness and amyloid-\u03b2\n                      <jats:sub>1\u201342<\/jats:sub>\n                      , wayfinding was associated with posterior medial temporal lobe (MTL) volume and p-tau\n                      <jats:sub>181<\/jats:sub>\n                      and perspective taking\/wayfinding was correlated with MRI measures of several brain regions and all CSF biomarkers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AD biomarker positive and negative older adults with aMCI had different profiles of spatial navigation deficits that were associated with posterior MTL and parietal atrophy and reflected AD pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2022.886778","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T07:18:47Z","timestamp":1654154327000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Different Profiles of Spatial Navigation Deficits In Alzheimer\u2019s Disease Biomarker-Positive Versus Biomarker-Negative Older Adults With Amnestic Mild Cognitive Impairment"],"prefix":"10.3389","volume":"14","author":[{"given":"Martina","family":"Lacz\u00f3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Martinkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ondrej","family":"Lerch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan M.","family":"Wiener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Kalinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Matuskova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Nedelska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Vyhnalek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Hort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Lacz\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease: recommendations from the national institute on aging-Alzheimer\u2019s association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement."},{"key":"B2","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3233\/JAD-150855","article-title":"Spatial navigation in preclinical Alzheimer\u2019s disease","volume":"52","author":"Allison","year":"2016","journal-title":"J. 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