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Aging Neurosci."],"abstract":"<jats:p>Emerging evidence suggests that some personality traits may link to the vulnerability to or protection for Alzheimer\u2019s disease (AD). A causal mechanism underlying this relationship, however, remains largely unknown. Using <jats:sup>18<\/jats:sup>F-Florbetaben positron emission tomography (PET) binding to beta-amyloid (A\u03b2) plaques, a pathological feature of AD, and functional magnetic resonance imaging (fMRI), we investigated pathological and functional correlates of extraversion and neuroticism in a group of healthy young and older subjects. We quantified the level of brain A\u03b2 deposition in older individuals. Brain activity was measured in young adults using a task-switching fMRI paradigm. When we correlated personality scores of extraversion and neuroticism with these pathological and functional measures, higher extraversion, but not neuroticism, was significantly associated with lower global A\u03b2 measures among older adults, accounting for age and sex. This association was present across widespread brain regions. Among young subjects, higher extraversion was associated with lower activity during task switching in the anterior cingulate cortex, left anterior insular cortex, left putamen, and middle frontal gyrus bilaterally, while higher neuroticism was associated with increased activity throughout the brain. The present results suggest that possibly <jats:italic>via<\/jats:italic> efficient neuronal activity, extraversion, one of the lifelong personality traits, may confer the protective mechanism against the development of A\u03b2 pathology during aging.<\/jats:p>","DOI":"10.3389\/fnagi.2022.900581","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T04:38:33Z","timestamp":1657687113000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Extraversion Is Associated With Lower Brain Beta-Amyloid Deposition in Cognitively Normal Older Adults"],"prefix":"10.3389","volume":"14","author":[{"given":"Hwamee","family":"Oh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1037\/0033-2909.121.2.219","article-title":"Intelligence, personality and interests: evidence for overlapping traits","volume":"121","author":"Ackerman","year":"1997","journal-title":"Psychol. 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