{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:53:57Z","timestamp":1790758437405,"version":"4.1.0"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/04923\/2020"],"award-info":[{"award-number":["UIDP\/04923\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Tinnitus is a phantom sound perceived in the absence of external acoustic stimulation. It is described in a variety of ways (e.g., buzzing, ringing, and roaring) and can be a single sound or a combination of different sounds. Our study evaluated associations between audiological parameters and the presence or severity of tinnitus, to improve tinnitus diagnosis, treatment, and prognosis. Our sample included 122 older participants (63 women and 59 men), aged 55\u201375 years from the Portuguese population, with or without sensory presbycusis and with or without tinnitus. All participants underwent a clinical evaluation through a structured interview, Ear, Nose, and Throat observation, and audiological evaluation (standard and extended audiometry, psychoacoustic tinnitus evaluation, auditory brainstem responses, and distortion product otoacoustic emissions). The Tinnitus Handicap Inventory was used to measure tinnitus symptom severity. Our data confirmed that the odds of developing tinnitus were significantly higher in the presence of noise exposure and hearing loss. Also, participants who had abrupt tinnitus onset and moderate or severe hyperacusis featured higher odds of at least moderate tinnitus. However, it was in the ABR that we obtained the most exciting and promising results, namely, in wave I, which was the common denominator in all findings. The increase in wave I amplitude is a protective factor to the odds of having tinnitus. Concerning the severity of tinnitus, the logistic regression model showed that for each unit of increase in the mean ratio V\/I of ABR, the likelihood of having at least moderate tinnitus was 10% higher. Advancing knowledge concerning potential tinnitus audiological biomarkers can be crucial for the adequate diagnosis and treatment of tinnitus.<\/jats:p>","DOI":"10.3389\/fnagi.2022.933117","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T05:41:55Z","timestamp":1661319715000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Audiological biomarkers of tinnitus in an older Portuguese population"],"prefix":"10.3389","volume":"14","author":[{"given":"Ha\u00fala F.","family":"Haider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara F.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Trigueiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Caria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"Borrego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iola","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L.","family":"Papoila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek J.","family":"Hoare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Pa\u00e7o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1044\/1059-0889(2012\/12-0010)","article-title":"Psychometric evaluation of visual analog scale for the assessment of chronic tinnitus.","volume":"21","author":"Adamchic","year":"2012","journal-title":"Am. J. Audiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1097\/MLG.0b013e318161e521","article-title":"Relation of distortion product otoacoustic emission with tinnitus.","volume":"118","author":"Ami","year":"2008","journal-title":"Laryngoscope"},{"key":"B3","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/0378-5955(93)90026-w","article-title":"Auditory event related potentials in chronic tinnitus patients with noise induced hearing loss.","volume":"71","author":"Attias","year":"1993","journal-title":"Hear. Res."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2014.00206","article-title":"Central gain control in tinnitus and hyperacusis.","volume":"5","author":"Auerbach","year":"2014","journal-title":"Front. Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1080\/00401706.1962.10490038","article-title":"Transformation of the Independent Variables\u2019.","volume":"4","author":"Box","year":"1962","journal-title":"Technometrics"},{"key":"B6","year":"1996","journal-title":"BIAP Recommendation 02\/1: Audiometric Classification of Hearing Impairment."},{"key":"B7","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s00106-019-0633-7","article-title":"A multidisciplinary European guideline for tinnitus: Diagnostics, assessment, and treatment.","volume":"67","author":"Cima","year":"2019","journal-title":"HNO"},{"key":"B8","first-page":"11","article-title":"Classification of causes, mechanisms of patient disturbance, and associated counseling","author":"Coles","year":"1995","journal-title":"Mechanisms of Tinnitus"},{"key":"B9","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1093\/oxfordjournals.bmb.a072230","article-title":"Tinnitus and its management.","volume":"43","author":"Coles","year":"1987","journal-title":"Br. Med. Bull."},{"key":"B10","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.heares.2012.01.005","article-title":"Hearing loss, hyperacusis, or tinnitus: What is modeled in animal research?\u2019.","volume":"295","author":"Eggermont","year":"2013","journal-title":"Hear. Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1111\/ejn.12759","article-title":"The auditory cortex and tinnitus \u2013 a review of animal and human studies.","volume":"41","author":"Eggermont","year":"2015","journal-title":"Eur. J. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.tins.2004.08.010","article-title":"The neuroscience of tinnitus.","volume":"27","author":"Eggermont","year":"2004","journal-title":"Trends Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"CR765","DOI":"10.12659\/msm.883606","article-title":"The relationship between distortion product otoacoustic emissions and extended high-frequency audiometry in tinnitus patients. Part 1: Normally hearing patients with unilateral tinnitus.","volume":"18","author":"Fabija\u0144ska","year":"2012","journal-title":"Med. Sci. Monit."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.heares.2019.01.022","article-title":"Residual inhibition: From the putative mechanisms to potential tinnitus treatment.","volume":"375","author":"Galazyuk","year":"2019","journal-title":"Hear. Res."},{"key":"B15","first-page":"293","article-title":"Tinnitus evaluation","author":"Goldstein","year":"1997","journal-title":"Tinnitus: diagnosis\/treatment"},{"key":"B16","first-page":"293","article-title":"Tinnitus evaluation","author":"Goldstein","year":"2007","journal-title":"Tinnitus: diagnosis\/treatment"},{"key":"B17","first-page":"83","article-title":"Tinnitus - hyperacusis and the loudness discomfort level test - a preliminary report.","volume":"2","author":"Goldstein","year":"1996","journal-title":"Int. Tinnitus J."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00031","article-title":"Analysis of audiometric differences of patients with and without tinnitus in a large clinical database.","volume":"8","author":"Gollnast","year":"2017","journal-title":"Front. Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1080\/14992020400050064","article-title":"Auditory measures in clinically depressed individuals. II. Auditory evoked potentials and behavioral speech tests.","volume":"43","author":"Gopal","year":"2004","journal-title":"Int. J. Audiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"742","DOI":"10.3766\/jaaa.16106","article-title":"Potential audiological and MRI markers of tinnitus.","volume":"28","author":"Gopal","year":"2017","journal-title":"J. Am. Acad. Audiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.otohns.2004.09.031","article-title":"DPOAE-grams in patients with acute tonal tinnitus.","volume":"132","author":"Gouveris","year":"2005","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"B22","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.otohns.2007.11.012","article-title":"Transient and distortion product evoked oto-acoustic emissions in normal hearing patients with and without tinnitus.","volume":"138","author":"Granjeiro","year":"2008","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"B23","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1007\/s10162-012-0344-1","article-title":"Brainstem auditory evoked potentials suggest a role for the ventral cochlear nucleus in tinnitus.","volume":"13","author":"Gu","year":"2012","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-018-0888-9","article-title":"A narrative synthesis of research evidence for tinnitus-related complaints as reported by patients and their significant others.","volume":"16","author":"Hall","year":"2018","journal-title":"Health Qual. Life Outcomes"},{"key":"B25","doi-asserted-by":"publisher","first-page":"037","DOI":"10.1055\/s-2001-13019","article-title":"Audiologic assessment and consultation of the tinnitus patient\u2019.","volume":"22","author":"Hall","year":"2001","journal-title":"Semin. Hear."},{"key":"B26","article-title":"Psychological aspects of tinnitus","author":"Hallam","year":"1984","journal-title":"Contributions To Medical Psychology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3109\/03005368109081442","article-title":"Tinnitus masking-a significant contribution to tinnitus management.","volume":"15","author":"Hazell","year":"1981","journal-title":"Br. J. Audiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1682\/jrrd.2012.05.0090","article-title":"Evaluating psychoacoustic measures for establishing presence of tinnitus.","volume":"50","author":"Henry","year":"2013","journal-title":"J. Rehabil. Res. Dev."},{"key":"B29","first-page":"101","article-title":"Auditory efferent dysfunction in normal-hearing chronic idiopathic tinnitus.","volume":"9","author":"Hsu","year":"2013","journal-title":"B-ENT"},{"key":"B30","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1097\/00003446-199002000-00005","article-title":"The effect of tinnitus on ABR latencies.","volume":"11","author":"Ikner","year":"1990","journal-title":"Ear Hear."},{"key":"B31","doi-asserted-by":"publisher","first-page":"3418","DOI":"10.1121\/1.423053","article-title":"Growth behavior of the 2 f1-f2 distortion product otoacoustic emission in tinnitus.","volume":"103","author":"Janssen","year":"1998","journal-title":"J. Acoust. Soc. Am."},{"key":"B32","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/0013-4694(58)90053-1","article-title":"Report of the committee on methods of clinical examination in electroencephalography\u2019.","volume":"10","author":"Jasper","year":"1958","journal-title":"Electroencephal. Clin. Neurophysiol."},{"key":"B33","first-page":"5","article-title":"Important revision of ANSI S3.6-1989: ANSI S3.6-1996 American national standard specification for audiometers\u2019.","volume":"22","author":"Jiang","year":"1998","journal-title":"Rev. D\u2019Orthophonie et D\u2019Audiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1121\/1.1334597","article-title":"Distortion-product source unmixing: A test of the two-mechanism model for DPOAE generation.","volume":"109","author":"Kalluri","year":"2001","journal-title":"J. Acoust. Soc. Am."},{"key":"B35","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1001\/archotol.134.6.647","article-title":"Comparison of auditory brainstem response results in normal-hearing patients with and without tinnitus.","volume":"134","author":"Kehrle","year":"2008","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"B36","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.pneurobio.2013.08.002","article-title":"Advances in the neurobiology of hearing disorders: Recent developments regarding the basis of tinnitus and hyperacusis.","volume":"111","author":"Knipper","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.heares.2006.07.007","article-title":"Course of hearing loss and occurrence of tinnitus.","volume":"221","author":"K\u00f6nig","year":"2006","journal-title":"Hear. Res."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2012.00002","article-title":"Tinnitus does not require macroscopic tonotopic map reorganization.","volume":"6","author":"Langers","year":"2012","journal-title":"Front. Syst. Neurosci."},{"key":"B39","first-page":"321","article-title":"Otoacoustic emissions as a preclinical measure of noise-induced hearing loss and susceptibility to noise-induced hearing loss","author":"Lapsley","year":"2007","journal-title":"Otoacoustic Emissions: Clinical Applications"},{"key":"B40","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s10162-004-5009-2","article-title":"Disruption of lateral olivocochlear neurons via a dopaminergic neurotoxin depresses sound-evoked auditory nerve activity.","volume":"6","author":"Le Prell","year":"2005","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s10162-002-3018-6","article-title":"Disruption of lateral efferent pathways: Functional changes in auditory evoked responses.","volume":"4","author":"Le Prell","year":"2003","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B42","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3109\/00206099509071919","article-title":"Brainstem auditory evoked responses in patients with tinnitus.","volume":"34","author":"Lemaire","year":"1995","journal-title":"Audiology"},{"key":"B43","doi-asserted-by":"publisher","first-page":"3210","DOI":"10.1121\/1.4935516","article-title":"Tone-burst auditory brainstem response wave V latencies in normal-hearing and hearing-impaired ears.","volume":"138","author":"Lewis","year":"2015","journal-title":"J. Acoust. Soc. Am."},{"key":"B44","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/S0079-6123(06)57022-0","article-title":"Neural plasticity in tinnitus.","volume":"157","author":"M\u00f8ller","year":"2006","journal-title":"Prog. Brain Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.heares.2010.01.003","article-title":"The relationship between tinnitus pitch and the edge frequency of the audiogram in individuals with hearing impairment and tonal tinnitus.","volume":"261","author":"Moore","year":"2010","journal-title":"Hear. Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1001\/archotol.1996.01890140029007","article-title":"Development of the tinnitus handicap inventory.","volume":"122","author":"Newman","year":"1996","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"B47","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.heares.2012.08.016","article-title":"GRM7 variants associated with age-related hearing loss based on auditory perception.","volume":"294","author":"Newman","year":"2012","journal-title":"Hear. Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1159\/000066156","article-title":"Psychoacoustic characterization of the tinnitus spectrum: Implications for the underlying mechanisms of tinnitus.","volume":"7","author":"Norena","year":"2002","journal-title":"Audiol. Neuro-Otol."},{"key":"B49","first-page":"101","article-title":"Balan\u00e7o da utiliza\u00e7\u00e3o da vers\u00e3o portuguesa do tinnitus handicap inventory (THI)\u2019.","volume":"1","author":"Oliveira","year":"2008","journal-title":"Audiol. Rev."},{"key":"B50","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1121\/1.2141297","article-title":"Distortion product otoacoustic emission (DPOAE) in tinnitus patients.","volume":"119","author":"Ozimek","year":"2006","journal-title":"J. Acoust. Soc. Am."},{"key":"B51","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1080\/14992020802581974","article-title":"The relationship between tinnitus pitch and the audiogram.","volume":"48","author":"Pan","year":"2009","journal-title":"Int. J. Audiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"35","DOI":"10.5935\/0946-5448.20170008","article-title":"Detailed analysis of high frequency auditory brainstem response in patients with tinnitus: A preliminary study.","volume":"21","author":"Pinkl","year":"2017","journal-title":"Int. Tinnitus J."},{"key":"B53","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1080\/03655230600895358","article-title":"Residual inhibition functions in relation to tinnitus spectra and auditory threshold shift.","volume":"126","author":"Roberts","year":"2006","journal-title":"Acta Oto-laryngol. Suppl."},{"key":"B54","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s10162-008-0136-9","article-title":"Residual inhibition functions overlap tinnitus spectra and the region of auditory threshold shift.","volume":"9","author":"Roberts","year":"2008","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3109\/01050399509047521","article-title":"Auditory brainstem response latencies in patients with tinnitus.","volume":"24","author":"Rosenhall","year":"1995","journal-title":"Scand. Audiol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"13452","DOI":"10.1523\/JNEUROSCI.2156-11.2011","article-title":"Tinnitus with a normal audiogram: Physiological evidence for hidden hearing loss and computational model.","volume":"31","author":"Schaette","year":"2011","journal-title":"J. Neurosci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/00034894931020S101","article-title":"Cochlear pathology in presbycusis.","volume":"102","author":"Schuknecht","year":"1993","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.11476","article-title":"Neural signatures of perceptual inference.","volume":"5","author":"Sedley","year":"2016","journal-title":"eLife"},{"key":"B59","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1055\/s-0035-1570311","article-title":"Pitch and Loudness Tinnitus in Individuals with Presbycusis.","volume":"20","author":"Seimetz","year":"2016","journal-title":"Int. Arch. Otorhinolaryngol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"303","DOI":"10.3109\/14992027.2010.551221","article-title":"Re-examining the relationship between audiometric profile and tinnitus pitch.","volume":"50","author":"Sereda","year":"2011","journal-title":"Int. J. Audiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1055\/s-0034-1374648","article-title":"The study of otoacoustic emissions and the suppression of otoacoustic emissions in subjects with tinnitus and normal hearing: An insight to tinnitus etiology.","volume":"19","author":"Sereda","year":"2015","journal-title":"Int. Arch. Otorhinolaryngol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"555","DOI":"10.3766\/jaaa.15.8.3","article-title":"ABR and DPOAE indices of normal loudness in children and adults.","volume":"15","author":"Serpanos","year":"2004","journal-title":"J. Am. Acad. Audiol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/s0378-5955(97)00043-9","article-title":"Characteristics of DPOAE audiogram in tinnitus patients.","volume":"108","author":"Shiomi","year":"1997","journal-title":"Hear. Res."},{"key":"B64","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1097\/01.AUD.0000100204.08771.3D","article-title":"Risk factors for tinnitus in a population of older adults: The blue mountains hearing study.","volume":"24","author":"Sindhusake","year":"2003","journal-title":"Ear Hear."},{"key":"B65","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1044\/jshd.5503.439","article-title":"Characterization of tinnitus by tinnitus patients.","volume":"55","author":"Stouffer","year":"1990","journal-title":"J. Speech Hear. Disord."},{"key":"B66","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.heares.2014.10.007","article-title":"Biological correlates of tinnitus-related distress: An exploratory study.","volume":"318","author":"Szczepek","year":"2014","journal-title":"Hear. Res."},{"key":"B67","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.anl.2009.05.001","article-title":"DPOAE in estimation of the function of the cochlea in tinnitus patients with normal hearing.","volume":"37","author":"Sztuka","year":"2010","journal-title":"Auris Nasus Larynx"},{"key":"B68","doi-asserted-by":"publisher","first-page":"245","DOI":"10.3109\/03005368309081485","article-title":"Parametric studies of tinnitus masking and residual inhibition.","volume":"17","author":"Terry","year":"1983","journal-title":"Br. J. Audiol."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.831581","article-title":"Spectrally matched near-threshold noise for subjective tinnitus loudness attenuation based on stochastic resonance\u2019.","volume":"16","author":"Tziridis","year":"2022","journal-title":"Front. Neurosci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1044\/jshr.3401.197","article-title":"Tinnitus reaction questionnaire: Psychometric properties of a measure of distress associated with tinnitus.","volume":"34","author":"Wilson","year":"1991","journal-title":"J. Speech Hear. Res."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2022.933117\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T05:42:05Z","timestamp":1661319725000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2022.933117\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,24]]},"references-count":70,"alternative-id":["10.3389\/fnagi.2022.933117"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2022.933117","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,24]]},"article-number":"933117"}}