{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:55:16Z","timestamp":1792418116503,"version":"4.4.0"},"reference-count":228,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["695714"],"award-info":[{"award-number":["695714"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["693606"],"award-info":[{"award-number":["693606"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["101069397"],"award-info":[{"award-number":["101069397"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["754345"],"award-info":[{"award-number":["754345"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PNRR National Centers Program (National Biodiversity Future Center \u2013 NBFC)"],"award-info":[{"award-number":["PNRR National Centers Program (National Biodiversity Future Center \u2013 NBFC)"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002565","name":"Alzheimer's Drug Discovery Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007366","name":"Fondazione Italiana Sclerosi Multipla","doi-asserted-by":"publisher","award":["2019\/PR-single\/044"],"award-info":[{"award-number":["2019\/PR-single\/044"]}],"id":[{"id":"10.13039\/100007366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Leukocyte migration into the central nervous system (CNS) represents a central process in the development of neurological diseases with a detrimental inflammatory component. Infiltrating neutrophils have been detected inside the brain of patients with several neuroinflammatory disorders, including stroke, multiple sclerosis and Alzheimer\u2019s disease. During inflammatory responses, these highly reactive innate immune cells can rapidly extravasate and release a plethora of pro-inflammatory and cytotoxic factors, potentially inducing significant collateral tissue damage. Indeed, several studies have shown that neutrophils promote blood-brain barrier damage and increased vascular permeability during neuroinflammatory diseases. Recent studies have shown that neutrophils migrate into the meninges and choroid plexus, suggesting these cells can also damage the blood-cerebrospinal fluid barrier (BCSFB). In this review, we discuss the emerging role of neutrophils in the dysfunction of brain barriers across different neuroinflammatory conditions and describe the molecular basis and cellular interplays involved in neutrophil-mediated injury of the CNS borders.<\/jats:p>","DOI":"10.3389\/fnagi.2022.965169","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T07:44:22Z","timestamp":1660203862000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":88,"title":["The role of neutrophils in the dysfunction of central nervous system barriers"],"prefix":"10.3389","volume":"14","author":[{"given":"Bruno","family":"Santos-Lima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica Caterina","family":"Pietronigro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Terrabuio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Zenaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Constantin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1212\/WNL.0000000000001587","article-title":"Gadolinium-based MRI characterization of leptomeningeal inflammation in multiple sclerosis.","volume":"85","author":"Absinta","year":"2015","journal-title":"Neurology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1096\/fj.02-0035com","article-title":"Lymphocyte trafficking through the blood\u2013brain barrier is dependent on endothelial cell heterotrimeric G-protein signaling.","volume":"16","author":"Adamson","year":"2002","journal-title":"FASEB J."},{"key":"B3","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00381-012-1910-x","article-title":"The intracranial arachnoid mater: A comprehensive review of its history, anatomy, imaging, and pathology.","volume":"29","author":"Adeeb","year":"2013","journal-title":"Child\u2019s Nervous Syst."},{"key":"B4","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1046\/j.1469-7580.2002.00057.x","article-title":"Extracellular matrix, junctional integrity and matrix metalloproteinase interactions in endothelial permeability regulation.","volume":"200","author":"Aexander","year":"2002","journal-title":"J. Anatomy"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1084\/jem.20051342","article-title":"Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis.","volume":"203","author":"Agrawal","year":"2006","journal-title":"J. Exp. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e191","DOI":"10.1212\/nxi.0000000000000191","article-title":"Lipocalin-2 is increased in progressive multiple sclerosis and inhibits remyelination.","volume":"3","author":"Al Nimer","year":"2016","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"B7","doi-asserted-by":"publisher","first-page":"6564585","DOI":"10.1155\/2021\/6564585","article-title":"Blood-Brain Barrier Overview: Structural and Functional Correlation.","volume":"2021","author":"Alahmari","year":"2021","journal-title":"Neural Plast."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/J.1365-2990.1988.TB00862.X","article-title":"The cranial arachnoid and pia mater in man: Anatomical and ultrastructural observations.","volume":"14","author":"Alcolado","year":"1988","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1177\/1971400917714280","article-title":"Diffusion-weighted magnetic resonance imaging in the assessment of choroid plexus aging.","volume":"30","author":"Alicioglu","year":"2017","journal-title":"Neuroradiol. J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/s0165-0173(97)00011-8","article-title":"Short (or topical). review. Is the pial microvessel a good model for blood-brain barrier studies?","volume":"24","author":"Allt","year":"1997","journal-title":"Brain Res. Rev."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1038\/S41590-020-0776-4","article-title":"Meningeal \u03b3\u03b4 T cells regulate anxiety-like behavior via IL-17a signaling in neurons.","volume":"21","author":"Alves de Lima","year":"2020","journal-title":"Nat. Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1146\/annurev-immunol-102319-103410","article-title":"Meningeal immunity and its function in maintenance of the central nervous system in health and disease.","volume":"38","author":"Alves De Lima","year":"2020","journal-title":"Annu. Rev. Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41598-018-36769-3","article-title":"The tri-phasic role of hydrogen peroxide in blood-brain barrier endothelial cells.","volume":"9","author":"Anasooya Shaji","year":"2019","journal-title":"Sci. Rep."},{"key":"B14","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.molmed.2014.10.003","article-title":"Regulation of T cell trafficking by the T cell immunoglobulin and mucin domain 1 glycoprotein.","volume":"20","author":"Angiari","year":"2014","journal-title":"Trends Mol. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.immuni.2014.03.004","article-title":"TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity.","volume":"40","author":"Angiari","year":"2014","journal-title":"Immunity"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1093\/BRAIN\/AWG118","article-title":"B lymphocytes in the normal brain: Contrasts with HIV-associated lymphoid infiltrates and lymphomas.","volume":"126","author":"Anthony","year":"2003","journal-title":"Brain"},{"key":"B17","doi-asserted-by":"publisher","first-page":"23463","DOI":"10.1074\/jbc.274.33.23463","article-title":"Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1 a potential mechanism for vascular permeability in diabetic retinopathy and tumors.","volume":"274","author":"Antonetti","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1159\/000015873","article-title":"Increasing levels of leukocyte-derived inflammatory mediators in plasma and cAMP in platelets during follow-up after acute cerebral ischemia.","volume":"8","author":"Anwaar","year":"1998","journal-title":"Cerebrovasc. Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"7724","DOI":"10.1523\/jneurosci.21-19-07724.2001","article-title":"Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia.","volume":"21","author":"Asahi","year":"2001","journal-title":"J. Neurosci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.4049\/jimmunol.1400401","article-title":"Neutrophils mediate blood\u2013spinal cord barrier disruption in demyelinating neuroinflammatory diseases.","volume":"193","author":"Aub\u00e9","year":"2014","journal-title":"J. Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"7910","DOI":"10.1523\/JNEUROSCI.16-24-07910.1996","article-title":"Matrix metalloproteinase-9 (MMP-9). is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-\u03b2 peptide (1\u201340).","volume":"16","author":"Backstrom","year":"1996","journal-title":"J. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/J.NBD.2003.12.016","article-title":"The blood-brain barrier: An overview: Structure, regulation, and clinical implications.","volume":"16","author":"Ballabh","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/nature08478","article-title":"Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions.","volume":"462","author":"Bartholom\u00e4us","year":"2009","journal-title":"Nature"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1038\/jcbfm.2010.1","article-title":"Increased plasma and tissue MMP levels are associated with BCSFB and BBB disruption evident on post-contrast FLAIR after experimental stroke.","volume":"30","author":"Batra","year":"2010","journal-title":"J. Cerebral Blood Flow Metabolism"},{"key":"B25","doi-asserted-by":"publisher","first-page":"4775","DOI":"10.1182\/BLOOD-2002-10-3309","article-title":"CD8 + T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: A critical role for P-selectin glycoprotein ligand-1.","volume":"101","author":"Battistini","year":"2003","journal-title":"Blood"},{"key":"B26","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.it.2006.11.007","article-title":"What is the blood-brain barrier (not)?","volume":"28","author":"Bechmann","year":"2007","journal-title":"Trends Immunol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1186\/s12864-015-2159-z","article-title":"Gene expression and functional annotation of human choroid plexus epithelium failure in Alzheimer\u2019s disease.","volume":"16","author":"Bergen","year":"2015","journal-title":"BMC Genomics"},{"key":"B28","doi-asserted-by":"publisher","first-page":"e01675","DOI":"10.1128\/MBIO.01675-19","article-title":"Gamma interferon alters junctional integrity via rho kinase, resulting in blood-brain barrier leakage in experimental viral encephalitis.","volume":"10","author":"Bonney","year":"2019","journal-title":"mBio"},{"key":"B29","doi-asserted-by":"publisher","first-page":"18584","DOI":"10.1073\/pnas.0803945105","article-title":"Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase.","volume":"105","author":"Breckwoldt","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B30","doi-asserted-by":"publisher","first-page":"eabf9277","DOI":"10.1126\/science.abf9277","article-title":"Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders.","volume":"373","author":"Brioschi","year":"2021","journal-title":"Science"},{"key":"B31","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3389\/fnins.2015.00075","article-title":"Outer brain barriers in rat and human development.","volume":"9","author":"Br\u00f8chner","year":"2015","journal-title":"Front. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/J.BBI.2020.12.003","article-title":"IL-4R\u03b1 deletion disrupts psychomotor performance and reference memory in mice while sparing behavioural phenotype associated with spatial learning.","volume":"92","author":"Brombacher","year":"2021","journal-title":"Brain Behav. Immunity"},{"key":"B33","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.bbamem.2008.08.027","article-title":"Cytokine regulation of tight junctions.","volume":"1788","author":"Capaldo","year":"2009","journal-title":"Biochim. et Biophysica Acta - Biomembranes"},{"key":"B34","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1159\/000334916","article-title":"Neuroinflammation and blood-brain barrier changes in capillary amyloid angiopathy.","volume":"10","author":"Carrano","year":"2012","journal-title":"Neurodegener. Dis."},{"key":"B35","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1023\/a:1015438624949","article-title":"Development of endothelial paracellular clefts and their tight junctions in the pial microvessels of the rat.","volume":"26","author":"Cassella","year":"1997","journal-title":"J. Neurocytol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1093\/brain\/awn004","article-title":"Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.","volume":"131","author":"Chen","year":"2008","journal-title":"Brain"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1161\/ATVBAHA.119.312725","article-title":"Inhibition of MPO (myeloperoxidase). attenuates endothelial dysfunction in mouse models of vascular inflammation and atherosclerosis.","volume":"39","author":"Cheng","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/ki.1993.94","article-title":"Beta2 integrins are required for neutrophil degranulation induced by hemodialysis membranes.","volume":"43","author":"Cheung","year":"1993","journal-title":"Kidney Int."},{"key":"B39","doi-asserted-by":"publisher","first-page":"38","DOI":"10.17140\/NOJ-2-109","article-title":"Lipocalin-2 in Stroke.","volume":"2","author":"Chou","year":"2015","journal-title":"Neuro Open J."},{"key":"B40","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/J.TINS.2015.08.003","article-title":"The molecular constituents of the blood-brain barrier.","volume":"38","author":"Chow","year":"2015","journal-title":"Trends Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.jaut.2012.11.003","article-title":"Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE.","volume":"42","author":"Christy","year":"2013","journal-title":"J. Autoimmun."},{"key":"B42","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0304-3940(97)00859-8","article-title":"Increased gelatinase A (MMP-2). and gelatinase B (MMP-9). activities in human brain after focal ischemia.","volume":"238","author":"Clark","year":"1997","journal-title":"Neurosci. Lett."},{"key":"B43","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0304-3940(02)00303-8","article-title":"The myeloperoxidase gene in Alzheimer\u2019s disease: A case-control study and meta-analysis.","volume":"326","author":"Combarros","year":"2002","journal-title":"Neurosci. Lett."},{"key":"B44","doi-asserted-by":"publisher","first-page":"3374","DOI":"10.1161\/STROKEAHA.120.033513","article-title":"Neutrophil enzyme myeloperoxidase modulates neuronal response in a model of subarachnoid hemorrhage by venous injury.","volume":"52","author":"Coulibaly","year":"2021","journal-title":"Stroke"},{"key":"B45","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1006\/exnr.2000.7560","article-title":"Association between Alzheimer\u2019s disease and a functional polymorphism in the myeloperoxidase gene.","volume":"167","author":"Crawford","year":"2001","journal-title":"Exp. Neurol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/s41593-018-0329-4","article-title":"Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer\u2019s disease mouse models.","volume":"22","author":"Cruz Hern\u00e1ndez","year":"2019","journal-title":"Nat. Neurosci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"eabf7844","DOI":"10.1126\/science.abf7844","article-title":"Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma.","volume":"373","author":"Cugurra","year":"2021","journal-title":"Science"},{"key":"B48","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1128\/mcb.06029-11","article-title":"Occludin: One Protein. Many Forms","volume":"32","author":"Cummins","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"763","DOI":"10.3233\/JAD-160330","article-title":"Neutrophil gelatinase-associated lipocalin and its receptors in Alzheimer\u2019s Disease (AD). brain regions: Differential findings in AD with and without depression.","volume":"55","author":"Dekens","year":"2017","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1084\/jem.20091419","article-title":"Regulation of learning and memory by meningeal immunity: A key role for IL-4.","volume":"207","author":"Derecki","year":"2010","journal-title":"J. Exp. Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"703944","DOI":"10.3389\/fncel.2021.703944","article-title":"Living on the edge of the cns: Meninges cell diversity in health and disease.","volume":"15","author":"Derk","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.it.2009.07.012","article-title":"Opening the flood-gates: How neutrophil-endothelial interactions regulate permeability.","volume":"30","author":"DiStasi","year":"2009","journal-title":"Trends Immunol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"e0218965","DOI":"10.1371\/journal.pone.0218965","article-title":"Effects of lipocalin-2 on brain endothelial adhesion and permeability.","volume":"14","author":"Du","year":"2019","journal-title":"PLoS One"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1172\/JCI6886","article-title":"Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions.","volume":"104","author":"Dubois","year":"1999","journal-title":"J. Clin. Inves."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.3389\/FIMMU.2019.02436\/BIBTEX","article-title":"LFA-1 controls Th1 and Th17 motility behavior in the inflamed central nervous system.","volume":"10","author":"Dusi","year":"2019","journal-title":"Front. Immunol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"108260","DOI":"10.1016\/J.CELREP.2020.108260","article-title":"Neutrophils Obstructing Brain Capillaries Are a Major Cause of No-Reflow in Ischemic Stroke.","volume":"33","author":"El Amki","year":"2020","journal-title":"Cell Rep."},{"key":"B57","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.it.2005.07.004","article-title":"The ins and outs of T-lymphocyte trafficking to the CNS: Anatomical sites and molecular mechanisms.","volume":"26","author":"Engelhardt","year":"2005","journal-title":"Trends Immunol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/ni.3666","article-title":"The movers and shapers in immune privilege of the CNS.","volume":"18","author":"Engelhardt","year":"2017","journal-title":"Nat. Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1038\/NM.1878","article-title":"A role for leukocyte-endothelial adhesion mechanisms in epilepsy.","volume":"14","author":"Fabene","year":"2008","journal-title":"Nat. Med."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-1054-7_21","article-title":"The Filtration Concept of the Blood-CSF-Barrier as Basis for the Differentiation of CSF Proteins","author":"Felgenhauer","year":"1995","journal-title":"New Concepts of a Blood\u2014Brain Barrier<sup>**<\/sup>"},{"key":"B61","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/NATURE18626","article-title":"Unexpected role of interferon-\u03b3 in regulating neuronal connectivity and social behaviour.","volume":"535","author":"Filiano","year":"2016","journal-title":"Nature"},{"key":"B62","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41572-018-0041-4","article-title":"Multiple sclerosis.","volume":"4","author":"Filippi","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"B63","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/s41590-022-01166-6","article-title":"Neutrophils direct preexisting matrix to initiate repair in damaged tissues.","volume":"23","author":"Fischer","year":"2022","journal-title":"Nat. Immunol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/jcbfm.2014.222","article-title":"Myeloperoxidase propagates damage and is a potential therapeutic target for subacute stroke.","volume":"35","author":"Forghani","year":"2015","journal-title":"J. Perinatol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1148\/RADIOL.12111593","article-title":"Demyelinating diseases: Myeloperoxidase as an imaging biomarker and therapeutic target.","volume":"263","author":"Forghani","year":"2012","journal-title":"Radiol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.it.2006.11.004","article-title":"What is immune privilege (not)?","volume":"28","author":"Galea","year":"2007","journal-title":"Trends Immunol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1183\/09031936.00212114","article-title":"Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis.","volume":"46","author":"Garratt","year":"2015","journal-title":"Eur. Respiratory J."},{"key":"B68","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s00441-017-2626-8","article-title":"Myeloperoxidase-immunoreactive cells are significantly increased in brain areas affected by neurodegeneration in Parkinson\u2019s and Alzheimer\u2019s disease.","volume":"369","author":"Gellhaar","year":"2017","journal-title":"Cell Tissue Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1038\/s41598-021-04677-8","article-title":"Matrix metalloproteinases (MMP). 3 and 9 as biomarkers of severity in COVID-19 patients.","volume":"12","author":"Gelzo","year":"2022","journal-title":"Sci. Rep."},{"key":"B70","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3390\/biomedicines10020224","article-title":"Choroid Plexus in Alzheimer\u2019s Disease\u2014The Current State of Knowledge.","volume":"10","author":"Gi\u00e3o","year":"2022","journal-title":"Biomedicines"},{"key":"B71","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1152\/ajpheart.01275.2004.-Results","article-title":"Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia.","volume":"289","author":"Gidday","year":"2005","journal-title":"Am. J. Physiol. Heart Circulatory Physiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"324","DOI":"10.4049\/jimmunol.1300858","article-title":"\u03b2 2 Integrin\u2013mediated crawling on endothelial ICAM-1 and ICAM-2 Is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood\u2013brain barrier.","volume":"192","author":"Gorina","year":"2014","journal-title":"J. Immunol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12987-019-0123-z","article-title":"Claudin-5: Gatekeeper of neurological function.","volume":"16","author":"Greene","year":"2019","journal-title":"Fluids Barriers of the CNS"},{"key":"B74","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.pharmthera.2013.03.009","article-title":"Matrix metalloproteinase (MMP)-9: A proximal biomarker for cardiac remodeling and a distal biomarker for inflammation.","volume":"139","author":"Halade","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"B75","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1161\/01.str.17.2.246","article-title":"Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period.","volume":"17","author":"Hallenbeck","year":"1986","journal-title":"Stroke"},{"key":"B76","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3109\/00207454.2011.623808","article-title":"Combination of reactive oxygen species and tissue-type plasminogen activator enhances the induction of gelatinase B in brain endothelial cells.","volume":"122","author":"Harada","year":"2012","journal-title":"Int. J. Neurosci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s00401-020-02187-x","article-title":"Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood\u2013brain barrier.","volume":"140","author":"Hauptmann","year":"2020","journal-title":"Acta Neuropathol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1038\/S41593-018-0213-2","article-title":"Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration.","volume":"21","author":"Herisson","year":"2018","journal-title":"Nat. Neurosci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"3609","DOI":"10.1016\/J.NEURON.2021.10.022","article-title":"GABAergic neuronal IL-4R mediates T cell effect on memory.","volume":"109","author":"Herz","year":"2021","journal-title":"Neuron"},{"key":"B80","doi-asserted-by":"publisher","first-page":"102939","DOI":"10.1016\/j.nicl.2022.102939","article-title":"Leptomeningeal enhancement in multiple sclerosis and other neurological diseases: A systematic review and Meta-Analysis.","volume":"33","author":"Ineichen","year":"2022","journal-title":"NeuroImage"},{"key":"B81","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/S12031-011-9496-4","article-title":"Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood-brain barrier in a focal cerebral ischemic insult.","volume":"44","author":"Jiao","year":"2011","journal-title":"J. Mol. Neurosci."},{"key":"B82","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/S0167-5699(99)01544-3","article-title":"The \u03b14-integrin: An alternative pathway for neutrophil recruitment?","volume":"20","author":"Johnston","year":"1999","journal-title":"Immunol. Today"},{"key":"B83","doi-asserted-by":"publisher","first-page":"eaat7554","DOI":"10.1126\/science.aat7554","article-title":"Neuroimmunology: Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation.","volume":"363","author":"Jord\u00e3o","year":"2019","journal-title":"Science"},{"key":"B84","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1177\/0272989","article-title":"Variation and information in white blood cell differential counts.","volume":"4","author":"Juul","year":"1984","journal-title":"Med. Dec. Making"},{"key":"B85","doi-asserted-by":"publisher","first-page":"3000","DOI":"10.1161\/STROKEAHA.107.489765","article-title":"NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke.","volume":"38","author":"Kahles","year":"2007","journal-title":"Stroke"},{"key":"B86","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1038\/s41467-020-16191-y","article-title":"Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke.","volume":"11","author":"Kang","year":"2020","journal-title":"Nat. Commun."},{"key":"B87","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12987-018-0120-7","article-title":"Choroid plexus genes for CSF production and brain homeostasis are altered in Alzheimer\u2019s disease.","volume":"15","author":"Kant","year":"2018","journal-title":"Fluids Barriers CNS"},{"key":"B88","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1097\/01.WCB.0000117812.35136.5B","article-title":"Leukocyte-endothelium interactions during permanent focal cerebral ischemia in mice.","volume":"24","author":"Kataoka","year":"2004","journal-title":"J. Cerebral Blood Flow Mmetabolism"},{"key":"B89","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.4049\/jimmunol.169.2.1000","article-title":"Overlapping roles of P-Selectin and \u03b1 4 integrin to recruit leukocytes to the central nervous system in experimental autoimmune encephalomyelitis.","volume":"169","author":"Kerfoot","year":"2002","journal-title":"J. Immunol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1093\/brain\/121.1.159","article-title":"Matrix metalloproteinase-9 and-7 are regulated in experimental autoimmune encephalomyelitis.","volume":"121","author":"Kieseier","year":"1998","journal-title":"Brain"},{"key":"B91","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1124\/jpet.116.235127","article-title":"Myeloperoxidase inhibition increases neurogenesis after ischemic stroke.","volume":"359","author":"Kim","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1177\/0271678","article-title":"Reducing myeloperoxidase activity decreases inflammation and increases cellular protection in ischemic stroke.","volume":"39","author":"Kim","year":"2019","journal-title":"J. Cerebral Blood Flow Metabolism"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1002\/glia.23174","article-title":"Astrocyte-derived lipocalin-2 mediates hippocampal damage and cognitive deficits in experimental models of vascular dementia.","volume":"65","author":"Kim","year":"2017","journal-title":"Glia"},{"key":"B94","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s40478-019-0747-x","article-title":"Neutrophil extracellular trap induced by HMGB1 exacerbates damages in the ischemic brain.","volume":"7","author":"Kim","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"B95","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation.","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s00401-013-1227-1","article-title":"Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation.","volume":"128","author":"Kooij","year":"2014","journal-title":"Acta Neuropathol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1007\/s00418-012-1001-9","article-title":"Complexity and developmental changes in the expression pattern of claudins at the blood-CSF barrier.","volume":"138","author":"Kratzer","year":"2012","journal-title":"Histochem. Cell Biol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3389\/fphar.2012.00075","article-title":"Pathological alteration in the choroid plexus of Alzheimer\u2019s disease: Implication for new therapy aroaches.","volume":"3","author":"Krzyzanowska","year":"2012","journal-title":"Front. Pharmacol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"3427","DOI":"10.1093\/brain\/awt259","article-title":"IFN-\u03b3-dependent activation of the brain\u2019s choroid plexus for CNS immune surveillance and repair.","volume":"136","author":"Kunis","year":"2013","journal-title":"Brain"},{"key":"B100","doi-asserted-by":"publisher","first-page":"3070","DOI":"10.1161\/CIRCULATIONAHA.112.097097","article-title":"Neutrophil-Derived Matrix Metalloproteinase 9 Triggers Acute Aortic Dissection.","volume":"26","author":"Kurihara","year":"2012","journal-title":"Circulation."},{"key":"B101","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/J.JNEUMETH.2014.03.002","article-title":"Interleukin-1\u03b2 induces an inflammatory response and the breakdown of the endothelial cell layer in an improved human THBMEC-based in vitro blood-brain barrier model.","volume":"228","author":"Labus","year":"2014","journal-title":"J. Neurosci. Methods"},{"key":"B102","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/J.MVR.2004.07.005","article-title":"Hydrogen peroxide-induced alterations of tight junction proteins in bovine brain microvascular endothelial cells.","volume":"68","author":"Lee","year":"2004","journal-title":"Microvasc. Res."},{"key":"B103","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/NRI2156","article-title":"Getting to the site of inflammation: The leukocyte adhesion cascade updated.","volume":"7","author":"Ley","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.2174\/1570159","article-title":"The Role of VE-cadherin in Blood-brain Barrier Integrity Under Central Nervous System Pathological Conditions Current Neuropharmacology.","author":"Li","year":"2018"},{"key":"B105","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/1742-2094-10-80","article-title":"Disruption of the blood-brain barrier after generalized tonic-clonic seizures correlates with cerebrospinal fluid MMP-9 levels.","volume":"10","author":"Li","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"B106","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s00401-018-1815-1","article-title":"Functional morphology of the blood\u2013brain barrier in health and disease.","volume":"135","author":"Liebner","year":"2018","journal-title":"Acta Neuropathol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/s41467-020-14373-2","article-title":"Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia.","volume":"11","author":"Llorens","year":"2020","journal-title":"Nat. Commun."},{"key":"B108","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/s41586-019-0964-2","article-title":"\u03b2-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration.","volume":"566","author":"Lodygin","year":"2019","journal-title":"Nature"},{"key":"B109","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.4049\/jimmunol.178.2.1136","article-title":"CD99 Is a Key Mediator of the Transendothelial Migration of Neutrophils.","volume":"178","author":"Lou","year":"2007","journal-title":"J. Immunol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/NATURE14432","article-title":"Structural and functional features of central nervous system lymphatic vessels.","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature"},{"key":"B111","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nrn3921","article-title":"Development and functions of the choroid plexus-cerebrospinal fluid system.","volume":"6","author":"Lun","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"B112","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1038\/sj.bjp.0707358","article-title":"Myeloperoxidase: A target for new drug development?","volume":"152","author":"Malle","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"136","DOI":"10.3389\/FNCEL.2015.00136\/BIBTEX","article-title":"The choroid plexus is modulated by various peripheral stimuli: Implications to diseases of the central nervous system.","volume":"9","author":"Marques","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"B114","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3389\/fncel.2012.00033","article-title":"Lipocalin 2 is present in the EAE brain and is modulated by natalizumab.","volume":"6","author":"Marques","year":"2012","journal-title":"Front. Cell. Neurosci."},{"key":"B115","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1038\/jcbfm.2009.15","article-title":"Kinetic profile of the transcriptome changes induced in the choroid plexus by peripheral inflammation.","volume":"29","author":"Marques","year":"2009","journal-title":"J. Cerebral Blood Flow Metabolism"},{"key":"B116","doi-asserted-by":"publisher","first-page":"eaav0492","DOI":"10.1126\/sciimmunol.aav0492","article-title":"The anatomy and immunology of vasculature in the central nervous system.","volume":"4","author":"Mastorakos","year":"2019","journal-title":"Sci. Immunol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1161\/01.str.25.7.1469","article-title":"Correlation between myeloperoxidase-quantified neutrophil accumulation and ischemic brain injury in the rat effects of neutrophil depletion.","volume":"25","author":"Matsuo","year":"1994","journal-title":"Stroke"},{"key":"B118","doi-asserted-by":"publisher","first-page":"390","DOI":"10.4161\/cam.21054","article-title":"Cell trafficking through the choroid plexus.","volume":"6","author":"Meeker","year":"2012","journal-title":"Cell Adhesion Migration"},{"key":"B119","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/S11055-009-9110-1","article-title":"Leukocyte-endothelial interactions in pial arterioles and venules on development of cerebral ischemia in rats.","volume":"39","author":"Mel\u2019nikova","year":"2009","journal-title":"Neurosci. Behavioral Physiol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1038\/s41380-020-0731-7","article-title":"Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: A conceptual framework.","volume":"26","author":"Mentis","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"B121","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1097\/00005072-199812000-00012","article-title":"Curly fiber and tangle-like inclusions in the ependyma and choroid Plexus\u2014A pathogenetic relationship with the cortical alzheimer-type changes?","volume":"57","author":"Miklossy","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1038\/s41598-022-05627-8","article-title":"Aluminium co-localises with Biondi ring tangles in Parkinson\u2019s disease and epilepsy.","volume":"12","author":"Mold","year":"2022","journal-title":"Sci. Rep."},{"key":"B123","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1189\/jlb.3a1215-568r","article-title":"TLR2-mediated leukocyte trafficking to the developing brain.","volume":"101","author":"Mottahedin","year":"2017","journal-title":"J. Leukocyte Biol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1097\/NEN.0B013E31820D94A5","article-title":"Neutrophil depletion reduces blood-brain barrier breakdown, axon injury, and inflammation after intracerebral hemorrhage.","volume":"70","author":"Moxon-Emre","year":"2011","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.immuni.2018.01.011","article-title":"High-dimensional single-cell maing of central nervous system immune cells reveals distinct myeloid subsets in health, aging, and disease.","volume":"48","author":"Mrdjen","year":"2018","journal-title":"Immunity"},{"key":"B126","doi-asserted-by":"publisher","first-page":"R1203","DOI":"10.1152\/ajpregu.1998.274.5.R1203","article-title":"Gelatinase B modulates selective opening of the blood-brain barrier during inflammation.","volume":"274","author":"Mun-bryce","year":"1998","journal-title":"Am. J. Physiol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"21036","DOI":"10.1074\/jbc.M109.016766","article-title":"Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability.","volume":"284","author":"Murakami","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B128","doi-asserted-by":"publisher","first-page":"639140","DOI":"10.3389\/fnins.2021.639140","article-title":"Glymphatic System as a Gateway to Connect Neurodegeneration From Periphery to CNS.","volume":"15","author":"Natale","year":"2021","journal-title":"Front. Neurosci."},{"key":"B129","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1046\/J.1365-2249.2002.01855.X","article-title":"Up-regulation of MMP-8 and MMP-9 activity in the BALB\/c mouse spinal cord correlates with the severity of experimental autoimmune encephalomyelitis.","volume":"128","author":"Nyg\u00e5rdas","year":"2002","journal-title":"Clin. Exp. Immunol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/J.CELL.2017.08.006","article-title":"Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch.","volume":"171","author":"Oetjen","year":"2017","journal-title":"Cell"},{"key":"B131","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12974-017-0801-1","article-title":"Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis.","volume":"14","author":"Ong","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"B132","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1161\/STROKEAHA.118.023837","article-title":"Location of neutrophils in different compartments of the damaged mouse brain after severe ischemia\/reperfusion.","volume":"50","author":"Otxoa-De-Amezaga","year":"2019","journal-title":"Stroke"},{"key":"B133","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00401-014-1381-0","article-title":"Neutrophil recruitment to the brain in mouse and human ischemic stroke.","volume":"129","author":"Perez-de-Puig","year":"2015","journal-title":"Acta Neuropathol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"5805","DOI":"10.4049\/JIMMUNOL.174.9.5805","article-title":"Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VII.","volume":"174","author":"Piccio","year":"2005","journal-title":"J. Immunol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.4049\/JIMMUNOL.168.4.1940","article-title":"Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: Critical Roles for P-Selectin Glycoprotein Ligand-1 and Heterotrimeric Gi-Linked Receptors.","volume":"168","author":"Piccio","year":"2002","journal-title":"J. Immunol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"211","DOI":"10.3389\/fimmu.2017.00211","article-title":"NETosis in Alzheimer\u2019s disease.","volume":"8","author":"Pietronigro","year":"2017","journal-title":"Front. Immunol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3389\/fimmu.2016.00033","article-title":"Imaging of leukocyte trafficking in Alzheimer\u2019s disease.","volume":"7","author":"Pietronigro","year":"2016","journal-title":"Front. Immunol."},{"key":"B138","doi-asserted-by":"publisher","first-page":"12055","DOI":"10.1038\/s41598-019-48538-x","article-title":"Blockade of \u03b14 integrins reduces leukocyte\u2013endothelial interactions in cerebral vessels and improves memory in a mouse model of Alzheimer\u2019s disease.","volume":"9","author":"Pietronigro","year":"2019","journal-title":"Sci. Rep."},{"key":"B139","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1016\/j.immuni.2015.11.010","article-title":"Integration of Th17- and Lymphotoxin-derived signals initiates meningeal-resident stromal cell remodeling to propagate neuroinflammation.","volume":"43","author":"Pikor","year":"2015","journal-title":"Immunity"},{"key":"B140","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1093\/aje\/kwj146","article-title":"Myeloperoxidase polymorphism and cognitive decline in older adults in the health, aging, and body composition study.","volume":"163","author":"Pope","year":"2006","journal-title":"Am. J. Epidemiol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/NN.4475","article-title":"The role of peripheral immune cells in the CNS in steady state and disease.","volume":"20","author":"Prinz","year":"2017","journal-title":"Nat. Neurosci."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.3171\/2010.12.JNS101732","article-title":"The collagenic architecture of human dura mater: Laboratory investigation.","volume":"114","author":"Protasoni","year":"2011","journal-title":"J. Neurosurgery"},{"key":"B143","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1148\/radiol.14141495","article-title":"Multiple sclerosis: Myeloperoxidase immunoradiology improves detection of acute and chronic disease in experimental model.","volume":"275","author":"Pulli","year":"2015","journal-title":"Radiology"},{"key":"B144","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3389\/fnagi.2014.00247","article-title":"Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer\u2019s disease: Evidence for a pro-amyloidogenic role of MT1-MMP.","volume":"6","author":"Py","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"B145","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.brainres.2013.09.044","article-title":"Increased metalloprotease activity in the epileptogenic lesion - Lobectomy reduces metalloprotease activity and urokinase-type uPAR circulating levels.","volume":"1538","author":"Quirico-Santos","year":"2013","journal-title":"Brain Res."},{"key":"B146","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/mp.2013.79","article-title":"Dynamics of the meningeal CD4 + T-cell repertoire are defined by the cervical lymph nodes and facilitate cognitive task performance in mice.","volume":"19","author":"Radjavi","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"B147","doi-asserted-by":"publisher","first-page":"C906","DOI":"10.1152\/ajpcell.2000.279.4.C906","article-title":"Protein kinase C-mediates TNF-induced ICAM-1 gene transcription in endothelial cells.","volume":"279","author":"Rahman","year":"2000","journal-title":"Am. J. physiol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/nri1130","article-title":"Three or more routes for leukocyte migration into the central nervous system.","volume":"3","author":"Ransohoff","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1006\/exnr.1998.6977","article-title":"Myeloperoxidase polymorphism Is associated with gender specific risk for alzheimer\u2019s disease.","volume":"155","author":"Reynolds","year":"1999","journal-title":"Exp. Neurol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"eaay5199","DOI":"10.1126\/sciimmunol.aay5199","article-title":"Meningeal \u03b3\u03b4 T cell-derived IL-17 controls synaptic plasticity and short-term memory.","volume":"4","author":"Ribeiro","year":"2019","journal-title":"Sci. Immunol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"9472","DOI":"10.1073\/pnas.87.23.9472","article-title":"Tumor necrosis factor-induced degranulation in adherent human neutrophils is dependent on CD1lb\/CD18-integrin-triggered oscillations of cytosolic free Ca2 +.","volume":"87","author":"Richter","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S. A."},{"key":"B152","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s40478-020-0885-1","article-title":"Inflammation of the choroid plexus in progressive multiple sclerosis: Accumulation of granulocytes and T cells.","volume":"8","author":"Rodr\u00edguez-Lorenzo","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"B153","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1089\/ars.2013.5745","article-title":"Redox control of microglial function: Molecular mechanisms and functional significance.","volume":"21","author":"Rojo","year":"2014","journal-title":"Antioxidants Redox Signaling"},{"key":"B154","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1161\/01.str.29.5.1020","article-title":"Matrix metalloproteinase expression increases after cerebral focal ischemia in rats inhibition of matrix metalloproteinase-9 reduces infarct size.","volume":"29","author":"Romanic","year":"1998","journal-title":"Stroke"},{"key":"B155","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1161\/STROKEAHA.107.500868","article-title":"MMP-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke.","volume":"39","author":"Rosell","year":"2008","journal-title":"Stroke"},{"key":"B156","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1189\/jlb.0710432","article-title":"Vascular inflammation in central nervous system diseases: Adhesion receptors controlling leukocyte-endothelial interactions.","volume":"89","author":"Rossi","year":"2011","journal-title":"J. Leukocyte Biol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"151865","DOI":"10.1016\/j.imbio.2019.10.014","article-title":"The emerging role of neutrophils in neurodegeneration.","volume":"225","author":"Rossi","year":"2020","journal-title":"Immunobiology"},{"key":"B158","doi-asserted-by":"publisher","first-page":"639369","DOI":"10.3389\/fimmu.2021.639369","article-title":"Common peripheral immunity mechanisms in multiple sclerosis and Alzheimer\u2019s disease.","volume":"12","author":"Rossi","year":"2021","journal-title":"Front. Immunol."},{"key":"B159","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.molmed.2018.04.003","article-title":"Advances in Meningeal Immunity.","volume":"24","author":"Rua","year":"2018","journal-title":"Trends Mol. Med."},{"key":"B160","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.trsl.2014.08.005","article-title":"The meninges: New therapeutic targets for multiple sclerosis.","volume":"165","author":"Russi","year":"2015","journal-title":"Trans. Res."},{"key":"B161","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.cell.2020.12.040","article-title":"Functional characterization of the dural sinuses as a neuroimmune interface.","volume":"184","author":"Rustenhoven","year":"2021","journal-title":"Cell"},{"key":"B162","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.schres.2009.02.005","article-title":"Functional polymorphism of the matrix metalloproteinase-9 (MMP-9). gene in schizophrenia.","volume":"109","author":"Rybakowski","year":"","journal-title":"Schizophrenia Res."},{"key":"B163","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/S12017-009-8072-3","article-title":"Matrix metalloproteinase-9 gene and bipolar mood disorder.","volume":"11","author":"Rybakowski","year":"","journal-title":"Neuromolec. Med."},{"key":"B164","doi-asserted-by":"publisher","first-page":"279814","DOI":"10.1155\/2015\/279814","article-title":"Histology and morphology of the brain subarachnoid trabeculae.","volume":"2015","author":"Saboori","year":"2015","journal-title":"Anatomy Res. Int."},{"key":"B165","doi-asserted-by":"publisher","first-page":"851","DOI":"10.3390\/CELLS9040851","article-title":"Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles.","volume":"9","author":"Saint-Pol","year":"2020","journal-title":"Cells"},{"key":"B166","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s11010-009-0088-3","article-title":"Hiocampal neurodegeneration in experimental autoimmune encephalomyelitis (EAE): Potential role of inflammation activated myeloperoxidase.","volume":"328","author":"Sajad","year":"2009","journal-title":"Mol. Cell. Biochem."},{"key":"B167","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s40478-020-00968-9","article-title":"Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis.","volume":"8","author":"Saul","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"B168","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nature16939","article-title":"Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid.","volume":"530","author":"Schl\u00e4ger","year":"2016","journal-title":"Nature"},{"key":"B169","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/1742-2094-9-187","article-title":"Brain leukocyte infiltration initiated by peripheral inflammation or experimental autoimmune encephalomyelitis occurs through pathways connected to the CSF-filled compartments of the forebrain and midbrain.","volume":"9","author":"Schmitt","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"B170","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/embj.201386609","article-title":"The resolution of neuroinflammation in neurodegeneration: Leukocyte recruitment via the choroid plexus.","volume":"33","author":"Schwartz","year":"2014","journal-title":"EMBO J."},{"key":"B171","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/PL00007412","article-title":"Morphological alterations of the choroid plexus in late-onset Alzheimer\u2019s disease.","volume":"99","author":"Serot","year":"2000","journal-title":"Acta Neuropathol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1172\/JCI8692","article-title":"The CD44-initiated pathway of T-cell extravasation uses VLA-4 but not LFA-1 for firm adhesion.","volume":"105","author":"Siegelman","year":"2000","journal-title":"J. Clin. Inves."},{"key":"B173","doi-asserted-by":"publisher","first-page":"2544","DOI":"10.3389\/FNEUR.2021.807658\/BIBTEX","article-title":"Adhesion of leukocytes to cerebral venules precedes neuronal cell death and is sufficient to trigger tissue damage after cerebral ischemia.","volume":"12","author":"Sienel","year":"2022","journal-title":"Front. Neurol."},{"key":"B174","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1515\/revneuro-2018-0017","article-title":"Cortical and meningeal pathology in progressive multiple sclerosis: A new therapeutic target?","volume":"30","author":"Silva","year":"2019","journal-title":"Rev. Neurosci."},{"key":"B175","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1212\/WNL.57.10.1763","article-title":"The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer\u2019s type.","volume":"57","author":"Silverberg","year":"2001","journal-title":"Neurology"},{"key":"B176","doi-asserted-by":"publisher","first-page":"4593","DOI":"10.1038\/s41467-018-07053-9","article-title":"Tissue-resident memory T cells populate the human brain.","volume":"9","author":"Smolders","year":"2018","journal-title":"Nat. Commun."},{"key":"B177","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s40478-022-01347-2","article-title":"Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer\u2019s disease.","volume":"10","author":"Smyth","year":"2022","journal-title":"Acta Neuropathol. Commun."},{"key":"B178","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1093\/jnen\/63.4.338","article-title":"Activation of matrix metalloproteinase-3 and agrin cleavage in cerebral ischemia\/reperfusion.","volume":"63","author":"Sol\u00e9","year":"2004","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B179","first-page":"1819","article-title":"ICAM-1, VCAM-1, and MAdCAM-1 are expressed on choroid plexus epithelium but not endothelium and mediate binding of lymphocytes in vitro.","volume":"148","author":"Steffen","year":"1996","journal-title":"Am. J. Pathol."},{"key":"B180","first-page":"189","article-title":"Evidence for Involvement of IAM-1 and VCAM-1 in Lymphocyte Interaction with Endothelium in Experimental Autoimmune Encephalomyelitis in the Central Nervous System in the SJL\/J Mouse.","volume":"145","author":"Steffen","year":"1994","journal-title":"Am. J. Pathol."},{"key":"B181","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3389\/fnana.2016.00016","article-title":"Claudin-1, -2 and -3 are selectively expressed in the epithelia of the choroid plexus of the mouse from early development and into adulthood while claudin-5 is restricted to endothelial cells.","volume":"10","author":"Steinemann","year":"2016","journal-title":"Front. Neuroanatomy"},{"key":"B182","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1172\/JCI20682","article-title":"VEGF: A critical player in neurodegeneration.","volume":"113","author":"Storkebaum","year":"2004","journal-title":"J. Clin. Inves."},{"key":"B183","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.3389\/fimmu.2018.01066","article-title":"The choroid plexus functions as a niche for T-cell stimulation within the central nervous system.","volume":"9","author":"Strominger","year":"2018","journal-title":"Front. Immunol."},{"key":"B184","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s00281-013-0412-6","article-title":"Neutrophil and monocyte recruitment by PECAM. CD99, and other molecules via the LBRC.","volume":"36","author":"Sullivan","year":"2014","journal-title":"Sem. Immunopathol."},{"key":"B185","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1523\/JNEUROSCI.4391-06.2007","article-title":"Matrix metalloproteinase-9 gene knock-out protects the immature brain after cerebral hypoxia\u2013ischemia.","volume":"27","author":"Svedin","year":"2007","journal-title":"J. Neurosci."},{"key":"B186","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1152\/PHYSREV.00050.2017","article-title":"Blood-brain barrier: From physiology to disease and back.","volume":"99","author":"Sweeney","year":"2019","journal-title":"Physiol. Rev."},{"key":"B187","doi-asserted-by":"publisher","first-page":"e0167677","DOI":"10.1371\/journal.pone.0167677","article-title":"The involvement of pial microvessels in leukocyte invasion after mild traumatic brain injury.","volume":"11","author":"Szmydynger-Chodobska","year":"2016","journal-title":"PLoS One"},{"key":"B188","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/jcbfm.2011.111","article-title":"Posttraumatic invasion of monocytes across the blood-cerebrospinal fluid barrier.","volume":"32","author":"Szmydynger-Chodobska","year":"2012","journal-title":"J. Cerebral Blood Flow Metabolism"},{"key":"B189","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1038\/jcbfm.2009.71","article-title":"The role of the choroid plexus in neutrophil invasion after traumatic brain injury.","volume":"29","author":"Szmydynger-Chodobska","year":"2009","journal-title":"J. Cerebral Blood Metabolism"},{"key":"B190","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.neurobiolaging.2020.01.005","article-title":"Choroid plexus volume is associated with levels of CSF proteins: Relevance for Alzheimer\u2019s and Parkinson\u2019s disease.","volume":"89","author":"Tadayon","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"B191","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.neuint.2010.03.003","article-title":"Matrix metalloproteinase-9 activity increased by two different types of epileptic seizures that do not induce neuronal death: A possible role in homeostatic synaptic plasticity.","volume":"56","author":"Tak\u00e1cs","year":"2010","journal-title":"Neurochem. Int."},{"key":"B192","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1083\/jcb.201412147","article-title":"Brain barriers: Crosstalk between complex tight junctions and adherens junctions.","volume":"209","author":"Tietz","year":"2015","journal-title":"J. Cell Biol."},{"key":"B193","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1046\/j.1432-1327.2001.02066.x","article-title":"The human neutrophil lipocalin suorts the allosteric activation of matrix metalloproteinases.","volume":"268","author":"Tschesche","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"B194","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/B978-0-12-804279-3.00002-2","article-title":"The cerebrospinal fluid and barriers - anatomic and physiologic considerations.","volume":"146","author":"Tumani","year":"2017","journal-title":"Handbook Clin. Neurol."},{"key":"B195","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3389\/fncel.2016.00056","article-title":"Implications of MMP9 for blood brain barrier disruption and hemorrhagic transformation following ischemic stroke.","volume":"10","author":"Turner","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"B196","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1007\/s12035-018-1207-5","article-title":"Involvement of claudin-11 in disruption of blood-brain, -spinal cord, and -arachnoid barriers in multiple sclerosis.","volume":"56","author":"Uchida","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"B197","doi-asserted-by":"publisher","first-page":"e64034","DOI":"10.1371\/journal.pone.0064034","article-title":"Myeloperoxidase-derived oxidants induce blood-brain barrier dysfunction in vitro and in vivo.","volume":"8","author":"\u00dcllen","year":"2013","journal-title":"PLoS One"},{"key":"B198","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1038\/s41593-019-0393-4","article-title":"A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.","volume":"22","author":"Van Hove","year":"2019","journal-title":"Nat. Neurosci."},{"key":"B199","doi-asserted-by":"publisher","first-page":"e1382671","DOI":"10.1080\/21688370.2017.1382671","article-title":"Phosphorylation of tight junction transmembrane proteins: Many sites, much to do.","volume":"6","author":"Van Itallie","year":"2018","journal-title":"Tissue Barriers"},{"key":"B200","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jneuroim.2008.04.035","article-title":"Involvement of the choroid plexus in multiple sclerosis autoimmune inflammation: A neuropathological study.","volume":"199","author":"Vercellino","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"B201","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/NRI3908","article-title":"How leukocytes cross the vascular endothelium.","volume":"15","author":"Vestweber","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"B202","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3389\/FNCEL.2019.00405\/BIBTEX","article-title":"The evolving concept of the blood brain barrier (BBB): From a single static barrier to a heterogeneous and dynamic relay center.","volume":"13","author":"Villabona-Rueda","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"B203","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.1182\/blood-2013-04-499228","article-title":"How T cells trigger the dissociation of the endothelial receptor phosphatase VE-PTP from VE-cadherin.","volume":"122","author":"Vockel","year":"2013","journal-title":"Blood"},{"key":"B204","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jneuroim.2014.12.009","article-title":"Dynamic changes in meningeal inflammation correspond to clinical exacerbations in a murine model of relapsing-remitting multiple sclerosis.","volume":"278","author":"Walker-Caulfield","year":"2015","journal-title":"J. Neuroimmunol."},{"key":"B205","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1002\/jlb.56.5.625","article-title":"Cross-linking of CD18 in human neutrophils induces an increase of intracellular free Ca2 +, exocytosis of azurophilic granules, quantitative up-regulation of CD18, shedding of L-selectin, and actin polymerization.","volume":"56","author":"Walzog","year":"1994","journal-title":"J. Leukocyte Biol."},{"key":"B206","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1152\/jn.00510.2016","article-title":"Resveratrol defends blood-brain barrier integrity in experimental autoimmune encephalomyelitis mice.","volume":"116","author":"Wang","year":"2016","journal-title":"J. Neurophysiol."},{"key":"B207","doi-asserted-by":"publisher","first-page":"6253","DOI":"10.3390\/ijms21176253","article-title":"Neutralization of lipocalin-2 diminishes stroke-reperfusion injury.","volume":"21","author":"Wang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B208","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1089\/152308602753625843","article-title":"The signaling pathways induced by neutrophil-endothelial cell adhesion.","volume":"4","author":"Wang","year":"2002","journal-title":"Antioxidants Redox Signaling"},{"key":"B209","doi-asserted-by":"publisher","first-page":"H434","DOI":"10.1152\/ajpheart.2001.280.1.H434","article-title":"VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly.","volume":"280","author":"Wang","year":"2001","journal-title":"Heart Circulatory physiol."},{"key":"B210","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.4103\/1673-5374.332130","article-title":"Myeloperoxidase: A new target for the treatment of stroke?","volume":"17","author":"Wang","year":"2022","journal-title":"Neural Regen. Res."},{"key":"B211","doi-asserted-by":"publisher","first-page":"e110024","DOI":"10.1371\/journal.pone.0110024","article-title":"Interleukin-1\u03b2 induces blood-brain barrier disruption by downregulating sonic hedgehog in astrocytes.","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"B212","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1038\/289646A0","article-title":"Control of vascular permeability by polymorphonuclear leukocytes in inflammation.","volume":"289","author":"Wedmore","year":"1981","journal-title":"Nature"},{"key":"B213","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/s0006-899301466-3","article-title":"Biondi ring tangles in the choroid plexus of Alzheimer\u2019s disease and normal aging brains: A quantitative study.","volume":"832","author":"Wen","year":"1999","journal-title":"Brain Res."},{"key":"B214","doi-asserted-by":"publisher","first-page":"278","DOI":"10.4172\/2155-9562.1000278","article-title":"Neutrophil gelatinase-associated lipocalin and matrix metalloproteinase-9 as potential biomarkers for stroke: A Pilot Study.","volume":"6","author":"Weng","year":"2015","journal-title":"J. Neurol. Neurophysiol."},{"key":"B215","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.msard.2018.09.025","article-title":"Leptomeningeal inflammation in multiple sclerosis: Insights from animal and human studies.","volume":"26","author":"Wicken","year":"2018","journal-title":"Mult. Scler. Relat. Disord."},{"key":"B216","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1083\/jcb.200708213","article-title":"Important role of matrix metalloproteinase 9 in epileptogenesis.","volume":"180","author":"Wilczynski","year":"2008","journal-title":"J. Cell Biol."},{"key":"B217","doi-asserted-by":"publisher","first-page":"3979","DOI":"10.4049\/jimmunol.0801218","article-title":"CD4-Positive T Lymphocytes Provide a Neuroimmunological Link in the Control of Adult Hiocampal Neurogenesis.","volume":"182","author":"Wolf","year":"2009","journal-title":"J. Immunol."},{"key":"B218","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0165-572890170-p","article-title":"Upregulation of intercellular adhesion molecule-1 (ICAM-1). expression in primary cultures of human brain microvessel endothelial cells by cytokines and lipopolysaccharide.","volume":"39","author":"Wong","year":"1992","journal-title":"J. Neuroimmunol."},{"key":"B219","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s00418-009-0673-2","article-title":"Extensive infiltration of neutrophils in the acute phase of experimental autoimmune encephalomyelitis in C57BL\/6 mice.","volume":"133","author":"Wu","year":"2010","journal-title":"Histochem. Cell Biol."},{"key":"B220","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1124\/DMD.112.050344","article-title":"Drug transporters on arachnoid barrier cells contribute to the blood-cerebrospinal fluid barrier.","volume":"41","author":"Yasuda","year":"2013","journal-title":"Drug Metabolism Disposition"},{"key":"B221","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1124\/jpet.117.245688","article-title":"Inhibition of myeloperoxidase by N-Acetyl lysyltyrosylcysteine amide reduces oxidative stress-mediated inflammation, neuronal damage, and neural stem cell injury in a murine model of stroke.","volume":"364","author":"Yu","year":"2018","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B222","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1001\/ARCHNEUR.61.3.341","article-title":"Increased risk for Alzheimer disease with the interaction of MPO and A2M polymorphisms.","volume":"61","author":"Zappia","year":"2004","journal-title":"Arch. Neurol."},{"key":"B223","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.nbd.2016.07.007","article-title":"The blood-brain barrier in Alzheimer\u2019s disease.","volume":"107","author":"Zenaro","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"B224","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/nm.3913","article-title":"Neutrophils promote Alzheimer\u2019s disease-like pathology and cognitive decline via LFA-1 integrin.","volume":"21","author":"Zenaro","year":"2015","journal-title":"Nat. Med."},{"key":"B225","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1111\/jnc.13426","article-title":"Inhibition of myeloperoxidase at the peak of experimental autoimmune encephalomyelitis restores blood-brain barrier integrity and ameliorates disease severity.","volume":"136","author":"Zhang","year":"2016","journal-title":"J. Neurochem."},{"key":"B226","doi-asserted-by":"publisher","first-page":"5244","DOI":"10.4049\/jimmunol.0901309","article-title":"Role of Endothelial TLR4 for Neutrophil Recruitment into Central Nervous System Microvessels in Systemic Inflammation.","volume":"183","author":"Zhou","year":"2009","journal-title":"J. Immunol."},{"key":"B227","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.neuron.2008.01.003","article-title":"The blood-brain barrier in health and chronic neurodegenerative disorders.","volume":"57","author":"Zlokovic","year":"2008","journal-title":"Neuron"},{"key":"B228","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40035-019-0147-y","article-title":"Blocking meningeal lymphatic drainage aggravates Parkinson\u2019s disease-like pathology in mice overexpressing mutated \u03b1-synuclein.","volume":"8","author":"Zou","year":"2019","journal-title":"Trans. Neurodegener."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2022.965169\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T07:44:32Z","timestamp":1660203872000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2022.965169\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,11]]},"references-count":228,"alternative-id":["10.3389\/fnagi.2022.965169"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2022.965169","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,11]]},"article-number":"965169"}}