{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:14:57Z","timestamp":1790612097691,"version":"4.1.0"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971237"],"award-info":[{"award-number":["81971237"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Cognitive and motor dysfunctions in older people become more evident while dual-tasking. Several dual-task paradigms have been used to identify older individuals at the risk of developing Alzheimer\u2019s disease and dementia. This study evaluated gait kinematic parameters for dual-task (DT) conditions in older adults with mild cognitive impairment (MCI), subjective cognitive decline (SCD), and normal cognition (NC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This is a cross-sectional, clinical-based study carried out at the Zhongshan Rehabilitation Branch of First Affiliated Hospital of Nanjing Medical University, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>We recruited 83 community-dwelling participants and sorted them into MCI (<jats:italic>n<\/jats:italic>\u2009=\u200924), SCD (<jats:italic>n<\/jats:italic>\u2009=\u200933), and NC (<jats:italic>n<\/jats:italic>\u2009=\u200926) groups based on neuropsychological tests. Their mean age was 72.0 (5.55) years, and male\u2013female ratio was 42\/41 (<jats:italic>p<\/jats:italic>\u2009=\u20090.112). Each participant performed one single-task walk and four DT walks: DT calculation with subtracting serial sevens; DT naming animals; DT story recall; and DT words recall.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome and measures<\/jats:title><jats:p>Kinematic gait parameters of speed, knee peak extension angle, and dual-task cost (DTC) were obtained using the Vicon Nexus motion capture system and calculated by Visual 3D software. A mixed-effect linear regression model was used to analyze the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The difference in gait speed under DT story recall and DT calculation was \u22120.099 m\/s and \u2212\u20090.119 m\/s (<jats:italic>p<\/jats:italic>\u2009=\u20090.04, <jats:italic>p<\/jats:italic>\u2009=\u20090.013) between MCI and SCD, respectively. Knee peak extension angle under DT story recall, words recall, and single task was bigger in the MCI group compared to the NC group, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.001, <jats:italic>p<\/jats:italic>\u2009=\u20090.001, <jats:italic>p<\/jats:italic>\u2009=\u20090.004). DTC was higher in the DT story recall test than all other DT conditions (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Kinematic gait parameters of knee peak extension angle for the DT story recall were found to be sensitive enough to discriminate MCI individuals from NC group. DTC under DT story recall was higher than the other DT conditions.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2022.992873","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T05:36:54Z","timestamp":1671082614000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["A novel dual-task paradigm with story recall shows significant differences in the gait kinematics in older adults with cognitive impairment: A cross-sectional study"],"prefix":"10.3389","volume":"14","author":[{"given":"Nawab","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiyun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1186\/s12877-020-01645-1","article-title":"Dual-task tests discriminate between dementia, mild cognitive impairment, subjective cognitive impairment, and healthy controls\u2014a cross-sectional cohort study","volume":"20","author":"\u00c5hman","year":"2020","journal-title":"BMC Geriatr."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.3233\/JAD-190038","article-title":"Structural brain volume covariance associated with gait speed in patients with amnestic and nonamnestic mild cognitive impairment: a double dissociation","volume":"71","author":"Allali","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.neubiorev.2010.08.008","article-title":"Cognitive motor interference while walking: a systematic review and meta-analysis","volume":"35","author":"Al-Yahya","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.arr.2015.09.005","article-title":"Successful aging: advancing the science of physical independence in older adults","volume":"24","author":"Anton","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1080\/13803395.2011.645020","article-title":"Comparison between the story recall test and the word-list learning test in Korean patients with mild cognitive impairment and early stage of Alzheimer's disease","volume":"34","author":"Baek","year":"2011","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1159\/000445831","article-title":"The impact of mild cognitive impairment on gait and balance: a systematic review and meta-analysis of studies using instrumented assessment","volume":"63","author":"Bahureksa","year":"2017","journal-title":"Gerontology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.jamda.2015.12.092","article-title":"Poor gait performance and prediction of dementia: results from a meta-analysis","volume":"17","author":"Beauchet","year":"2016","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1080\/03091900500445353","article-title":"Ageing effects on knee and ankle joint angles at key events and phases of the gait cycle","volume":"30","author":"Begg","year":"2006","journal-title":"J. Med. Eng. Technol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1080\/13607863.2020.1802576","article-title":"Dual task walking costs in older adults with mild cognitive impairment: a systematic review and meta-analysis","volume":"25","author":"Bishnoi","year":"2021","journal-title":"Aging Ment. Health"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3233\/jad-140276","article-title":"Neuropsychological criteria for mild cognitive impairment improves diagnostic precision, biomarker associations, and progression rates","volume":"42","author":"Bondi","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1186\/s12877-022-03405-9","article-title":"Quantitative gait analysis in mild cognitive impairment, dementia, and cognitively intact individuals: a cross-sectional case-control study","volume":"22","author":"Bovonsunthonchai","year":"2022","journal-title":"BMC Geriatr."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1080\/13548500500093688","article-title":"Factor structure of the Chinese version of the geriatric depression scale","volume":"11","author":"Chau","year":"2006","journal-title":"Psychol. Health Med."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1080\/13803395.2020.1817338","article-title":"Insight into memory and functional abilities in individuals with amnestic mild cognitive impairment","volume":"42","author":"Chudoba","year":"2020","journal-title":"J. Clin. Exp. 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A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1186\/s12877-020-01678-6","article-title":"Functional parameters indicative of mild cognitive impairment: a systematic review using instrumented kinematic assessment","volume":"20","author":"Fuentes-Abolafio","year":"2020","journal-title":"BMC Geriatr."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1093\/ageing\/afaa135","article-title":"Functional objective parameters which may discriminate patients with mild cognitive impairment from cognitively healthy individuals: a systematic review and meta-analysis using an instrumented kinematic assessment","volume":"50","author":"Fuentes-Abolafio","year":"2021","journal-title":"Age Ageing"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"102249","DOI":"10.1016\/j.bspc.2020.102249","article-title":"Detection of mild cognitive impairment and Alzheimer's disease using dual-task gait assessments and machine learning","volume":"64","author":"Ghoraani","year":"2021","journal-title":"Biomed. Signal. Process. Control"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1159\/000322196","article-title":"Bridging the gap between clinical and behavioural gerontology part I: promoting late-life mobility and Independence age-related effects on postural control under multi-task conditions","volume":"57","author":"Granacher","year":"2011","journal-title":"Gerontology"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1001\/archneurol.2011.1698","article-title":"Optimizing the Hachinski ischemic scale","volume":"69","author":"Hachinski","year":"2012","journal-title":"Arch. Neurol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"534","DOI":"10.12117\/jccmi.2018.08.002","article-title":"Recommendations for diagnosis and treatment of subjective cognitive decline due to preclinical Alzheimer disease in China","volume":"29","author":"Han","year":"2018","journal-title":"J. Chin. Clin. Med. 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Disord."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/s0149-7634(02)00073-8","article-title":"Relations between aging sensory\/sensorimotor and cognitive functions","volume":"26","author":"Li","year":"2002","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"e028188","DOI":"10.1136\/bmjopen-2018-028188","article-title":"Sino longitudinal study on cognitive decline (SILCODE): protocol for a Chinese longitudinal observational study to develop risk prediction models of conversion to mild cognitive impairment in individuals with subjective cognitive decline","volume":"9","author":"Li","year":"2019","journal-title":"BMJ Open"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/j.clinbiomech.2006.06.01","article-title":"Role of knee kinematics and kinetics on performance and disability in people with medial compartment knee osteoarthritis","volume":"21","author":"Maly","year":"2006","journal-title":"Clin. Biomech."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"111393","DOI":"10.1016\/j.mad.2020.111393","article-title":"The use of motor cognitive dual-task quantitative assessment on subjects with mild cognitive impairment: a systematic review","volume":"193","author":"Mancioppi","year":"2020","journal-title":"Mech. Ageing Dev."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1159\/000322193","article-title":"Editorial: maintaining and promoting mobility and functional Independence in older adults","volume":"57","author":"Martin","year":"2011","journal-title":"Gerontology"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1056\/NEJMoa2100708","article-title":"Donanemab in early Alzheimer's disease","volume":"384","author":"Mintun","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.3233\/JAD-190790","article-title":"Gait disorders in Alzheimer\u2019s disease and other dementias: there is something in the way you walk","volume":"71","author":"Montero-Odasso","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"111102","DOI":"10.1016\/j.exger.2020.111102","article-title":"Dual-task gait speed assessments with an electronic walkway and a stopwatch in older adults. A reliability study","volume":"142","author":"Montero-Odasso","year":"2020","journal-title":"Exp. Gerontol."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1001\/jamaneurol.2017.0643","article-title":"Association of Dual-Task Gait with Incident Dementia in mild cognitive impairment","volume":"74","author":"Montero-Odasso","year":"2017","journal-title":"JAMA Neurol."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1093\/gerona\/60.10.1304","article-title":"Gait velocity as a single predictor of adverse events in healthy seniors aged 75 years and older","volume":"60","author":"Montero-Odasso","year":"2005","journal-title":"J. Gerontol. A Biol. Sci."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1212\/wnl.43.11.2412-a","article-title":"The clinical dementia rating (CDR): current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.gaitpost.2011.08.014","article-title":"Gait assessment in mild cognitive impairment and Alzheimer's disease: the effect of dual-task challenges across the cognitive spectrum","volume":"35","author":"Muir","year":"2012","journal-title":"Gait Posture"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"109723","DOI":"10.1016\/j.jbiomech.2020.109723","article-title":"Relevance of sex, age and gait kinematics when predicting fall-risk and mortality in older adults","volume":"105","author":"Porta","year":"2020","journal-title":"J. Biomech."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"769462","DOI":"10.3389\/fnagi.2021.769462","article-title":"Dual-task gait as a predictive tool for cognitive impairment in older adults: a systematic review","volume":"13","author":"Ram\u00edrez","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1093\/gerona\/gly084","article-title":"Entorhinal cortex volume is associated with dual-task gait cost among older adults with MCI: results from the gait and brain study","volume":"74","author":"Sakurai","year":"2019","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.intell.2011.03.001","article-title":"What cognitive abilities are involved in trail-making performance?","volume":"39","author":"Salthouse","year":"2011","journal-title":"Intelligence"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1007\/s11357-020-00202-3","article-title":"Patterns of multi-domain cognitive aging in participants of the long life family study","volume":"42","author":"Sebastiani","year":"2020","journal-title":"GeroScience."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.jalz.2018.10.003","article-title":"Subjective cognitive decline and rates of incident Alzheimer\u2019s disease and non\u2013Alzheimer\u2019s disease dementia","volume":"15","author":"Slot","year":"2018","journal-title":"Alzheimers Dement."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1080\/13803395.2015.1119254","article-title":"Boston naming test automatic credits inflate scores of nonaphasic mild dementia patients","volume":"38","author":"St\u00e5lhammar","year":"2015","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"S15","DOI":"10.3233\/JAD-181173","article-title":"Associations between gait speed and cognitive domains in older people with cognitive impairment","volume":"71","author":"Toots","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s11556-019-0218-1","article-title":"A taxonomy of cognitive tasks to evaluate cognitive-motor interference on spatiotemoporal gait parameters in older people: a systematic review and meta-analysis","volume":"16","author":"Wollesen","year":"2019","journal-title":"Eur. Rev. Aging Phys. Act."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s11556-021-00270-0","article-title":"Functional capacity and dual-task cost in the institutionalized older adults, both affected and unaffected by mild cognitive impairment","volume":"18","author":"Zak","year":"2021","journal-title":"Eur. Rev. Aging Phys. 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