{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:59:02Z","timestamp":1793066342085,"version":"4.5.0"},"reference-count":99,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Extensive literature supporting the view of tinnitus induced stress in patients is available. However, limited evidence has been produced studying the opposite, that is, does stress cause tinnitus? The hypothalamus pituitary adrenal axis, one of the main neuroendocrine systems involved in stress response, is commonly disturbed in tinnitus patients. Patients with chronic tinnitus have been shown to develop abnormal responses to psycho-social stress, where the hypothalamus pituitary adrenal axis response is weaker and delayed, suggesting chronic stress contributes to the development of chronic tinnitus. The sympathetic branch of the autonomic nervous system also plays a major role in stress response and its chronic hyperactivity seems to be involved in developing tinnitus. Psycho-social stress has been shown to share the same probability of developing tinnitus as occupational noise and contributes to worsening tinnitus. Additionally, exposure to high stress levels and occupational noise doubles the likelihood of developing tinnitus. Interestingly, short-term stress has been shown to protect the cochlea in animals, but chronic stress exposure has negative consequences. Emotional stress also worsens pre-existing tinnitus and is identified as an important indicator of tinnitus severity. Although there is limited body of literature, stress does seem to play a vital role in the development of tinnitus. This review aims to highlight the association between stress, emotional states, and the development of tinnitus while also addressing the neural and hormonal pathways involved.<\/jats:p>","DOI":"10.3389\/fnagi.2023.1131979","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T05:15:17Z","timestamp":1683090917000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":78,"title":["The association between stress, emotional states, and tinnitus: a mini-review"],"prefix":"10.3389","volume":"15","author":[{"given":"Jayaditya Devpal","family":"Patil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar Abdulkarim","family":"Alrashid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayah","family":"Eltabbakh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Fredericks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1080\/14992027.2018.1537524","article-title":"Tinnitus loudness and the severity of insomnia: a mediation analysis","volume":"58","author":"Aazh","year":"2019","journal-title":"Int. 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Rev."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1097\/AUD.0b013e31822229bd","article-title":"Tinnitus in the general population with a focus on noise and stress: a public health study","volume":"32","author":"Baigi","year":"2011","journal-title":"Ear Hear."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"764368","DOI":"10.3389\/fpsyt.2022.764368","article-title":"Psychological treatment effects unrelated to hair-cortisol and hair-BDNF levels in chronic tinnitus","volume":"13","author":"Basso","year":"2022","journal-title":"Front. Psych."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1038\/s41598-022-04811-0","article-title":"Hair-cortisol and hair-BDNF as biomarkers of tinnitus loudness and distress in chronic tinnitus","volume":"12","author":"Basso","year":"2022","journal-title":"Sci. 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Neurosci."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/S0378-5955(02)00717-7","article-title":"Expanding the biological basis of tinnitus: crossmodal origins and the role of neuroplasticity","volume":"175","author":"Cacace","year":"2003","journal-title":"Hear. Res."},{"key":"ref15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1569-7339(07)00007-0","article-title":"Brain mechanisms of Pavlovian and instrumental aversive conditioning","volume-title":"Handbook of anxiety and fear","author":"Cain","year":"2008"},{"key":"ref16","volume-title":"What helps\u2013and what doesn\u2019t?","year":"2006"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"264","DOI":"10.2174\/1745017901814010264","article-title":"Tinnitus: the sound of stress?","volume":"14","author":"Ciminelli","year":"2018","journal-title":"Clin. Pract. Epidemiol. Ment. Health"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"233121651988557","DOI":"10.1177\/2331216519885571","article-title":"Hearing difficulties and tinnitus in construction, agricultural, music, and finance industries: contributions of demographic, health, and lifestyle factors","volume":"23","author":"Couth","year":"2019","journal-title":"Trends Hear."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nrn2555","article-title":"How do you feel: now? The anterior insula and human awareness","volume":"10","author":"Craig","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/j.neuroscience.2005.07.032","article-title":"Chronic stress impairs acoustic conditioning more than visual conditioning in rats: morphological and behavioural evidence","volume":"135","author":"Dagnino-Subiabre","year":"2005","journal-title":"Neuroscience"},{"key":"ref21","first-page":"20","article-title":"Tinnitus, heart rate variability, and some biochemical indicators","volume":"5","author":"Datzov","year":"1999","journal-title":"Int. Tinnitus J."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.12659\/MSM.890949","article-title":"Determination of correlation among heart rate variability, left atrium global strain, and nighttime blood pressure among patients with tinnitus","volume":"20","author":"De\u011firmenci","year":"2014","journal-title":"Med. Sci. 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Res."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.tins.2004.08.010","article-title":"The neuroscience of tinnitus","volume":"27","author":"Eggermont","year":"2004","journal-title":"Trends Neurosci."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1176\/appi.ajp.2007.07030504","article-title":"Functional neuroimaging of anxiety: a meta-analysis of emotional processing of PTSD, social anxiety disorder and specific phobia","volume":"164","author":"Etkin","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1044\/1059-0889(2007\/015)","article-title":"The association between tinnitus and posttraumatic stress disorder","volume":"16","author":"Fagelson","year":"2007","journal-title":"Am. J. Audiol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/S0194-5998(99)70123-3","article-title":"Tinnitus severity, loudness, and depression","volume":"121","author":"Folmer","year":"1999","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"209","DOI":"10.2147\/ndt.s10361","article-title":"Tinnitus psychopharmacology: a comprehensive review of its pathomechanisms and management","volume":"6","author":"Fornaro","year":"2010","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1007\/s00405-013-2715-6","article-title":"Depression, anxiety and stress scale in patients with tinnitus and hearing loss","volume":"271","author":"Gomaa","year":"2014","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3389\/fnsys.2012.00012","article-title":"Tinnitus: pathology of synaptic plasticity at the cellular and system levels","volume":"6","author":"Guitton","year":"2012","journal-title":"Front. Syst. Neurosci."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3988\/jcn.2009.5.1.11","article-title":"Tinnitus: characteristics, causes, mechanisms, and treatments","volume":"5","author":"Han","year":"2009","journal-title":"J. Clin. Neurol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/1471-2458-11-130","article-title":"Stress and prevalence of hearing problems in the Swedish working population","volume":"11","author":"Hasson","year":"2011","journal-title":"BMC Public Health"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1159\/000335043","article-title":"Emotional exhaustion as a predictor of tinnitus","volume":"81","author":"H\u00e9bert","year":"2012","journal-title":"Psychother. Psychosom."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.neulet.2006.10.028","article-title":"The sound of stress: blunted cortisol reactivity to psychosocial stress in tinnitus sufferers","volume":"411","author":"H\u00e9bert","year":"2007","journal-title":"Neurosci. 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Res."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1080\/14992020500190235","article-title":"Predictive factors for development of severe tinnitus suffering-further characterisation","volume":"44","author":"Holgers","year":"2005","journal-title":"Int. J. Audiol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.devbrainres.2005.06.014","article-title":"Prenatal stress may increase vulnerability to life events: comparison with the effects of prenatal dexamethasone","volume":"159","author":"Hougaard","year":"2005","journal-title":"Brain Res. Dev. Brain Res."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"621145","DOI":"10.3389\/fnins.2021.621145","article-title":"The neural mechanisms of tinnitus: a perspective from functional magnetic resonance imaging","volume":"15","author":"Hu","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.neuroscience.2010.04.057","article-title":"Behavioral and [F-18] fluorodeoxyglucose micro positron emission tomography imaging study in a rat chronic mild stress model of depression","volume":"169","author":"Hu","year":"2010","journal-title":"Neuroscience"},{"key":"ref43","first-page":"886","article-title":"Tinnitus: an epidemiologic study in Iranian population","volume":"51","author":"Jalessi","year":"2013","journal-title":"Acta Med. Iran."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1097\/00001756-200604240-00015","article-title":"Low-frequency hearing loss in prenatally stressed rats","volume":"17","author":"Kadner","year":"2006","journal-title":"Neuroreport"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.heares.2006.01.002","article-title":"The dorsal cochlear nucleus as a participant in the auditory, attentional and emotional components of tinnitus","author":"Kaltenbach","year":"2006","journal-title":"Hear. Res."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.heares.2010.12.003","article-title":"Tinnitus: Models and mechanisms","volume":"276","author":"Kaltenbach","year":"2011","journal-title":"Hear. Res."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1080\/13651501.2020.1757117","article-title":"Anxiety sensitivities, anxiety and depression levels, and personality traits of patients with chronic subjective tinnitus: a case-control study","volume":"24","author":"Karaaslan","year":"2020","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1159\/000306630","article-title":"Epidemiological study of chronic tinnitus in Assiut, Egypt","volume":"35","author":"Khedr","year":"2010","journal-title":"Neuroepidemiology"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"2915","DOI":"10.1007\/s00405-013-2785-5","article-title":"Diagnostic value and clinical significance of stress hormones in patients with tinnitus","volume":"271","author":"Kim","year":"2014","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1002\/lary.29691","article-title":"Evidence of tinnitus development due to stress: an experimental study in rats","volume":"131","author":"Kim","year":"2021","journal-title":"Laryngoscope"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.bbr.2004.05.030","article-title":"Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophrenia","volume":"156","author":"Koenig","year":"2005","journal-title":"Behav. Brain Res."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.heares.2012.02.009","article-title":"Neuronal connectivity and interactions between the auditory and limbic systems. Effects of noise and tinnitus","volume":"288","author":"Kraus","year":"2012","journal-title":"Hear. Res."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"13","DOI":"10.4103\/nah.nah_75_21","article-title":"Evaluation of anxiety sensitivity, anxiety, depression, and attention deficit hyperactivity disorder in patients with tinnitus","volume":"24","author":"Kumbul","year":"2022","journal-title":"Noise Health"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"553449","DOI":"10.3389\/fpsyg.2020.553449","article-title":"The association between effectiveness of tinnitus intervention and cognitive function-a systematic review","volume":"11","author":"Lan","year":"2020","journal-title":"Front. Psychol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.neuron.2012.02.004","article-title":"Rethinking the emotional brain","volume":"73","author":"Ledoux","year":"2012","journal-title":"Neuron"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1212\/WNL.50.1.114","article-title":"The functional neuroanatomy of tinnitus: evidence for limbic system links and neural plasticity","volume":"50","author":"Lockwood","year":"1998","journal-title":"Neurology"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.bandc.2007.02.007","article-title":"The effects of stress and stress hormones on human cognition: implications for the field of brain and cognition","volume":"65","author":"Lupien","year":"2007","journal-title":"Brain Cogn."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/nrn2639","article-title":"Effects of stress throughout the lifespan on the brain, behaviour and cognition","volume":"10","author":"Lupien","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.neuroscience.2015.01.074","article-title":"Acute restraint stress alters sound-evoked neural responses in the rat auditory cortex","volume":"290","author":"Ma","year":"2015","journal-title":"Neuroscience"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.psc.2009.05.004","article-title":"The neurobiology of anxiety disorders: brain, imaging, genetics and psychoneuroendocrinology","volume":"32","author":"Martin","year":"2009","journal-title":"Psychiatr. Clin. N. Am."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1097\/AUD.0000000000000573","article-title":"Tinnitus, depression, anxiety, and suicide in recent veterans: a retrospective analysis","volume":"39","author":"Martz","year":"2018","journal-title":"Ear Hear."},{"key":"ref62","first-page":"67","article-title":"Increased parasympathetic nerve tone in tinnitus patients following electrical promontory stimulation","volume":"2","author":"Matsushima","year":"1996","journal-title":"Int. Tinnitus J."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"e467","DOI":"10.1097\/MAO.0000000000002180","article-title":"Association between stress and tinnitus-new aspects","volume":"40","author":"Mazurek","year":"2019","journal-title":"Otol. Neurotol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.heares.2009.10.006","article-title":"Stress induces transient auditory hypersensitivity in rats","volume":"259","author":"Mazurek","year":"2010","journal-title":"Hear. Res."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.neulet.2012.08.019","article-title":"Exposure of Wistar rats to 24-h psychosocial stress alters gene expression in the inferior colliculus","volume":"527","author":"Mazurek","year":"2012","journal-title":"Neurosci. Lett."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3389\/fnsys.2012.00047","article-title":"Stress and tinnitus-from bedside to bench and back","volume":"6","author":"Mazurek","year":"2012","journal-title":"Front. Syst. Neurosci."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1007\/s00106-014-2973-7","article-title":"Stress and tinnitus","volume":"63","author":"Mazurek","year":"2015","journal-title":"HNO"},{"key":"ref68","first-page":"332","article-title":"The hypothalamus-pituitary-thyroid axis in critical illness","volume":"67","author":"Mebis","year":"2009","journal-title":"Neth. J. Med."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.genhosppsych.2013.02.008","article-title":"The influence of psychological factors on tinnitus severity","volume":"35","author":"Milerov\u00e1","year":"2013","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"144996","DOI":"10.1016\/j.gene.2020.144996","article-title":"Recent advancements in understanding the role of epigenetics in the auditory system","volume":"761","author":"Mittal","year":"2020","journal-title":"Gene"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.heares.2015.10.001","article-title":"The consequences of tinnitus and tinnitus severity on cognition: a review of the behavioural evidence","volume":"332","author":"Mohamad","year":"2016","journal-title":"Hear. Res."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0079-6123(07)66003-8","article-title":"The role of neural plasticity in tinnitus","volume":"166","author":"M\u00f8ller","year":"2007","journal-title":"Prog. Brain Res."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/s12529-017-9702-z","article-title":"Tinnitus, traumatic brain injury, and posttraumatic stress disorder in the military","volume":"25","author":"Moring","year":"2018","journal-title":"Int. J. Behav. Med."},{"key":"ref74","first-page":"52","volume-title":"Peripheral processes involved in tinnitus. Tinnitus: Theory and management","author":"Nuttall","year":"2004"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/coa.12232","article-title":"Prevalence and risk factors of tinnitus: the Korean National Health and nutrition examination survey 2010-2011, a cross-sectional study","volume":"39","author":"Park","year":"2014","journal-title":"Clin. Otolaryngol."},{"key":"ref76","doi-asserted-by":"publisher","first-page":"4236","DOI":"10.3390\/ijerph18084236","article-title":"Loud music and leisure noise is a common cause of chronic hearing loss, tinnitus and Hyperacusis","volume":"18","author":"Pienkowski","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/0006-3223(87)90141-7","article-title":"Locus coeruleus and anxiety","volume":"22","author":"Pohl","year":"1987","journal-title":"Biol. Psychiatry"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"31166","DOI":"10.1038\/srep31166","article-title":"Emotion dynamics and tinnitus: daily life data from the \u201cTrackYourTinnitus\u201d application","volume":"6","author":"Probst","year":"2016","journal-title":"Sci. Rep."},{"key":"ref79","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1111\/j.1365-2273.2004.00879.x","article-title":"Tinnitus and psychological morbidity: a cross-sectional study to investigate psychological morbidity in tinnitus patients and its relationship with severity of symptoms and illness perceptions","volume":"29","author":"Reynolds","year":"2004","journal-title":"Clin. Otolaryngol. Allied Sci."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"3209","DOI":"10.3390\/ijerph18063209","article-title":"Insomnia associated with tinnitus and gender differences","volume":"18","author":"Richter","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1097\/01.psy.0000174174.38908.c6","article-title":"Psychophysiologic treatment of chronic tinnitus: a randomized clinical trial","volume":"67","author":"Rief","year":"2005","journal-title":"Psychosom. Med."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.brainres.2013.01.006","article-title":"Endogenous dynorphins, glutamate and N-methyl-daspartate (NMDA) receptors may participate in a stress-mediated type-I auditory neural exacerbation of tinnitus","volume":"1499","author":"Sahley","year":"2013","journal-title":"Brain Res."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s00106-013-2798-9","article-title":"Chronic stress as an influencing factor in tinnitus patients","volume":"62","author":"Schaaf","year":"2014","journal-title":"HNO"},{"key":"ref84","first-page":"13","article-title":"SPECT imaging of brain and tinnitus\u2014Neurotologic\/neurologic implications","volume":"1","author":"Shulman","year":"1995","journal-title":"Int. Tinnitus J."},{"key":"ref85","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1472-6815-12-4","article-title":"Cortisol suppression and hearing thresholds in tinnitus after low-dose dexamethasone challenge","volume":"12","author":"Simoens","year":"2012","journal-title":"BMC Ear Nose Throat Disord."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1101\/lm.79504","article-title":"Emotional preservation: an update on prefrontal-amygdala interactions in fear extinction","volume":"11","author":"Sotres-Bayon","year":"2004","journal-title":"Learn. Mem."},{"key":"ref87","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/7854_2020_215","article-title":"Neurobiology of stress-induced tinnitus","volume":"51","author":"Szczepek","year":"2021","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"ref88","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.nbd.2006.09.004","article-title":"Sound conditioning protects hearing by activating the hypothalamic-pituitary-adrenal axis","volume":"25","author":"Tahera","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"ref89","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0014-2999(00)00569-0","article-title":"Noradrenaline systems in the hypothalamus, amygdala and locus coeruleus are involved in the provocation of anxiety: basic studies","volume":"405","author":"Tanaka","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1080\/14992027.2016.1185168","article-title":"The impact of tinnitus upon cognition in adults: a systematic review","volume":"55","author":"Tegg-Quinn","year":"2016","journal-title":"Int. J. Audiol."},{"key":"ref91","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.jad.2016.06.055","article-title":"Psychological mediators of chronic tinnitus: the critical role of depression","volume":"204","author":"Trevis","year":"2016","journal-title":"J. Affect. Disord."},{"key":"ref92","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nrn2647","article-title":"Neural regulation of endocrine and autonomic stress responses","volume":"10","author":"Ulrich-Lai","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"ref93","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.smrv.2012.04.003","article-title":"Tinnitus and insomnia: is hyperarousal the common denominator?","volume":"17","author":"Wallh\u00e4usser-Franke","year":"2013","journal-title":"Sleep Med. Rev."},{"key":"ref94","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/S0378-5955(02)00289-7","article-title":"Restraint stress and protection from acoustic injury in mice","volume":"165","author":"Wang","year":"2002","journal-title":"Hear. Res."},{"key":"ref95","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0022-3999(01)00281-1","article-title":"Impact of a relaxation training on psychometric and immunologic parameters in tinnitus sufferers","volume":"52","author":"Weber","year":"2002","journal-title":"J. Psychosom. Res."},{"key":"ref96","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.psychres.2016.01.065","article-title":"Which tinnitus-related characteristics affect current health-related quality of life and depression? 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Sci."},{"key":"ref99","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1176\/appi.psy.47.4.282","article-title":"Relationship between tinnitus severity and psychiatric disorders","volume":"47","author":"Z\u00f6ger","year":"2006","journal-title":"Psychosomatics"}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2023.1131979\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T05:15:27Z","timestamp":1683090927000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2023.1131979\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,3]]},"references-count":99,"alternative-id":["10.3389\/fnagi.2023.1131979"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2023.1131979","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,3]]},"article-number":"1131979"}}