{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:56:00Z","timestamp":1779378960676,"version":"3.53.1"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2022-MS-317"],"award-info":[{"award-number":["2022-MS-317"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Alzheimer\u2019s disease (AD) is a neurodegenerative disease characterized by progressive progress and memory loss, which eventually develops into dementia. It can cause personality disorders and decreased quality of life of patients. Currently, AD patients account for 60\u201370% of global dementia patients and the incidence rate of AD is increasing annually. AD not only causes pain to patients but also brings a heavy burden to the entire family. Studies have found that there is a connection between mitochondrial dysfunction and other biochemical changes in AD like classical neuropathological hallmarks (<jats:italic>\u03b2<\/jats:italic>-amyloid and tau protein), inflammation pathways, oxidative stress, and so on. Evidence shows that early treatment targeted directly to mitochondria could extend the lifespan of model mice and decrease the relevant neuropathological markers. Therefore, research on the mitochondrial dysfunction of AD can be of potential significance for clinical treatment. To date, few bibliometric analysis articles related to mitochondrial dysfunction of AD have been published. Bibliometric analysis refers to quantitatively analyzing certain aspects of articles like publishers, authors, and countries by using statistical and mathematical methods. Combined with statistical software, a large number of papers can be converted to visualization figures and tables, which provide vital information such as keyword hotspots and the names of contributing authors. Through the bibliometric analysis method, our study aimed to provide study trends and keyword hotpots for researchers to conduct further relevant research in this field.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the Web of Science core collection database as a literature retrieval tool to obtain data related to mitochondrial changes in Alzheimer\u2019s disease during the last 20\u2009years. The retrieval type was [TS\u2009=\u2009(Alzheimer\u2019s disease)] ND [TS\u2009=\u2009(mitochondrion)], ranging from January 1, 2000 to June 30, 2022. VOSviewer v1.6.18, Arcgis 10.8, and HistCite pro 2.1 were used to conduct data visualization analysis. VOSviewer v1.6.18 made relevant network visualization maps of the cooperative relationship between relevant countries, institutions, and authors (co-authorship), the frequency of different keywords appearing together (co-occurrence), and the frequency of different articles cited together (co-cited). Arcgis 10.8 created the world map of publications distribution in this field and Histcite pro 2.1 was used to count the local citation score (LCS) of references. In addition, Journal Citation Reports were used to consult the latest journal import factor and JCI quartile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As of June 30, 2022, from the Web of Science core collection, we selected 2,474 original articles in English, excluding the document types of the news items, meeting abstracts, and some articles that had little relevance to our theme. The United States acted as the leader and enjoyed a high reputation in this field. The University of California System was the institution that made the greatest contribution (3.64% with 90 papers). Most articles were published in the Journal of Alzheimer\u2019s Disease (8.21%, with 203 papers). The most frequently co-cited journal in Q1 was the Journal of Biological Chemistry (8,666 citations, TLS: 1039591). Russel H. Swerdlow (55 publications) was the most productive author and PH Reddy was the most co-cited author with 1,264 citations (TLS: 62971). The hotpots of mitochondrial dysfunction in AD were as follows: \u201coxidative stress,\u201d \u201camyloid-beta-protein,\u201d \u201ctau,\u201d \u201capoptosis,\u201d \u201cinflammation,\u201d \u201cautophagy,\u201d \u201cprecursor protein,\u201d \u201cendoplasmic-reticulum,\u201d \u201cdynamics\u201d and \u201cmitochondrial unfolded protein response.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This bibliometric analysis research will help readers rapidly identify current hotpots and milestone studies related to directions of interest in AD research.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2023.1136400","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T05:38:47Z","timestamp":1684215527000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Trends of mitochondrial changes in AD: a bibliometric study"],"prefix":"10.3389","volume":"15","author":[{"given":"Ruiyao","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongling","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hairong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongting","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusong","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1038\/s41419-022-05153-5","article-title":"ER stress and UPR in Alzheimer\u2019s disease: mechanisms, pathogenesis, treatments","volume":"13","author":"Amir","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.1007\/s12035-017-0503-9","article-title":"Mitochondrial quality control and disease: insights into ischemia-reperfusion injury","volume":"55","author":"Anzell","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/ana.20624","article-title":"Mitochondria take center stage in aging and neurodegeneration","volume":"58","author":"Beal","year":"2005","journal-title":"Ann. Neurol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s12264-013-1424-x","article-title":"Neuronal failure in Alzhemier\u2019s disease: a view through the oxidative stress looking-glass","volume":"30","author":"Bonda","year":"2014","journal-title":"Neurosci. Bull."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"5789","DOI":"10.3390\/molecules25245789","article-title":"Comprehensive review on Alzheimer\u2019s disease: causes and treatment","volume":"25","author":"Breijyeh","year":"2020","journal-title":"Molecules"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1007\/s00253-015-7001-7","article-title":"A specific RAGE-binding peptide biopanning from phage display random peptide library that ameliorates symptoms in amyloid beta peptide-mediated neuronal disorder","volume":"100","author":"Cai","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3390\/cells9010150","article-title":"Mitophagy in Alzheimer\u2019s disease and other age-related neurodegenerative disease","volume":"9","author":"Cai","year":"2020","journal-title":"Cells"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.nbd.2009.10.006","article-title":"Inflammation, microglia, and Alzheimer\u2019s disease","volume":"37","author":"Cameron","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/s0197-4580(03)00033-2","article-title":"Cytochrome c oxidase is decreased in Alzheimer\u2019s disease platelets","volume":"25","author":"Cardoso","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1093\/hmg\/ddp3w26","article-title":"Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases","volume":"18","author":"Chen","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s12264-013-1423-y","article-title":"Oxidative stress in Alzheimer\u2019s disease","volume":"30","author":"Chen","year":"2014","journal-title":"Neurosci. Bull."},{"key":"ref500","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1126\/science.1171091","article-title":"S-Nitrosylation of Drp1 Mediates beta-Amyloid-Related Mitochondrial Fission and Neuronal Injury","volume":"324","author":"Cho","year":"2009","journal-title":"Science"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/nature07534","article-title":"Mitofusin 2 tethers endoplasmic reticulum to mitochondria","volume":"456","author":"De Brito","year":"2008","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"9057","DOI":"10.1523\/JNEUROSCI.1469-06.2006","article-title":"Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction","volume":"26","author":"Devi","year":"2006","journal-title":"J. Neurosci."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1097\/HJH.0000000000002143","article-title":"Bibliometric analysis of research relating to hypertension reported over the period 1997-2016","volume":"37","author":"Devos","year":"2019","journal-title":"J. Hypertens."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"670220","DOI":"10.3389\/fneur.2021.670220","article-title":"Bibliometric analysis study on the mechanisms of brain energy metabolism disorders in Alzheimer\u2019s disease from 2000 to 2020","volume":"12","author":"Du","year":"2021","journal-title":"Front Neurol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.biopha.2003.11.004","article-title":"Neurodegenerative diseases and oxidative stress","volume":"58","author":"Emerit","year":"2004","journal-title":"Biomed. Pharmacother."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"3330","DOI":"10.3390\/ijms22073330","article-title":"Alzheimer\u2019s disease pathogenesis: role of autophagy and Mitophagy focusing in microglia","volume":"22","author":"Eshraghi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1037068","DOI":"10.3389\/fnagi.2022.1037068","article-title":"Bibliometric analysis of research on Alzheimer\u2019s disease and non-coding RNAs: opportunities and challenges","volume":"14","author":"Fei","year":"2022","journal-title":"Aging Neurosci."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1212\/wnl.33.8.961","article-title":"Alzheimer\u2019s disease: focal cortical changes shown by positron emission tomography","volume":"33","author":"Foster","year":"1983","journal-title":"Neurology"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1093\/brain\/104.4.753","article-title":"Reginal cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography","volume":"104","author":"Frackowiak","year":"1981","journal-title":"Brain"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.bbrc.2016.09.073","article-title":"Microglial response to LPS increases in wild-type mice during aging but diminishes in an progression","volume":"479","author":"Go","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"101529","DOI":"10.1016\/j.arr.2021.101529","article-title":"Deregulated mitochondrial microRNAs in Alzheimer's disease: focus on synapse and mitochondria","volume":"73","author":"Gowda","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.neurobiolaging.2021.07.014","article-title":"Emerging roles of oxidative stress in brain aging and Alzheimer's disease","volume":"107","author":"Ionescu-Tucker","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"3489","DOI":"10.1111\/bph.14585","article-title":"Mitochondrial dysfunction in Alzheimer's disease: role in pathogenesis and novel therapeutic opportunities","volume":"176","author":"Judit","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.bbadis.2016.08.018","article-title":"Is Alzheimer's disease a type 3 diabetes? A critical appraisal","volume":"1863","author":"Kandimalla","year":"2017","journal-title":"Biochim. Biophys. Acta."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.tins.2017.01.002","article-title":"Mitophagy and Alzheimer\u2019s disease: cellular and molecular mechanisms","volume":"40","author":"Kerr","year":"2017","journal-title":"Trends Neurosci."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.freeradbiomed.2020.12.013","article-title":"Mitochondrial unfolded protein response: an emerging pathway in human diseases","volume":"163","author":"Li","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"7916","DOI":"10.1073\/pnas.1300677110","article-title":"Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models","volume":"110","author":"Louise","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref100","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1126\/science.1091230","article-title":"ABAD directly links A beta to mitochondrial toxicity in Alzheimer\u2019s disease","volume":"304","author":"Lustbader","year":"2004","journal-title":"Science"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1093\/hmg\/ddl066","article-title":"Mitochondria are a direct site of A beta accumulation in Alzheimer\u2019s disease neurons: implications for free radical generation and oxidative damage in disease progression","volume":"15","author":"Manczak","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1093\/hmg\/ddl066","article-title":"Mitochondria are a direct site of a beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression","volume":"15","author":"Maria","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1002\/jnr.24781","article-title":"Mitochondrial dysfunction, mitophagy, and role of dynamin-related protein 1 in Alzheimer's disease","volume":"99","author":"Medala","year":"2021","journal-title":"J. Neurosci. Res."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1017\/neu.2020.43","article-title":"Systematic review and meta-analysis on the role of mitochondrial cytochrome c oxidase in Alzheimer\u2019s disease","volume":"33","author":"Morais","year":"2021","journal-title":"Acta Neuropsychiatr."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1212\/wnl.40.8.1302","article-title":"Cytochrome oxidase deficiency in Alzheimer\u2019s disease","volume":"40","author":"Parker","year":"1990","journal-title":"Neurology"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"11185","DOI":"10.3390\/ijms222011185","article-title":"ATP synthase and mitochondrial bioenergetics dysfunction in Alzheimer's disease","volume":"22","author":"Patro","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"488","DOI":"10.3390\/cells8050488","article-title":"Amyloid Beta and Phosphorylated tau-induced defective autophagy and Mitophagy in Alzheimer's disease","volume":"8","author":"Reddy","year":"2019","journal-title":"Cells"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/s41569-021-00051-w","article-title":"Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases","volume":"18","author":"Ren","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1007\/s00266-022-02904-9","article-title":"Trends in breast augmentation research: a bibliometric analysis","volume":"46","author":"Ri","year":"2022","journal-title":"Anesthetic Plast. Surg."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5114\/fn.2013.34190","article-title":"Molecular mechanisms of neuropathological changes in Alzheimer\u2019s disease: a review","volume":"1","author":"Ser\u00fd","year":"2013","journal-title":"Folia Neuropathol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.1007\/s11064-021-03418-7","article-title":"Apoptotic pathways and Alzheimer\u2019s disease: probing therapeutic potential","volume":"46","author":"Sharma","year":"2021","journal-title":"Neurochem. Res."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"983","DOI":"10.7150\/ijbs.66871","article-title":"The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer\u2019s disease","volume":"18","author":"Shen","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.3233\/JAD-170585","article-title":"Mitochondria and mitochondrial cascades in Alzheimer\u2019s disease","volume":"62","author":"Swerdlow","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/j.bbadis.2013.09.010","article-title":"The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives","volume":"1842","author":"Swerdlow","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.3389\/fnagi.2022.804177","article-title":"A bibliometric review on gut microbiome and Alzheimer's disease between 2012 and 2021","volume":"14","author":"Trejo-Castro","year":"2022","journal-title":"Aging Neurosci."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.phrs.2018.03.010","article-title":"VDAC1, mitochondrial dysfunction, and Alzheimer's disease","volume":"131","author":"Varda","year":"2018","journal-title":"Pharmacol. Res."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1111\/j.1471-4159.2005.03615.x","article-title":"Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment","volume":"96","author":"Wang","year":"2006","journal-title":"J. Neurochem."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"9090","DOI":"10.1523\/JNEUROSCI.1357-09.2009","article-title":"Impaired balance of mitochondrial fission and fusion in Alzheimer's disease","volume":"29","author":"Wang","year":"2009","journal-title":"J. Neurosci."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1016\/j.bbadis.2013.10.015","article-title":"Oxidative stress and mitochondrial dysfunction in Alzheimer's disease","volume":"1842","author":"Wang","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"6697","DOI":"10.1096\/fj.201801751R","article-title":"Ca2+ homeostasis dysregulation in Alzheimer\u2019s disease: a focus on plasma membrane and cell organelles","volume":"33","author":"Wang","year":"2019","journal-title":"FASEB J."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"329","DOI":"10.2174\/1567205016666191210091302","article-title":"Mitochondrial calcium signaling as a therapeutic target for Alzheimer\u2019s disease","volume":"17","author":"Wu","year":"2020","journal-title":"Curr. Alzheimer Res."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1007\/s11064-020-03192-y","article-title":"Hypermathylation of mitochondrial cytochrome b and cytochrome c OxidaseIIGenes with decreased mitochondrial DNA copy numbers in the APP\/PS1 transgenic mouse model of Alzheimer\u2019s disease","volume":"46","author":"Xu","year":"2021","journal-title":"Neurochem. Res."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.bbadis.2014.05.006","article-title":"Endoplasmic reticulum stress and protein quality control in diabetic cardiomyopathy","volume":"1852","author":"Yang","year":"2015","journal-title":"Biochim. Biophys. Acta. (BBA)-Mol. Basis Dis."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1186\/s12967-021-03009-8","article-title":"Emerging trends and focus of human gastrointestinal microbiome research from 2010-2021: a visualized study","volume":"19","author":"Yuan","year":"2021","journal-title":"J. Transl. Med."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3390\/ijms21010209","article-title":"Phosphorylation signaling in APP processing in Alzheimer\u2019s disease","volume":"21","author":"Zhang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"926982","DOI":"10.3389\/fnagi.2022.926982","article-title":"Alzheimer\u2019s disease and epilepsy: the top 100 cited papers","volume":"14","author":"Zhang","year":"2022","journal-title":"Aging Neurosci."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2023.1136400\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T05:38:49Z","timestamp":1684215529000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2023.1136400\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":56,"alternative-id":["10.3389\/fnagi.2023.1136400"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2023.1136400","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,16]]},"article-number":"1136400"}}