{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:38:30Z","timestamp":1792103910861,"version":"4.4.0"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Balance disturbances in Parkinson\u2019s Disease (PD) are usually assessed in a single-task as well as standard balance physiotherapy is carried out in isolated environments. Conversely, daily activities are developed in highly challenging environments. Although functional balance training (FBT) is included in the latest protocols, several methodological issues have not yet been considered. In the proposed single-blinded randomized control trial with crossover (NCT04963894), the aims are (1) to quantify the effects achieved by domiciliary FBT (balanceHOME program) in participants with and without cognitive impairment, and (2) to compare them with the effects of a passive-control period and a conventional face-to-face physiotherapy program for PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The initial recruitment was estimated at 112 people with idiopathic PD. Two-thirds of the participants will be randomized to one of the two groups to make the crossover. In contrast, the other third will do a face-to-face group program only. The balanceHOME protocol consists of challenging balance exercises incorporated into functional daily tasks, developed in-home and conducted two times per week for 60-min over an 8-weeks period. The primary strategy will consist of splitting functional tasks of daily life into static and dynamic balance components, besides standardized facilitate and disturbing strategies to execution of each exercise. Biomechanics and clinical performance of balance and gait, perception of quality of life, cognitive and mental functioning, and severity of PD will be measured at baseline (T0), post-8 weeks training (T1), and follow-up (T2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The primary outcome of the study will be the center of pressure sway area. The secondary outcomes consist of biomechanics and clinical variables related to static and dynamic balance. Outcomes from biomechanical of gait, quality of life, cognitive and mental state, and severity of PD, represent the tertiary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The balanceHOME program standardizes the FBT in demanding and daily environments for people with PD who prefer individualized treatment from home. This is the first time that the effects of group versus individual balance rehabilitation have been compared in people with and without cognitive impairment and evaluated in complex environments. This still-to-be-finished study will open the possibility of new strategies according to changes in post-pandemic therapeutic approaches.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2023.1137360","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T05:36:38Z","timestamp":1682573798000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Functional balance training in people with Parkinson\u2019s disease: a protocol of balanceHOME randomized control trial with crossover"],"prefix":"10.3389","volume":"15","author":[{"given":"Sara","family":"Monle\u00f3n Guinot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"San Mart\u00edn Valenzuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivina","family":"Aranda Asensi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"de Salazar Ant\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Villanueva Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Tom\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1002\/mds.23790","article-title":"Balance and falls in Parkinson\u2019s disease: a meta-analysis of the effect of exercise and motor training","volume":"26","author":"Allen","year":"2011","journal-title":"Mov. Disord."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.gaitpost.2017.04.006","article-title":"Balance training in individuals with Parkinson\u2019s disease: therapist-supervised vs. home-based exercise programme","volume":"55","author":"Atterbury","year":"2017","journal-title":"Gait Posture"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.otorri.2012.03.006","article-title":"Static posturography with dynamic tests. Usefulness of biomechanical parameters in assessing vestibular patients","volume":"63","author":"Balaguer Garc\u00eda","year":"2012","journal-title":"Acta Otorrinolaringol. Esp."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.26603\/ijspt20201036","article-title":"Reliability of center of pressure-based measures during dual-task postural control testing in a youth population","volume":"15","author":"Campolettano","year":"2020","journal-title":"Int. J. Sports Phys. Ther."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.apmr.2016.11.003","article-title":"Wearable sensor-based biofeedback training for balance and gait in Parkinson disease: a pilot randomized controlled trial","volume":"98","author":"Carpinella","year":"2017","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e7586","DOI":"10.1136\/bmj.e7586","article-title":"SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials","volume":"346","author":"Chan","year":"2013","journal-title":"BMJ"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1177\/1545968314567150","article-title":"The effects of highly challenging balance training in elderly with Parkinson\u2019s disease: a randomized controlled trial","volume":"29","author":"Conradsson","year":"2015","journal-title":"Neurorehabil. Neural Repair"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1186\/s12883-015-0418-x","article-title":"Randomized controlled trial protocol: balance training with rhythmical cues to improve and maintain balance control in Parkinson\u2019s disease","volume":"15","author":"da Capato","year":"2015","journal-title":"BMC Neurol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1212\/WNL.55.11.1621","article-title":"The FAB: a frontal assessment battery at bedside","volume":"55","author":"Dubois","year":"2000","journal-title":"Neurology"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"7684","DOI":"10.3390\/s21227684","article-title":"An assessment of balance through Posturography in healthy about women: an observational study","volume":"21","author":"Escamilla-Mart\u00ednez","year":"2021","journal-title":"Sensors (Basel)"},{"key":"ref11","first-page":"153","article-title":"Unified Parkinson\u2019s disease rating scale","volume-title":"Recent Developments in Parkinson\u2019s Disease II","author":"Fahn","year":"1987"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/2076942","article-title":"Cognition deficits in Parkinson\u2019s disease: mechanisms and treatment","volume":"2020","author":"Fang","year":"2020","journal-title":"Parkinsons Dis"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav. Res. Methods"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"4186","DOI":"10.12659\/MSM.916455","article-title":"Virtual reality rehabilitation versus conventional physical therapy for improving balance and gait in Parkinson\u2019s disease patients: a randomized controlled trial","volume":"25","author":"Feng","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"208","DOI":"10.17712\/nsj.2018.3.20180021","article-title":"Sensorimotor integration training in Parkinson\u2019s disease","volume":"23","author":"Fil-Balkan","year":"2018","journal-title":"Neurosciences (Riyadh)"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"323","DOI":"10.2340\/16501977-0537","article-title":"Using psychometric techniques to improve the balance evaluation systems test: the mini-BESTest","volume":"42","author":"Franchignoni","year":"2010","journal-title":"J. Rehabil. Med."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"5614242","DOI":"10.1155\/2018\/5614242","article-title":"Instrumental or physical-exercise rehabilitation of balance improves both balance and gait in Parkinson\u2019s disease","volume":"2018","author":"Giardini","year":"2018","journal-title":"Neural Plast."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/s1353-8020(99)00062-0","article-title":"Construction of freezing of gait questionnaire for patients with parkinsonism","volume":"6","author":"Giladi","year":"2000","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating","volume":"32","author":"Hamilton","year":"1959","journal-title":"Br. J. Med. Psychol."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1212\/wnl.17.5.427","article-title":"Parkinsonism: onset, progression and mortality","volume":"17","author":"Hoehn","year":"1967","journal-title":"Neurology"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1097\/PHM.0000000000000858","article-title":"Trunk exercises improve gait symmetry in Parkinson disease: a blind phase II randomized controlled trial","volume":"97","author":"Hubble","year":"2018","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"eAO5940","DOI":"10.31744\/einstein_journal\/2021AO5940","article-title":"Effects of resistance training on metabolic and cardiovascular responses to a maximal cardiopulmonary exercise test in Parkinson\u2019s disease","volume":"19","author":"Kanegusuku","year":"2021","journal-title":"Einstein (Sao Paulo)"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"351","DOI":"10.3233\/NRE-2012-0766","article-title":"The effect of supervised exercises on static and dynamic balance in Parkinson\u2019s disease patients","volume":"30","author":"Kara","year":"2012","journal-title":"Neuro. Rehabil."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.2522\/ptj.20070007","article-title":"Reliability and validity of the Tinetti mobility test for individuals with Parkinson disease","volume":"87","author":"Kegelmeyer","year":"2007","journal-title":"Phys. Ther."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/NPT.0000000000000117","article-title":"Effects of exercise therapy on postural instability in Parkinson disease: a meta-analysis","volume":"40","author":"Klamroth","year":"2016","journal-title":"J. Neurol. Phys. Ther."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1097\/NPT.0000000000000298","article-title":"Outcome evaluation of highly challenging balance training for people with Parkinson disease: a multicenter effectiveness-implementation study","volume":"44","author":"Leavy","year":"2020","journal-title":"J. Neurol. Phys. Ther."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3233\/BEN-1995-8102","article-title":"Mini-mental Parkinson: first validation study of a new bedside test constructed for Parkinson\u2019s disease","volume":"8","author":"Mahieux","year":"1995","journal-title":"Behav. Neurol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1212\/01.WNL.0000091864.39702.1C","article-title":"Assessment of cognition in Parkinson\u2019s disease","volume":"61","author":"Marinus","year":"2003","journal-title":"Neurology"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1001\/jama.1965.03090220013003","article-title":"Improvement in brain oxygenation and clinical improvement in patients with strokes treated with papaverine hydrochloride","volume":"194","author":"Meyer","year":"1965","journal-title":"JAMA"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"9871070","DOI":"10.1155\/2017\/9871070","article-title":"Effect on gait speed, balance, motor symptom rating, and quality of life in those with stage I Parkinson\u2019s disease utilizing LSVT BIG\u00ae","volume":"2017","author":"Millage","year":"2017","journal-title":"Rehabil. Res. Pract."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"c869","DOI":"10.1136\/bmj.c869","article-title":"CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials","volume":"340","author":"Moher","year":"2010","journal-title":"BMJ"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.3389\/fpsyg.2020.01256","article-title":"Postural stability and cognitive performance of subjects with Parkinson\u2019s disease during a dual-task in an upright stance","volume":"11","author":"Morenilla","year":"2020","journal-title":"Front. Psychol."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.jbmt.2016.06.001","article-title":"Nintendo Wii fit for balance rehabilitation in patients with Parkinson\u2019s disease: a comparative study","volume":"21","author":"Negrini","year":"2017","journal-title":"J. Bodyw. Mov. Ther."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"109","DOI":"10.14802\/jmd.15018","article-title":"What is wrong with balance in Parkinson\u2019s disease?","volume":"8","author":"Park","year":"2015","journal-title":"J. Mov. Disord"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1080\/08990220.2016.1278203","article-title":"Instruction prioritization in task-based balance training for individuals with idiopathic Parkinson\u2019s disease","volume":"34","author":"Perumal","year":"2017","journal-title":"Somatosens. Mot. Res."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/BF02260863","article-title":"The development and validation of a short measure of functioning and well being for individuals with Parkinson\u2019s disease","volume":"4","author":"Peto","year":"1995","journal-title":"Qual. Life Res."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1378\/chest.08-1389","article-title":"Impact of expiratory muscle strength training on voluntary cough and swallow function in Parkinson disease","volume":"135","author":"Pitts","year":"2009","journal-title":"Chest"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1007\/s00221-016-4665-x","article-title":"Anticipatory postural adjustments are unaffected by age and are not absent in patients with the freezing of gait phenomenon","volume":"234","author":"Plate","year":"2016","journal-title":"Exp. Brain Res."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Primers."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"M28","DOI":"10.1093\/gerona\/50A.1.M28","article-title":"The activities-specific balance confidence (ABC) scale","author":"Powell","year":"1995","journal-title":"J Gerontol. A. Biol. Sci. Med. Sci."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1378\/chest.12-1442","article-title":"Respiratory muscle training for respiratory deficits in neurodegenerative disorders: a systematic review","volume":"143","author":"Reyes","year":"2013","journal-title":"Chest"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1186\/s12891-020-03431-x","article-title":"Interference of functional dual-tasks on gait in untrained people with Parkinson\u2019s disease and healthy controls: a cross-sectional study","volume":"21","author":"San Mart\u00edn Valenzuela","year":"","journal-title":"BMC Musculoskelet. Disord."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1016\/j.apmr.2020.07.008","article-title":"Effects of dual-task group training on gait, cognitive executive function, and quality of life in people with Parkinson disease: results of randomized controlled DUALGAIT trial","volume":"101","author":"San Mart\u00edn Valenzuela","year":"","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5944\/rppc.27569","article-title":"Impacto psicol\u00f3gico de la pandemia de COVID-19: Efectos negativos y positivos en poblaci\u00f3n espa\u00f1ola asociados al periodo de confinamiento nacional","volume":"25","author":"Sand\u00edn","year":"2020","journal-title":"Revista de Psicopatolog\u00eda y Psicolog\u00eda Cl\u00ednica"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"173","DOI":"10.23736\/S1973-9087.16.04313-6","article-title":"Balance versus resistance training on postural control in patients with Parkinson\u2019s disease: a randomized controlled trial","volume":"53","author":"Santos","year":"2017","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1007\/s11845-020-02462-6","article-title":"The correlation of non-motor symptoms and sleep on balance in Parkinson\u2019s disease patients with normal cognition and mild cognitive impairment","volume":"190","author":"Saricaoglu","year":"2021","journal-title":"Ir. J. Med. Sci."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"902","DOI":"10.3389\/fneur.2019.00902","article-title":"Progressive modular rebalancing system and visual cueing for gait rehabilitation in Parkinson\u2019s disease: a pilot, randomized controlled trial with crossover","volume":"10","author":"Serrao","year":"2019","journal-title":"Front. Neurol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1177\/1545968310376057","article-title":"Effect of balance training on postural instability in patients with idiopathic Parkinson\u2019s disease","volume":"24","author":"Smania","year":"2010","journal-title":"Neurorehabil. Neural Repair"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s13760-019-01247-8","article-title":"Task-oriented circuit training combined with aerobic training improves motor performance and balance in people with Parkinson\u2032s disease","volume":"121","author":"Soke","year":"2019","journal-title":"Acta Neurol. Belg."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1007\/s40520-015-0506-1","article-title":"The effect of the rehabilitation program on balance, gait, physical performance and trunk rotation in Parkinson\u2019s disease","volume":"28","author":"Sto\u017cek","year":"2016","journal-title":"Aging Clin. Exp. Res."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.rehab.2014.01.003","article-title":"Effort training in Parkinson\u2019s disease: a systematic review","volume":"57","author":"Tambosco","year":"2014","journal-title":"Ann. Phys. Rehabil. Med."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1111\/j.1532-5415.1986.tb05480.x","article-title":"Performance-oriented assessment of mobility problems in elderly patients","volume":"34","author":"Tinetti","year":"1986","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"CD002817","DOI":"10.1002\/14651858.CD002817.pub4","article-title":"Physiotherapy versus placebo or no intervention in Parkinson\u2019s disease","volume":"2013","author":"Tomlinson","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.3233\/jpd-202223","article-title":"The effects of respiratory training in Parkinson\u2019s disease: a systematic review","volume":"10","author":"van de Wetering-van Dongen","year":"2020","journal-title":"J. Parkinsons Dis."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"026921551878433","DOI":"10.1177\/0269215518784338","article-title":"Long-term effects of highly challenging balance training in Parkinson\u2019s disease\u2014a randomized controlled trial","volume":"32","author":"Wall\u00e9n","year":"2018","journal-title":"Clin. Rehabil."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.parkreldis.2015.03.022","article-title":"Multi-dimensional balance training programme improves balance and gait performance in people with Parkinson\u2019s disease: a pragmatic randomized controlled trial with 12-month follow-up","volume":"21","author":"Wong-Yu","year":"","journal-title":"Parkinsonism Related Disorders"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1016\/j.apmr.2015.08.409","article-title":"Task-and context-specific balance training program enhances dynamic balance and functional performance in parkinsonian nonfallers: a randomized controlled trial with six-month follow-up","volume":"96","author":"Wong-Yu","year":"","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref59","volume-title":"International Classification of Functioning, Disability and Health (ICF)","year":"2001"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"862","DOI":"10.2522\/ptj.20100050","article-title":"Effects of virtual reality-augmented balance training on sensory organization and attentional demand for postural control in people with Parkinson disease: a randomized controlled trial","volume":"91","author":"Yen","year":"2011","journal-title":"Phys. Ther."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s13102-016-0042-0","article-title":"The effectiveness of physiotherapy treatment on balance dysfunction and postural instability in persons with Parkinson\u2019s disease: a systematic review and meta-analysis","volume":"8","author":"Yitayeh","year":"2016","journal-title":"BMC Sports Sci. Med. Rehabil."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12984-020-00725-y","article-title":"Effects of interactive video-game-based exercise on balance in older adults with mild-to-moderate Parkinson\u2019s disease","volume":"17","author":"Yuan","year":"2020","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref63","first-page":"65","article-title":"Visual feedback training using WII fit improves balance in Parkinson\u2019s disease","volume":"53","author":"Zalecki","year":"2013","journal-title":"Folia Med. Cracov."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2023.1137360\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T16:55:31Z","timestamp":1684342531000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2023.1137360\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,26]]},"references-count":63,"alternative-id":["10.3389\/fnagi.2023.1137360"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2023.1137360","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,26]]},"article-number":"1137360"}}