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In the absence of disease-modifying therapies, physical activity has emerged as the single most accessible lifestyle modification with the potential to fight off cognitive decline and neurodegeneration. In this review, we discuss findings from epidemiological, clinical, and molecular studies investigating the potential of lifestyle modifications in promoting brain health. We propose an evidence-based multidomain approach that includes physical activity, diet, cognitive training, and sleep hygiene to treat and prevent neurodegenerative diseases.<\/jats:p>","DOI":"10.3389\/fnagi.2023.1185671","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T04:29:30Z","timestamp":1685075370000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":63,"title":["Physical activity and lifestyle modifications in the treatment of neurodegenerative diseases"],"prefix":"10.3389","volume":"15","author":[{"given":"Jose A.","family":"Santiago","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Potashkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1007\/s12640-015-9566-4","article-title":"Exercise improves cognitive impairment and dopamine metabolism in MPTP-treated mice","volume":"29","author":"Aguiar","year":"2016","journal-title":"Neurotox Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.14283\/jpad.2022.9","article-title":"Mechanisms underlying non-pharmacological dementia prevention strategies: a translational perspective","volume":"9","author":"Alanko","year":"2022","journal-title":"J. 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