{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:08:44Z","timestamp":1791925724493,"version":"4.3.4"},"reference-count":193,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>\n                    Aldehyde dehydrogenase 2 (ALDH2) is an enzyme found in the mitochondrial matrix that plays a central role in alcohol and aldehyde metabolism. A common ALDH2 polymorphism in East Asians descent (called ALDH2*2 or E504K missense variant, SNP ID: rs671), present in approximately 8% of the world\u2019s population, has been associated with a variety of diseases. Recent meta-analyses support the relationship between this ALDH2 polymorphism and Alzheimer\u2019s disease (AD). And AD-like pathology observed in ALDH2\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    null mice and ALDH2*2 overexpressing transgenic mice indicate that ALDH2 deficiency plays an important role in the pathogenesis of AD. Recently, the worldwide increase in alcohol consumption has drawn attention to the relationship between heavy alcohol consumption and AD. Of potential clinical significance, chronic administration of alcohol in ALDH2*2\/*2 knock-in mice exacerbates the pathogenesis of AD-like symptoms. Therefore, ALDH2 polymorphism and alcohol consumption likely play an important role in the onset and progression of AD. Here, we review the data on the relationship between ALDH2 polymorphism, alcohol, and AD, and summarize what is currently known about the role of the common ALDH2 inactivating mutation, ALDH2*2, and alcohol in the onset and progression of AD.\n                  <\/jats:p>","DOI":"10.3389\/fnagi.2023.1223977","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T08:07:54Z","timestamp":1692864474000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Impact of common ALDH2 inactivating mutation and alcohol consumption on Alzheimer\u2019s disease"],"prefix":"10.3389","volume":"15","author":[{"given":"Takuya","family":"Seike","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che-Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Mochly-Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1161\/atvbaha.112.247668","article-title":"The mechanisms of cerebral vascular dysfunction and neuroinflammation by MMP-mediated degradation of VEGFR-2 in alcohol ingestion.","volume":"32","author":"Abdul Muneer","year":"2012","journal-title":"Arteriosc. Thromb. Vasc. Biol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0694-x","article-title":"Endogenous formaldehyde is a memory-related molecule in mice and humans.","volume":"2","author":"Ai","year":"2019","journal-title":"Commun. Biol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"47504","DOI":"10.1021\/acsomega.2c05609","article-title":"Preclinical models for Alzheimer\u2019s disease: Past, present, and future approaches.","volume":"7","author":"Akhtar","year":"2022","journal-title":"ACS Omega"},{"key":"B4","first-page":"177","article-title":"Uber eine eigenartige Erkrankung der Hirnrinde.","volume":"18","author":"Alzheimer","year":"1907","journal-title":"Zentralbl. Nervenh. Psych."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1097\/01.wnr.0000185015.44563.5d","article-title":"Reduction of NR1 and phosphorylated Ca2+\/calmodulin-dependent protein kinase II levels in Alzheimer\u2019s disease.","volume":"16","author":"Amada","year":"2005","journal-title":"Neuroreport"},{"key":"B6","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1161\/strokeaha.122.040578","article-title":"Blood-brain barrier dysfunction in normal aging and neurodegeneration: Mechanisms, impact, and treatments.","volume":"54","author":"Andjelkovic","year":"2023","journal-title":"Stroke"},{"key":"B7","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1097\/JGP.0b013e3181a2fd07","article-title":"Alcohol consumption as a risk factor for dementia and cognitive decline: Meta-analysis of prospective studies.","volume":"17","author":"Anstey","year":"2009","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"B8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.neuropharm.2017.09.030","article-title":"Ethanol differentially modulates P2X4 and P2X7 receptor activity and function in BV2 microglial cells.","volume":"128","author":"Asatryan","year":"2018","journal-title":"Neuropharmacology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/s12640-010-9183-1","article-title":"Overexpression of aldehyde dehydrogenase-2 attenuates neurotoxicity induced by 4-hydroxynonenal in cultured primary hippocampal neurons.","volume":"19","author":"Bai","year":"2011","journal-title":"Neurotox Res"},{"key":"B10","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nrd.2015.21","article-title":"From blood-brain barrier to blood-brain interface: New opportunities for CNS drug delivery.","volume":"15","author":"Banks","year":"2016","journal-title":"Nat. Rev. Drug Discov"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1016\/j.neuropharm.2011.08.030","article-title":"Ethanol protects cultured neurons against amyloid-\u03b2 and \u03b1-synuclein-induced synapse damage.","volume":"61","author":"Bate","year":"2011","journal-title":"Neuropharmacology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.pharmthera.2013.12.009","article-title":"Genetic mouse models of brain ageing and Alzheimer\u2019s disease.","volume":"142","author":"Bilkei-Gorzo","year":"2014","journal-title":"Pharmacol. Ther"},{"key":"B13","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/s0891-5849(02)00787-6","article-title":"Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells.","volume":"32","author":"Bohr","year":"2002","journal-title":"Free Radic. Biol. Med"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202154405","article-title":"Isotope-labeled amyloid-\u03b2 does not transmit to the brain in a prion-like manner after peripheral administration.","volume":"23","author":"Brackhan","year":"2022","journal-title":"EMBO Rep"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000050","article-title":"The alcohol flushing response: An unrecognized risk factor for esophageal cancer from alcohol consumption.","volume":"6","author":"Brooks","year":"2009","journal-title":"PLoS Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1097\/00005072-199803000-00007","article-title":"4-Hydroxynonenal, a product of lipid peroxidation, damages cholinergic neurons and impairs visuospatial memory in rats.","volume":"57","author":"Bruce-Keller","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.neulet.2005.12.017","article-title":"Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment.","volume":"397","author":"Butterfield","year":"2006","journal-title":"Neurosci. Lett"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-023-03354-0","article-title":"ALDH2 rs671 and MTHFR rs1801133 polymorphisms are risk factors for arteriosclerosis in multiple arteries.","volume":"23","author":"Cai","year":"2023","journal-title":"BMC Cardiovasc. Disord"},{"key":"B19","doi-asserted-by":"publisher","first-page":"282","DOI":"10.14336\/ad.2014.002","article-title":"Metabolic risk factors of sporadic Alzheimer\u2019s disease: Implications in the pathology, pathogenesis and treatment.","volume":"6","author":"Chakrabarti","year":"2015","journal-title":"Aging Dis"},{"key":"B20","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1007\/s11481-018-9796-3","article-title":"Ethanol\u2019s effects on transient receptor potential channel expression in brain microvascular endothelial cells.","volume":"13","author":"Chang","year":"2018","journal-title":"J. Neuroimmune Pharmacol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1086\/302540","article-title":"Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism.","volume":"65","author":"Chen","year":"1999","journal-title":"Am. J. Hum. Genet"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1126\/science.1158554","article-title":"Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart.","volume":"321","author":"Chen","year":"2008","journal-title":"Science"},{"key":"B23","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/978-981-13-6260-6_3","article-title":"ALDH2 and Cardiovascular disease.","volume":"1193","author":"Chen","year":"2019","journal-title":"Adv. Exp. Med. Biol"},{"key":"B24","first-page":"111","article-title":"The role of mitochondrial Aldehyde Dehydrogenase 2 (ALDH2) in neuropathology and neurodegeneration.","volume":"25","author":"Chen","year":"2016","journal-title":"Acta Neurol. Taiwan"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.049601","article-title":"ALDH2 variance in disease and populations.","volume":"15","author":"Chen","year":"2022","journal-title":"Dis. Model. Mech"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.1057059","article-title":"The potential diagnostic accuracy of urine formaldehyde levels in Alzheimer\u2019s disease: A systematic review and meta-analysis.","volume":"14","author":"Chen","year":"2022","journal-title":"Front. Aging Neurosci"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1111\/j.1471-4159.2006.04181.x","article-title":"Potential inplications of endogenous aldehydes in beta-amyloid misfolding, oligomerization and fibrillogenesis.","volume":"99","author":"Chen","year":"2006","journal-title":"J. Neurochem"},{"key":"B28","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1097\/FPC.0b013e32832ecf2e","article-title":"Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene allele.","volume":"19","author":"Chen","year":"2009","journal-title":"Pharmacogenet. Genomics"},{"key":"B29","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/s0197-4580(00)00196-2","article-title":"Deficits in the expression of the NR2B subunit in the hippocampus of aged Fisher 344 rats.","volume":"22","author":"Clayton","year":"2001","journal-title":"Neurobiol. Aging"},{"key":"B30","doi-asserted-by":"publisher","first-page":"3628","DOI":"10.1523\/jneurosci.22-09-03628.2002","article-title":"A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat.","volume":"22","author":"Clayton","year":"2002","journal-title":"J. Neurosci"},{"key":"B31","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.neuropharm.2017.01.031","article-title":"The role of neuroimmune signaling in alcoholism.","volume":"122","author":"Crews","year":"2017","journal-title":"Neuropharmacology"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1038\/cdd.2013.138","article-title":"Cell death and diseases related to oxidative stress: 4-Hydroxynonenal (HNE) in the balance.","volume":"20","author":"Dalleau","year":"2013","journal-title":"Cell Death Differ"},{"key":"B33","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.freeradbiomed.2016.10.490","article-title":"Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of Alzheimer disease and other selected age-related neurodegenerative disorders.","volume":"111","author":"Di Domenico","year":"2017","journal-title":"Free Radic. Biol. Med"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101728","article-title":"Nutrients and amyloid \u03b2 status in the brain: A narrative review.","volume":"81","author":"D\u00edaz","year":"2022","journal-title":"Ageing Res. Rev"},{"key":"B35","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/j.molcel.2020.10.012","article-title":"Two aldehyde clearance systems are essential to prevent lethal formaldehyde accumulation in mice and humans.","volume":"80","author":"Dingler","year":"2020","journal-title":"Mol. Cell"},{"key":"B36","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.neulet.2003.11.047","article-title":"4-Hydroxynonenal oxidatively modifies histones: Implications for Alzheimer\u2019s disease.","volume":"356","author":"Drake","year":"2004","journal-title":"Neurosci. Lett"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-015-0117-y","article-title":"Characterization of Aldh2 (-\/-) mice as an age-related model of cognitive impairment and Alzheimer\u2019s disease.","volume":"8","author":"D\u2019Souza","year":"2015","journal-title":"Mol. Brain"},{"key":"B38","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/nrgastro.2013.86","article-title":"Genetics and alcoholism.","volume":"10","author":"Edenberg","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1126\/science.1194516","article-title":"Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.","volume":"330","author":"Eisele","year":"2010","journal-title":"Science"},{"key":"B40","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1046\/j.1471-4159.2002.00838.x","article-title":"Involvement of glycogen synthase kinase-3beta and tau phosphorylation in neuronal Golgi disassembly.","volume":"81","author":"Elyaman","year":"2002","journal-title":"J. Neurochem"},{"key":"B41","doi-asserted-by":"publisher","first-page":"227","DOI":"10.2220\/biomedres.30.227","article-title":"Elevated levels of 4-hydroxynonenal-histidine Michael adduct in the hippocampi of patients with Alzheimer\u2019s disease.","volume":"30","author":"Fukuda","year":"2009","journal-title":"Biomed. Res"},{"key":"B42","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.exger.2016.03.014","article-title":"Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence.","volume":"80","author":"Gri\u00f1an-Ferr\u00e9","year":"2016","journal-title":"Exp. Gerontol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"664","DOI":"10.18632\/aging.100906","article-title":"Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice.","volume":"8","author":"Gri\u00f1\u00e1n-Ferr\u00e9","year":"2016","journal-title":"Aging"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abp9952","article-title":"SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant.","volume":"15","author":"Guo","year":"2023","journal-title":"Sci. Transl. Med"},{"key":"B45","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1111\/j.1474-9726.2012.00817.x","article-title":"Oxidative lipid modification of nicastrin enhances amyloidogenic \u03b3-secretase activity in Alzheimer\u2019s disease.","volume":"11","author":"Gwon","year":"2012","journal-title":"Aging Cell"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1189\/jlb.0605340","article-title":"Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction.","volume":"78","author":"Haorah","year":"2005","journal-title":"J. Leukoc Biol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1007\/s11427-010-4112-3","article-title":"Formaldehyde stress.","volume":"53","author":"He","year":"2010","journal-title":"Sci. China Life Sci"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1212\/WNL.0b013e31828726f5","article-title":"Alzheimer disease in the United States (2010-2050) estimated using the 2010 census.","volume":"80","author":"Hebert","year":"2013","journal-title":"Neurology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/bs.irn.2019.10.017","article-title":"Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer\u2019s disease.","volume":"148","author":"Hoffman","year":"2019","journal-title":"Int Rev. Neurobiol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"747","DOI":"10.3233\/jad-150977","article-title":"Homocysteine and Alzheimer\u2019s disease: Evidence for a causal link from mendelian randomization.","volume":"52","author":"Hu","year":"2016","journal-title":"J. Alzheimers Dis"},{"key":"B51","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1002\/em.20599","article-title":"DNA cross-link induced by trans-4-hydroxynonenal.","volume":"51","author":"Huang","year":"2010","journal-title":"Environ. Mol. Mutagen"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-023-01635-5","article-title":"Changes of neurofilament light chain in patients with alcohol dependence following withdrawal and the genetic effect from ALDH2 Polymorphism.","author":"Huang","year":"2023","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci"},{"key":"B53","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1111\/j.1471-4159.2004.02548.x","article-title":"Differential expression of N-methyl-D-aspartate receptor NR2 isoforms in Alzheimer\u2019s disease.","volume":"90","author":"Hynd","year":"2004","journal-title":"J. Neurochem"},{"key":"B54","doi-asserted-by":"publisher","first-page":"204","DOI":"10.2174\/157488471003150820145539","article-title":"Alcohol consumption, dementia and cognitive decline: An overview of systematic reviews.","volume":"10","author":"Ilomaki","year":"2015","journal-title":"Curr. Clin. Pharmacol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.54771","article-title":"Changes in alcohol consumption and risk of dementia in a nationwide cohort in South Korea.","volume":"6","author":"Jeon","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.710966","article-title":"Associations of alcohol dehydrogenase and aldehyde dehydrogenase polymorphism with cognitive impairment among the oldest-old in China.","volume":"13","author":"Jin","year":"2021","journal-title":"Front. Aging Neurosci"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-019-0839-7","article-title":"Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer\u2019s disease related pathology.","volume":"7","author":"Joshi","year":"2019","journal-title":"Acta Neuropathol. Commun"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00282","article-title":"Alcohol use disorder, neurodegeneration, Alzheimer\u2019s and Parkinson\u2019s Disease: Interplay between oxidative stress, neuroimmune response and excitotoxicity.","volume":"14","author":"Kamal","year":"2020","journal-title":"Front. Cell Neurosci"},{"key":"B59","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1006\/bbrc.2000.2923","article-title":"Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer\u2019s disease in the Japanese population.","volume":"273","author":"Kamino","year":"2000","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"B60","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.neulet.2014.12.033","article-title":"Oxidative stress accelerates amyloid deposition and memory impairment in a double-transgenic mouse model of Alzheimer\u2019s disease.","volume":"587","author":"Kanamaru","year":"2015","journal-title":"Neurosci. Lett"},{"key":"B61","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1523\/jneurosci.21-02-00372.2001","article-title":"Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer\u2019s disease.","volume":"21","author":"Kawarabayashi","year":"2001","journal-title":"J. Neurosci"},{"key":"B62","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1046\/j.1471-4159.1997.69010273.x","article-title":"Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: Role of the lipid peroxidation product 4-hydroxynonenal.","volume":"69","author":"Keller","year":"1997","journal-title":"J. Neurochem"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1212\/01.Wnl.0000156156.13641.Ba","article-title":"Evidence of increased oxidative damage in subjects with mild cognitive impairment.","volume":"64","author":"Keller","year":"2005","journal-title":"Neurology"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.2174\/1570159x18666200528142429","article-title":"Recent advancements in pathogenesis, diagnostics and treatment of Alzheimer\u2019s disease.","volume":"18","author":"Khan","year":"2020","journal-title":"Curr. Neuropharmacol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/s0197-4580(03)00114-3","article-title":"Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer\u2019s disease in an older Korean population.","volume":"25","author":"Kim","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"B66","doi-asserted-by":"publisher","first-page":"135","DOI":"10.5483\/BMBRep.2011.44.2.135","article-title":"Effects of chronic alcohol consumption on expression levels of APP and A\u03b2-producing enzymes.","volume":"44","author":"Kim","year":"2011","journal-title":"BMB Rep"},{"key":"B67","doi-asserted-by":"publisher","first-page":"4445","DOI":"10.1021\/bi9521093","article-title":"Possible role of liver cytosolic and mitochondrial aldehyde dehydrogenases in acetaldehyde metabolism.","volume":"35","author":"Klyosov","year":"1996","journal-title":"Biochemistry"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101486","article-title":"Interaction of oxidative stress and neurotrauma in ALDH2(-\/-) mice causes significant and persistent behavioral and pro-inflammatory effects in a tractable model of mild traumatic brain injury.","volume":"32","author":"Knopp","year":"2020","journal-title":"Redox Biol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.10319","article-title":"Alcohol consumption and risk of dementia and cognitive decline among older adults with or without mild cognitive impairment.","volume":"2","author":"Koch","year":"2019","journal-title":"JAMA Netw. Open"},{"key":"B70","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00702-013-1112-z","article-title":"Polymorphisms in the aldehyde dehydrogenase 2 and dopamine \u03b2 hydroxylase genes are not associated with Alzheimer\u2019s disease.","volume":"121","author":"Komatsu","year":"2014","journal-title":"J. Neural Transm."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101512","article-title":"Formaldehyde toxicity in age-related neurological dementia.","volume":"73","author":"Kou","year":"2022","journal-title":"Ageing Res. Rev"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001358","article-title":"Synthesis of human amyloid restricted to liver results in an Alzheimer disease-like neurodegenerative phenotype.","volume":"19","author":"Lam","year":"2021","journal-title":"PLoS Biol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer\u2019s disease.","volume":"25","author":"Lane","year":"2018","journal-title":"Eur. J. Neurol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1007\/s40520-020-01605-0","article-title":"Association between alcohol intake, mild cognitive impairment and progression to dementia: A dose-response meta-analysis.","volume":"33","author":"Lao","year":"2021","journal-title":"Aging Clin. Exp. Res"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2021.778456","article-title":"Alcohol-induced neuroinflammatory response and mitochondrial dysfunction on aging and Alzheimer\u2019s disease.","volume":"15","author":"Le\u00f3n","year":"2021","journal-title":"Front. Behav. Neurosci"},{"key":"B76","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.bbr.2014.01.001","article-title":"Disturbance of endogenous hydrogen sulfide generation and endoplasmic reticulum stress in hippocampus are involved in homocysteine-induced defect in learning and memory of rats.","volume":"262","author":"Li","year":"2014","journal-title":"Behav. Brain Res"},{"key":"B77","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1093\/ijnp\/pyw103","article-title":"Hydrogen sulfide ameliorates homocysteine-induced cognitive dysfunction by inhibition of reactive aldehydes involving upregulation of ALDH2.","volume":"20","author":"Li","year":"2017","journal-title":"Int. J. Neuropsychopharmacol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3390\/genes12060913","article-title":"Formaldehyde and De\/Methylation in age-related cognitive impairment.","volume":"12","author":"Li","year":"2021","journal-title":"Genes"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-021-00494-9","article-title":"Synaptic dysfunction of Aldh1a1 neurons in the ventral tegmental area causes impulsive behaviors.","volume":"16","author":"Li","year":"2021","journal-title":"Mol. Neurodegener"},{"key":"B80","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1016\/j.jmb.2008.01.057","article-title":"Promotion of amyloid beta protein misfolding and fibrillogenesis by a lipid oxidation product.","volume":"377","author":"Liu","year":"2008","journal-title":"J. Mol. Biol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/s0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission.","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"B82","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.neulet.2013.10.051","article-title":"Characterization of the APP\/PS1 mouse model of Alzheimer\u2019s disease in senescence accelerated background.","author":"Lok","year":"2013","journal-title":"Neurosci. Lett"},{"key":"B83","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/s0197-4580(97)00108-5","article-title":"Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer\u2019s disease.","volume":"18","author":"Lovell","year":"1997","journal-title":"Neurobiol. Aging"},{"key":"B84","doi-asserted-by":"publisher","first-page":"4102","DOI":"10.1016\/j.bbagen.2013.04.028","article-title":"Formaldehyde induces hyperphosphorylation and polymerization of Tau protein both in vitro and in vivo.","volume":"1830","author":"Lu","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-016-0103-6","article-title":"A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer\u2019s disease.","volume":"11","author":"Luo","year":"2016","journal-title":"Mol. Neurodegener"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.4238\/gmr.15048740","article-title":"Role of ADH1B rs1229984 and ALDH2 rs671 gene polymorphisms in the development of Alzheimer\u2019s disease.","volume":"15","author":"Ma","year":"2016","journal-title":"Genet. Mol. Res"},{"key":"B87","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1016\/s0140-6736(18)32744-2","article-title":"Global alcohol exposure between 1990 and 2017 and forecasts until 2030: A modelling study.","volume":"393","author":"Manthey","year":"2019","journal-title":"Lancet"},{"key":"B88","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1517\/17425255.4.6.697","article-title":"Non-P450 aldehyde oxidizing enzymes: The aldehyde dehydrogenase superfamily.","volume":"4","author":"Marchitti","year":"2008","journal-title":"Expert Opin. Drug Metab. Toxicol"},{"key":"B89","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1046\/j.1471-4159.1997.68010255.x","article-title":"A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide.","volume":"68","author":"Mark","year":"1997","journal-title":"J. Neurochem"},{"key":"B90","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/s0197-4580(98)00009-8","article-title":"Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer\u2019s disease.","volume":"19","author":"Markesbery","year":"1998","journal-title":"Neurobiol. Aging"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.56","article-title":"Alzheimer\u2019s disease.","volume":"1","author":"Masters","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.3233\/jad-191067","article-title":"Morphometric analysis of hippocampal and neocortical pyramidal neurons in a mouse model of late onset Alzheimer\u2019s disease.","volume":"74","author":"Mehder","year":"2020","journal-title":"J. Alzheimers Dis"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.3233\/jad-201024","article-title":"Age-related neuronal deterioration specifically within the dorsal CA1 region of the hippocampus in a mouse model of late onset Alzheimer\u2019s disease.","volume":"79","author":"Mehder","year":"2021","journal-title":"J. Alzheimers Dis"},{"key":"B94","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/s0197-4580(03)00116-7","article-title":"Sulindac improves memory and increases NMDA receptor subunits in aged Fischer 344 rats.","volume":"25","author":"Mesches","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"B95","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1093\/alcalc\/agac013","article-title":"Alcohol consumption: Medical implications, the liver and beyond.","volume":"57","author":"Meza","year":"2022","journal-title":"Alcohol Alcohol"},{"key":"B96","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1038\/nn.2560","article-title":"Cortical DNA methylation maintains remote memory.","volume":"13","author":"Miller","year":"2010","journal-title":"Nat. Neurosci"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-01087-1","article-title":"Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer\u2019s disease.","volume":"8","author":"Morales","year":"2020","journal-title":"Acta Neuropathol. Commun"},{"key":"B98","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1182\/blood.2020009111","article-title":"Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5\/ALDH2 deficiency.","volume":"137","author":"Mu","year":"2021","journal-title":"Blood"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9765027","article-title":"ALDH2 activity reduces mitochondrial oxygen reserve capacity in endothelial cells and induces senescence properties.","volume":"2018","author":"Nannelli","year":"2018","journal-title":"Oxid. Med. Cell Longev"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8010004","article-title":"Endothelial aldehyde dehydrogenase 2 as a target to maintain vascular wellness and function in ageing.","volume":"8","author":"Nannelli","year":"2020","journal-title":"Biomedicines"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-8-9","article-title":"Amyloid-like aggregates of neuronal tau induced by formaldehyde promote apoptosis of neuronal cells.","volume":"8","author":"Nie","year":"","journal-title":"BMC Neurosci"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000629","article-title":"Formaldehyde at low concentration induces protein tau into globular amyloid-like aggregates in vitro and in vivo.","volume":"2","author":"Nie","year":"","journal-title":"PLoS One"},{"key":"B103","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1007\/s12035-018-1114-9","article-title":"Multifaceted regulation of ALDH1A1 by Cdk5 in Alzheimer\u2019s disease pathogenesis.","volume":"56","author":"Nikhil","year":"2019","journal-title":"Mol. Neurobiol"},{"key":"B104","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1038\/nm.3407","article-title":"Development, maintenance and disruption of the blood-brain barrier.","volume":"19","author":"Obermeier","year":"2013","journal-title":"Nat. Med"},{"key":"B105","doi-asserted-by":"publisher","first-page":"6239","DOI":"10.1523\/jneurosci.4956-07.2008","article-title":"Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity.","volume":"28","author":"Ohsawa","year":"2008","journal-title":"J. Neurosci"},{"key":"B106","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1046\/j.1471-4159.2003.01619.x","article-title":"Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells.","volume":"84","author":"Ohsawa","year":"2003","journal-title":"J. Neurochem"},{"key":"B107","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/978-3-662-41088-2_4","article-title":"Mitochondrial ALDH2 deficiency as an oxidative stress.","volume":"1011","author":"Ohta","year":"2004","journal-title":"Ann. N. Y. Acad. Sci"},{"key":"B108","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.arcmed.2012.12.004","article-title":"Ethanol reduces amyloid aggregation in vitro and prevents toxicity in cell lines.","volume":"44","author":"Orme\u00f1o","year":"2013","journal-title":"Arch. Med. Res"},{"key":"B109","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1016\/j.freeradbiomed.2010.09.013","article-title":"Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for A\u03b2 accumulation in AD brain.","volume":"49","author":"Owen","year":"2010","journal-title":"Free Radic. Biol. Med"},{"key":"B110","first-page":"401","article-title":"The oxidative stress hypothesis in Alzheimer\u2019s disease.","volume":"25","author":"Padurariu","year":"2013","journal-title":"Psychiatr. Danub"},{"key":"B111","doi-asserted-by":"publisher","first-page":"13","DOI":"10.5483\/bmbrep.2015.48.1.125","article-title":"Amyloid pore-channel hypothesis: Effect of ethanol on aggregation state using frog oocytes for an Alzheimer\u2019s disease study.","volume":"48","author":"Parodi","year":"2015","journal-title":"BMB Rep"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072316","article-title":"Role of alcohol drinking in Alzheimer\u2019s disease, Parkinson\u2019s disease, and amyotrophic lateral sclerosis.","volume":"21","author":"Peng","year":"2020","journal-title":"Int. J. Mol. Sci"},{"key":"B113","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1089\/ars.2011.4406","article-title":"4-Hydroxy-2-nonenal, a reactive product of lipid peroxidation, and neurodegenerative diseases: A toxic combination illuminated by redox proteomics studies.","volume":"17","author":"Perluigi","year":"2012","journal-title":"Antioxid. Redox Signal"},{"key":"B114","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1002\/prca.200800161","article-title":"Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer\u2019s disease: Role of lipid peroxidation in Alzheimer\u2019s disease pathogenesis.","volume":"3","author":"Perluigi","year":"2009","journal-title":"Proteom. Clin. Appl"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00513","article-title":"Effects of drugs of abuse on the blood-brain barrier: A brief overview.","volume":"14","author":"Pimentel","year":"2020","journal-title":"Front. Neurosci"},{"key":"B116","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1093\/pubmed\/fdx186","article-title":"The relationship between alcohol use and long-term cognitive decline in middle and late life: A longitudinal analysis using UK Biobank.","volume":"40","author":"Piumatti","year":"2018","journal-title":"J. Public Health"},{"key":"B117","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.tips.2008.09.001","article-title":"Oxidative stress hypothesis in Alzheimer\u2019s disease: A reappraisal.","volume":"29","author":"Pratic\u00f2","year":"2008","journal-title":"Trends Pharmacol. Sci"},{"key":"B118","doi-asserted-by":"publisher","first-page":"4183","DOI":"10.1523\/jneurosci.21-12-04183.2001","article-title":"Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.","volume":"21","author":"Pratic\u00f2","year":"2001","journal-title":"J. Neurosci"},{"key":"B119","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/s0304-3940(01)02011-0","article-title":"Ethanol induced changes in cyclin-dependent kinase-5 activity and its activators, P35, P67 (Munc-18) in rat brain.","volume":"308","author":"Rajgopal","year":"2001","journal-title":"Neurosci. Lett"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.910298","article-title":"Innate immune activation: Parallels in alcohol use disorder and Alzheimer\u2019s disease.","volume":"15","author":"Ramos","year":"2022","journal-title":"Front. Mol. Neurosci"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1017\/s2045796020001183","article-title":"Alcohol, coffee and tea intake and the risk of cognitive deficits: A dose-response meta-analysis.","volume":"30","author":"Ran","year":"2021","journal-title":"Epidemiol. Psychiatr. Sci"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010206","article-title":"Relationship of wine consumption with Alzheimer\u2019s disease.","volume":"12","author":"Reale","year":"2020","journal-title":"Nutrients"},{"key":"B123","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.brainres.2009.04.009","article-title":"Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD.","volume":"1274","author":"Reed","year":"2009","journal-title":"Brain Res"},{"key":"B124","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1016\/j.freeradbiomed.2008.03.012","article-title":"Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease.","volume":"44","author":"Resende","year":"2008","journal-title":"Free Radic. Biol. Med"},{"key":"B125","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1021\/acs.chemrestox.8b00256","article-title":"Role of aldehyde dehydrogenases in physiopathological processes.","volume":"32","author":"Rodr\u00edguez-Zavala","year":"2019","journal-title":"Chem. Res. Toxicol"},{"key":"B126","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1002\/cbf.3468","article-title":"Aldehyde dehydrogenase 2 inhibition potentiates 4-hydroxy-2-nonenal induced decrease in angiogenesis of coronary endothelial cells.","volume":"38","author":"Roy","year":"2020","journal-title":"Cell Biochem. Funct"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2020.106762","article-title":"4-hydroxy-2-nonenal decreases coronary endothelial cell migration: Potentiation by aldehyde dehydrogenase 2 inhibition.","volume":"131","author":"Roy","year":"2020","journal-title":"Vascul. Pharmacol"},{"key":"B128","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1111\/adb.12376","article-title":"Disruption of blood-brain barrier integrity in postmortem alcoholic brain: Preclinical evidence of TLR4 involvement from a binge-like drinking model.","volume":"22","author":"Rubio-Araiz","year":"2017","journal-title":"Addict. Biol"},{"key":"B129","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/s1470-2045(21)00279-5","article-title":"Global burden of cancer in 2020 attributable to alcohol consumption: A population-based study.","volume":"22","author":"Rumgay","year":"2021","journal-title":"Lancet Oncol"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k2927","article-title":"Alcohol consumption and risk of dementia: 23 year follow-up of Whitehall II cohort study.","volume":"362","author":"Sabia","year":"2018","journal-title":"BMJ"},{"key":"B131","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1046\/j.1471-4159.1997.68052092.x","article-title":"4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer\u2019s disease.","volume":"68","author":"Sayre","year":"1997","journal-title":"J. Neurochem"},{"key":"B132","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/s0140-6736(20)32205-4","article-title":"Alzheimer\u2019s disease.","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"key":"B133","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1212\/01.wnl.0000271090.28148.24","article-title":"Mixed brain pathologies account for most dementia cases in community-dwelling older persons.","volume":"69","author":"Schneider","year":"2007","journal-title":"Neurology"},{"key":"B134","doi-asserted-by":"publisher","first-page":"e124","DOI":"10.1016\/s2468-2667(18)30022-7","article-title":"Contribution of alcohol use disorders to the burden of dementia in France 2008-13: A nationwide retrospective cohort study.","volume":"3","author":"Schwarzinger","year":"2018","journal-title":"Lancet Public Health"},{"key":"B135","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.jcmgh.2022.06.008","article-title":"Hydroxynonenal causes hepatocyte death by disrupting lysosomal integrity in nonalcoholic steatohepatitis.","volume":"14","author":"Seike","year":"2022","journal-title":"Cell Mol. Gastroenterol. Hepatol"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.20517\/2394-5079.2021.46","article-title":"Role of CD4+ T-cells in the pathology of non-alcoholic fatty liver disease and related diseases.","volume":"7","author":"Seike","year":"2021","journal-title":"Hepatoma Res"},{"key":"B137","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1007\/s00535-020-01679-7","article-title":"Fatty acid-driven modifications in T-cell profiles in non-alcoholic fatty liver disease patients.","volume":"55","author":"Seike","year":"2020","journal-title":"J. Gastroenterol"},{"key":"B138","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1056\/NEJMoa011613","article-title":"Plasma homocysteine as a risk factor for dementia and Alzheimer\u2019s disease.","volume":"346","author":"Seshadri","year":"2002","journal-title":"N. Engl. J. Med"},{"key":"B139","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1126\/science.290.5494.1170","article-title":"NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation.","volume":"290","author":"Shimizu","year":"2000","journal-title":"Science"},{"key":"B140","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1002\/gps.1401","article-title":"Mitochondrial aldehyde dehydrogenase polymorphism is not associated with incidence of Alzheimer\u2019s disease.","volume":"20","author":"Shin","year":"2005","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8090326","article-title":"4-hydroxynonenal immunoreactivity is increased in the frontal cortex of 5XFAD transgenic mice.","volume":"8","author":"Shin","year":"2020","journal-title":"Biomedicines"},{"key":"B142","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1007\/pl00000660","article-title":"4-Hydroxynonenal-modified amyloid-beta peptide inhibits the proteasome: Possible importance in Alzheimer\u2019s disease.","volume":"57","author":"Shringarpure","year":"2000","journal-title":"Cell Mol. Life Sci"},{"key":"B143","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1021\/bi061853s","article-title":"The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation.","volume":"46","author":"Siegel","year":"2007","journal-title":"Biochemistry"},{"key":"B144","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1093\/alcalc\/agl120","article-title":"Effects of chronic ethanol drinking on the blood brain barrier and ensuing neuronal toxicity in alcohol-preferring rats subjected to intraperitoneal LPS injection.","volume":"42","author":"Singh","year":"2007","journal-title":"Alcohol Alcohol"},{"key":"B145","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1097\/01.Alc.0000087086.50089.59","article-title":"Evaluation of aldehyde dehydrogenase 1 promoter polymorphisms identified in human populations.","volume":"27","author":"Spence","year":"2003","journal-title":"Alcohol Clin. Exp. Res"},{"key":"B146","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.freeradbiomed.2012.09.027","article-title":"Lipid peroxidation triggers neurodegeneration: A redox proteomics view into the Alzheimer disease brain.","volume":"62","author":"Sultana","year":"2013","journal-title":"Free Radic. Biol. Med"},{"key":"B147","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nrneurol.2017.188","article-title":"Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders.","volume":"14","author":"Sweeney","year":"2018","journal-title":"Nat. Rev. Neurol"},{"key":"B148","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1006\/nbdi.2002.0515","article-title":"Oxidative stress increases expression and activity of BACE in NT2 neurons.","volume":"10","author":"Tamagno","year":"2002","journal-title":"Neurobiol. Dis"},{"key":"B149","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1111\/j.1471-4159.2004.02895.x","article-title":"Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways.","volume":"92","author":"Tamagno","year":"2005","journal-title":"J. Neurochem"},{"key":"B150","doi-asserted-by":"publisher","first-page":"3669","DOI":"10.1096\/fj.201701239R","article-title":"Formaldehyde induces diabetes-associated cognitive impairments.","volume":"32","author":"Tan","year":"2018","journal-title":"FASEB J"},{"key":"B151","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3233\/jad-220683","article-title":"Machine learning selection of most predictive brain proteins suggests role of sugar metabolism in Alzheimer\u2019s disease.","volume":"92","author":"Tandon","year":"2023","journal-title":"J. Alzheimers Dis"},{"key":"B152","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1021\/acs.analchem.1c04520","article-title":"In situ imaging of formaldehyde in live mice with high spatiotemporal resolution reveals aldehyde dehydrogenase-2 as a potential target for Alzheimer\u2019s disease treatment.","volume":"94","author":"Tao","year":"2022","journal-title":"Anal. Chem"},{"key":"B153","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/s0009-2797(00)00272-6","article-title":"The formaldehyde metabolic detoxification enzyme systems and molecular cytotoxic mechanism in isolated rat hepatocytes.","author":"Teng","year":"2001","journal-title":"Chem. Biol. Interact"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1038\/srep01807","article-title":"Aging-associated excess formaldehyde leads to spatial memory deficits.","volume":"3","author":"Tong","year":"","journal-title":"Sci. Rep"},{"key":"B155","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s11357-012-9388-8","article-title":"Accumulated hippocampal formaldehyde induces age-dependent memory decline.","volume":"35","author":"Tong","year":"","journal-title":"Age"},{"key":"B156","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.neurobiolaging.2014.07.018","article-title":"Age-related formaldehyde interferes with DNA methyltransferase function, causing memory loss in Alzheimer\u2019s disease.","volume":"36","author":"Tong","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"B157","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.neurobiolaging.2009.07.013","article-title":"Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia.","volume":"32","author":"Tong","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j2353","article-title":"Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: Longitudinal cohort study.","volume":"357","author":"Topiwala","year":"2017","journal-title":"BMJ"},{"key":"B159","doi-asserted-by":"publisher","first-page":"863","DOI":"10.3233\/jad-215627","article-title":"Association study and meta-analysis of polymorphisms and blood mRNA expression of the ALDH2 gene in patients with Alzheimer\u2019s disease.","volume":"87","author":"Ueno","year":"2022","journal-title":"J. Alzheimers Dis"},{"key":"B160","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.archger.2008.03.009","article-title":"Hyperhomocysteinemia and Alzheimer\u2019s disease: A systematic review.","volume":"48","author":"Van Dam","year":"2009","journal-title":"Arch. Gerontol. Geriatr"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agw101","article-title":"Alcohol and Alzheimer\u2019s disease-does alcohol dependence contribute to beta-amyloid deposition, neuroinflammation and neurodegeneration in Alzheimer\u2019s disease?","volume":"52","author":"Venkataraman","year":"2017","journal-title":"Alcohol Alcohol"},{"key":"B162","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/YCO.0000000000000679","article-title":"Alcohol use and dementia: New research directions.","volume":"34","author":"Visontay","year":"2021","journal-title":"Curr. Opin. Psychiatry"},{"key":"B163","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.jns.2007.12.006","article-title":"The association of mitochondrial aldehyde dehydrogenase gene (ALDH2) polymorphism with susceptibility to late-onset Alzheimer\u2019s disease in Chinese.","volume":"268","author":"Wang","year":"2008","journal-title":"J. Neurol. Sci"},{"key":"B164","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.bbrc.2003.09.003","article-title":"Oxidized neprilysin in aging and Alzheimer\u2019s disease brains.","volume":"310","author":"Wang","year":"2003","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"B165","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/nrneurol.2017.111","article-title":"A systemic view of Alzheimer disease - insights from amyloid-\u03b2 metabolism beyond the brain.","volume":"13","author":"Wang","year":"2017","journal-title":"Nat. Rev. Neurol"},{"key":"B166","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1111\/j.1471-4159.2008.05855.x","article-title":"Effects of HNE-modification induced by Abeta on neprilysin expression and activity in SH-SY5Y cells.","volume":"108","author":"Wang","year":"2009","journal-title":"J. Neurochem"},{"key":"B167","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1523\/jneurosci.22-05-01858.2002","article-title":"The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer\u2019s disease.","volume":"22","author":"Westerman","year":"2002","journal-title":"J. Neurosci"},{"key":"B168","doi-asserted-by":"publisher","first-page":"87","DOI":"10.2147\/ndt.S198772","article-title":"Alcohol and dementia - what is the link? A systematic review.","volume":"16","author":"Wiegmann","year":"2020","journal-title":"Neuropsychiatr. Dis. Treat"},{"key":"B169","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.neurobiolaging.2005.06.004","article-title":"Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer\u2019s disease.","volume":"27","author":"Williams","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101409","article-title":"The role of the immune system in Alzheimer\u2019s disease.","volume":"70","author":"Wu","year":"2021","journal-title":"Ageing Res. Rev"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.625885","article-title":"Association study of alcohol dehydrogenase and aldehyde dehydrogenase polymorphism with Alzheimer disease in the Taiwanese population.","volume":"15","author":"Wu","year":"2021","journal-title":"Front. Neurosci"},{"key":"B172","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1111\/j.1582-4934.2010.01181.x","article-title":"Role of aldehyde dehydrogenase 2 Glu504lys polymorphism in acute coronary syndrome.","volume":"15","author":"Xu","year":"2011","journal-title":"J. Cell Mol. Med"},{"key":"B173","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s10654-017-0225-3","article-title":"Alcohol consumption and dementia risk: A dose-response meta-analysis of prospective studies.","volume":"32","author":"Xu","year":"2017","journal-title":"Eur. J. Epidemiol"},{"key":"B174","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.bbrc.2018.08.081","article-title":"ALDH2 mediates the dose-response protection of chronic ethanol against endothelial senescence through SIRT1\/p53 pathway.","volume":"504","author":"Xue","year":"2018","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"B175","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bbrc.2019.03.037","article-title":"Appropriate dose of ethanol exerts anti-senescence and anti-atherosclerosis protective effects by activating ALDH2.","volume":"512","author":"Xue","year":"2019","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"B176","first-page":"2161","article-title":"Hydroxynonenal causes lysosomal and autophagic failure in the monkey POMC neurons.","volume":"12","author":"Yamashima","year":"2022","journal-title":"J. Alzheimers Dis. Parkinson"},{"key":"B177","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1093\/advances\/nmaa072","article-title":"Intake of \u03c9-6 polyunsaturated fatty acid-rich vegetable oils and risk of lifestyle diseases.","volume":"11","author":"Yamashima","year":"2020","journal-title":"Adv. Nutr"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.1063632","article-title":"Hsp70.1 carbonylation induces lysosomal cell death for lifestyle-related diseases.","volume":"9","author":"Yamashima","year":"2023","journal-title":"Front. Mol. Biosci."},{"key":"B179","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1093\/abbs\/gmab057","article-title":"Impact of mitochondrial aldehyde dehydrogenase 2 on cognitive impairment in the AD model mouse.","volume":"53","author":"Yang","year":"2021","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"B180","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/978-981-13-6260-6_7","article-title":"Association of East Asian variant aldehyde dehydrogenase 2 genotype (ALDH2*2*) with coronary spasm and acute myocardial infarction.","volume":"1193","author":"Yasue","year":"2019","journal-title":"Adv. Exp. Med. Biol"},{"key":"B181","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1093\/carcin\/23.11.1851","article-title":"Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma.","volume":"23","author":"Yokoyama","year":"2002","journal-title":"Carcinogenesis"},{"key":"B182","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1111\/j.1530-0277.2008.00739.x","article-title":"Salivary acetaldehyde concentration according to alcoholic beverage consumed and aldehyde dehydrogenase-2 genotype.","volume":"32","author":"Yokoyama","year":"2008","journal-title":"Alcohol Clin. Exp. Res"},{"key":"B183","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1469-1809.1989.tb01116.x","article-title":"Cytosolic aldehyde dehydrogenase (ALDH1) variants found in alcohol flushers.","volume":"53","author":"Yoshida","year":"1989","journal-title":"Ann. Hum. Genet"},{"key":"B184","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.trci.2019.09.007","article-title":"New insight into Alzheimer\u2019s disease: Light reverses A\u03b2-obstructed interstitial fluid flow and ameliorates memory decline in APP\/PS1 mice.","volume":"5","author":"Yue","year":"2019","journal-title":"Alzheimers Dement."},{"key":"B185","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.2353\/ajpath.2009.081036","article-title":"Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain.","volume":"174","author":"Zhang","year":"2009","journal-title":"Am. J. Pathol"},{"key":"B186","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1016\/j.apsb.2021.02.008","article-title":"The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment.","volume":"11","author":"Zhang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"B187","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1089\/ars.2018.7520","article-title":"Illumination with 630 nm red light reduces oxidative stress and restores memory by photo-activating catalase and formaldehyde dehydrogenase in SAMP8 mice.","volume":"30","author":"Zhang","year":"2019","journal-title":"Antioxid. Redox Signal"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12370","article-title":"Alcohol use disorder is associated with higher risks of Alzheimer\u2019s and Parkinson\u2019s diseases: A study of US insurance claims data.","volume":"14","author":"Zhang","year":"2022","journal-title":"Alzheimers Dement."},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.7922","article-title":"Association of low to moderate alcohol drinking with cognitive functions from middle to older age among US adults.","volume":"3","author":"Zhang","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"B190","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.neulet.2009.11.022","article-title":"Absence of association on aldehyde dehydrogenase 2 (ALDH2) polymorphism with Mongolian Alzheimer patients.","volume":"468","author":"Zhou","year":"2010","journal-title":"Neurosci. Lett"},{"key":"B191","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/s1474-4422(04)00707-0","article-title":"Alzheimer\u2019s disease: The two-hit hypothesis.","volume":"3","author":"Zhu","year":"2004","journal-title":"Lancet Neurol"},{"key":"B192","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41401-021-00635-2","article-title":"Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP\/PS1 murine model of Alzheimer\u2019s disease via inhibition of ACSL4-dependent ferroptosis.","volume":"43","author":"Zhu","year":"2022","journal-title":"Acta Pharmacol. Sin"},{"key":"B193","doi-asserted-by":"publisher","first-page":"681","DOI":"10.2174\/1567205011666140812115004","article-title":"Severe psychiatric disorders in mid-life and risk of dementia in late- life (age 65-84 years): A population based case-control study.","volume":"11","author":"Zilkens","year":"2014","journal-title":"Curr. Alzheimer Res"}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2023.1223977\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T08:08:01Z","timestamp":1692864481000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2023.1223977\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,24]]},"references-count":193,"alternative-id":["10.3389\/fnagi.2023.1223977"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2023.1223977","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,24]]},"article-number":"1223977"}}