{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:46:47Z","timestamp":1790102807756,"version":"4.0.1"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study aims to investigate the health factors associated with cognitive frailty in frail and pre-frail older adults living in the community.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 233 older adults meeting Fried\u2019s criteria for pre-frailty or frailty were included. Cognitive status was evaluated using the Short Portable Mental Status Questionnaire. Health factors encompassed nutritional status (evaluated using the Mini Nutritional Assessment tool, body mass index, and waist, arm, and leg circumferences), physical function (assessed with the Short Physical Performance Battery), quality of life (measured with the total index of the EuroQoL 5-Dimension 5-Level questionnaire - EQoL-Index -, and the Visual-Analogue Scale - QoL-VAS - for today\u2019s health state), as well as sleep, physical activity, and inactivity estimated through wrist-worn accelerometers. Multivariable logistic regression analyses were conducted to identify potential predictors of cognitive frailty, considering age as a confounding factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cognitive frail participants exhibited advanced age, heightened self-reported exhaustion, diminished overall physical performance, reduced leg perimeter, decreased engagement in moderate-to-vigorous physical activity, and higher levels of inactivity (all p&amp;lt;0.05). However, after adjusting for age, only QoL-VAS emerged as a cognitive frailty risk factor (Odds ratio: 1.024), while the EQoL-Index, calf perimeter, and levels of moderate-to-vigorous physical activity were identified as protective factors (Odds ratios: 0.025, 0.929, and 0.973, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This study highlights the complex relationship between non-modifiable factors such as age, and modifiable factors including quality of life, nutritional status, and physical activity in the development of cognitive frailty among older adults with a frailty phenotype living in the community.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2023.1232460","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T07:37:46Z","timestamp":1695109066000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Health factors associated with cognitive frailty in older adults living in the community"],"prefix":"10.3389","volume":"15","author":[{"given":"Juan","family":"Corral-P\u00e9rez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Casals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"\u00c1vila-Cabeza-de-Vaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gonz\u00e1lez-Mariscal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildefonsa","family":"Mart\u00ednez-Zaragoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Villa-Estrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remedios","family":"Reina-Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda \u00c1.","family":"V\u00e1zquez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3389\/fmed.2017.00199","article-title":"Neuropsychological correlates of pre-frailty in neurocognitive disorders: a possible role for metacognitive dysfunction and mood changes","volume":"4","author":"Amanzio","year":"2017","journal-title":"Front. 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Psychol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1111\/ene.14882","article-title":"Physical and cognitive profiles in motoric cognitive risk syndrome in an older population from Southern Italy","volume":"28","author":"Bortone","year":"2021","journal-title":"Eur. J. Neurol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"861","DOI":"10.3390\/brainsci12070861","article-title":"Motoric cognitive risk syndrome, subtypes and 8-year all-cause mortality in aging phenotypes: the salus in apulia study","volume":"12","author":"Bortone","year":"2022","journal-title":"Brain Sci."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"820","DOI":"10.20960\/nh.1672","article-title":"Frailty in older adults with type 2 diabetes mellitus and its relation with glucemic control, lipid profile, blood pressure, balance, disability grade and nutritional status","volume":"35","author":"Casals","year":"2018","journal-title":"Nutr. Hosp."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.rce.2015.02.012","article-title":"Randomized clinical trial of nutritional counseling for malnourished hospital patients","volume":"215","author":"Casals","year":"2015","journal-title":"Rev. Cl\u00ednica Espa\u00f1ola"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.20960\/nh.1070","article-title":"Relationship between quality of life, physical activity, nutrition, glycemic control and sarcopenia in older adults with type 2 diabetes mellitus","volume":"34","author":"Casals-V\u00e1zquez","year":"2017","journal-title":"Nutr. Hosp."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/S0140-6736(12)62167-9","article-title":"Frailty in elderly people","volume":"381","author":"Clegg","year":"2013","journal-title":"Lancet"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"813398","DOI":"10.3389\/fpsyg.2021.813398","article-title":"Cognitive frailty: an update","volume":"12","author":"Facal","year":"2021","journal-title":"Front. Psychol."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.maturitas.2018.12.006","article-title":"Cognitive frailty: A conceptual systematic review and an operational proposal for future research","volume":"121","author":"Facal","year":"2019","journal-title":"Maturitas"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1007\/s11136-011-9903-x","article-title":"Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L)","volume":"20","author":"Herdman","year":"2011","journal-title":"Qual. Life Res."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1007\/s11136-018-1877-5","article-title":"Validity of the EQ\u20135D\u20135L and reference norms for the Spanish population","volume":"27","author":"Hernandez","year":"2018","journal-title":"Qual. Life Res."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.jamda.2020.05.031","article-title":"Lifestyle activity patterns related to physical frailty and cognitive impairment in urban community-dwelling older adults in Japan","volume":"22","author":"Katayama","year":"2021","journal-title":"J. Am. Med. Dir. 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Gerontol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0025-7753(01)72040-4","article-title":"Adaptaci\u00f3n y validaci\u00f3n al castellano del cuestionario de Pfeiffer (SPMSQ) para detectar la existencia de deterioro cognitivo en personas mayores e 65 a\u00f1os","volume":"117","author":"Mart\u00ednez de la Iglesiaa","year":"2001","journal-title":"Med. Clin. (Barc.)"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"936","DOI":"10.3390\/brainsci13060936","article-title":"Association of motoric cognitive risk syndrome with sarcopenia and systemic inflammation in pre-frail older adults","volume":"13","author":"Merchant","year":"2023","journal-title":"Brain Sci."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"968","DOI":"10.3390\/brainsci10120968","article-title":"Prevalence of cognitive frailty, do psychosocial-related factors matter?","volume":"10","author":"Navarro-Pardo","year":"2020","journal-title":"Brain Sci."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e198398","DOI":"10.1001\/jamanetworkopen.2019.8398","article-title":"Global incidence of frailty and prefrailty among community-dwelling older adults: a systematic review and meta-analysis","volume":"2","author":"Ofori-Asenso","year":"2019","journal-title":"JAMA Netw. 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Sci."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"495","DOI":"10.4321\/S1135-57272012000500004","article-title":"Validation of a spanish short version of the minnesota leisure time physical activity questionnaire (VREM)","volume":"86","author":"Ruiz Comellas","year":"2012","journal-title":"Rev. Esp. Salud Publica"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s12916-015-0390-8","article-title":"Prevalence, risk factors and disability associated with fall-related injury in older adults in low-and middle-incomecountries: results from the WHO Study on global AGEing and adult health (SAGE)","volume":"13","author":"Stewart Williams","year":"2015","journal-title":"BMC Med."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.regg.2012.10.001","article-title":"El Mini Nutritional Assessment. Veinte a\u00f1os de desarrollo ayudando a la valoraci\u00f3n nutricional","volume":"47","author":"Salv\u00e0 Casanovas","year":"2012","journal-title":"Rev. Esp. Geriatr. Gerontol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1080\/02640414.2018.1555904","article-title":"Evaluation of wrist and hip sedentary behaviour and moderate-to-vigorous physical activity raw acceleration cutpoints in older adults","volume":"37","author":"Sanders","year":"2019","journal-title":"J. Sports Sci."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s12603-016-0685-2","article-title":"Impact of cognitive frailty on daily activities in older persons","volume":"20","author":"Shimada","year":"2016","journal-title":"J. Nutr. Health Aging"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/ggi.14322","article-title":"An update on cognitive frailty: Its definition, impact, associated factors and underlying mechanisms, and interventions","volume":"22","author":"Sugimoto","year":"2022","journal-title":"Geriatr Gerontol Int"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.arr.2018.03.002","article-title":"Epidemiological and clinical significance of cognitive frailty: A mini review","volume":"44","author":"Sugimoto","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"16359","DOI":"10.1038\/s41598-017-16347-9","article-title":"Calf circumference as a novel tool for risk of disability of the elderly population","volume":"7","author":"Sun","year":"2017","journal-title":"Sci. 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Nurs."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1152\/japplphysiol.00421.2014","article-title":"Autocalibration of accelerometer data for free-living physical activity assessment using local gravity and temperature: an evaluation on four continents","volume":"117","author":"van Hees","year":"2014","journal-title":"J. Appl. Physiol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"12975","DOI":"10.1038\/s41598-018-31266-z","article-title":"Estimating sleep parameters using an accelerometer without sleep diary","volume":"8","author":"van Hees","year":"2018","journal-title":"Sci. Rep."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1093\/gerona\/gls191","article-title":"Motoric cognitive risk syndrome and the risk of dementia","volume":"68","author":"Verghese","year":"2013","journal-title":"J. Gerontol. A Biol. Sci. Med. 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