{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T19:22:35Z","timestamp":1772824955341,"version":"3.50.1"},"reference-count":99,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HE 3592\/16-1"],"award-info":[{"award-number":["HE 3592\/16-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Healthy aging affects several domains of cognitive and motor performance and is further associated with multiple structural and functional neural reorganization patterns. However, gap of knowledge exists, referring to the impact of these age-related alterations on the neural basis of tool use\u2013an important, complex action involved in everyday life throughout the entire lifespan. The current fMRI study aims to investigate age-related changes of neural correlates involved in planning and executing a complex object manipulation task, further providing a better understanding of impaired tool use performance in apraxia patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A balanced number of sixteen older and younger healthy adults repeatedly manipulated everyday tools in an event-related Go-No-Go fMRI paradigm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our data indicates that the left-lateralized network, including widely distributed frontal, temporal, parietal and occipital regions, involved in tool use performance is not subjected to age-related functional reorganization processes. However, age-related changes regarding the applied strategical procedure can be detected, indicating stronger investment into the planning, preparatory phase of such an action in older participants.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2023.1238731","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T09:26:18Z","timestamp":1692696378000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Investigating the effects of the aging brain on real tool use performance\u2014an fMRI study"],"prefix":"10.3389","volume":"15","author":[{"given":"Clara","family":"Seifert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingkang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Luise","family":"Brandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thabea","family":"Kampe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Hermsd\u00f6rfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afra","family":"Wohlschl\u00e4ger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"B1","author":"Ashburner","year":"2014","journal-title":"SPM12 manual."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1016\/j.neuroimage.2012.06.031","article-title":"Prefrontal hyperactivity in older people during motor planning.","volume":"62","author":"Berchicci","year":"2012","journal-title":"Neuroimage"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1016\/j.neuroimage.2009.09.051","article-title":"Age-related networks of regional covariance in MRI gray matter: Reproducible multivariate patterns in healthy aging.","volume":"49","author":"Bergfield","year":"2010","journal-title":"Neuroimage"},{"key":"B4","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/nature08983","article-title":"Neural mechanisms of ageing and cognitive decline.","volume":"464","author":"Bishop","year":"2010","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"publisher","first-page":"353","DOI":"10.2217\/nmt.13.35","article-title":"Limb apraxia in neurodegenerative disorders.","volume":"3","author":"Bohlhalter","year":"2013","journal-title":"Neurodegener. 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