{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:38:32Z","timestamp":1788485912626,"version":"build-2803163510"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Clinical and cognitive progression in alpha-synucleinopathies is highly heterogeneous. While some patients remain stable over long periods of time, other suffer early dementia or fast motor deterioration. Sleep disturbances and nocturnal blood pressure abnormalities have been identified as independent risk factors for clinical progression but a mechanistic explanation linking both aspects is lacking. We hypothesize that impaired glymphatic system might play a key role on clinical progression. Glymphatic system clears brain waste during specific sleep stages, being blood pressure the motive force that propels the interstitial fluid through brain tissue to remove protein waste. Thus, the combination of severe sleep alterations, such as REM sleep behavioral disorder, and lack of the physiological nocturnal decrease of blood pressure due to severe dysautonomia may constitute the perfect storm for glymphatic failure, causing increased abnormal protein aggregation and spreading. In Lewy body disorders (Parkinson\u2019s disease and dementia with Lewy bodies) the increment of intraneuronal alpha-synuclein and extracellular amyloid-\u03b2 would lead to cognitive deterioration, while in multisystemic atrophy, increased pathology in oligodendroglia would relate to the faster and malignant motor progression. We present a research model that may help in developing studies aiming to elucidate the role of glymphatic function and associated factors mainly in alpha-synucleinopathies, but that could be relevant also for other protein accumulation-related neurodegenerative diseases. If the model is proven to be useful could open new lines for treatments targeting glymphatic function (for example through control of nocturnal blood pressure) with the objective to ameliorate cognitive and motor progression in alpha-synucleinopathies.<\/jats:p>","DOI":"10.3389\/fnagi.2023.1251755","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T17:35:45Z","timestamp":1692898545000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Altered sleep and neurovascular dysfunction in alpha-synucleinopathies: the perfect storm for glymphatic failure"],"prefix":"10.3389","volume":"15","author":[{"given":"Mariateresa","family":"Buongiorno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Marzal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Cullell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"de Mena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"S\u00e1nchez-Benavides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"de la Sierra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Krupinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaroslau","family":"Compta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1212\/WNL.0000000000000842","article-title":"Predictors of dementia in Parkinson disease.","volume":"83","author":"Anang","year":"2014","journal-title":"Neurology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3233\/JPD-160925","article-title":"Dementia predictors in Parkinson disease: A validation study.","volume":"7","author":"Anang","year":"2017","journal-title":"J. Parkinsons. Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1007\/S13760-019-01113-7","article-title":"Nocturnal blood pressure changes in Parkinson\u2019s disease: Correlation with autonomic dysfunction and vitamin D levels.","volume":"120","author":"Arici Duz","year":"2020","journal-title":"Acta Neurol. Belg."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.1093\/BRAIN\/AWM056","article-title":"Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease.","volume":"130","author":"Boeve","year":"2007","journal-title":"Brain"},{"key":"B5","doi-asserted-by":"publisher","first-page":"S281","DOI":"10.3233\/JPD-191721","article-title":"Brain-first versus gut-first Parkinson\u2019s disease: A hypothesis.","volume":"9","author":"Borghammer","year":"2019","journal-title":"J. Parkinsons. Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease.","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.3233\/JAD-160698","article-title":"Cross-sectional and longitudinal cognitive correlates of FDDNP PET and CSF amyloid-\u03b2 and tau in Parkinson\u2019s disease.","volume":"55","author":"Buongiorno","year":"2017","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jns.2011.06.046","article-title":"Amyloid-\u03b2 and \u03c4 biomarkers in Parkinson\u2019s disease-dementia.","volume":"310","author":"Buongiorno","year":"2011","journal-title":"J. Neurol. Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/J.TRCI.2017.05.001","article-title":"The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer\u2019s disease.","volume":"3","author":"Burfeind","year":"2017","journal-title":"Alzheimer\u2019s Dement."},{"key":"B10","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/CNS.13984","article-title":"Diffusion along perivascular spaces provides evidence interlinking compromised glymphatic function with aging in Parkinson\u2019s disease.","volume":"29","author":"Cai","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/FNINS.2022.842498\/BIBTEX","article-title":"Dysautonomia in Parkinson\u2019s disease: Impact of glucocerebrosidase gene mutations on cardiovascular autonomic control.","volume":"16","author":"Carandina","year":"2022","journal-title":"Front. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/ene.13797","article-title":"Modifiable vascular risk factors, white matter disease and cognition in early Parkinson\u2019s disease.","volume":"26","author":"Chahine","year":"2019","journal-title":"Eur. J. Neurol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3233\/JPD-130189","article-title":"Pacific northwest udall center of excellence clinical consortium: Study design and baseline cohort characteristics.","volume":"3","author":"Cholerton","year":"2013","journal-title":"J. Parkinsons. Dis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.parkreldis.2018.02.007","article-title":"Sex differences in progression to mild cognitive impairment and dementia in Parkinson\u2019s disease.","volume":"50","author":"Cholerton","year":"2018","journal-title":"Park. Relat. Disord."},{"key":"B15","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.jns.2016.06.009","article-title":"White matter hyperintensities, cerebrospinal amyloid-\u03b2 and dementia in Parkinson\u2019s disease.","volume":"367","author":"Compta","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/J.PARKRELDIS.2022.05.006","article-title":"Combined CSF \u03b1-SYN RT-QuIC, CSF NFL and midbrain-pons planimetry in degenerative parkinsonisms: From bedside to bench, and back again.","volume":"99","author":"Compta","year":"2022","journal-title":"Park. Relat. Disord."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1093\/brain\/awr031","article-title":"Lewy- and Alzheimer-type pathologies in Parkinson\u2019s disease dementia: Which is more important?","volume":"134","author":"Compta","year":"2011","journal-title":"Brain"},{"key":"B18","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.parkreldis.2013.03.009","article-title":"Combined dementia-risk biomarkers in Parkinson\u2019s disease: A prospective longitudinal study.","volume":"19","author":"Compta","year":"2013","journal-title":"Park. Relat. Disord."},{"key":"B19","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1017\/NEU.2019.28","article-title":"Systematic review of genetic variants associated with cognitive impairment and depressive symptoms in Parkinson\u2019s disease.","volume":"32","author":"D\u2019Souza","year":"2020","journal-title":"Acta Neuropsychiatr."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102353","article-title":"Cognitive and motor correlates of grey and white matter pathology in Parkinson\u2019s disease.","volume":"27","author":"Dadar","year":"2020","journal-title":"Neuroimage Clin"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0016-5","article-title":"REM sleep behaviour disorder.","volume":"4","author":"Dauvilliers","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1212\/WNL.0000000000002304","article-title":"Absence of LRRK2 mutations in a cohort of patients with idiopathic REM sleep behavior disorder.","volume":"86","author":"Fern\u00e1ndez-Santiago","year":"2016","journal-title":"Neurology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1126\/SCIENCE.AAX5440","article-title":"Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep.","volume":"366","author":"Fultz","year":"2019","journal-title":"Science"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104909","article-title":"Non-REM sleep electrophysiology in REM sleep behaviour disorder: A narrative mini-review.","volume":"142","author":"Gorgoni","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B25","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/HR.2009.172","article-title":"Abnormal nocturnal blood pressure profile is associated with mild cognitive impairment in the elderly: The J-SHIPP study.","volume":"33","author":"Guo","year":"2010","journal-title":"Hypertens. Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1002\/mds.20324","article-title":"Sydney Multicenter Study of Parkinson\u2019s disease: Non-L-dopa-responsive problems dominate at 15 years.","volume":"20","author":"Hely","year":"2005","journal-title":"Mov. Disord."},{"key":"B27","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1002\/mds.21956","article-title":"The Sydney multicenter study of Parkinson\u2019s disease: The inevitability of dementia at 20 years.","volume":"23","author":"Hely","year":"2008","journal-title":"Mov. Disord."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1126\/SCITRANSLMED.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2.","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"18190","DOI":"10.1523\/JNEUROSCI.1592-13.2013","article-title":"Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain.","volume":"33","author":"Iliff","year":"2013","journal-title":"J. Neurosci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/S1474-4422(13)70056-5","article-title":"Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: An observational cohort study.","volume":"12","author":"Iranzo","year":"2013","journal-title":"Lancet Neurol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1159\/000341998","article-title":"Cognitive impairment in Parkinson\u2019s disease: The dual syndrome hypothesis.","volume":"11","author":"Kehagia","year":"2013","journal-title":"Neurodegener. Dis."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1212\/WNL.0B013E31826C1ACD","article-title":"Association of cognitive dysfunction with neurocirculatory abnormalities in early Parkinson disease.","volume":"79","author":"Kim","year":"2012","journal-title":"Neurology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1177\/0271678X15622047","article-title":"Ultra-fast magnetic resonance encephalography of physiological brain activity - Glymphatic pulsation mechanisms?","volume":"36","author":"Kiviniemi","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B34","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1212\/WNL.56.1.42","article-title":"Cardiovascular risk factors and cognitive decline in middle-aged adults.","volume":"56","author":"Knopman","year":"2001","journal-title":"Neurology"},{"key":"B35","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/S1474-4422(18)30162-5","article-title":"In-vivo staging of pathology in REM sleep behaviour disorder: A multimodality imaging case-control study.","volume":"17","author":"Knudsen","year":"2018","journal-title":"Lancet Neurol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1002\/MDS.26874","article-title":"Profile of cognitive impairment and underlying pathology in multiple system atrophy.","volume":"32","author":"Koga","year":"2017","journal-title":"Mov. Disord."},{"key":"B37","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1136\/jnnp-2018-319592","article-title":"Hippocampal subfield atrophy of CA1 and subicular structures predict progression to dementia in idiopathic Parkinson\u2019s disease.","volume":"90","author":"Low","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B38","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB consortium.","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"key":"B39","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/J.PARKRELDIS.2021.06.004","article-title":"Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease.","volume":"89","author":"McKnight","year":"2021","journal-title":"Park. Relat. Disord."},{"key":"B40","doi-asserted-by":"publisher","first-page":"6365","DOI":"10.1523\/JNEUROSCI.1974-18.2019","article-title":"Impaired glymphatic transport in spontaneously hypertensive rats.","volume":"39","author":"Mortensen","year":"2019","journal-title":"J. Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/J.NEUROSCIENCE.2004.08.053","article-title":"Aquaporin-4 in the central nervous system: Cellular and subcellular distribution and coexpression with KIR4.1.","volume":"129","author":"Nagelhus","year":"2004","journal-title":"Neuroscience"},{"key":"B42","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1126\/science.abb8739","article-title":"Glymphatic failure as a final common pathway to dementia.","volume":"370","author":"Nedergaard","year":"2020","journal-title":"Science"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1136\/JNNP-2019-320846","article-title":"Orthostatic hypotension and REM sleep behaviour disorder: Impact on clinical outcomes in \u03b1-synucleinopathies.","volume":"90","author":"Pilotto","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWAB431","article-title":"Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies.","volume":"145","author":"Poggiolini","year":"2022","journal-title":"Brain"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0132368","article-title":"Sleep disorders in parkinsonian and nonparkinsonian LRRK2 mutation carriers.","volume":"10","author":"Pont-Sunyer","year":"2015","journal-title":"PLoS One"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/S41398-018-0094-X","article-title":"Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain A\u03b2-amyloid burden.","volume":"8","author":"Rainey-Smith","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1136\/jnnp.2010.232678","article-title":"Dementia in Parkinson\u2019s disease: A 20-year neuropsychological study (Sydney multicentre study).","volume":"82","author":"Reid","year":"2011","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B48","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/WAD.0b013e31819c5ef4","article-title":"Parkinson disease with dementia: Comparing patients with and without Alzheimer pathology.","volume":"23","author":"Sabbagh","year":"2009","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1001\/JAMANEUROL.2017.4019","article-title":"Progression in the LRRK2-associated Parkinson disease population.","volume":"75","author":"Saunders-Pullman","year":"2018","journal-title":"JAMA Neurol."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1186\/S40035-023-00342-4","article-title":"\u03b1-Synuclein conformers reveal link to clinical heterogeneity of \u03b1-synucleinopathies.","volume":"12","author":"Schmitz","year":"2023","journal-title":"Transl. Neurodegener."},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30328-3","article-title":"Clinical variables and biomarkers in prediction of cognitive impairment in patients with newly diagnosed Parkinson\u2019s disease: A cohort study.","volume":"16","author":"Schrag","year":"2017","journal-title":"Lancet Neurol."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS232112928","article-title":"Glymphatic system dysfunction and sleep disturbance may contribute to the pathogenesis and progression of Parkinson\u2019s disease.","volume":"23","author":"Scott-Massey","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/BF01819664","article-title":"Ambulatory blood pressure in patients with Parkinson\u2019s disease without and with orthostatic hypotension.","volume":"2","author":"Senard","year":"1992","journal-title":"Clin. Auton. Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1212\/WNL.0b013e3181f39a78","article-title":"CSF amyloid 1-42 predicts cognitive decline in Parkinson disease.","volume":"75","author":"Siderowf","year":"2010","journal-title":"Neurology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1136\/jnnp-2019-321111","article-title":"Neuropathology of dementia in patients with Parkinson\u2019s disease: A systematic review of autopsy studies.","volume":"90","author":"Smith","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1002\/MDS.27200","article-title":"Sleep fragmentation and Parkinson\u2019s disease pathology in older adults without Parkinson\u2019s disease.","volume":"32","author":"Sohail","year":"2017","journal-title":"Mov. Disord."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1016\/J.MAYOCP.2017.09.007","article-title":"REM sleep behavior disorder: Diagnosis, clinical implications, and future directions.","volume":"92","author":"St Louis","year":"2017","journal-title":"Mayo Clin. Proc."},{"key":"B58","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1002\/MDS.25880","article-title":"Cognitive impairment in multiple system atrophy: A position statement by the neuropsychology task force of the MDS multiple system atrophy (MODIMSA) study group.","volume":"29","author":"Stankovic","year":"2014","journal-title":"Mov. Disord."},{"key":"B59","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/S10286-015-0270-5","article-title":"Non-dipping nocturnal blood pressure and psychosis parameters in Parkinson disease.","volume":"25","author":"Stuebner","year":"2015","journal-title":"Clin. Auton. Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/J.NEUBIOREV.2019.05.016","article-title":"Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson\u2019s disease.","volume":"103","author":"Sundaram","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa160","article-title":"Nonrapid eye movement sleep electroencephalographic oscillations in idiopathic rapid eye movement sleep behavior disorder: A study of sleep spindles and slow oscillations.","volume":"44","author":"Sunwoo","year":"2021","journal-title":"Sleep"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1038\/s41440-022-01032-w","article-title":"Abnormal circadian blood pressure regulation and cognitive impairment in \u03b1-synucleinopathies.","volume":"45","author":"Tanaka","year":"2022","journal-title":"Hypertens. Res."},{"key":"B63","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/J.PARKRELDIS.2017.10.014","article-title":"Association between abnormal nocturnal blood pressure profile and dementia in Parkinson\u2019s disease.","volume":"46","author":"Tanaka","year":"2018","journal-title":"Park. Relat. Disord."},{"key":"B64","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/J.PARKRELDIS.2013.05.008","article-title":"Autonomic dysfunction in parkinsonian LRRK2 mutation carriers.","volume":"19","author":"Tijero","year":"2013","journal-title":"Park. Relat. Disord."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1002\/MDS.29005","article-title":"The movement disorder society criteria for the diagnosis of multiple system atrophy.","volume":"37","author":"Wenning","year":"2022","journal-title":"Mov. Disord."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/NPJPARKD.2015.27","article-title":"Different PD-MCI criteria and risk of dementia in Parkinson\u2019s disease: 4-year longitudinal study.","volume":"2","author":"Wood","year":"2016","journal-title":"NPJ Park. Dis."},{"key":"B67","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1126\/SCIENCE.1241224","article-title":"Sleep drives metabolite clearance from the adult brain.","volume":"342","author":"Xie","year":"2013","journal-title":"Science"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3136415","article-title":"A meta-analysis of GBA-related clinical symptoms in Parkinson\u2019s disease.","volume":"2018","author":"Zhang","year":"2018","journal-title":"Parkinsons. Dis."},{"key":"B69","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1007\/S12035-023-03212-2","article-title":"Interaction between the glymphatic system and \u03b1-synuclein in Parkinson\u2019s disease.","volume":"60","author":"Zhang","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1186\/S40035-019-0147-Y","article-title":"Blocking meningeal lymphatic drainage aggravates Parkinson\u2019s disease-like pathology in mice overexpressing mutated \u03b1-synuclein.","volume":"8","author":"Zou","year":"2019","journal-title":"Transl. Neurodegener."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2023.1251755\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T17:35:48Z","timestamp":1692898548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2023.1251755\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,24]]},"references-count":70,"alternative-id":["10.3389\/fnagi.2023.1251755"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2023.1251755","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,24]]},"article-number":"1251755"}}