{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:50:17Z","timestamp":1794012617039,"version":"4.8.0"},"reference-count":244,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160223"],"award-info":[{"award-number":["82160223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Neurodegenerative diseases (NDs), such as Alzheimer\u2019s disease, Parkinson\u2019s disease, Huntington\u2019s disease, and motor neuron disease, are diseases characterized by neuronal damage and dysfunction. NDs are considered to be a multifactorial disease with diverse etiologies (immune, inflammatory, aging, genetic, etc.) and complex pathophysiological processes. Previous studies have found that neuroinflammation and typical microglial activation are important mechanisms of NDs, leading to neurological dysfunction and disease progression. Pyroptosis is a new mode involved in this process. As a form of programmed cell death, pyroptosis is characterized by the expansion of cells until the cell membrane bursts, resulting in the release of cell contents that activates a strong inflammatory response that promotes NDs by accelerating neuronal dysfunction and abnormal microglial activation. In this case, abnormally activated microglia release various pro-inflammatory factors, leading to the occurrence of neuroinflammation and exacerbating both microglial and neuronal pyroptosis, thus forming a vicious cycle. The recognition of the association between pyroptosis and microglia activation, as well as neuroinflammation, is of significant importance in understanding the pathogenesis of NDs and providing new targets and strategies for their prevention and treatment.<\/jats:p>","DOI":"10.3389\/fnagi.2023.1284214","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T03:33:30Z","timestamp":1699846410000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":42,"title":["To re-examine the intersection of microglial activation and neuroinflammation in neurodegenerative diseases from the perspective of pyroptosis"],"prefix":"10.3389","volume":"15","author":[{"given":"Yuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Qiong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cells"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.3390\/cells10071584","article-title":"The impact of obesity on microglial function: immune, metabolic and endocrine perspectives","volume":"10","author":"Alexaki","year":"2021","journal-title":"Cells"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41531-020-00147-6","article-title":"Plasma-borne indicators of Inflammasome activity in Parkinson's disease patients","volume":"7","author":"Anderson","year":"2021","journal-title":"NPJ Parkinsons Dis"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3389\/fnmol.2017.00191","article-title":"The pathophysiological role of microglia in dynamic surveillance, phagocytosis and structural remodeling of the developing Cns","volume":"10","author":"Arcuri","year":"2017","journal-title":"Front. 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Pharmacol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"28743","DOI":"10.3402\/pba.v5.28743","article-title":"Rapamycin improves motor function, reduces 4-Hydroxynonenal adducted protein in brain, and attenuates synaptic injury in a mouse model of Synucleinopathy","volume":"5","author":"Bai","year":"2015","journal-title":"Pathobiol Aging Age Relat Dis"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e379","DOI":"10.1038\/cddis.2012.123","article-title":"Ifn-\u0393 signaling, with the synergistic contribution of Tnf-\u0391, mediates cell specific microglial and Astroglial activation in experimental models of Parkinson's disease","volume":"3","author":"Barcia","year":"2012","journal-title":"Cell Death Dis."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"9593","DOI":"10.1073\/pnas.1609291113","article-title":"Reducing C-terminal truncation mitigates Synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy","volume":"113","author":"Bassil","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1007\/s13311-016-0451-5","article-title":"Inflammation and the silent sequelae of stroke","volume":"13","author":"Becker","year":"2016","journal-title":"Neurotherapeutics"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"15558","DOI":"10.1073\/pnas.0807419105","article-title":"Cd4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited Als","volume":"105","author":"Beers","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"13957","DOI":"10.1523\/JNEUROSCI.4457-08.2008","article-title":"Interleukin-6 mediates the increase in Nadph-oxidase in the ketamine model of schizophrenia","volume":"28","author":"Behrens","year":"2008","journal-title":"J. Neurosci."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/s41598-017-17533-5","article-title":"Pilot study to assess visualization and therapy of inflammatory mechanisms after vessel reopening in a mouse stroke model","volume":"8","author":"Beller","year":"2018","journal-title":"Sci. Rep."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.tins.2020.08.008","article-title":"Immunometabolism in the brain: how metabolism shapes microglial function","volume":"43","author":"Bernier","year":"2020","journal-title":"Trends Neurosci."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.tins.2018.05.005","article-title":"Epigenetic regulation in neurodegenerative diseases","volume":"41","author":"Berson","year":"2018","journal-title":"Trends Neurosci."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/6072357","article-title":"DNA methylation and chromatin remodeling: the blueprint of Cancer epigenetics","volume":"2016","author":"Bhattacharjee","year":"2016","journal-title":"Scientifica (Cairo)"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1084\/jem.20080178","article-title":"A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease","volume":"205","author":"Bj\u00f6rkqvist","year":"2008","journal-title":"J. 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Int."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1111\/j.1471-4159.2011.07594.x","article-title":"Resveratrol mitigates lipopolysaccharide- and A\u03b2-mediated microglial inflammation by inhibiting the Tlr4\/Nf-\u039ab\/Stat signaling Cascade","volume":"120","author":"Capiralla","year":"2012","journal-title":"J. Neurochem."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nn1715","article-title":"Control of microglial neurotoxicity by the Fractalkine receptor","volume":"9","author":"Cardona","year":"2006","journal-title":"Nat. Neurosci."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.coph.2015.09.001","article-title":"Role of Micrornas in the regulation of innate immune cells under Neuroinflammatory conditions","volume":"26","author":"Cardoso","year":"2016","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1042\/BJ20120546","article-title":"Amp-activated protein kinase: new regulation, new roles?","volume":"445","author":"Carling","year":"2012","journal-title":"Biochem. J."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1038\/cr.2016.100","article-title":"Pyroptosis is driven by non-selective Gasdermin-D pore and its morphology is different from Mlkl Channel-mediated necroptosis","volume":"26","author":"Chen","year":"2016","journal-title":"Cell Res."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s12974-022-02419-9","article-title":"A selective inhibitor of the Nlrp3 Inflammasome as a potential therapeutic approach for neuroprotection in a transgenic mouse model of Huntington's disease","volume":"19","author":"Chen","year":"2022","journal-title":"J. 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Sci."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"7777","DOI":"10.3390\/ijms21207777","article-title":"Neurotrophic factor Bdnf, physiological functions and therapeutic potential in depression, neurodegeneration and brain Cancer","volume":"21","author":"Colucci-D'Amato","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"e0270972","DOI":"10.1371\/journal.pone.0270972","article-title":"Inhibition of experimental autoimmune uveitis by intravitreal Aav-equine-Il10 gene therapy","volume":"17","author":"Crabtree","year":"2022","journal-title":"PLoS One"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2023\/4752502","article-title":"Epiisopiloturine, an alkaloid from Pilocarpus Microphyllus, attenuates Lps-induced Neuroinflammation by interfering in the Tlr4\/Nf-\u039ab-Mapk signaling pathway in microglial cells","volume":"2023","author":"de Sousa","year":"2023","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.bbi.2016.12.014","article-title":"Inhibiting the Nlrp3 Inflammasome with Mcc950 promotes non-Phlogistic clearance of amyloid-\u0392 and cognitive function in app\/Ps1 mice","volume":"61","author":"Dempsey","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"E28","DOI":"10.1038\/s41586-022-05109-x","article-title":"Author correction: streptococcal pyrogenic exotoxin B cleaves Gsdma and triggers Pyroptosis","volume":"608","author":"Deng","year":"2022","journal-title":"Nature"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/nri3532","article-title":"Autophagy in infection, inflammation and immunity","volume":"13","author":"Deretic","year":"2013","journal-title":"Nat. Rev. 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Rev."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.cell.2017.01.008","article-title":"Snapshot: the noncanonical Inflammasome","volume":"168","author":"Ding","year":"2017","journal-title":"Cells"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"5917","DOI":"10.2147\/JIR.S384020","article-title":"Inhibition of Dectin-1 alleviates Neuroinflammatory injury by attenuating Nlrp3 Inflammasome-mediated Pyroptosis after intracerebral hemorrhage in mice: preliminary study results","volume":"15","author":"Ding","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"620948","DOI":"10.3389\/fneur.2021.620948","article-title":"Effects of microglial activation and polarization on brain injury after stroke","volume":"12","author":"Dong","year":"2021","journal-title":"Front. Neurol."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s13041-018-0418-z","article-title":"Erib targeted inhibition of microglia activity attenuates Mpp(+) induced Da neuron injury through the Nf-\u039ab signaling pathway","volume":"11","author":"Dou","year":"2018","journal-title":"Mol. Brain"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"a028035","DOI":"10.1101\/cshperspect.a028035","article-title":"Pathology of neurodegenerative diseases","volume":"9","author":"Dugger","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1515\/hsz-2015-0295","article-title":"Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function","volume":"397","author":"Esteras","year":"2016","journal-title":"Biol. Chem."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.3389\/fnins.2019.01320","article-title":"Dysregulated Long non-coding Rnas in Parkinson's disease contribute to the apoptosis of human neuroblastoma cells","volume":"13","author":"Fan","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"12459","DOI":"10.3390\/ijms222212459","article-title":"Ripk1 and Tradd regulate Tnf-induced signaling and Ripoptosome formation","volume":"22","author":"Feoktistova","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"4312","DOI":"10.1073\/pnas.0707370105","article-title":"Anthrax lethal toxin and Salmonella elicit the common cell death pathway of Caspase-1-dependent Pyroptosis via distinct mechanisms","volume":"105","author":"Fink","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.cgh.2018.06.012","article-title":"Emricasan improves liver function in patients with cirrhosis and high model for end-stage liver disease scores compared with placebo","volume":"17","author":"Frenette","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1014013","DOI":"10.3389\/fimmu.2022.1014013","article-title":"Advances in the research of the role of macrophage\/microglia polarization-mediated inflammatory response in spinal cord injury","volume":"13","author":"Fu","year":"2022","journal-title":"Front. 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Neurosci."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s40824-022-00311-4","article-title":"Modified Exosomal Sirp\u03b1 variants alleviate white matter injury after intracerebral hemorrhage via microglia\/macrophages","volume":"26","author":"Gao","year":"2022","journal-title":"Biomater Res"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s00011-020-01426-x","article-title":"Burn injury induces elevated inflammatory traffic: the role of Nf-\u039ab","volume":"70","author":"George","year":"2021","journal-title":"Inflamm. Res."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/s41423-023-01018-9","article-title":"The critical role of apoptosis in mesenchymal stromal cell therapeutics and implications in homeostasis and Normal tissue repair","volume":"20","author":"Giacomini","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1002\/mnfr.201600111","article-title":"Resveratrol alleviates Mptp-induced motor impairments and pathological changes by Autophagic degradation of \u0391-Synuclein via Sirt1-Deacetylated Lc3","volume":"60","author":"Guo","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"496","DOI":"10.3390\/ijms18030496","article-title":"Complex roles of microglial cells in ischemic stroke pathobiology: new insights and future directions","volume":"18","author":"Guruswamy","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"e0130624","DOI":"10.1371\/journal.pone.0130624","article-title":"Nlrp3 Inflammasome is expressed and functional in mouse brain microglia but not in astrocytes","volume":"10","author":"Gustin","year":"2015","journal-title":"PLoS One"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1042\/BJ20150617","article-title":"Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease","volume":"471","author":"Gustot","year":"2015","journal-title":"Biochem. J."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1037\/1064-1297.16.2.178","article-title":"7-Nitroindazole attenuates 6-Hydroxydopamine-induced spatial learning deficits and dopamine neuron loss in a Presymptomatic animal model of Parkinson's disease","volume":"16","author":"Haik","year":"2008","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s12272-012-0415-1","article-title":"Control of Jnk for an activation of Nadph oxidase in Lps-stimulated Bv2 microglia","volume":"35","author":"Han","year":"2012","journal-title":"Arch. Pharm. Res."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s12974-018-1139-z","article-title":"Lncrna H19 contributes to hippocampal glial cell activation via Jak\/Stat signaling in a rat model of temporal lobe epilepsy","volume":"15","author":"Han","year":"2018","journal-title":"J. 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Neuroimmune Pharmacol."},{"key":"ref79","first-page":"1584","article-title":"Mint oils: in vitro ability to perform anti-inflammatory, antioxidant, and antimicrobial activities and to enhance intestinal barrier integrity","volume":"10","author":"Hejna","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nature11729","article-title":"Nlrp3 is activated in Alzheimer's disease and contributes to pathology in app\/Ps1 mice","volume":"493","author":"Heneka","year":"2013","journal-title":"Nature"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.nbd.2005.01.003","article-title":"Transforming growth factor-Beta 1 produced by hippocampal cells modulates microglial reactivity in culture","volume":"19","author":"Herrera-Molina","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/jnr.10749","article-title":"Protective effects of Sesamin and Sesamolin on hypoxic neuronal and Pc12 cells","volume":"74","author":"Hou","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/8853720","article-title":"Electroacupuncture improves cognitive function in senescence-accelerated P8 (Samp8) mice via the Nlrp3\/Caspase-1 pathway","volume":"2020","author":"Hou","year":"2020","journal-title":"Neural Plast."},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14333","article-title":"Ultrasound reduces inflammation by modulating M1\/M2 polarization of microglia through Stat1\/Stat6\/Ppar\u03b3 signaling pathways","author":"Hsu","year":"2023","journal-title":"CNS Neurosci. 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Ther."},{"key":"ref94","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2008\/725174","article-title":"Disruption of Nrf2 enhances upregulation of nuclear factor-Kappab activity, Proinflammatory cytokines, and intercellular adhesion Molecule-1 in the brain after traumatic brain injury","volume":"2008","author":"Jin","year":"2008","journal-title":"Mediat. 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Rep."},{"key":"ref109","doi-asserted-by":"publisher","first-page":"736310","DOI":"10.3389\/fncel.2021.736310","article-title":"Microglial phenotypic transition: signaling pathways and influencing modulators involved in regulation in central nervous system diseases","volume":"15","author":"Li","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"ref110","doi-asserted-by":"publisher","first-page":"261","DOI":"10.2147\/NDT.S279147","article-title":"Schisandrin inhibits Nlrp1 Inflammasome-mediated neuronal Pyroptosis in mouse models of Alzheimer's disease","volume":"17","author":"Li","year":"2021","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref111","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1007\/s13577-017-0187-5","article-title":"Microrna-30e regulates Neuroinflammation in Mptp model of Parkinson's disease by targeting Nlrp3","volume":"31","author":"Li","year":"2018","journal-title":"Hum. 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Sci."},{"key":"ref121","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.immuni.2019.04.017","article-title":"Crystal structures of the full-length murine and human Gasdermin D reveal mechanisms of autoinhibition, lipid binding, and oligomerization","volume":"51","author":"Liu","year":"2019","journal-title":"Immunity"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/s41573-021-00154-z","article-title":"Channelling inflammation: Gasdermins in physiology and disease","volume":"20","author":"Liu","year":"","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref123","doi-asserted-by":"publisher","first-page":"113700","DOI":"10.1016\/j.expneurol.2021.113700","article-title":"Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced Neuroinflammation and Pyroptosis by modulating microglia M1\/M2 phenotypes","volume":"341","author":"Liu","year":"","journal-title":"Exp. Neurol."},{"key":"ref124","doi-asserted-by":"publisher","first-page":"587","DOI":"10.3390\/md19110587","article-title":"\u03a9-3 Dpa protected neurons from Neuroinflammation by balancing microglia M1\/M2 polarizations through inhibiting Nf-\u039ab\/Mapk P38 signaling and activating neuron-Bdnf-Pi3k\/Akt pathways","volume":"19","author":"Liu","year":"2021","journal-title":"Mar. Drugs"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/s41420-023-01440-y","article-title":"Targeting Pyroptosis as a preventive and therapeutic approach for stroke","volume":"9","author":"Long","year":"2023","journal-title":"Cell Death Discov"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1186\/s13046-021-02065-8","article-title":"Pyroptosis at the forefront of anticancer immunity","volume":"40","author":"Loveless","year":"2021","journal-title":"J. Exp. Clin. 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Biol."},{"key":"ref128","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40824-023-00339-0","article-title":"Engineered exosomes enriched in Netrin-1 Modrna promote axonal growth in spinal cord injury by attenuating inflammation and Pyroptosis","volume":"27","author":"Lu","year":"2023","journal-title":"Biomater Res"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"113776","DOI":"10.1016\/j.jep.2021.113776","article-title":"Salvianolic acids for injection alleviates cerebral ischemia\/reperfusion injury by switching M1\/M2 phenotypes and inhibiting Nlrp3 Inflammasome\/Pyroptosis Axis in microglia in vivo and in vitro","volume":"270","author":"Ma","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref130","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The Inflammasomes: guardians of the body","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"ref131","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1172\/JCI11916","article-title":"Nf-Kappab in neuronal plasticity and neurodegenerative disorders","volume":"107","author":"Mattson","year":"2001","journal-title":"J. Clin. Invest."},{"key":"ref132","doi-asserted-by":"publisher","first-page":"1072046","DOI":"10.3389\/fnmol.2022.1072046","article-title":"Transcriptional and epigenetic regulation of microglia in maintenance of brain homeostasis and neurodegeneration","volume":"15","author":"Maurya","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"ref133","doi-asserted-by":"publisher","first-page":"E6065","DOI":"10.1073\/pnas.1722041115","article-title":"Caspase-1 inhibition prevents glial Inflammasome activation and Pyroptosis in models of multiple sclerosis","volume":"115","author":"McKenzie","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref134","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/1083596","article-title":"The critical role of Il-10 in the Antineuroinflammatory and Antioxidative effects of Rheum Tanguticum on activated microglia","volume":"2018","author":"Meng","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref135","doi-asserted-by":"publisher","first-page":"12990","DOI":"10.3390\/ijms232112990","article-title":"Microglia and Alzheimer's disease","volume":"23","author":"Merighi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"ref136","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1093\/brain\/awv066","article-title":"Roles of microglia in brain development, tissue maintenance and repair","volume":"138","author":"Michell-Robinson","year":"2015","journal-title":"Brain"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1038\/nn.3469","article-title":"M2 microglia and macrophages drive oligodendrocyte differentiation during Cns Remyelination","volume":"16","author":"Miron","year":"2013","journal-title":"Nat. Neurosci."},{"key":"ref138","doi-asserted-by":"publisher","first-page":"102943","DOI":"10.1016\/j.ebiom.2020.102943","article-title":"Cancer metabolism and mitochondria: finding novel mechanisms to fight Tumours","volume":"59","author":"Missiroli","year":"2020","journal-title":"EBioMedicine"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1016\/j.ajpath.2011.06.011","article-title":"Interleukin-34 selectively enhances the neuroprotective effects of microglia to attenuate oligomeric amyloid-\u0392 neurotoxicity","volume":"179","author":"Mizuno","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref140","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s12974-019-1493-5","article-title":"Deletion of P38\u03b1 Mapk in microglia blunts trauma-induced inflammatory responses in mice","volume":"16","author":"Morganti","year":"2019","journal-title":"J. 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Neuroinflammation"},{"key":"ref150","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/nrneurol.2010.17","article-title":"\"microglia in neurodegenerative disease.\" nature reviews","volume":"6","author":"Perry","year":"2010","journal-title":"Neurology"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/nm.2266","article-title":"Microrna-124 promotes microglia quiescence and suppresses Eae by deactivating macrophages via the C\/Ebp-\u0391-Pu.1 pathway","volume":"17","author":"Ponomarev","year":"2011","journal-title":"Nat. Med."},{"key":"ref152","doi-asserted-by":"publisher","first-page":"6687","DOI":"10.3390\/ijms22136687","article-title":"Functional role of non-muscle myosin ii in microglia: an updated review","volume":"22","author":"Porro","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref153","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1172\/JCI200317522","article-title":"Neurodegeneration: what is it and where are we?","volume":"111","author":"Przedborski","year":"2003","journal-title":"J. Clin. Invest."},{"key":"ref154","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1080\/10717544.2020.1762262","article-title":"Brain delivery of quercetin-loaded exosomes improved cognitive function in ad mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles","volume":"27","author":"Qi","year":"2020","journal-title":"Drug Deliv."},{"key":"ref155","doi-asserted-by":"publisher","first-page":"817732","DOI":"10.3389\/fncel.2022.817732","article-title":"The impact of acupuncture on neuroplasticity after ischemic stroke: a literature review and perspectives","volume":"16","author":"Qin","year":"2022","journal-title":"Front. Cell. 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A."},{"key":"ref202","doi-asserted-by":"publisher","first-page":"2828","DOI":"10.3390\/molecules23112828","article-title":"8e protects against acute cerebral ischemia by inhibition of Pi3k\u03b3-mediated superoxide generation in microglia","volume":"23","author":"Wang","year":"2018","journal-title":"Molecules"},{"key":"ref203","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1111\/jcmm.13368","article-title":"Salidroside attenuates Neuroinflammation and improves functional recovery after spinal cord injury through microglia polarization regulation","volume":"22","author":"Wang","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"ref204","doi-asserted-by":"publisher","first-page":"952876","DOI":"10.3389\/fphar.2022.952876","article-title":"Integrating network pharmacology analysis and Pharmacodynamic evaluation for exploring the active components and molecular mechanism of Moutan seed coat extract to improve cognitive impairment","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref205","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.intimp.2018.12.019","article-title":"The mechanisms of Nlrp3 Inflammasome\/Pyroptosis activation and their role in Parkinson's disease","volume":"67","author":"Wang","year":"2019","journal-title":"Int. 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Based Complement. Alternat. Med."},{"key":"ref209","doi-asserted-by":"publisher","first-page":"59","DOI":"10.18388\/abp.2015_1153","article-title":"Interleukin 18 (Il-18) as a target for immune intervention","volume":"63","author":"Wawrocki","year":"2016","journal-title":"Acta Biochim. Pol."},{"key":"ref210","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.bbrc.2017.05.005","article-title":"Lncrna Gm4419 contributes to Ogd\/R injury of cerebral microglial cells via I\u03bab phosphorylation and Nf-\u039ab activation","volume":"487","author":"Wen","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref211","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3389\/fncel.2019.00019","article-title":"Lipoxin A4 regulates lipopolysaccharide-induced Bv2 microglial activation and differentiation via the notch signaling pathway","volume":"13","author":"Wu","year":"2019","journal-title":"Front. Cell. 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Physiol."},{"key":"ref243","doi-asserted-by":"publisher","first-page":"107422","DOI":"10.1016\/j.intimp.2021.107422","article-title":"Curcumin protects against cognitive impairments in a rat model of chronic cerebral Hypoperfusion combined with diabetes mellitus by suppressing Neuroinflammation, apoptosis, and Pyroptosis","volume":"93","author":"Zheng","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref244","doi-asserted-by":"publisher","first-page":"C52","DOI":"10.1152\/ajpcell.00278.2017","article-title":"Long noncoding Rna Malat1 contributes to inflammatory response of microglia following spinal cord injury via the modulation of a Mir-199b\/Ikk\u03b2\/Nf-\u039ab signaling pathway","volume":"315","author":"Zhou","year":"2018","journal-title":"Am. J. Physiol. 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