{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:51:05Z","timestamp":1790704265739,"version":"4.1.0"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Oligomeric A\u03b2 (OA\u03b2) is a promising candidate marker for Alzheimer\u2019s disease (AD) diagnosis. Electroencephalography (EEG) is a potential tool for early detection of AD. Still, whether EEG power ratios, particularly the theta\/alpha ratio (TAR) and theta\/beta ratio (TBR), reflect A\u03b2 burden\u2014a primary mechanism underlying cognitive impairment and AD. This study investigated the association of TAR and TBR with amyloid burden in older adults based on MDS-OA\u03b2 levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>529 individuals (aged \u226560\u2009years) were recruited. All participants underwent EEG (MINDD SCAN, Ybrain Inc., South Korea) and AlzOn\u2122 test (PeopleBio Inc., Gyeonggi-do, Republic of Korea) for quantifying MDS-OA\u03b2 values in the plasma. EEG variables were log-transformed to normalize the data distribution. Using the MDS-OA\u03b2 cutoff value (0.78\u2009ng\/mL), all participants were classified into two groups: high MDS-OA\u03b2 and low MDS-OA\u03b2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants with high MDS-OA\u03b2 levels had significantly higher TARs and TBRs than those with low MDS-OA\u03b2 levels. The log-transformed TBRs in the central lobe (\u03b2\u2009=\u20090.161, <jats:italic>p<\/jats:italic>\u2009=\u20090.0026), frontal lobe (\u03b2\u2009=\u20090.145, <jats:italic>p<\/jats:italic>\u2009=\u20090.0044), parietal lobe (\u03b2\u2009=\u20090.166, <jats:italic>p<\/jats:italic>\u2009=\u20090.0028), occipital lobe (\u03b2\u2009=\u20090.158, <jats:italic>p<\/jats:italic>\u2009=\u20090.0058), and temporal lobe (beta\u2009=\u20090.162, <jats:italic>p<\/jats:italic>\u2009=\u20090.0042) were significantly and positively associated with increases in MDS-OA\u03b2 levels. After adjusting for the Bonferroni correction, the TBRs in all lobe regions, except the occipital lobe, were significantly associated with increased MDS-OA\u03b2 levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found a significant association of MDS-OA\u03b2 with TBR in older adults. This finding indicates that an increase in amyloid burden may be associated with an increase in the low-frequency band and a decrease in the relatively high-frequency band.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2023.1291881","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T12:28:50Z","timestamp":1701433730000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of plasma amyloid-\u03b2 oligomerization with theta\/beta ratio in older adults"],"prefix":"10.3389","volume":"15","author":[{"given":"Heewon","family":"Bae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Ju","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Won","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Eun","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiwon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungui","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Young","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung-Bok","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s13195-017-0310-6","article-title":"Dynamic changes of oligomeric amyloid beta levels in plasma induced by spiked synthetic Abeta(42)","volume":"9","author":"An","year":"2017","journal-title":"Alzheimers Res. 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