{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:03:17Z","timestamp":1787169797149,"version":"build-2736575974"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:00:00Z","timestamp":1706227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Nutrition plays a pivotal role in the multidisciplinary approach to rehabilitating middle to old-aged patients with neurological diseases including movement disorders (MDs). Despite the prevalence of vitamin D deficiency in many patients with MDs, data supporting supplementation\u2019s effectiveness and safety is sparse and conflicting, therefore, our explicit objective was to provide an all-encompassing review of the subject.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive search of PubMed, Embase, and other scientific databases was conducted up to November 1 2023. The searches included RCTs in all languages with human participants aged 35 and above and not meeting these requirements led to exclusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four studies on Parkinson\u2019s disease (PD) and one on restless legs syndrome (RLS) including 369 MD patients, however, none in a rehabilitation context, were found. Although three of the four PD studies showed better outcomes, such as decreasing levodopa-induced dyskinesia or enhancing physical performance in some or all domains, the RLS study did not identify symptom improvement. The one serious adverse effect observed, cerebral infarction, aroused safety concerns, however its relationship to vitamin D consumption is questionable. Structurally the studies can be characterized by large variations in patient populations, in primary outcomes, and disease severity, but typically a relatively short duration of therapy in most cases. With other limitations such as the small number of studies, major trial design heterogeneity, limited sample sizes, and a greatly variable Cochrane risk of bias (RoB) evaluation, only a qualitative synthesis was feasible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Two main implications can be inferred from these results, which we interpret as cautiously promising but overall insufficient for firm recommendations. First, there is an urgent need for more research on the role of vitamin D in MDs in the middle- to older-aged population, particularly during rehabilitation. Second, given the benefits of vitamin D supplementation for those who are deficient, we recommend routine screening and supplementation for MD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2024.1333217","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T23:26:52Z","timestamp":1706225212000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Vitamin D supplementation in later life: a systematic review of efficacy and safety in movement disorders"],"prefix":"10.3389","volume":"16","author":[{"given":"Carl N.","family":"Homann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Homann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Ivanic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadea","family":"Urbanic-Purkart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1016\/j.clnu.2018.09.011","article-title":"Effect of vitamin D supplementation on depression in elderly patients: a randomized clinical trial","volume":"38","author":"Alavi","year":"2019","journal-title":"Clin. 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Endocrinol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"10200","DOI":"10.3390\/ijms241210200","article-title":"Effect of 12-week BMI-based vitamin D3 supplementation in Parkinson\u2019s disease with deep brain stimulation on physical performance, inflammation, and vitamin D metabolites","volume":"24","author":"Bytowska","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s11064-022-03728-4","article-title":"Vitamin D (VD3) intensifies the effects of exercise and prevents alterations of behavior, brain oxidative stress, and neuroinflammation, in hemiparkinsonian rats","volume":"48","author":"da Costa","year":"2023","journal-title":"Neurochem. Res."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/954027","article-title":"Stereotypes of aging: their effects on the health of older adults","volume":"2015","author":"Dionigi","year":"2015","journal-title":"J. Geriatr."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1007\/s00421-019-04104-x","article-title":"Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state","volume":"119","author":"Dzik","year":"2019","journal-title":"Eur. J. Appl. Physiol. Occup. Physiol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"73","DOI":"10.29359\/BJHPA.12.2.08","article-title":"Well-being and mental health\u2212 diet, supplements, exercise or sleep? A review of reports from the last five years","volume":"12","author":"Grzywacz","year":"2020","journal-title":"Baltic J. Health Phys. Act."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"7737","DOI":"10.4081\/ni.2018.7737","article-title":"Treatment of Levodopainduced dyskinesia with vitamin D: a randomized, double-blind, placebo-controlled trial","volume":"10","author":"Habibi","year":"2018","journal-title":"Neurol. 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Neurosci."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e003367","DOI":"10.1136\/bmjopen-2013-003367","article-title":"The impact of neurological disorders on the risk for falls in the community dwelling elderly: a case-controlled study","volume":"3","author":"Homann","year":"2013","journal-title":"BMJ Open"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1136\/jnnp-2018-320199","article-title":"Effects of vitamin D supplementation on cognitive function and blood Abeta-related biomarkers in older adults with Alzheimer's disease: a randomised, double-blind, placebo-controlled trial","volume":"90","author":"Jia","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/B978-0-12-801893-4.00003-1","article-title":"Epidemiology of Huntington disease","volume":"144","author":"Kay","year":"2017","journal-title":"Handb. Clin. Neurol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.3390\/antiox11112120","article-title":"Vitamin D3 and ischemic stroke: a narrative review","volume":"11","author":"Laso\u0144","year":"2022","journal-title":"Antioxidants"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"97","DOI":"10.14802\/jmd.20006","article-title":"Nutrition and lifestyle interventions for managing parkinson\u2019s disease: a narrative review","volume":"13","author":"Lister","year":"2020","journal-title":"J. Move. Disord."},{"key":"ref20","volume-title":"The role of exercise and age on vitamin D metabolism (Doctoral dissertation, Edinburgh Napier University)","author":"Lithgow","year":"2019"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1111\/j.1532-5415.2011.03733.x","article-title":"Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis","volume":"59","author":"Muir","year":"2011","journal-title":"J. Am. Geriatr. 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Int."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1210\/jc.2011-2218","article-title":"IOM committee members respond to Endocrine Society vitamin D guideline","volume":"97","author":"Rosen","year":"2012","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1001\/jama.2010.594","article-title":"Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial","volume":"303","author":"Sanders","year":"2010","journal-title":"JAMA"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7189\/jogh.11.04028","article-title":"The global prevalence of essential tremor, with emphasis on age and sex: a meta-analysis","volume":"11","author":"Song","year":"2021","journal-title":"J. Glob. Health"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1177\/0960327115595685","article-title":"Vitamin D exposures reported to US poison centers 2000\u20132014: temporal trends and outcomes","volume":"35","author":"Spiller","year":"2016","journal-title":"Hum. Exp. Toxicol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15761\/PRR.1000117","article-title":"Exercise therapy in Parkinson\u2019s disease\u2013an overview of current interventional studies","volume":"2","author":"Steiger","year":"2019","journal-title":"Physiother. Res. Rep."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1007\/s40520-015-0506-1","article-title":"The effect of the rehabilitation program on balance, gait, physical performance and trunk rotation in Parkinson\u2019s disease","volume":"28","author":"Sto\u017cek","year":"2016","journal-title":"Aging Clin. Exp. Res."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.3945\/ajcn.112.051664","article-title":"Randomized, double-blind, placebo-controlled trial of vitamin D supplementation in Parkinson disease","volume":"97","author":"Suzuki","year":"2013","journal-title":"Amer. Clin. 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