{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:24:17Z","timestamp":1793366657723,"version":"4.5.0"},"reference-count":98,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Non-motor symptoms are prevalent among individuals with Parkinson\u2019s disease (PD) and seriously affect patient quality of life, even more so than motor symptoms. In the past decade, an increasing number of studies have investigated non-motor symptoms in PD. The present study aimed to comprehensively analyze the global literature, trends, and hotspots of research investigating non-motor symptoms in PD through bibliometric methods. Studies addressing non-motor symptoms in the Web of Science Core Collection (WoSCC), published between January 2013 and December 2022, were retrieved. Bibliometric methods, including the R package \u201cBibliometrix,\u201d VOS viewer, and CiteSpace software, were used to investigate and visualize parameters, including yearly publications, country\/region, institution, and authors, to collate and quantify information. Analysis of keywords and co-cited references explored trends and hotspots. There was a significant increase in the number of publications addressing the non-motor symptoms of PD, with a total of 3,521 articles retrieved. The United States was ranked first in terms of publications (<jats:italic>n<\/jats:italic>\u2009=\u2009763) and citations (<jats:italic>n<\/jats:italic>\u2009=\u200911,269), maintaining its leadership position among all countries. King\u2019s College London (United Kingdom) was the most active institution among all publications (<jats:italic>n<\/jats:italic>\u2009=\u2009133) and K Ray Chaudhuri was the author with the most publications (<jats:italic>n<\/jats:italic>\u2009=\u2009131). <jats:italic>Parkinsonism &amp;amp; Related Disorders<\/jats:italic> published the most articles, while <jats:italic>Movement Disorders<\/jats:italic> was the most cited journal. Reference explosions have shown that early diagnosis, biomarkers, novel magnetic resonance imaging techniques, and deep brain stimulation have become research \u201chotspots\u201d in recent years. Keyword clustering revealed that alpha-synuclein is the largest cluster for PD. The keyword heatmap revealed that non-motor symptoms appeared most frequently (<jats:italic>n<\/jats:italic>\u2009=\u20091,104), followed by quality of life (<jats:italic>n<\/jats:italic>\u2009=\u2009502), dementia (<jats:italic>n<\/jats:italic>\u2009=\u2009403), and depression (<jats:italic>n<\/jats:italic>\u2009=\u2009397). Results of the present study provide an objective, comprehensive, and systematic analysis of these publications, and identifies trends and \u201chot\u201d developments in this field of research. This work will inform investigators worldwide to help them conduct further research and develop new therapies.<\/jats:p>","DOI":"10.3389\/fnagi.2024.1335550","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T04:29:40Z","timestamp":1705465780000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Trends and hotspots in non-motor symptoms of Parkinson\u2019s disease: a 10-year bibliometric analysis"],"prefix":"10.3389","volume":"16","author":[{"given":"Xuefeng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhou","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1212\/wnl.56.6.730","article-title":"Risk of dementia in Parkinson\u2019s disease: a community-based, prospective study","volume":"56","author":"Aarsland","year":"2001","journal-title":"Neurology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nrneurol.2017.27","article-title":"Cognitive decline in Parkinson disease","volume":"13","author":"Aarsland","year":"2017","journal-title":"Nat. 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