{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T14:57:28Z","timestamp":1784991448949,"version":"3.55.0"},"reference-count":84,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although depression symptoms are commonly reported in patients with subcortical vascular mild cognitive impairment (svMCI), their impact on brain functions remains largely unknown, with diagnoses mainly dependent on behavioral assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we analyzed resting-state fMRI data from a cohort of 34 svMCI patients, comprising 18 patients with depression symptoms (svMCI+D) and 16 patients without (svMCI-D), along with 34 normal controls (NC). The study used the fraction of the amplitude of low-frequency fluctuations (fALFF), resting-state functional connectivity, correlation analyses, and support vector machine (SVM) techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The fALFF of the right cerebellum (CERE.R) differed among the svMCI+D, svMCI-D, and NC groups. Specifically, the regional mean fALFF of CERE. R was lower in svMCI-D patients compared to NC but higher in svMCI+D patients compared to svMCI-D patients. Moreover, the adjusted fALFF of CERE. R showed a significant correlation with Montreal Cognitive Assessment (MOCA) scores in svMCI-D patients. The fALFF of the right orbital part of the superior frontal gyrus was significantly correlated with Hamilton Depression Scale scores in svMCI+D patients, whereas the fALFF of the right postcingulate cortex (PCC.R) showed a significant correlation with MOCA scores in svMCI-D patients. Furthermore, RSFC between PCC. R and right precuneus, as well as between CERE. R and the right lingual gyrus (LING.R), was significantly reduced in svMCI-D patients compared to NC. In regional analyses, the adjusted RSFC between PCC. R and PreCUN. R, as well as between CERE. R and LING. R, was decreased in svMCI-D patients compared to NC but increased in svMCI+D patients compared to svMCI-D. Further SVM analyses achieved good performances, with an area under the curve (AUC) of 0.82 for classifying svMCI+D, svMCI-D, and NC; 0.96 for classifying svMCI+D and svMCI-D; 0.82 for classifying svMCI+D and NC; and 0.92 for classifying svMCI-D and NC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study revealed disruptive effects of cognitive impairment, along with both disruptive and complementary effects of depression symptoms on spontaneous brain activity in svMCI. Moreover, these findings suggest that the identified features might serve as potential biomarkers for distinguishing between svMCI+D, svMCI-D, and NC, thereby guiding clinical treatments such as transcranial magnetic stimulation for svMCI.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2024.1338179","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T12:24:55Z","timestamp":1726662295000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Disruptive and complementary effects of depression symptoms on spontaneous brain activity in the subcortical vascular mild cognitive impairment"],"prefix":"10.3389","volume":"16","author":[{"given":"Liyu","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqing","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2943","DOI":"10.1016\/j.neuropsychologia.2008.06.005","article-title":"Modulation of the spatial attention network by incentives in healthy aging and mild cognitive impairment","volume":"46","author":"Bagurdes","year":"2008","journal-title":"Neuropsychologia"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.clineuro.2008.05.013","article-title":"Cerebellar neurocognition: insights into the bottom of the brain","volume":"110","author":"Baillieux","year":"2008","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1080\/00325481.2019.1663127","article-title":"Understanding the effect of cognitive\/brain reserve and depression on regional atrophy in early Alzheimer\u2019s disease","volume":"131","author":"Capogna","year":"2019","journal-title":"Postgrad. Med."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1145\/1961189.1961199","article-title":"LIBSVM","volume":"2","author":"Chang","year":"2011","journal-title":"ACM Trans. Intell. Syst. Technol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.neurobiolaging.2008.06.015","article-title":"Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer\u2019s disease","volume":"31","author":"Choo","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"ref6","first-page":"71","article-title":"Impact of oxidative stress on cognition and depressive symptoms in mild cognitive impairment in the elderly","volume":"17","author":"Cinar","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1176\/appi.ajp.2014.14070878","article-title":"Modifiable predictors of dementia in mild cognitive impairment: a systematic review and meta-analysis","volume":"172","author":"Cooper","year":"2015","journal-title":"Am. J. Psychiatry"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"595758","DOI":"10.3389\/fnagi.2021.595758","article-title":"Correlation of frontal atrophy and CSF tau levels with neuropsychiatric symptoms in patients with cognitive impairment: a memory clinic experience","volume":"13","author":"Cotta","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1231361","DOI":"10.3389\/fpsyt.2024.1231361","article-title":"Role of fronto-limbic circuit in neuropsychiatric symptoms of dementia: clinical evidence from an exploratory study","volume":"15","author":"Cotta Ramusino","year":"2024","journal-title":"Front. Psych."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.neuroimage.2016.02.022","article-title":"Mapping the self in the brain\u2019s default mode network","volume":"132","author":"Davey","year":"2016","journal-title":"NeuroImage"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.neuroimage.2017.11.025","article-title":"A comprehensive analysis of resting state fMRI measures to classify individual patients with Alzheimer\u2019s disease","volume":"167","author":"de Vos","year":"2018","journal-title":"NeuroImage"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"4278","DOI":"10.1109\/EMBC.2015.7319340","article-title":"Multimodal MRI classification in vascular mild cognitive impairment","volume":"2015","author":"Diciotti","year":"2015","journal-title":"Conf. Proc. IEEE Eng. Med. Biol. Soc."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jns.2016.12.003","article-title":"Resting state fMRI regional homogeneity correlates with cognition measures in subcortical vascular cognitive impairment","volume":"373","author":"Diciotti","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e0138180","DOI":"10.1371\/journal.pone.0138180","article-title":"Altered functional connectivity in patients with subcortical vascular cognitive impairment--a resting-state functional magnetic resonance imaging study","volume":"10","author":"Ding","year":"2015","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1017\/S0033291717003956","article-title":"Neuropsychiatric symptoms and cognitive profile in mild cognitive impairment with Lewy bodies","volume":"48","author":"Donaghy","year":"2018","journal-title":"Psychol. Med."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"351","DOI":"10.2214\/ajr.149.2.351","article-title":"MR signal abnormalities at 1.5 T in Alzheimer\u2019s dementia and normal aging","volume":"149","author":"Fazekas","year":"1987","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1159\/000320991","article-title":"Reduced precuneus deactivation during object naming in patients with mild cognitive impairment, Alzheimer\u2019s disease, and frontotemporal lobar degeneration","volume":"30","author":"Frings","year":"2010","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1177\/0706743716648296","article-title":"Neuropsychiatric symptoms in mild cognitive impairment","volume":"62","author":"Gallagher","year":"2017","journal-title":"Can. J. Psychiatr."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1002\/gps.3845","article-title":"Depression as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies","volume":"28","author":"Gao","year":"2013","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.nicl.2013.08.016","article-title":"Widespread reductions in gray matter volume in depression","volume":"3","author":"Grieve","year":"2013","journal-title":"Neuroimage Clin."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3389\/fnagi.2017.00146","article-title":"Conversion discriminative analysis on mild cognitive impairment using multiple cortical features from MR images","volume":"9","author":"Guo","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e560","DOI":"10.1097\/MD.0000000000000560","article-title":"Increased cerebellar-default-mode-network connectivity in drug-naive major depressive disorder at rest","volume":"94","author":"Guo","year":"2015","journal-title":"Medicine"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/35094500","article-title":"Searching for a baseline: functional imaging and the resting human brain","volume":"2","author":"Gusnard","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"e28664","DOI":"10.1371\/journal.pone.0028664","article-title":"Anatomical and functional deficits in patients with amnestic mild cognitive impairment","volume":"7","author":"Han","year":"2012","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.neuroimage.2010.11.059","article-title":"Frequency-dependent changes in the amplitude of low-frequency fluctuations in amnestic mild cognitive impairment: a resting-state fMRI study","volume":"55","author":"Han","year":"2011","journal-title":"NeuroImage"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jad.2016.06.031","article-title":"Disrupted orbitomedial prefrontal limbic network in individuals with later-life depression","volume":"204","author":"Harada","year":"2016","journal-title":"J. Affect. Disord."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1471-2377-2-9","article-title":"Cingulate cortex hypoperfusion predicts Alzheimer\u2019s disease in mild cognitive impairment","volume":"2","author":"Huang","year":"2002","journal-title":"BMC Neurol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1192\/bjp.140.6.566","article-title":"A new clinical scale for the staging of dementia","volume":"140","author":"Hughes","year":"1982","journal-title":"Br. J. Psychiatry"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1001\/jamapsychiatry.2016.3162","article-title":"Prevalence of depression in patients with mild cognitive impairment","volume":"74","author":"Ismail","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1097\/JGP.0b013e31819431d5","article-title":"Quantification of five neuropsychological approaches to defining mild cognitive impairment","volume":"17","author":"Jak","year":"2009","journal-title":"Am. J. Geriatr. Psychiatr."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1016\/j.neurobiolaging.2005.09.017","article-title":"Activation of brain regions vulnerable to Alzheimer\u2019s disease: the effect of mild cognitive impairment","volume":"27","author":"Johnson","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1017\/neu.2019.20","article-title":"Reduced grey matter volume in frontal and temporal areas in depression: contributions from voxel-based morphometry study","volume":"31","author":"Kandilarova","year":"2019","journal-title":"Acta Neuropsychiatr."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1016\/j.clineuro.2012.11.029","article-title":"Neuropsychiatric predictors of conversion to dementia both in patients with amnestic mild cognitive impairment and those with subcortical vascular MCI","volume":"115","author":"Kim","year":"2013","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1007\/s00702-017-1789-5","article-title":"Changes in connectivity of the posterior default network node during visual processing in mild cognitive impairment: staged decline between normal aging and Alzheimer\u2019s disease","volume":"124","author":"Krajcovicova","year":"2017","journal-title":"J. Neural Transm."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"964","DOI":"10.4088\/JCP.v66n0801","article-title":"Antidepressant exposure may protect against decrement in frontal gray matter volumes in geriatric depression","volume":"66","author":"Lavretsky","year":"2005","journal-title":"J. Clin. Psychiatry"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1111\/ene.13500","article-title":"Longitudinal cortical thinning and cognitive decline in patients with early\u2010 versus late\u2010stage subcortical vascular mild cognitive impairment","volume":"25","author":"Lee","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.3233\/JAD-161282","article-title":"Frequency-dependent changes in the amplitude of low-frequency fluctuations in mild cognitive impairment with mild depression","volume":"58","author":"Li","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s12311-019-01099-1","article-title":"Cerebellar volume is associated with cognitive decline in mild cognitive impairment: Results from ADNI","volume":"19","author":"Lin","year":"2020","journal-title":"Cerebellum"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/1672708","article-title":"Altered intrinsic coupling between functional connectivity density and amplitude of low-frequency fluctuation in mild cognitive impairment with depressive symptoms","volume":"2018","author":"Liu","year":"2018","journal-title":"Neural Plast."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.jad.2012.10.001","article-title":"Abnormal amplitude low-frequency oscillations in medication-naive, first-episode patients with major depressive disorder: a resting-state fMRI study","volume":"146","author":"Liu","year":"2013","journal-title":"J. Affect. Disord."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1097\/WAD.0000000000000356","article-title":"Association between neuropsychiatric symptom trajectory and conversion to Alzheimer disease","volume":"34","author":"Lo","year":"2020","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.neuroscience.2016.06.025","article-title":"A support vector machine-based method to identify mild cognitive impairment with multi-level characteristics of magnetic resonance imaging","volume":"331","author":"Long","year":"2016","journal-title":"Neuroscience"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1001\/jama.288.12.1475","article-title":"Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment","volume":"288","author":"Lyketsos","year":"2002","journal-title":"JAMA"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3389\/fnagi.2019.00241","article-title":"Structural and functional disruptions in subcortical vascular mild cognitive impairment with and without depressive symptoms","volume":"11","author":"Lyu","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1109\/EMBC.2017.8036875","article-title":"A study of feature extraction for Alzheimer\u2019s disease based on resting-state fMRI","volume":"2017","author":"Mao","year":"2017","journal-title":"Conf. Proc. IEEE Eng. Med. Biol. Soc."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"101843","DOI":"10.1016\/j.nicl.2019.101843","article-title":"Predicting conversion from mild cognitive impairment to Alzheimer\u2019s disease using brain 1H-MRS and volumetric changes: a two- year retrospective follow-up study","volume":"23","author":"Mitolo","year":"2019","journal-title":"Neuroimage Clin."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1002\/gps.4406","article-title":"Depressive symptoms increase the risk of progression to dementia in subjects with mild cognitive impairment: systematic review and meta-analysis","volume":"31","author":"Mourao","year":"2016","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"7173","DOI":"10.1523\/JNEUROSCI.0698-19.2019","article-title":"Stimulation of the posterior cingulate cortex impairs episodic memory encoding","volume":"39","author":"Natu","year":"2019","journal-title":"J. Neurosci."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"3716","DOI":"10.1007\/s00330-017-4768-1","article-title":"The effect of hippocampal function, volume and connectivity on posterior cingulate cortex functioning during episodic memory fMRI in mild cognitive impairment","volume":"27","author":"Papma","year":"2017","journal-title":"Eur. Radiol."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1148\/radiol.2451061847","article-title":"Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging","volume":"245","author":"Petrella","year":"2007","journal-title":"Radiology"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.neurobiolaging.2014.06.021","article-title":"Cortical pyroglutamate amyloid-\u03b2 levels and cognitive decline in Alzheimer\u2019s disease","volume":"36","author":"Pivtoraiko","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1016\/j.neuroimage.2011.10.018","article-title":"Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion","volume":"59","author":"Power","year":"2012","journal-title":"NeuroImage"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1002\/mrm.25036","article-title":"Abnormal brain anatomical topological organization of the cognitive-emotional and the frontoparietal circuitry in major depressive disorder","volume":"72","author":"Qin","year":"2014","journal-title":"Magn. Reson. Med."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"449","DOI":"10.2174\/1567205019666220620112831","article-title":"Vascular lesions and brain atrophy in Alzheimer\u2019s, vascular and mixed dementia: an optimized 3T MRI protocol reveals distinctive radiological profiles","volume":"19","author":"Ramusino","year":"2022","journal-title":"Curr. Alzheimer Res."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1159\/000089515","article-title":"Conversion of mild cognitive impairment to dementia: predictive role of mild cognitive impairment subtypes and vascular risk factors","volume":"21","author":"Ravaglia","year":"2005","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.neubiorev.2016.05.007","article-title":"A non-reward attractor theory of depression","volume":"68","author":"Rolls","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/S1474-4422(02)00190-4","article-title":"Subcortical ischaemic vascular dementia","volume":"1","author":"Rom\u00e1n","year":"2002","journal-title":"Lancet Neurol."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1212\/01.WNL.0000134664.80320.92","article-title":"Efficacy of donepezil in mild cognitive impairment","volume":"63","author":"Salloway","year":"2004","journal-title":"Neurology"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1016\/j.neuroimage.2010.11.011","article-title":"Prefrontal cortical abnormalities in currently depressed versus currently remitted patients with major depressive disorder","volume":"54","author":"Salvadore","year":"2011","journal-title":"NeuroImage"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.tics.2019.07.003","article-title":"The default mode Network\u2019s role in discrete emotion","volume":"23","author":"Satpute","year":"2019","journal-title":"Trends Cogn. Sci."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.neuroimage.2012.08.052","article-title":"An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity data","volume":"64","author":"Satterthwaite","year":"2013","journal-title":"NeuroImage"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1552-6569.2008.00292.x","article-title":"Subcortical vascular versus amnestic mild cognitive impairment: comparison of cerebral glucose metabolism","volume":"19","author":"Seo","year":"2009","journal-title":"J. Neuroimaging"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.biopsych.2012.02.002","article-title":"Depressive symptoms and mild cognitive impairment in the elderly: an ominous combination","volume":"71","author":"Steffens","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.neuroimage.2008.08.039","article-title":"Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies","volume":"44","author":"Stoodley","year":"2009","journal-title":"NeuroImage"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.bbr.2011.05.006","article-title":"Abnormal functional connectivity in patients with vascular cognitive impairment, no dementia: a resting-state functional magnetic resonance imaging study","volume":"223","author":"Sun","year":"2011","journal-title":"Behav. Brain Res."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.nicl.2017.01.018","article-title":"Multicenter stability of resting state fMRI in the detection of Alzheimer\u2019s disease and amnestic MCI","volume":"14","author":"Teipel","year":"2017","journal-title":"Neuroimage Clin."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"152","DOI":"10.3389\/fnagi.2019.00152","article-title":"Altered static and temporal dynamic amplitude of low-frequency fluctuations in the background network during working memory states in mild cognitive impairment","volume":"11","author":"Wang","year":"2019","journal-title":"Front. 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Neurosci."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1177\/0284185114533329","article-title":"Changes of gray matter volume and amplitude of low-frequency oscillations in amnestic MCI: an integrative multi-modal MRI study","volume":"56","author":"Zhao","year":"2015","journal-title":"Acta Radiol."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.jalz.2008.04.006","article-title":"Abnormal connectivity in the posterior cingulate and hippocampus in early Alzheimer\u2019s disease and mild cognitive impairment","volume":"4","author":"Zhou","year":"2008","journal-title":"Alzheimers Dement."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.jad.2013.04.028","article-title":"Severity classification on the Hamilton depression rating scale","volume":"150","author":"Zimmerman","year":"2013","journal-title":"J. Affect. 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