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Aging Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Parkinson's disease (PD) is a progressive neurodegenerative condition. Chinese medicine therapies have demonstrated effectiveness for PD in controlled settings. However, the utilization of Chinese medicine therapies for PD in real-world clinical practice and the characteristics of patients seeking these therapies have not been thoroughly summarized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The study retrospectively analyzed initial patient encounters (PEs) with a first-listed diagnosis of PD, based on electronic medical records from Guangdong Provincial Hospital of Chinese Medicine between July 2018 and July 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3,206 PEs, each corresponding to an individual patient, were eligible for analyses. Approximately 60% of patients made initial visits to the Chinese medicine hospital after receiving a PD diagnosis, around 4.59 years after the onset of motor symptoms. Over 75% of the patients visited the Internal Medicine Outpatient Clinic at their initial visits, while a mere 13.85% visited PD Chronic Care Clinic. Rest tremor (61.98%) and bradykinesia (52.34%) are the most commonly reported motor symptoms, followed by rigidity (40.70%). The most commonly recorded non-motor symptoms included constipation (31.88%) and sleep disturbance (25.27%). Integration of Chinese medicine and conventional medicine therapies was the most common treatment method (39.15%), followed by single use of Chinese herbal medicine (27.14%). The most frequently prescribed herbs for PD included <jats:italic>Glycyrrhiza uralensis<\/jats:italic> Fisch. (<jats:italic>gan cao<\/jats:italic>), <jats:italic>Astragalus mongholicus<\/jats:italic> Bunge (<jats:italic>huang qi<\/jats:italic>), <jats:italic>Atractylodes macrocephala<\/jats:italic> Koidz. (<jats:italic>bai zhu<\/jats:italic>), <jats:italic>Angelica sinensis<\/jats:italic> (Oliv.) Diels (<jats:italic>dang gui<\/jats:italic>), <jats:italic>Rehmannia glutinosa<\/jats:italic> (Gaertn.) DC. (<jats:italic>di huang<\/jats:italic>), <jats:italic>Paeonia lactiflora<\/jats:italic> Pall. (<jats:italic>bai shao<\/jats:italic>), <jats:italic>Bupleurum chinense<\/jats:italic> DC. (<jats:italic>chai hu<\/jats:italic>), <jats:italic>Citrus aurantium<\/jats:italic> L. (<jats:italic>zhi qiao<\/jats:italic>\/<jats:italic>zhi shi\/chen pi<\/jats:italic>), <jats:italic>Panax ginseng<\/jats:italic> C. A. Mey. (<jats:italic>ren shen<\/jats:italic>), and <jats:italic>Poria cocos<\/jats:italic> (Schw.) Wolf (<jats:italic>fu ling<\/jats:italic>). These herbs contribute to formulation of <jats:italic>Bu zhong yi qi tang<\/jats:italic> (BZYQT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients typically initiated Chinese medical care after the establishment of PD diagnosis, ~4.59 years post-onset of motor symptoms. The prevalent utilization of CHM decoctions and patented Chinese herbal medicine products, underscores its potential in addressing both motor and non-motor symptoms. Despite available evidence, rigorous clinical trials are needed to validate and optimize the integration of CHM, particularly BZYQT, into therapeutic strategies for PD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2024.1362948","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T04:54:13Z","timestamp":1714625653000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Real-world Chinese herbal medicine for Parkinson's disease: a hospital-based retrospective analysis of electronic medical records"],"prefix":"10.3389","volume":"16","author":[{"given":"Shaohua","family":"Lyu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire Shuiqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhui","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaozhen","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1145\/170035.170072","article-title":"\u201cMining association rules between sets of items in large databases,\u201d","volume-title":"Proceedings of the 1993 ACM SIGMOD international conference on Management of data.","author":"Agrawal","year":"1993"},{"key":"B2","volume-title":"Postural Instability.","author":"Appeadu","year":"2023"},{"key":"B3","doi-asserted-by":"publisher","first-page":"S90","DOI":"10.1016\/S1353-8020(National","article-title":"Epidemiology, diagnosis and differential diagnosis in Parkinson's disease tremor","volume":"18","author":"Baumann","year":"2012","journal-title":"Parkinsonism Relat. 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