{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:32:31Z","timestamp":1792150351952,"version":"4.4.0"},"reference-count":166,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Sensorineural hearing loss (SNHL) is a category of hearing loss that often leads to difficulty in understanding speech and other sounds. Auditory system dysfunction, including deafness and auditory trauma, results in cognitive deficits via neuroplasticity. Cognitive impairment (CI) refers to an abnormality in the brain\u2019s higher intellectual processes related to learning, memory, thinking and judgment that can lead to severe learning and memory deficits. Studies have established a strong correlation between SNHL and CI, but it remains unclear how SNHL contributes to CI. The purpose of this article is to describe three hypotheses regarding this relationship, the mainstream cognitive load hypothesis, the co-morbidity hypothesis, and the sensory deprivation hypothesis, as well as the latest research progress related to each hypothesis.<\/jats:p>","DOI":"10.3389\/fnagi.2024.1368232","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T04:57:09Z","timestamp":1709096229000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Sensorineural hearing loss and cognitive impairment: three hypotheses"],"prefix":"10.3389","volume":"16","author":[{"given":"He","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanjing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.neuroscience.2023.03.022","article-title":"Theta\/gamma co-modulation disruption after NMDAr blockade by MK-801 is associated with spatial working memory deficits in mice","volume":"519","author":"Abad-Perez","year":"2023","journal-title":"Neuroscience"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e0265961","DOI":"10.1371\/journal.pone.0265961","article-title":"Improved cognition impairment by activating cannabinoid receptor type 2: modulating CREB\/BDNF expression and impeding TLR-4\/NF\u03baBp65\/M1 microglia signaling pathway in D-galactose-injected ovariectomized rats","volume":"17","author":"Abd El-Rahman","year":"2022","journal-title":"PLoS One"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1002\/alz.13016","article-title":"Alzheimer's disease facts and figures","volume":"19","year":"2023","journal-title":"Alzheimer's & dementia: J Alzheimer's Assoc"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1001\/jamaoto.2019.1610","article-title":"Association of Midlife Hearing Impairment with Late-Life Temporal Lobe Volume Loss","volume":"145","author":"Armstrong","year":"2019","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"8979","DOI":"10.3390\/ijms23168979","article-title":"Targeting NLRP3-mediated Neuroinflammation in Alzheimer's disease treatment","volume":"23","author":"Barczuk","year":"2022","journal-title":"Int. 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