{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:58:08Z","timestamp":1791644288655,"version":"4.3.4"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Olfactory dysfunction was associated with poorer cognition. However, the association between transient receptor potential cation channel subfamily A member 1 (TRPA1) and cognitive function have not been studied. This study aimed to evaluate the mediation effect of TRPA1 on the association between olfactory and cognitive function among Chinese older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 121 participants with cognitive impairment (CI) and 135 participants with normal cognition (NC) from a memory clinic and the \u201cShanghai Aging Study.\u201d Olfactory identification of each participant was measured by the Sniffin\u2019 Sticks Screening Test 12 (SSST-12). Serum TRPA1 were quantified using the Enzyme-Linked Immunosorbent Assay. The mediation effects of TRPA1 on the association between olfactory function and cognitive function were explored using mediation analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The CI group had a significantly higher proportion of the high level of serum TRPA1 (58.7%) than the NC group (42.2%) (<jats:italic>p<\/jats:italic>\u2009=\u20090.0086). After adjusted for gender, age, and years of education, mediation analysis verified that TRPA1 partially mediated the association between SSST-12 and Mini Mental State Examination (MMSE). It also verified that TRPA1 partially mediated the association between the identification of peppermint and MMSE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study emphasizes the mediation role of TRPA1 in the relationship between olfactory and cognitive function among older adults. Further research is necessary to explore the mechanism of TRPA1 on the relationship between olfactory and cognitive decline.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2024.1411031","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T20:41:38Z","timestamp":1718224898000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum TRPA1 mediates the association between olfactory function and cognitive function"],"prefix":"10.3389","volume":"16","author":[{"given":"Xiaoniu","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.pain.2009.10.008","article-title":"Pain in European long-term care facilities: cross-national study in Finland, Italy and the Netherlands","volume":"148","author":"Achterberg","year":"2010","journal-title":"Pain"},{"key":"ref2","volume-title":"DSM-IV: Diagnostic and statistical manual of mental disorders","year":"1994"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00401-014-1261-7","article-title":"Olfactory bulb involvement in neurodegenerative diseases","volume":"127","author":"Attems","year":"2014","journal-title":"Acta Neuropathol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2978","DOI":"10.1038\/ncomms3978","article-title":"Differential methylation of the TRPA1 promoter in pain sensitivity","volume":"5","author":"Bell","year":"2014","journal-title":"Nat. Commun."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s11357-019-00083-1","article-title":"Important regulatory function of transient receptor potential ankyrin 1 receptors in age-related learning and memory alterations of mice","volume":"41","author":"Borbely","year":"2019","journal-title":"Geroscience"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s13024-017-0194-8","article-title":"TRPA1 channels promote astrocytic ca(2+) hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-beta peptide","volume":"12","author":"Bosson","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/j.neuron.2023.01.015","article-title":"Social deprivation induces astrocytic TRPA1-GABA suppression of hippocampal circuits","volume":"111","author":"Cheng","year":"2023","journal-title":"Neuron"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1002\/alr.22078","article-title":"Olfactory dysfunction and cognition among older adults in the United States","volume":"8","author":"Choi","year":"2018","journal-title":"Int. Forum Aller. Rhinol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1212\/WNL.0000000000001132","article-title":"Olfactory deficits predict cognitive decline and Alzheimer dementia in an urban community","volume":"84","author":"Devanand","year":"2015","journal-title":"Neurology"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.jalz.2013.11.002","article-title":"Prevalence of mild cognitive impairment in an urban community in China: a cross-sectional analysis of the Shanghai aging study","volume":"11","author":"Ding","year":"2015","journal-title":"Alzheimers Dement."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1159\/000366163","article-title":"The Shanghai aging study: study design, baseline characteristics, and prevalence of dementia","volume":"43","author":"Ding","year":"2014","journal-title":"Neuroepidemiology"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1002\/alz.12777","article-title":"Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults","volume":"19","author":"Dong","year":"2023","journal-title":"Alzheimers Dement."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1097\/00006199-199807000-00009","article-title":"Analgesic drug prescription and use in cognitively impaired nursing home residents","volume":"47","author":"Horgas","year":"1998","journal-title":"Nurs. Res."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"115392","DOI":"10.1016\/j.ejmech.2023.115392","article-title":"Transient receptor potential ankyrin 1 (TRPA1) modulators: recent update and future perspective","volume":"257","author":"Hu","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1177\/000348940111001015","article-title":"Screening of olfactory function with a four-minute odor identification test: reliability, normative data, and investigations in patients with olfactory loss","volume":"110","author":"Hummel","year":"2001","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1111\/j.1532-5415.2012.04036.x","article-title":"Discrepancy between self-and proxy-rated pain in Alzheimer's disease: results from the Danish Alzheimer intervention study","volume":"60","author":"Jensen-Dahm","year":"2012","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s12974-016-0557-z","article-title":"Role of transient receptor potential ankyrin 1 channels in Alzheimer's disease","volume":"13","author":"Lee","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"3606","DOI":"10.1007\/s12035-016-9908-0","article-title":"Loss of transient receptor potential Ankyrin 1 channel deregulates emotion, learning and memory, cognition, and social behavior in mice","volume":"54","author":"Lee","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref19","volume-title":"Encyclopedia of common natural ingredients used in food, drugs and cosmetics","author":"Leung","year":"1980"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/s12883-016-0725-x","article-title":"Association between olfactory identification and cognitive function in community-dwelling elderly: the Shanghai aging study","volume":"16","author":"Liang","year":"2016","journal-title":"BMC Neurol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1159\/000505485","article-title":"Inability to smell peppermint is related to cognitive decline: a prospective community-based study","volume":"54","author":"Liang","year":"2020","journal-title":"Neuroepidemiology"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1093\/ageing\/afh165","article-title":"Effects of dementia on perceived daily pain in home-dwelling elderly people: a population-based study","volume":"33","author":"Mantyselka","year":"2004","journal-title":"Age Ageing"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1212\/wnl.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/s0885-3924(00)00113-5","article-title":"A comparison of pain and its treatment in advanced dementia and cognitively intact patients with hip fracture","volume":"19","author":"Morrison","year":"2000","journal-title":"J. Pain Symptom Manag."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1080\/00207450601042094","article-title":"Modulation of cognitive performance and mood by aromas of peppermint and ylang-ylang","volume":"118","author":"Moss","year":"2009","journal-title":"Int. J. Neurosci."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"188","DOI":"10.29399\/npa.28183","article-title":"Potential effects of melatonin on TRPA1 channels in the prevention and treatment of Alzheimer's disease","volume":"59","author":"Ozsimsek","year":"2022","journal-title":"Noro Psikiyatr. Ars."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1093\/brain\/awab281","article-title":"Astrocyte-neuron interplay is critical for Alzheimer's disease pathogenesis and is rescued by TRPA1 channel blockade","volume":"145","author":"Paumier","year":"2022","journal-title":"Brain"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","article-title":"Mild cognitive impairment as a diagnostic entity","volume":"256","author":"Petersen","year":"2004","journal-title":"J. Intern. Med."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1001\/jamaneurol.2015.2952","article-title":"Association between olfactory dysfunction and amnestic mild cognitive impairment and Alzheimer disease dementia","volume":"73","author":"Roberts","year":"2016","journal-title":"JAMA Neurol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1080\/00332747.1999.11024871","article-title":"Alzheimer patients report less pain intensity and pain affect than non-demented elderly","volume":"62","author":"Scherder","year":"1999","journal-title":"Psychiatry"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1017\/s1355617713001409","article-title":"Olfactory impairment and subjective olfactory complaints independently predict conversion to dementia: a longitudinal, population-based study","volume":"20","author":"Stanciu","year":"2014","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1093\/pm\/pnv088","article-title":"Correlation between DNA methylation of TRPA1 and chronic pain states in human whole blood cells","volume":"17","author":"Sukenaga","year":"2016","journal-title":"Pain Med."},{"key":"ref34","volume-title":"PDR for herbal medicines","year":"2007"},{"key":"ref35","first-page":"199","article-title":"Effects of olfactory stimulation on performance and stress in a visual sustained attention task","volume":"42","author":"Warm","year":"1991","journal-title":"J. Soc. Cosmet. Chem."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1159\/000090250","article-title":"Odor identification and decline in different cognitive domains in old age","volume":"26","author":"Wilson","year":"2006","journal-title":"Neuroepidemiology"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s13195-021-00864-x","article-title":"Plasma biomarker profiles and the correlation with cognitive function across the clinical spectrum of Alzheimer's disease","volume":"13","author":"Xiao","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1212\/wnl.0000000000003558","article-title":"Olfaction and risk of dementia in a biracial cohort of older adults","volume":"88","author":"Yaffe","year":"2017","journal-title":"Neurology"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1002\/ana.410270412","article-title":"The prevalence of dementia and Alzheimer's disease in Shanghai, China: impact of age, gender, and education","volume":"27","author":"Zhang","year":"1990","journal-title":"Ann. Neurol."}],"updated-by":[{"DOI":"10.3389\/fnagi.2024.1485432","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000}}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2024.1411031\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T12:52:02Z","timestamp":1726663922000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2024.1411031\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,10]]},"references-count":39,"alternative-id":["10.3389\/fnagi.2024.1411031"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2024.1411031","relation":{"corrigendum":[{"id-type":"doi","id":"10.3389\/fnagi.2024.1485432","asserted-by":"object"}]},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,10]]},"article-number":"1411031"}}