{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:57:14Z","timestamp":1789588634657,"version":"build-2803163510"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>The Chilean degu (<jats:italic>Octodon degus<\/jats:italic>) is a medium sized, long-lived rodent with traits that make them a natural model for neuroscience research. Their social behaviors, diurnality, and extended developmental time course, when compared to other rodents, make them useful for social behavioral, chronobiology, and developmental research. Lab-kept degus have a long lifespan (5\u20138\u202fyears) and may naturally develop age-related diseases that resemble Alzheimer\u2019s disease. While there is significant interest in using the <jats:italic>Octodon degus<\/jats:italic> for neuroscience research, including aging and Alzheimer\u2019s disease studies, laboratory management and methods for degus research are currently not standardized. This lack of standardization potentially impacts study reproducibility and makes it difficult to compare results between different laboratories. Degus require species-specific housing and handling methods that reflect their ecology, life history, and group-living characteristics. Here we introduce major principles and ethological considerations of colony management and husbandry. We provide clear instructions on laboratory practices necessary for maintaining a healthy and robust colony of degus for Alzheimer\u2019s disease neuroscience research towards conducting reproducible studies. We also report detailed procedures and methodical information for degu <jats:italic>Apoe<\/jats:italic> genotyping and ethologically relevant burrowing behavioral tasks in laboratory settings.<\/jats:p>","DOI":"10.3389\/fnagi.2024.1517416","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T07:23:10Z","timestamp":1737357790000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Octodon degus laboratory colony management principles and methods for behavioral analysis for Alzheimer\u2019s disease neuroscience research"],"prefix":"10.3389","volume":"16","author":[{"given":"B. Maximiliano","family":"Gardu\u00f1o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd C.","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M. J.","family":"Deacon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangmin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Cogram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1126\/science.1248903","article-title":"Hippocampal neurogenesis regulates forgetting during adulthood and infancy","volume":"344","author":"Akers","year":"2014","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"3708","DOI":"10.1002\/alz.13809","article-title":"2024 Alzheimer\u2019s disease facts and figures","volume":"20","year":"2024","journal-title":"Alzheimers Dement."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1101\/pdb.emo071357","article-title":"Octodon degus (Molina 1782): a model in comparative biology and biomedicine","volume":"2013","author":"Ardiles","year":"2013","journal-title":"Cold Spring Harb. 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Anim."},{"key":"ref49","unstructured":"Chilean brush-tailed mouse (Octodon degus): a diurnal precocial rodent as a new model to study visual receptive field properties of superior colliculus neurons\n          \n          \n            \n              M\u00e1rquez\n              N. I.\n            \n            \n              Fern\u00e1ndez-Aburto\n              P. F.\n            \n            \n              Deichler\n              A.\n            \n            \n              Perales\n              I.\n            \n            \n              Letelier\n              J.-C.\n            \n            \n              Mar\u00edn\n              G. J.\n            \n          \n          \n          2024"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"15056","DOI":"10.1038\/nrdp.2015.56","article-title":"Alzheimer\u2019s disease","volume":"1","author":"Masters","year":"2015","journal-title":"Nat. Rev. Dis. 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