{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:43:16Z","timestamp":1794012196501,"version":"4.8.0"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Improving sleep in murine Alzheimer\u2019s disease (AD) is associated with reduced brain amyloidosis. However, the window of opportunity for successful sleep-targeted interventions, regarding the reduction in pathological hallmarks and related cognitive performance, remains poorly characterized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, we enhanced slow-wave activity (SWA) during sleep via sodium oxybate (SO) oral administration for 2 weeks at early (6\u202fmonths old) or moderately late (11\u202fmonths old) disease stages in Tg2576 mice and evaluated resulting neuropathology and behavioral performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed that the cognitive performance of 6-month-old Tg2576 mice significantly improved upon SO treatment, whereas no change was observed in 11-month-old mice. Histochemical assessment of amyloid plaques demonstrated that SO-treated 11-month-old Tg2576 mice had significantly less plaque burden than placebo-treated ones, whereas ELISA of insoluble protein fractions from brains of 6-month-old Tg2576 mice indicated lower A\u03b2-42\/A\u03b2-40 ratio in SO-treated group vs. placebo-treated controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Altogether, our results suggest that SWA-dependent reduction in brain amyloidosis leads to alleviated behavioral impairment in Tg2576 mice only if administered early in the disease course, potentially highlighting the key importance of early sleep-based interventions in clinical cohorts.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2024.1519225","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T06:50:28Z","timestamp":1735887028000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Pharmacological enhancement of slow-wave activity at an early disease stage improves cognition and reduces amyloid pathology in a mouse model of Alzheimer\u2019s disease"],"prefix":"10.3389","volume":"16","author":[{"given":"Sedef","family":"Kollarik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorita","family":"Bimbiryte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aakriti","family":"Sethi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos G.","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Noain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"103460","DOI":"10.1016\/j.nicl.2023.103460","article-title":"Protective effects of sleep duration and physical activity on cognitive performance are influenced by \u03b2-amyloid and brain volume but not tau burden among cognitively unimpaired older adults","volume":"39","author":"Aslanyan","year":"2023","journal-title":"Neuroimage Clin."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/S0197-4580(99)00065-2","article-title":"Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice","volume":"20","author":"Benzing","year":"1999","journal-title":"Neurobiol. 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