{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:09:54Z","timestamp":1792523394486,"version":"4.5.0"},"reference-count":81,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Mild cognitive impairment (MCI) is characterized by a decline in cognitive functioning without significant interference in daily activities. Its high heterogeneity and elevated conversion rate to dementia pose challenges for accurate diagnosis and monitoring, highlighting the urgent need to identify methodologies focused on the early detection and intervention of MCI. Due to their biological characteristics, microRNAs (miRNAs) are potential candidates as non-invasive molecular markers for the identification and assessment of MCI progression. Therefore, in this study, we conducted a meta-analysis to identify the miRNAs commonly deregulated in MCI, focusing on expression profiles in plasma, serum, and extracellular vesicle samples. Our analysis identified eight upregulated miRNAs, including hsa-miR-149-3p, and four downregulated miRNAs, such as Let-7f-5p. Notably, hsa-miR-149-3p emerged as a central node in interaction networks, suggesting its crucial role in regulating cellular processes relevant to MCI. Additionally, pathway analysis revealed significant enrichment in biological processes associated with transcriptional regulation and neurodegeneration. Our results underscore the potential of circulating miRNAs as non-invasive molecular markers for MCI and open the possibility for new methodologies that enable more accurate diagnosis and monitoring of disease progression. Validating the expression of miRNAs such as hsa-miR-149-3p and Let-7f-5p, along with identifying their functional role in the specific context of MCI, is essential to establish their biological relevance. This work contributes to the understanding of the miRNA profile in mild cognitive impairment using easily accessible samples, which could be useful for the development of various strategies aimed at preventing or delaying MCI in individuals at risk of developing dementia, including Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.3389\/fnagi.2024.1524622","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T06:14:49Z","timestamp":1736921689000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["MicroRNAs signatures as potential molecular markers in mild cognitive impairment: a meta-analysis"],"prefix":"10.3389","volume":"16","author":[{"given":"Natalia","family":"Vargas-Rond\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeimy","family":"Gonz\u00e1lez-Giraldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela Y.","family":"Garc\u00eda Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneth","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s Felipe","family":"Aristizabal-Pachon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.3389\/fgene.2023.1231486","article-title":"A new perspective on Alzheimer\u2019s disease: microRNAs and circular RNAs","volume":"14","author":"Abidin","year":"2023","journal-title":"Front. 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Med."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s12152-023-09522-5","article-title":"Mild cognitive impairment in relation to Alzheimer\u2019s disease: an investigation of principles, classifications, ethics, and problems","volume":"16","author":"Lee","year":"2023","journal-title":"Neuroethics"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"R78","DOI":"10.1186\/gb-2013-14-7-r78","article-title":"A blood based 12-miRNA signature of Alzheimer disease patients","volume":"14","author":"Leidinger","year":"2013","journal-title":"Genome Biol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/s41398-024-03075-8","article-title":"MicroRNAs: pioneering regulators in Alzheimer\u2019s disease pathogenesis, diagnosis, and therapy","volume":"14","author":"Li","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s10565-022-09761-x","article-title":"The role of microRNAs in neurodegenerative diseases: a review","volume":"39","author":"Li","year":"2023","journal-title":"Cell Biol. Toxicol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"785433","DOI":"10.3389\/fncel.2021.785433","article-title":"Inflamma-MicroRNAs in Alzheimer\u2019s disease: from disease pathogenesis to therapeutic potentials","volume":"15","author":"Liang","year":"2021","journal-title":"Front. Cellul. Neurosci."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.3390\/jpm13091410","article-title":"New community and Sociohealth challenges arising from the early diagnosis of mild cognitive impairment (MCI)","volume":"13","author":"L\u00f3pez","year":"2023","journal-title":"J. Pers. Med."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/5006123","article-title":"MiR-149-3p is a potential prognosis biomarker and correlated with immune infiltrates in uterine Corpus endometrial carcinoma","volume":"2022","author":"Lu","year":"2022","journal-title":"Int. J. Endocrinol."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"6210","DOI":"10.1523\/JNEUROSCI.20-16-06210.2000","article-title":"NAC-1 is a brain POZ\/BTB protein that can prevent cocaine-induced sensitization in the rat","volume":"20","author":"Mackler","year":"2000","journal-title":"J. Neurosci."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.neuron.2012.07.005","article-title":"MicroRNAs shape the neuronal landscape","volume":"75","author":"McNeill","year":"2012","journal-title":"Neuron"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"e1787","DOI":"10.1002\/cnr2.1787","article-title":"Bioinformatics analysis of miRNA and its associated genes to identify potential biomarkers of oral submucous fibrosis and oral malignancy","volume":"6","author":"Mohanan","year":"2023","journal-title":"Cancer Reports"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"ref49","first-page":"9","article-title":"Mild cognitive impairment and preclinical Alzheimer\u2019s disease","volume":"9","author":"Morris","year":"2005","journal-title":"Geriatrics"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"6029","DOI":"10.1016\/j.biopha.2023.116029","article-title":"Mechanisms of microRNA-132 in central neurodegenerative diseases: a comprehensive review","volume":"170","author":"Mu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3390\/cells9010075","article-title":"Precision medicine in neurodegenerative diseases: some promising tips coming from the microRNAs\u2019 world","volume":"9","author":"Nuzziello","year":"2020","journal-title":"Cells"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of microRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O\u2019Brien","year":"2018","journal-title":"Front. Docrinol."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.molcel.2008.05.001","article-title":"MicroRNA-10a binds the 5\u2032UTR of ribosomal protein mRNAs and enhances their translation","volume":"30","author":"\u00d8rom","year":"2008","journal-title":"Mol. Cell"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"976","DOI":"10.3390\/ijms24108976","article-title":"CSF biomarkers in the early diagnosis of mild cognitive impairment and Alzheimer\u2019s disease","volume":"24","author":"Papaliagkas","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1016\/S0140-6736(06)68881-8","article-title":"Mild cognitive impairment","volume":"367","author":"Petersen","year":"2006","journal-title":"Lancet"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"427","DOI":"10.7326\/0003-4819-148-6-200803180-00005","article-title":"Prevalence of cognitive impairment without dementia in the United States","volume":"148","author":"Plassman","year":"2008","journal-title":"Ann Intern Med"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"229","DOI":"10.4103\/0973-029X.140762","article-title":"MicroRNAs \u2013 biology and clinical applications","volume":"18","author":"Ranganathan","year":"2014","journal-title":"J. Oral Maxillofacial Pathol."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s11523-020-00717-x","article-title":"MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as new tools for cancer therapy: first steps from bench to bedside","volume":"15","author":"Ratti","year":"2020","journal-title":"Target. Oncol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref002","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/s0165-0270(00)00228-4","article-title":"A simple procedure for quantification of neurite outgrowth based on stereological principles","volume":"100","author":"R\u00f8nn","year":"2000","journal-title":"J Neurosci Methods."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s40291-022-00627-w","article-title":"Candidate MicroRNA biomarkers in lupus nephritis: a meta-analysis of profiling studies in kidney, blood and urine samples","volume":"27","author":"Roointan","year":"2023","journal-title":"Mol. Diagn. Ther."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"256","DOI":"10.3390\/life12020256","article-title":"BH3-only proteins Noxa and Puma are key regulators of induced apoptosis","volume":"12","author":"Roufayel","year":"2022","journal-title":"Life"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"158","DOI":"10.14283\/jpad.2020.19","article-title":"Rationale for early diagnosis of mild cognitive impairment (MCI) supported by emerging digital technologies","volume":"7","author":"Sabbagh","year":"2020","journal-title":"J.Prevent. Alzheim. Dis."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1080\/13607863.2014.920303","article-title":"The new DSM-5 diagnosis of mild neurocognitive disorder and its relation to research in mild cognitive impairment","volume":"19","author":"Sachs-Ericsson","year":"2015","journal-title":"Aging Mental Health"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"347","DOI":"10.3389\/fnbeh.2015.00347","article-title":"Epigenetic alterations in Alzheimer\u2019s disease","volume":"9","author":"Sanchez-Mut","year":"2015","journal-title":"Front. Behav. Neurosci."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.ajhg.2016.12.013","article-title":"A recurrent De novo variant in NACC1 causes a syndrome characterized by infantile epilepsy, cataracts, and profound developmental delay","volume":"100","author":"Schoch","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"8903","DOI":"10.1523\/JNEUROSCI.1571-07.2007","article-title":"NAC1 regulates the recruitment of the proteasome complex into dendritic spines","volume":"27","author":"Shen","year":"2007","journal-title":"J. Neurosci."},{"key":"ref001","doi-asserted-by":"publisher","first-page":"4027","DOI":"10.1007\/s00018-015-1985-0","article-title":"Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes","volume":"72","author":"Sin","year":"2015","journal-title":"Cell Mol Life Sci."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbi.2015.07.003","article-title":"MicroRNAs mediating CNS inflammation: small regulators with powerful potential","volume":"52","author":"Su","year":"2016","journal-title":"Brain Behav. Immun"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"114","DOI":"10.34133\/research.0114","article-title":"Plasma extracellular vesicle MicroRNA analysis of Alzheimer\u2019s disease reveals dysfunction of a neural correlation network","volume":"6","author":"Sun","year":"2023","journal-title":"Research"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"233","DOI":"10.3389\/fneur.2020.00233","article-title":"The predicted key molecules, functions, and pathways that bridge mild cognitive impairment (MCI) and Alzheimer\u2019s disease (AD)","volume":"11","author":"Tao","year":"2020","journal-title":"Front. Neurol."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"103367","DOI":"10.1016\/j.retram.2022.103367","article-title":"Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment","volume":"71","author":"Tatara","year":"2023","journal-title":"Curr. Res. Transl. Med."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"W460","DOI":"10.1093\/nar\/gkv403","article-title":"DIANA-miRPath v3.0: deciphering microRNA function with experimental support","volume":"43","author":"Vlachos","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/978-1-4939-1062-5_28","article-title":"Comprehensive meta-analysis of MicroRNA expression using a robust rank aggregation approach","volume":"1182","author":"V\u00f5sa","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"3439","DOI":"10.3892\/mmr.2015.3790","article-title":"Integrative meta-analysis of differentially expressed genes in osteoarthritis using microarray technology","volume":"12","author":"Wang","year":"2015","journal-title":"Mol. Med. 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