{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:04:32Z","timestamp":1753891472152,"version":"3.41.2"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Parkinson\u2019s disease (PD) is a prevalent, disabling neurodegenerative disorder. Early diagnosis and treatment of PD remains challenging due to the absence of definitive diagnostic tests and the non-specificity of its clinical manifestations. Initial consultations for PD symptoms often involve specialists who are not specifically trained in PD. Consequently, it is imperative to assess the general knowledge regarding PD among these specialists to develop optimal educational strategies and enhance early recognition and diagnosis of PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We developed a questionnaire covering motor symptoms, non-motor symptoms, prodromal symptoms, risk factors and antiparkinsonian medications based on published guidelines, and conducted the web-based survey via <jats:italic>Wenjuan xing<\/jats:italic> (<jats:uri>https:\/\/www.wjx.cn\/<\/jats:uri>) among physicians not specializing in PD in Guangdong Province, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 312 respondents, working in 28 diverse departments across 64 hospitals of three different categories, were eligible for data analysis. Notably, 95.2% of the respondents were aware of rest tremor as a motor symptom, yet only 76.9% recognized bradykinesia as a motor symptom. Regarding non-motor symptoms, erectile dysfunction, urinary dysfunction, restless legs, olfactory loss, orthostatic hypotension, rapid eye movement behavior disorder (RBD), lower back pain and diaphoresis, were recognized by less than 50% of the respondents. Additionally, with the exception of subthreshold parkinsonism or abnormal quantitative motor testing, prodromal symptoms such as excessive daytime somnolence, depression (\u00b1 anxiety), olfactory loss, urinary dysfunction, RBD, and constipation were recognized by 36.5\u201348.7% of the respondents. First-degree relatives with PD received recognition from 86.5% of the respondents, whereas the remaining risk factors were recognized by 50\u201360% of the participants. Concerning protective factors for PD, recognition was limited to no more than 23%. Levodopa and dopamine releasers were the most widely recognized antiparkinsonian medications, while the recognition of other medications was below 70%. Variables such as medical degrees, professional titles, hospital categories, and education subjects contributed to statistical differences in PD knowledge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among non-PD specialists in south China, current knowledge regarding PD, including non-motor symptoms, prodromal symptoms, risk and protective factors, and antiparkinsonian medications, is relatively inadequate. This necessitates targeted education and training to improve their understanding and recognition of PD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2025.1488009","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T05:23:20Z","timestamp":1744176200000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Knowledge of Parkinson\u2019s disease among non-PD specialists: a web-based survey in South China"],"prefix":"10.3389","volume":"17","author":[{"given":"Shaohua","family":"Lyu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhui","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingbo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunye","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaozhen","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"year":"2023","key":"ref1"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"104671","DOI":"10.1016\/j.nbd.2019.104671","article-title":"Modifiable risk and protective factors in disease development, progression and clinical subtypes of Parkinson's disease: what do prospective studies suggest?","volume":"134","author":"Belvisi","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"812","DOI":"10.31128\/AJGP-07-21-6093","article-title":"Non-motor symptoms of Parkinson\u2019s disease","volume":"50","author":"Carroll","year":"2021","journal-title":"Austral. J. Gen. Pract."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"52","DOI":"10.4274\/tnd.2021.52993","article-title":"Prevalence of non-motor symptoms in Parkinson\u2019s disease: a study from South India","volume":"27","author":"Chaudhuri","year":"2021","journal-title":"Turk. J. Neurol."},{"volume-title":"Clinical effectiveness and cost-effectiveness of physiotherapy and occupational therapy versus no therapy in mild to moderate Parkinson\u2019s disease: a large pragmatic randomised controlled trial (PD REHAB), appendix 1, UK Parkinson\u2019s disease society brain Bank diagnostic criteria","year":"2016","author":"Clarke","key":"ref5"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1001\/jama.2014.3654","article-title":"Pharmacological treatment of Parkinson disease: a review","volume":"311","author":"Connolly","year":"2014","journal-title":"JAMA"},{"volume-title":"IBM SPSS statistics for windows","year":"2017","author":"Corp","key":"ref7"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/rheumatology\/38.7.627","article-title":"Extrapyramidal type rigidity in rheumatoid arthritis","volume":"38","author":"Ertan","year":"1999","journal-title":"Rheumatology (Oxford)"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1093\/ajhp\/55.6.524","article-title":"First COMT inhibitor approved for Parkinson's disease","volume":"55","year":"1998","journal-title":"Am. J. Health Syst. Pharm."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1097\/01.nrl.0000131146.08278.a5","article-title":"Parkinson disease: an update","volume":"10","author":"Frucht","year":"2004","journal-title":"Neurologist"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.nurpra.2021.03.004","article-title":"Insomnia: an Underrecognized nonmotor symptom in Parkinson disease","volume":"17","author":"Garrison","year":"2021","journal-title":"J. Nurse Pract."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1136\/bmj.39339.610000.BE","article-title":"The declaration of Helsinki","volume":"335","author":"Goodyear","year":"2007","journal-title":"Br. Med. J."},{"key":"ref13","doi-asserted-by":"crossref","DOI":"10.15586\/codonpublications.parkinsonsdisease.2018.ch6","article-title":"The differential diagnosis of Parkinson\u2019s disease","volume-title":"Parkinson\u2019s disease: pathogenesis and clinical aspects","author":"Greenland","year":"2018"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"E989","DOI":"10.1503\/cmaj.181504","article-title":"Canadian guideline for Parkinson disease","volume":"191","author":"Grimes","year":"2019","journal-title":"Can. Med. Assoc. J."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/psyg.12489","article-title":"Frequency of non-motor symptoms and their impact on the quality of life in patients with Parkinson's disease: a prospective descriptive case series","volume":"20","author":"Gulunay","year":"2020","journal-title":"Psychogeriatrics"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"58","DOI":"10.5334\/tohm.552","article-title":"Prevalence and relationship of rest tremor and action tremor in Parkinson's disease","volume":"10","author":"Gupta","year":"2020","journal-title":"Tremor. Other Hyperkinet. Mov. (N Y)"},{"volume-title":"Parkinson's disease in adults (NICE guideline NH71)","year":"2017","key":"ref17"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1002\/mds.27802","article-title":"Update of the MDS research criteria for prodromal Parkinson's disease","volume":"34","author":"Heinzel","year":"2019","journal-title":"Mov. Disord."},{"key":"ref19","article-title":"China\u2019s 3-tier hospital system: gaps and challenges","volume-title":"Hospital management Asia","author":"Heping","year":"2021"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"105240","DOI":"10.1016\/j.parkreldis.2022.105240","article-title":"Risk disclosure in prodromal Parkinson's disease - a survey of neurologists","volume":"106","author":"Kayis","year":"2023","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1016\/S0140-6736(20)30122-7","article-title":"Quality of primary health care in China: challenges and recommendations","volume":"395","author":"Li","year":"2020","journal-title":"Lancet"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2584","DOI":"10.1016\/S0140-6736(17)33109-4","article-title":"The primary health-care system in China","volume":"390","author":"Li","year":"2017","journal-title":"Lancet"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40035-019-0162-z","article-title":"Parkinson\u2019s disease in China: a forty-year growing track of bedside work","volume":"8","author":"Li","year":"2019","journal-title":"Transl. Neurodegener."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12913-022-07503-7","article-title":"A cross-sectional study of knowledge and practices in the management of patients with Parkinson\u2019s disease amongst public practice-based general practitioners and geriatricians","volume":"22","author":"Lim","year":"2022","journal-title":"BMC Health Serv. Res."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1093\/brain\/aws038","article-title":"Hypokinesia without decrement distinguishes progressive supranuclear palsy from Parkinson's disease","volume":"135","author":"Ling","year":"2012","journal-title":"Brain"},{"year":"2018","author":"Mantri","key":"ref26"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2147\/JPRLS.S177409","article-title":"Sialorrhea in Parkinson\u2019s disease: prevalence, impact and management strategies","volume":"9","author":"Miller","year":"2019","journal-title":"Res. Rev. Parkinson."},{"key":"ref28","first-page":"S183","article-title":"Early treatment of Parkinson's disease: opportunities for managed care","volume":"18","author":"Murman","year":"2012","journal-title":"Am. J. Manag. Care"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"776847","DOI":"10.3389\/fpubh.2021.776847","article-title":"Global trends in the incidence, prevalence, and years lived with disability of Parkinson's disease in 204 countries\/territories from 1990 to 2019","volume":"9","author":"Ou","year":"2021","journal-title":"Front. Public Health"},{"key":"ref30","first-page":"S176","article-title":"Improving outcomes through early diagnosis of Parkinson's disease","volume":"18","author":"Pagan","year":"2012","journal-title":"Am. J. Manag. Care"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"120198","DOI":"10.1016\/j.jns.2022.120198","article-title":"Essential tremor: clinical perspectives and pathophysiology","volume":"435","author":"Pan","year":"2022","journal-title":"J. Neurol. Sci."},{"key":"ref32","first-page":"268","article-title":"Diagnostic criteria for Parkinson's disease in China (2016) \u4e2d\u56fd\u5e15\u91d1\u68ee\u75c5\u7684\u8bca\u65ad\u6807\u51c6(2016\u7248) [published in Chinese]","volume":"4","year":"2016","journal-title":"Chin. J. Neurol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1093\/fampra\/cmu025","article-title":"Prodromal symptoms and early detection of Parkinson's disease in general practice: a nested case-control study","volume":"31","author":"Plouvier","year":"2014","journal-title":"Fam. Pract."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson's disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. Disord."},{"key":"ref35","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1212\/WNL.0000000000002350","article-title":"Accuracy of clinical diagnosis of Parkinson disease: a systematic review and meta-analysis","volume":"86","author":"Rizzo","year":"2016","journal-title":"Neurology"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"3179","DOI":"10.1007\/s11606-021-06737-1","article-title":"A consensus-based checklist for reporting of survey studies (CROSS)","volume":"36","author":"Sharma","year":"2021","journal-title":"J. Gen. Intern. Med."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S1353-8020(01)00015-3","article-title":"Non-recognition of depression and other non-motor symptoms in Parkinson's disease","volume":"8","author":"Shulman","year":"2002","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fmed.2023.1081087","article-title":"Early detection of Parkinson\u2019s disease through enriching the electronic health record using a biomedical knowledge graph","volume":"10","author":"Soman","year":"2023","journal-title":"Front. Med."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/8692509","article-title":"Analysis of motor complication and relative factors in a cohort of Chinese patients with Parkinson's disease","volume":"2020","author":"Sun","year":"2020","journal-title":"Parkinsons Dis."},{"article-title":"The value of early diagnosis and treatment in Parkinson\u2019s disease: a literature review of the potential clinical and socioeconomic impact of targeting unmet needs in Parkinson\u2019s disease","year":"2016","author":"Tinelli","key":"ref40"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1002\/mds.29317","article-title":"Clinical diagnostic accuracy of Parkinson's disease: where do we stand?","volume":"38","author":"Virameteekul","year":"2023","journal-title":"Mov. Disord."},{"key":"ref42","doi-asserted-by":"crossref","first-page":"793","DOI":"10.31128\/AJGP-07-21-6087","article-title":"The initial diagnosis and management of Parkinson\u2019s disease","volume":"50","author":"Waller","year":"2021","journal-title":"Austral. J. Gen. Pract."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"101078","DOI":"10.1016\/j.lanwpc.2024.101078","article-title":"Disease burden of Parkinson's disease in China and its provinces from 1990 to 2021: findings from the global burden of disease study 2021","volume":"46","author":"Xu","year":"2024","journal-title":"Lancet Reg. Health West. Pac."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"471","DOI":"10.3233\/JPD-150650","article-title":"The clinical evaluation of Parkinson's tremor","volume":"5","author":"Zach","year":"2015","journal-title":"J. Parkinsons Dis."},{"key":"ref45","first-page":"14","article-title":"\u4e2d\u56fd\u5e15\u91d1\u68ee\u75c5\u6cbb\u7597\u6307\u5357(\u7b2c\u56db\u7248)","volume":"53","year":"2020","journal-title":"\u4e2d\u534e\u795e\u7ecf\u79d1\u6742\u5fd7"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3969\/j.issn.1674-9316.2015.16.021","article-title":"The effect of health education in patients with Parkinson's disease [published in Chinese] \u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u5065\u5eb7\u6559\u80b2\u6548\u679c\u8c03\u67e5","volume":"16","year":"2015","journal-title":"\u4e2d\u56fd\u536b\u751f\u6807\u51c6\u7ba1\u7406China Health Stand Manag."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"995","DOI":"10.3760\/cma.j.issn.1006-7876.2015.11.013","article-title":"Potential influencing factors of time from onset to clinical diagnosis and misdiagnosis rate of Parkinson's patients in Shanghai [published in Chinese] \u5f71\u54cd\u4e0a\u6d77\u5730\u533a\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u8bca\u65ad\u65f6\u7a0b\u53ca\u4e34\u5e8a\u8bef\u8bca\u7387\u7684\u76f8\u5173\u56e0\u7d20\u5206\u6790","volume":"11","author":"\u6731\u83b9\u83b9","year":"2015","journal-title":"Chin J Neurol\u4e2d\u534e\u795e\u7ecf\u79d1\u6742\u5fd7"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"65","DOI":"10.12014\/j.issn.1002-0772.2021.03.16","article-title":"\u57fa\u4e8e\u6574\u5408\u533b\u5b66\u601d\u7ef4\u7684\u591a\u5b66\u79d1\u95e8\u8bca\u7684\u8bbe\u60f3\u53ca\u5c55\u671b","volume":"42","year":"2021","journal-title":"\u533b\u5b66\u4e0e\u54f2\u5b66."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3760\/cma.j.cn114798-20210928-00733","article-title":"Role of community physicians in early diagnosis of Parkinson's disease [published in Chinese] \u5168\u79d1\u533b\u751f\u5728\u5e15\u91d1\u68ee\u75c5\u65e9\u671f\u8bca\u65ad\u53ca\u793e\u533a\u7ba1\u7406\u4e2d\u7684\u4f5c\u7528. \u4e2d\u534e\u5168\u79d1\u533b\u5e08\u6742\u5fd7","volume":"3","year":"2022","journal-title":"Chin. Gen. Pract."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"825","DOI":"10.3760\/cma.j.issn.0254-9026.2019.08.001","article-title":"Diagnostic criteria for prodromal Parkinson's disease: an expert consensus in China [published in Chinese] \u5e15\u91d1\u68ee\u75c5\u524d\u9a71\u671f\u8bca\u65ad\u7814\u7a76\u6807\u51c6\u4e2d\u56fd\u4e13\u5bb6\u5171\u8bc6","volume":"38","year":"2019","journal-title":"\u4e2d\u534e\u8001\u5e74\u533b\u5b66\u6742\u5fd7."},{"key":"ref51","first-page":"1622","article-title":"\u4e9a\u4e13\u79d1\u5316\u548c\u4e13\u75c5\u5316\u5728\u526c\u7acb\u533b\u9662\u9ad8\u8d28\u91cf\u53d1\u5c55\u4e2d\u7684\u5b9e\u8df5\u63a2\u7d22","volume":"33","year":"2022","journal-title":"\u6c5f\u82cf\u536b\u751f\u4e8b\u4e1a\u7ba1\u7406."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2025.1488009\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T05:23:28Z","timestamp":1744176208000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2025.1488009\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,9]]},"references-count":51,"alternative-id":["10.3389\/fnagi.2025.1488009"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2025.1488009","relation":{},"ISSN":["1663-4365"],"issn-type":[{"type":"electronic","value":"1663-4365"}],"subject":[],"published":{"date-parts":[[2025,4,9]]},"article-number":"1488009"}}