{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:09:26Z","timestamp":1789664966614,"version":"4.0.1"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The triglyceride-glucose (TyG) index, a marker of insulin resistance, is linked to mortality in coronary artery disease, ischemic stroke, and heart failure. However, its association with functional disability remains unclear. This study explored the relationship between the TyG index, its related parameters, and functional disability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS). Functional disability was evaluated using the Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) scales. Multivariate logistic regression and restricted cubic spline (RCS) models were used to assess the associations between TyG-related indices and the risk of functional disability. Subgroup analyses stratified by age, sex, smoking, drinking, and diabetes were performed. Additionally, propensity score matching (PSM) was applied to ensure the robustness of the findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The diagnosis rates were 1,510(16.32%) for ADL limited and 2,620(28.32%) for ADL-IADL limited. The TyG-related indices were significantly associated with ADL limited. [TyG index: Full adjusted OR\u202f=\u202f1.23, 95%CI: 1.16\u20131.30, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001; TyG-BMI index: Full adjusted OR\u202f=\u202f1.11, 95%CI: 1.05\u20131.18, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001; TyG-WC index: Full adjusted OR\u202f=\u202f1.20, 95%CI: 1.13\u20131.27, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001; TyG-WHtR index: Full adjusted OR\u202f=\u202f1.07, 95%CI: 1.01\u20131.14, <jats:italic>p<\/jats:italic>\u202f=\u202f0.025]. The TyG-related indices were significantly associated with ADL-IADL limited. [TyG index: Full adjusted OR\u202f=\u202f1.20, 95%CI: 1.14\u20131.26, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001; TyG-BMI index: Full adjusted OR\u202f=\u202f1.13, 95%CI: 1.08\u20131.19, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001; TyG-WC index: Full adjusted OR\u202f=\u202f1.14, 95%CI: 1.09\u20131.20, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001; TyG-WHtR index: Full adjusted OR\u202f=\u202f1.13, 95%CI: 1.07\u20131.18, <jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicated a trend that, TyG-related indices significantly associated with increased risks of ADL limited and ADL-IADL limited populations.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2025.1488124","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T05:15:47Z","timestamp":1747631747000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of triglyceride-glucose index and its related parameters with functional disability: evidence from the China Health and Retirement Longitudinal Study"],"prefix":"10.3389","volume":"17","author":[{"given":"ZhiHong","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GuanHua","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HaoLin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MinXuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1186\/s12944-020-01414-4","article-title":"Inverse association between triglyceride glucose index and muscle mass in Korean adults: 2008\u20132011 KNHANES","volume":"19","author":"Ahn","year":"2020","journal-title":"Lipids Health Dis."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1093\/gerona\/63.6.610","article-title":"Persistent infection, inflammation, and functional impairment in older Latinos","volume":"63","author":"Aiello","year":"2008","journal-title":"J. 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