{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:01:28Z","timestamp":1792512088384,"version":"4.5.0"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cognitive impairment is a common dysfunction following stroke, significantly affecting patients\u2019 quality of life. Studies suggest that post-stroke cognitive impairment (PSCI) may be related to neural activity in specific brain regions. However, the neural mechanisms remain to be further explored. This study aimed to investigate the alterations in brain function in patients with PSCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a case\u2013control study. Thirty patients with PSCI, thirty with non-PSCI (NPSCI), and thirty age- and gender-matched healthy controls (HCs) were selected in a 1:1:1 ratio. Resting-state functional magnetic resonance imaging (rs-fMRI) were acquired from all participants to study the potential neural mechanisms of PSCI patients by comparing the differences in fractional amplitude of low-frequency fluctuation (fALFF), Kendall\u2019s coefficient of concordance-regional homogeneity (KCC-ReHo), and seed-based functional connectivity (FC). Additionally, the Montreal Cognitive Assessment (MoCA) scores of PSCI patients were collected, and Pearson correlation was used to analyze the correlation between functional indicators and cognitive performance in PSCI patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>fALFF analysis revealed that the PSCI group had decreased zfALFF values in the left caudate, right inferior temporal gyrus (ITG), anterior cingulate cortex (ACC), left putamen, and left superior temporal gyrus. In contrast, increased zfALFF values were observed in the right Cerebellum_6. KCC-ReHo analysis indicated that the PSCI group had decreased SzKCC-ReHo values in the right middle frontal gyrus (MFG) and left postcentral lobe, while increased SzKCC-ReHo values in the left cerebellum_ crus 1, and left cerebellum_4\u20135. Furthermore, seed-based FC analysis revealed decreased zFC values between brain regions in the PSCI group, especially between the angular gyrus and precuneus. Additionally, correlation analysis showed that the zfALFF value of ACC was positively correlated with MoCA scores in the PSCI group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated significant changes in the spontaneous neural activity intensity, regional homogeneity, and FC of multiple cognition-related brain regions in PSCI patients, shedding light on the underlying neural mechanisms of brain function in PSCI.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2025.1501082","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T06:48:45Z","timestamp":1739947725000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Alterations in brain function in patients with post-stroke cognitive impairment: a resting-state functional magnetic resonance imaging study"],"prefix":"10.3389","volume":"17","author":[{"given":"Kaiyue","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzi","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3389\/fnsys.2017.00053","article-title":"Sensory processing in the dorsolateral striatum: the contribution of thalamostriatal pathways","volume":"11","author":"Alloway","year":"2017","journal-title":"Front. Syst. Neurosci."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.mri.2008.05.008","article-title":"Spontaneous low-frequency blood oxygenation level-dependent fluctuations and functional connectivity analysis of the \u201cresting\u201d brain","volume":"26","author":"Auer","year":"2008","journal-title":"Magn. Reson. Imaging"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.nic.2017.06.001","article-title":"A review of resting-state analysis methods","volume":"27","author":"Azeez","year":"2017","journal-title":"Neuroimaging Clin. N. Am."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"5303","DOI":"10.1007\/s11357-024-01128-w","article-title":"Age-related changes in human brain functional connectivity using graph theory and machine learning techniques in resting-state fMRI data","volume":"46","author":"Baghernezhad","year":"2024","journal-title":"Geroscience"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/mrm.1910340409","article-title":"Functional connectivity in the motor cortex of resting human brain using echo-planar MRI","volume":"34","author":"Biswal","year":"1995","journal-title":"Magn. Reson. Med."},{"key":"ref6","first-page":"200","article-title":"Localisation des fonctions c\u00e9r\u00e9brales: Si\u00e8ge de langage articul\u00e9","volume":"4","author":"Broca","year":"1863","journal-title":"Cahiers. Du. Centre. De. Recherches. Anthropologiques."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1196\/annals.1440.011","article-title":"The brain\u2019s default network: anatomy, function, and relevance to disease","volume":"1124","author":"Buckner","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/s1364-6613(00)01483-2","article-title":"Cognitive and emotional influences in anterior cingulate cortex","volume":"4","author":"Bush","year":"2000","journal-title":"Trends Cogn. Sci."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1002\/ana.21905","article-title":"Resting interhemispheric functional magnetic resonance imaging connectivity predicts performance after stroke","volume":"67","author":"Carter","year":"2010","journal-title":"Ann. Neurol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1093\/brain\/awl004","article-title":"The precuneus: a review of its functional anatomy and behavioural correlates","volume":"129","author":"Cavanna","year":"2006","journal-title":"Brain"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1523\/JNEUROSCI.0778-16.2016","article-title":"The caudate nucleus mediates learning of stimulus-control state associations","volume":"37","author":"Chiu","year":"2017","journal-title":"J. Neurosci."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1097\/WCO.0000000000000150","article-title":"Assessment and modulation of resting-state neural networks after stroke","volume":"27","author":"Dijkhuizen","year":"2014","journal-title":"Curr. Opin. Neurol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.neuron.2006.04.031","article-title":"A core system for the implementation of task sets","volume":"50","author":"Dosenbach","year":"2006","journal-title":"Neuron"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.neuroimage.2012.03.024","article-title":"The behavioral significance of coherent resting-state oscillations after stroke","volume":"61","author":"Dubovik","year":"2012","journal-title":"NeuroImage"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1093\/cercor\/bhj097","article-title":"Role of prefrontal and anterior cingulate regions in decision-making processes shared by memory and nonmemory tasks","volume":"16","author":"Fleck","year":"2006","journal-title":"Cereb. Cortex"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1002\/mrm.1910350312","article-title":"Movement-related effects in fMRI time-series","volume":"35","author":"Friston","year":"1996","journal-title":"Magn. Reson. Med."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e282","DOI":"10.1161\/STR.0000000000000407","article-title":"2022 guideline for the Management of Patients with Spontaneous Intracerebral Hemorrhage: a guideline from the American Heart Association\/American Stroke Association","volume":"53","author":"Greenberg","year":"2022","journal-title":"Stroke"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/S1474-4422(13)70264-3","article-title":"Connectivity-based approaches in stroke and recovery of function","volume":"13","author":"Grefkes","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1073\/pnas.0135058100","article-title":"Functional connectivity in the resting brain: a network analysis of the default mode hypothesis","volume":"100","author":"Greicius","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"116589","DOI":"10.1016\/j.neuroimage.2020.116589","article-title":"Damage to the shortest structural paths between brain regions is associated with disruptions of resting-state functional connectivity after stroke","volume":"210","author":"Griffis","year":"2020","journal-title":"Neuroimage"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/npp.2009.129","article-title":"The reward circuit: linking primate anatomy and human imaging","volume":"35","author":"Haber","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.yebeh.2018.04.001","article-title":"The Montreal procedure: the legacy of the great Wilder Penfield","volume":"83","author":"Ladino","year":"2018","journal-title":"Epilepsy Behav."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.tins.2015.11.002","article-title":"Neural basis of strategic decision making","volume":"39","author":"Lee","year":"2016","journal-title":"Trends Neurosci."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"256","DOI":"10.5853\/jos.2015.17.3.256","article-title":"Stroke connectome and its implications for cognitive and behavioral sequela of stroke","volume":"17","author":"Lim","year":"2015","journal-title":"J. Stroke"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"297","DOI":"10.5853\/jos.2021.02376","article-title":"Post-stroke cognitive impairment: pathophysiological insights into brain disconnectome from advanced neuroimaging analysis techniques","volume":"23","author":"Lim","year":"2021","journal-title":"J. Stroke"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jns.2014.08.049","article-title":"Altered spontaneous activity in the default-mode network and cognitive decline in chronic subcortical stroke","volume":"347","author":"Liu","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"e2257","DOI":"10.1212\/WNL.0000000000008612","article-title":"Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups","volume":"93","author":"Lo","year":"2019","journal-title":"Neurology"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3389\/fnsys.2019.00061","article-title":"The cortico-basal ganglia-cerebellar network: past, present and future perspectives","volume":"13","author":"Milardi","year":"2019","journal-title":"Front. Syst. Neurosci."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1161\/STROKEAHA.115.011242","article-title":"Stroke location is an independent predictor of cognitive outcome","volume":"47","author":"Munsch","year":"2016","journal-title":"Stroke"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/372260a0","article-title":"Word recognition in the human inferior temporal lobe","volume":"372","author":"Nobre","year":"1994","journal-title":"Nature"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.neuroimage.2016.08.006","article-title":"Ten problems and solutions when predicting individual outcome from lesion site after stroke","volume":"145","author":"Price","year":"2017","journal-title":"Neuroimage"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1162\/jocn_a_02110","article-title":"Encoding-related brain activity predicts subsequent trial-level control of proactive interference in working memory","volume":"36","author":"Samrani","year":"2024","journal-title":"J. Cogn. Neurosci."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/s0926-6410(02)00142-8","article-title":"Event-related brain potential evidence for a response of inferior temporal cortex to familiar face repetitions","volume":"14","author":"Schweinberger","year":"2002","journal-title":"Brain Res. Cogn. Brain Res."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"104503","DOI":"10.1016\/j.neubiorev.2021.12.026","article-title":"Event-based control of autonomic and emotional states by the anterior cingulate cortex","volume":"133","author":"Seamans","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s10072-018-3254-0","article-title":"Diagnostic test accuracy of the Montreal cognitive assessment in the detection of post-stroke cognitive impairment under different stages and cutoffs: a systematic review and meta-analysis","volume":"39","author":"Shi","year":"2018","journal-title":"Neurol. Sci."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.nicl.2016.10.013","article-title":"Location of lesion determines motor vs. cognitive consequences in patients with cerebellar stroke","volume":"12","author":"Stoodley","year":"2016","journal-title":"Neuroimage Clin."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.neuroimage.2008.08.039","article-title":"Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies","volume":"44","author":"Stoodley","year":"2009","journal-title":"Neuroimage"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.bbr.2011.05.006","article-title":"Abnormal functional connectivity in patients with vascular cognitive impairment, no dementia: a resting-state functional magnetic resonance imaging study","volume":"223","author":"Sun","year":"2011","journal-title":"Behav. Brain Res."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3978\/j.issn.2305-5839.2014.08.05","article-title":"Post-stroke cognitive impairment: epidemiology, mechanisms and management","volume":"2","author":"Sun","year":"2014","journal-title":"Ann. Transl. Med."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"376","DOI":"10.3969\/j.issn.1673-5765.2021.04.011","article-title":"Experts consensus on post-stroke cognitive lmpairment management 2021","volume":"16","author":"Wang","year":"2021","journal-title":"Chin. J. Stroke"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"724267","DOI":"10.3389\/fnagi.2021.724267","article-title":"Using fractional amplitude of low-frequency fluctuations and functional connectivity in patients with post-stroke cognitive impairment for a simulated stimulation program","volume":"13","author":"Wang","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"3331","DOI":"10.1161\/STROKEAHA.119.027708","article-title":"Guidelines for the early Management of Patients with Acute Ischemic Stroke: 2019 update to the 2018 guidelines for the early Management of Acute Ischemic Stroke","volume":"50","author":"Warner","year":"2019","journal-title":"Stroke"},{"key":"ref43","first-page":"34","article-title":"The symptom complex of aphasia: A psychological study on an anatomical basis","volume-title":"Boston studies in the philosophy of science","author":"Wernicke","year":"1969"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"877281","DOI":"10.3389\/fnagi.2022.877281","article-title":"Regional homogeneity in patients with mild cognitive impairment: a resting-state functional magnetic resonance imaging study","volume":"14","author":"Wu","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.neubiorev.2014.02.005","article-title":"Prefrontal cortex and executive functions in healthy adults: a meta-analysis of structural neuroimaging studies","volume":"42","author":"Yuan","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"137097","DOI":"10.1016\/j.neulet.2023.137097","article-title":"Altered static and dynamic functional network connectivity in post-stroke cognitive impairment","volume":"799","author":"Yue","year":"2023","journal-title":"Neurosci. Lett."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.braindev.2006.07.002","article-title":"Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI","volume":"29","author":"Zang","year":"2007","journal-title":"Brain and Development"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"045010","DOI":"10.1117\/1.NPh.9.4.045010","article-title":"Early screening model for mild cognitive impairment based on resting-state functional connectivity: a functional near-infrared spectroscopy study","volume":"9","author":"Zhang","year":"2022","journal-title":"Neurophotonics"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jneumeth.2008.04.012","article-title":"An improved approach to detection of amplitude of low-frequency fluctuation (ALFF) for resting-state fMRI: fractional ALFF","volume":"172","author":"Zou","year":"2008","journal-title":"J. Neurosci. Methods"}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2025.1501082\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T06:48:50Z","timestamp":1739947730000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2025.1501082\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,19]]},"references-count":49,"alternative-id":["10.3389\/fnagi.2025.1501082"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2025.1501082","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,19]]},"article-number":"1501082"}}