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Despite growing interest, limited research has focused on links with cerebral and cognitive aspects of aging and with markers sensitive to Alzheimer\u2019s disease (AD) in a healthy elderly population and with a multimodal approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>At baseline, 111 older adults (without cognitive impairment) from the Age-Well trial completed blood and anthropometric markers collection, cognitive assessments and multimodal neuroimaging within 3\u202fmonths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AL was negatively associated with gray matter volume and white matter integrity within frontal and temporal regions and poorer attentional performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>AL is linked to structural brain integrity in aging- and stress-sensitive regions but not with AD-related markers (<jats:italic>\u03b2<\/jats:italic>-amyloid load) and only in two AD-sensitive brain regions in older adults. These results highlight the potential interest of AL as a sensitive index of stress-induced brain aging.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2025.1508677","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T06:56:22Z","timestamp":1743404182000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Allostatic load, a measure of cumulative physiological stress, impairs brain structure but not \u03b2-accumulation in older adults: an exploratory study"],"prefix":"10.3389","volume":"17","author":[{"given":"Cassandre","family":"Palix","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Chauveau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Felisatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Chocat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Coulbault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriane","family":"H\u00e9bert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"M\u00e9zenge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Landeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sacha","family":"Haudry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Fauvel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Collette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Klimecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie L.","family":"Marchant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"De La Sayette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Vivien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebl","family":"Ch\u00e9telat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Poisnel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Medit-Ageing Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"052019","DOI":"10.1088\/1757-899X\/928\/5\/052019","article-title":"The effect of serum cortisol on the prediabetes stage under normal and stress state","volume":"928","author":"Abdulraheem Jabbar","year":"2020","journal-title":"IOP Conf. 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