{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T14:03:10Z","timestamp":1793628190658,"version":"4.5.1"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic alcohol drinking is a modifiable risk factor for Alzheimer\u2019s disease (AD), but underlying mechanisms remain poorly understood. Most studies of alcohol feeding to AD mice have utilized young mice and delivered alcohol in drinking water without controlling nutritional intake.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the impact of Lieber-DeCarli (LDC) liquid alcohol diet, which balances nutritional intake, on AD pathology of aged Tg2576 and wild-type (WT) mice, which is unexplored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>13-month-old male and female Tg2576 or WT mice were fed LDC diet (5% ethanol or control) for six weeks (<jats:italic>n<\/jats:italic> =\u202f11-13\/group). Exploration (open-field test) and spatial reference memory (Y-maze test) were assessed after six weeks, and brains and livers were studied for A\u03b2 levels, and A\u03b2 synthesis and transport proteins (APP and LRP-1). Neuroinflammation, blood\u2013brain barrier function, and synaptic health were studied using immunoassays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LDC alcohol feeding significantly reduced survival (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05) and spatial memory (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05) in Tg2576 mice, but not in WT mice. Alcohol feeding increased (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.001) insoluble endogenous mouse A\u03b2<jats:sub>1-42<\/jats:sub> and reduced microgliosis (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05) in Tg2576 mice brains, but not in WT mice. LDC alcohol feeding to Tg2576 mice caused mild liver injury, and important amyloidosis-relevant hepatic proteins (LRP-1 and APP) were largely unaltered. However, brain A\u03b2 and microgliosis were positively correlated (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05) with serum alanine aminotransferase, a marker of liver injury, in Tg2576 mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chronic alcohol intake, resulting in mild liver injury, caused modest but significant AD-relevant changes in aged Tg2576 mice, which correlated with liver injury; the latter suggests significant liver-brain crosstalk in an AD model of moderate alcohol intake.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2025.1526571","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T07:48:00Z","timestamp":1742802480000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of chronic alcohol feeding using the Lieber-DeCarli diet on Alzheimer\u2019s disease pathology in Tg2576 mice"],"prefix":"10.3389","volume":"17","author":[{"given":"Devaraj V.","family":"Chandrashekar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataraj","family":"Jagadeesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudy","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross A.","family":"Steinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frankey","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Khal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Cribbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derick","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachita K.","family":"Sumbria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1002\/alz.12638","article-title":"2022 Alzheimer's disease facts and figures","volume":"18","year":"2022","journal-title":"Alzheimers Dement."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"884170","DOI":"10.3389\/fphar.2022.884170","article-title":"Adolescent binge alcohol enhances early Alzheimer's disease pathology in adulthood through Proinflammatory Neuroimmune activation","volume":"13","author":"Barnett","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/nprot.2013.032","article-title":"Mouse model of chronic and binge ethanol feeding (the NIAAA model)","volume":"8","author":"Bertola","year":"2013","journal-title":"Nat. Protoc."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1186\/1471-2458-14-643","article-title":"Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis","volume":"14","author":"Beydoun","year":"2014","journal-title":"BMC Public Health"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.neuron.2005.01.040","article-title":"Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice","volume":"45","author":"Billings","year":"2005","journal-title":"Neuron"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/0031-9384(92)90137-Q","article-title":"Reduced level of anxiety in adult Lewis rats after chronic ethanol consumption","volume":"51","author":"Blokland","year":"1992","journal-title":"Physiol. Behav."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.alcohol.2012.08.004","article-title":"Rodent models of alcoholic liver disease: of mice and men","volume":"46","author":"Brandon-Warner","year":"2012","journal-title":"Alcohol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"856376","DOI":"10.3389\/fimmu.2022.856376","article-title":"Microglia in the Neuroinflammatory pathogenesis of Alzheimer's disease and related therapeutic targets","volume":"13","author":"Cai","year":"2022","journal-title":"Front. Immunol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.exger.2012.03.019","article-title":"Alcohol use disorders in the elderly: a brief overview from epidemiology to treatment options","volume":"47","author":"Caputo","year":"2012","journal-title":"Exp. Gerontol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1002\/gps.2470","article-title":"Association between alcohol consumption and cognitive impairment in southern Chinese older adults","volume":"25","author":"Chan","year":"2010","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"106570","DOI":"10.1016\/j.nbd.2024.106570","article-title":"Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer's disease mice: potential role in chronic heavy alcohol feeding","volume":"199","author":"Chandrashekar","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"9492","DOI":"10.3390\/ijms24119492","article-title":"Alcohol as a modifiable risk factor for Alzheimer's disease-evidence from experimental studies","volume":"24","author":"Chandrashekar","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1258640","DOI":"10.3389\/fnagi.2023.1258640","article-title":"Blood-brain barrier dysfunction and Alzheimer's disease: associations, pathogenic mechanisms, and therapeutic potential","volume":"15","author":"Chen","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0167-4889(98)00125-6","article-title":"Tight junction proteins","volume":"1448","author":"Citi","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.neuropharm.2017.01.031","article-title":"The role of neuroimmune signaling in alcoholism","volume":"122","author":"Crews","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.neuro.2017.04.005","article-title":"Chronic ethanol intake induces partial microglial activation that is not reversed by long-term ethanol withdrawal in the rat hippocampal formation","volume":"60","author":"Cruz","year":"2017","journal-title":"Neurotoxicology"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"105967","DOI":"10.1016\/j.nbd.2022.105967","article-title":"Ethanol exposure alters Alzheimer's-related pathology, behavior, and metabolism in APP\/PS1 mice","volume":"177","author":"Day","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/0169-328X(95)00214-D","article-title":"Heat shock factor-1 mediates the transcriptional activation of Alzheimer's beta-amyloid precursor protein gene in response to stress","volume":"35","author":"Dewji","year":"1996","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/0169-328X(95)00131-B","article-title":"Transcriptional activation of Alzheimer's beta-amyloid precursor protein gene by stress","volume":"33","author":"Dewji","year":"1995","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.1007\/s12035-020-01967-6","article-title":"Ethanol-induced changes in brain of transgenic mice overexpressing DYRK1A","volume":"57","author":"Fructuoso","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"930402","DOI":"10.3389\/fphys.2022.930402","article-title":"Modulation of hepatic amyloid precursor protein and lipoprotein receptor-related protein 1 by chronic alcohol intake: potential link between liver steatosis and amyloid-\u03b2","volume":"13","author":"Garcia","year":"2022","journal-title":"Front. Physiol."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"112105","DOI":"10.1016\/j.fct.2021.112105","article-title":"Effects of alcohol intake on cognitive function and \u03b2-amyloid protein in APP\/PS1 transgenic mice","volume":"151","author":"Gong","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/bs.irn.2019.10.018","article-title":"A comparison of hippocampal microglial responses in aged and young rodents following dependent and non-dependent binge drinking","volume":"148","author":"Grifasi","year":"2019","journal-title":"Int. Rev. Neurobiol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1111\/acer.13840","article-title":"The Lieber-DeCarli diet-a flagship model for experimental alcoholic liver disease","volume":"42","author":"Guo","year":"2018","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref001","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/jcm12010310","article-title":"Markedly Elevated Aspartate Aminotransferase from Non-Hepatic Causes","volume":"12","author":"Han","year":"2023","journal-title":"J. Clin. Med."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1189\/jlb.0605340","article-title":"Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction","volume":"78","author":"Haorah","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.2174\/1567205013666160603005035","article-title":"The association between alcohol use and the progression of Alzheimer's disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/bs.irn.2019.10.017","article-title":"Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease","volume":"148","author":"Hoffman","year":"2019","journal-title":"Int. Rev. Neurobiol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"5006","DOI":"10.1007\/s12035-017-0703-3","article-title":"Ethanol alters APP processing and aggravates Alzheimer-associated phenotypes","volume":"55","author":"Huang","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/S0166-2236(00)02004-X","article-title":"Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier","volume":"24","author":"Huber","year":"2001","journal-title":"Trends Neurosci."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1523\/jneurosci.16-04-01380.1996","article-title":"PSD-95 is associated with the postsynaptic density and not with the presynaptic membrane at forebrain synapses","volume":"16","author":"Hunt","year":"1996","journal-title":"J. Neurosci."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1186\/s12967-024-05008-x","article-title":"Modulation of hippocampal protein expression by a brain penetrant biologic TNF-\u03b1 inhibitor in the 3xTg Alzheimer's disease mice","volume":"22","author":"Jagadeesan","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e2254771","DOI":"10.1001\/jamanetworkopen.2022.54771","article-title":"Changes in alcohol consumption and risk of dementia in a Nationwide cohort in South Korea","volume":"6","author":"Jeon","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1093\/jat\/bkae008","article-title":"Dubowski's stages of alcohol influence and clinical signs and symptoms of drunkenness in relation to a person's blood-alcohol concentration-historical background","volume":"48","author":"Jones","year":"2024","journal-title":"J. Anal. Toxicol."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s12974-018-1184-7","article-title":"Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis","volume":"15","author":"Kalinin","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1523\/jneurosci.21-02-00372.2001","article-title":"Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease","volume":"21","author":"Kawarabayashi","year":"2001","journal-title":"J. Neurosci."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"135","DOI":"10.5483\/BMBRep.2011.44.2.135","article-title":"Effects of chronic alcohol consumption on expression levels of APP and A\u03b2-producing enzymes","volume":"44","author":"Kim","year":"2011","journal-title":"BMB Rep."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.jhep.2021.05.029","article-title":"Development and prognostic relevance of a histologic grading and staging system for alcohol-related liver disease","volume":"75","author":"Lackner","year":"2021","journal-title":"J. Hepatol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1186\/s12974-020-01972-5","article-title":"Chronic alcohol-induced neuroinflammation involves CCR2\/5-dependent peripheral macrophage infiltration and microglia alterations","volume":"17","author":"Lowe","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fnana.2020.00052","article-title":"Microglia dystrophy following binge-like alcohol exposure in adolescent and adult male rats","volume":"14","author":"Marshall","year":"2020","journal-title":"Front. Neuroanat."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1136\/jnnp.2006.095869","article-title":"A widespread distinct pattern of cerebral atrophy in patients with alcohol addiction revealed by voxel-based morphometry","volume":"78","author":"Mechtcheriakov","year":"2007","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.3390\/pharmaceutics14102200","article-title":"Efficacy and safety of a brain-penetrant biologic TNF-\u03b1 inhibitor in aged APP\/PS1 mice","volume":"14","author":"Ou","year":"2022","journal-title":"Pharmaceutics"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1111\/bpa.12717","article-title":"The relationship between the morphological subtypes of microglia and Alzheimer's disease neuropathology","volume":"29","author":"Paasila","year":"2019","journal-title":"Brain Pathol."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nrneurol.2014.38","article-title":"Microglial priming in neurodegenerative disease","volume":"10","author":"Perry","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"948","DOI":"10.3390\/pharmaceutics16070948","article-title":"Low-density lipoprotein receptor-related protein 1 as a potential therapeutic target in Alzheimer\u2019s disease","volume":"16","author":"Petralla","year":"2024","journal-title":"Pharmaceutics"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1111\/acer.14420","article-title":"Chronic voluntary binge ethanol consumption causes sex-specific differences in microglial signaling pathways and withdrawal-associated behaviors in mice","volume":"44","author":"Rath","year":"2020","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"ENEURO.0456","DOI":"10.1523\/ENEURO.0456-22.2023","article-title":"A history of repeated alcohol intoxication promotes cognitive impairment and gene expression signatures of disease progression in the 3xTg mouse model of Alzheimer's disease","volume":"10","author":"Sanna","year":"2023","journal-title":"eNeuro"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.15252\/embj.201797397","article-title":"APP mouse models for Alzheimer's disease preclinical studies","volume":"36","author":"Sasaguri","year":"2017","journal-title":"EMBO J."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"3758","DOI":"10.1038\/s41467-019-11674-z","article-title":"Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer\u2019s disease model","volume":"10","author":"Spangenberg","year":"2019","journal-title":"Nat. Commun."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/glia.440010502","article-title":"Functional plasticity of microglia: a review","volume":"1","author":"Streit","year":"1988","journal-title":"Glia"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"13287","DOI":"10.1073\/pnas.94.24.13287","article-title":"Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology","volume":"94","author":"Sturchler-Pierrat","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/j.1530-0277.1985.tb05046.x","article-title":"Cyclical pattern of blood alcohol levels during continuous intragastric ethanol infusion in rats","volume":"9","author":"Tsukamoto","year":"1985","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.neuropharm.2018.02.014","article-title":"Morphological and functional evidence of increased excitatory signaling in the prelimbic cortex during ethanol withdrawal","volume":"133","author":"Varodayan","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"695479","DOI":"10.3389\/fncel.2021.695479","article-title":"Relationship between amyloid-\u03b2 deposition and blood-brain barrier dysfunction in Alzheimer's disease","volume":"15","author":"Wang","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1080\/01480545.2019.1681444","article-title":"Long-term consumption of alcohol exacerbates neural lesions by destroying the functional integrity of the blood-brain barrier","volume":"45","author":"Wei","year":"2022","journal-title":"Drug Chem. Toxicol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"530219","DOI":"10.3389\/fnins.2020.530219","article-title":"Metabolic dysregulation contributes to the progression of Alzheimer's disease","volume":"14","author":"Yan","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"e62628","DOI":"10.1371\/journal.pone.0062628","article-title":"A simple and novel method to monitor breathing and heart rate in awake and urethane-anesthetized newborn rodents","volume":"8","author":"Zehendner","year":"2013","journal-title":"PLoS One"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3109\/01677063.2014.892486","article-title":"Motor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95","volume":"28","author":"Zhang","year":"2014","journal-title":"J. Neurogenet."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2025.1526571\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T07:48:02Z","timestamp":1742802482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2025.1526571\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,24]]},"references-count":60,"alternative-id":["10.3389\/fnagi.2025.1526571"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2025.1526571","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,24]]},"article-number":"1526571"}}