{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:13:59Z","timestamp":1785161639089,"version":"3.55.0"},"reference-count":86,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a progressive and debilitating neurodegenerative disorder that significantly impairs cognitive function and daily living abilities, representing a major public health challenge. Given the multifactorial nature of AD, effective therapeutic interventions targeting both cognitive and functional decline are critical. This study aimed to conduct a comprehensive comparison of the therapeutic effects of music therapy, acupuncture therapy, game therapy, cognitive training therapy, and exercise therapy on AD patients through a network meta-analysis. Randomized controlled trials (RCTs) published up until 2024 were systematically retrieved from multiple databases. Data were extracted, including the first author, publication year, country, total sample size, mean participant age, type and duration of intervention, and outcome measures such as the Mini-Mental State Examination, Activities of Daily Living, and Alzheimer\u2019s Disease Assessment Scale-Cognitive Subscale. Statistical analyses were performed using the RevMan 5.3 and Stata 17 software. The analysis included 52 RCTs with a total of 3,409 participants, offering a strong dataset. The results indicated that game therapy produced statistically significant improvements in mental state and daily living abilities, while acupuncture therapy yielded the most pronounced improvements in cognitive function among AD patients. Notably, the comparative efficacy of these interventions suggests that game therapy may offer short-term benefits, particularly for mental health and functional abilities, whereas acupuncture therapy demonstrated superior long-term cognitive enhancements. In conclusion, tailored physical and cognitive interventions such as game therapy and acupuncture therapy may hold significant potential in optimizing treatment outcomes for AD patients, with implications for both clinical practice and future research.<\/jats:p>","DOI":"10.3389\/fnagi.2025.1541287","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T07:07:48Z","timestamp":1741158468000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparing the efficacy of physical therapy interventions in Alzheimer\u2019s disease: a network meta-analysis"],"prefix":"10.3389","volume":"17","author":[{"given":"Jiawen","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaming","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangtao","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songsong","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1007\/s11726-016-0954-y","article-title":"Therapeutic effect of acupuncture at Zusanli and Fenglong point in the treatment of senile dementia","volume":"14","author":"Bi","year":"2016","journal-title":"J. Acupunct. Tuina Sci."},{"key":"ref2","first-page":"3177","article-title":"Research progress of electroacupuncture in the treatment of Alzheimer's disease","volume":"29","author":"Cao","year":"2014","journal-title":"J. Tradit. Chin. Med."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.3969\/j.issn.1001-1242.2015.11.007","article-title":"Effect of aerobic training on the treatment of Alzheimer's disease","volume":"30","author":"Chang","year":"2015","journal-title":"J. Rehabil. Med."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"260","DOI":"10.3969\/j.issn.1008-8849.2012.03.015","article-title":"Effect of play therapy on cognitive function and subjective well-being of patients with mild senile dementia","volume":"21","author":"Chen","year":"2012","journal-title":"J. Modern Integr. Chin. Western Med."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"4171","DOI":"10.3760\/cma.j.issn.1674-2907.2016.29.007","article-title":"Effects of brain games on quality of life in elderly patients with dementia","volume":"22","author":"Chen","year":"2016","journal-title":"Chin. J. Modern Nurs."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.gerinurse.2019.08.002","article-title":"Effect of traditional opera on older adults with dementia","volume":"41","author":"Chen","year":"2020","journal-title":"Geriatr. Nurs."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"5475","DOI":"10.1038\/s41380-021-01307-7","article-title":"Correction: APOE4- mediated Alzheimer disease and \"vascular\"-\"meningeal lymphatic\" components: towards a novel therapeutic era?","volume":"26","author":"Chen","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3969\/j.issn.2095-6681.2017.22.098","article-title":"Clinical observation of acupuncture in the treatment of Alzheimer's disease","volume":"5","author":"Chen","year":"2017","journal-title":"J. Integr. Chin. Western Med. Cardiovasc. Dis. Electr."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.pneurobio.2013.06.004","article-title":"Decoding Alzheimer is disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies","volume":"108","author":"Chen","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"839099","DOI":"10.3389\/fphys.2022.839099","article-title":"Salivary testosterone and cortisol levels in Tunisian elderly male patients with mild Alzheimer's disease. Implications of musical therapy and\/or physical rehabilitation","volume":"13","author":"Cheour","year":"2022","journal-title":"Front. Physiol."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.jagp.2017.10.011","article-title":"Psychosis and clinical outcomes in Alzheimer disease: a longitudinal study","volume":"26","author":"Connors","year":"2018","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"426","DOI":"10.3870\/zgkf.2023.07.009","article-title":"Effect of play therapy on cognitive ability and self-efficacy of patients with Alzheimer's disease","volume":"38","author":"Du","year":"2019","journal-title":"Chin. J. Rehabil."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/j.1547-5069.2006.00127.x","article-title":"Improving cognition and function through exercise intervention in Alzheimer's disease","volume":"38","author":"Fang","year":"2006","journal-title":"J. Nurs. Scholarship"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.13703\/j.0255-2930.2019.01.001","article-title":"Long-term efficacy and safety evaluation of electroacupuncture in improving MMSE score in patients with Alzheimer's disease","volume":"39","author":"Feng","year":"2019","journal-title":"Chin. J. Acupunct. Moxib."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e0270682","DOI":"10.1371\/journal.pone.0270682","article-title":"Study protocol for the alzheimer and music therapy study: an RCT to compare the efficacy of music therapy and physical activity on brain plasticity, depressive symptoms, and cognitive decline, in a population with and at risk for Alzheimer's disease","volume":"17","author":"Flo","year":"2022","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"3138","DOI":"10.18632\/aging.101970","article-title":"Comparison between physical and cognitive treatment in patients with MCI and Alzheimer\u2019s disease","volume":"11","author":"Fonte","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"8067","DOI":"10.3390\/ijerph18158067","article-title":"Comparative efficacy of active group music intervention versus group music listening in Alzheimer's disease","volume":"18","author":"Gomez-gallego","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.3969\/j.issn.1005-9202.2024.04.060","article-title":"Effect of exercise on brain aging induced Alzheimer's disease","volume":"44","author":"Gu","year":"2019","journal-title":"Chin. J. Gerontol."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"113","DOI":"10.11954\/ytctyy.201706046","article-title":"Clinical study of combined therapy for Alzheimer's disease","volume":"13","author":"Guan","year":"2017","journal-title":"Asian Pac. Trad. Med."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3969\/j.issn.1671-945X.2018.02.012","article-title":"Research progress of acupuncture in the treatment of Alzheimer's disease","volume":"16","author":"Guan","year":"2018","journal-title":"China Prescript. Drugs"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e16238","DOI":"10.1111\/ene.16238","article-title":"The Australian National University Alzheimer's disease risk index (ANU- ADRI) score as a predictor for cognitive decline and potential surrogate outcome in the FINGER lifestyle randomized controlled trial","volume":"31","author":"Hall","year":"2024","journal-title":"Eur. J. Neurol."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"101","DOI":"10.5414\/CP203121","article-title":"Antidepressant medication in a German cohort of patients with Alzheimer's disease","volume":"56","author":"Hessmann","year":"2018","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"443","DOI":"10.3233\/JAD-150817","article-title":"Moderate-to-high intensity physical exercise in patients with Alzheimer\u2019s disease: a randomized controlled trial","volume":"50","author":"Hoffmann","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"ref24","first-page":"98","article-title":"Effect evaluation of comprehensive cognitive rehabilitation training in patients with Alzheimer's disease","volume":"58","author":"Hu","year":"2019","journal-title":"Chin. Modern Doctor"},{"key":"ref25","first-page":"451","article-title":"Analysis of evidence deletion bias risk assessment tool ROB-MEN in mesh meta-analysis","volume":"24","author":"Hu","year":"2024","journal-title":"Chin. J. Evid. Based Med."},{"key":"ref26","first-page":"1422","article-title":"Progress in nursing of patients with Alzheimer's disease","volume":"30","author":"Huang","year":"2016","journal-title":"Nurs. Res."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3233\/ADR-200249","article-title":"Incorporating a usual care comparator into a study of meditation and music listening for older adults with subjective cognitive decline: a randomized feasibility trial","volume":"5","author":"Innes","year":"2021","journal-title":"J. Alzheimerrs Dis. Rep."},{"key":"ref28","first-page":"457","article-title":"Acupuncture for spontaneous intracerebral hemorrhage; a systematic review and Meta-analysis","volume":"30","author":"Jang","year":"2023","journal-title":"Eur. J. Neurol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.13192\/j.issn.1000-1719.2017.09.043","article-title":"A randomized controlled clinical study of three-jiao acupuncture in the treatment of mild to moderate Alzheimer's disease","volume":"44","author":"Jia","year":"2017","journal-title":"Liaoning J. Trad. Chin. Med."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/alz.12328","article-title":"Alzheimer\u2019s disease facts and figures","volume":"17","author":"Joseph","year":"2021","journal-title":"Alzheimers Dement."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"86","DOI":"10.12779\/dnd.2020.19.3.86","article-title":"Effect of integrated cognitive intervention therapy in patients with mild to moderate Alzheimer's disease","volume":"19","author":"Jung","year":"2020","journal-title":"Dement. Neurocogn. Disord."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3969\/j.issn.1672-5298.2021.04.010","article-title":"Study on cognitive improvement of patients with mild to moderate Alzheimer's disease by adaptive cognitive training","volume":"34","author":"Li","year":"2019","journal-title":"J. Hunan Univ. Sci. Technol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1002\/gps.4543","article-title":"The effect of folk recreation program in improving symptoms: a study of Chinese elder dementia patients","volume":"32","author":"Li","year":"2017","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref34","first-page":"57","article-title":"37 cases of senile dementia treated by warm acupuncture","volume":"29","author":"Liang","year":"2016","journal-title":"Res. Trad. Chin. Med."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s10571-009-9488-x","article-title":"Biological mechanisms of physical activity in preventing cognitive decline","volume":"30","author":"Lista","year":"2010","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2881","DOI":"10.12102\/j.issn.1009-6493.2024.16.012","article-title":"Research progress of music therapy for Alzheimer's disease","volume":"38","author":"Liu","year":"2019","journal-title":"Nurs. Res."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.3969\/j.issn.1005-9202.2017.05.083","article-title":"Effect of music therapy on patients with Alzheimer's disease","volume":"37","author":"Liu","year":"2017","journal-title":"Chin. J. Gerontol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3870\/zgkf.2017.05.010","article-title":"Study on improving cognitive function of patients with Alzheimer's disease with moderate intensity aerobic exercise","volume":"32","author":"Liu","year":"2017","journal-title":"China Rehabil."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.3233\/JAD-160869","article-title":"Treadmill exercise exerts neuroprotection and regulates microglial polarization and oxidative stress in a streptozotocin-induced rat model of sporadic Alzheimer's disease","volume":"56","author":"Lu","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"3633","DOI":"10.19435\/j.1672-1721.2017.27.001","article-title":"Effect of cognitive training on rehabilitation of patients with Alzheimer's disease","volume":"21","author":"Luo","year":"2017","journal-title":"Primary Med. Forum"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1017\/S104161021600123X","article-title":"Comparison of neuropsychological and functional outcomes in Alzheimer's disease patients with good or bad response to a cognitive stimulation treatment: a retrospective analysis","volume":"28","author":"Martinez-moreno","year":"2016","journal-title":"Int. Psychogeriatr."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"4510","DOI":"10.3969\/j.issn.1005-9202.2019.18.045","article-title":"Comparison of different types of music in the treatment of Alzheimer's disease patients","volume":"39","author":"Meng","year":"2019","journal-title":"Chin. J. Gerontol."},{"key":"ref43","first-page":"451","article-title":"Effects of aerobic exercise on life ability, cognitive function and psychiatric symptoms in patients with mild to moderate Alzheimer's disease","volume":"15","author":"Mu","year":"2016","journal-title":"Chin. J. Geriatr. Multiple Organ Dis."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"157","DOI":"10.19379\/j.cnki.issn.1005-0256.2024.01.041","article-title":"Effects of audiovisual combined finger activity training on cognitive function of elderly patients with dementia","volume":"32","author":"Nie","year":"2019","journal-title":"Bull. Sports Sci. Technol. Lit."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1136\/bjsports-2019-100886","article-title":"Which specific modes of exercise training are most effective for treating low back pain? Network meta-analysis","volume":"54","author":"Owen","year":"2020","journal-title":"Br. J. Sports Med."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/597573","article-title":"Wii-fit for improving gait and balance in an assisted living facility: a pilot study","volume":"2012","author":"Padala","year":"2012","journal-title":"J. Aging Res."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1080\/13803395.2015.1026802","article-title":"Music enhances verbal episodic memory in Alzheimer's disease","volume":"37","author":"Palisson","year":"2015","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"5638","DOI":"10.1073\/pnas.0611721104","article-title":"An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus","volume":"104","author":"Pereira","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"663","DOI":"10.3233\/JAD-170410","article-title":"Can musical or painting interventions improve chronic pain, mood, quality of life, and cognition in patients with mild Alzheimer's disease? Evidence from a randomized controlled trial","volume":"60","author":"Pongan","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref50","volume-title":"World Alzheimer report 2015. The Global Impact of Dementia: An analysis of prevalence, incidence, cost and trends","author":"Prince","year":"2015"},{"key":"ref51","first-page":"761","article-title":"Efficacy of aerobic training based on resting state fMRI in patients with Alzheimer's disease","volume":"26","author":"Qi","year":"2015","journal-title":"Chin. J. Clin. Imaging"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.3969\/j.issn.1000-0399.2018.11.029","article-title":"Effect of music training intervention on functional magnetic resonance imaging and anxiety and depression in patients with Alzheimer's disease","volume":"39","author":"Qu","year":"2018","journal-title":"Anhui Med. J."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"e69830","DOI":"10.1371\/journal.pone.0069830","article-title":"Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer is disease","volume":"8","author":"Sancheti","year":"2013","journal-title":"PLoS One"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1016\/j.jamda.2020.04.018","article-title":"Effects of exergaming on cognitive and social functioning of people with dementia: a randomized controlled trial","volume":"21","author":"Santen","year":"2020","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1111\/j.1468-1331.2006.01632.x","article-title":"Acupuncture treatment improves nerve conduction in peripheral neuropathy","volume":"14","author":"Schroder","year":"2007","journal-title":"Eur. J. Neurol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3969\/j.issn.1674-3296.2011.25.073","article-title":"Physical therapy in combination with strengthening nursing intervention of the clinical observation of Alzheimer's disease","volume":"4","author":"Shufen","year":"2011","journal-title":"Chin. J. Clin. Ratnl. Drug Use"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.maturitas.2019.04.217","article-title":"Three months of multi\u2043modal training contributes to mobility and executive function in eld\u2043 erly individuals with mild cognitive impairment, but not in those with Alzheimer\u2019 s disease: a randomized controlled trial","volume":"126","author":"Silva","year":"2019","journal-title":"Maturitas"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.16448\/j.cjtcm.2023.0819","article-title":"Systematic review and meta-analysis of acupuncture treatment for Alzheimer's disease","volume":"35","author":"Song","year":"2019","journal-title":"J. Tradit. Chin. Med."},{"key":"ref59","first-page":"2861","article-title":"Effect of acupuncture at Baihui and Yongquan points on plasma acetylcholine and \u03b2-amyloid protein in the treatment of Alzheimer's disease","volume":"13","author":"Sun","year":"2018","journal-title":"World Chin. Med."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"e16302","DOI":"10.1111\/ene.16302","article-title":"What is Alzheimer's disease? An analysis of nosological perspectives from the 20th and 21st centuries","volume":"31","author":"Villain","year":"2024","journal-title":"Eur. J. Neurol."},{"key":"ref61","volume-title":"Effect and influence of computer-assisted cognitive training on mild Alzheimer's disease","author":"Wang","year":"2021"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"371","DOI":"10.3969\/j.issn.1001-1242.2019.04.002","article-title":"Changes of low-frequency amplitude fMRI and cognitive function in patients with Alzheimer's disease before and after aerobic exercise","volume":"34","author":"Wang","year":"2019","journal-title":"J. Rehabil. Med."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.12083\/SYSJ.220736","article-title":"Effect of family coordinated continuous care model combined with music therapy on quality of life of patients with Alzheimer's disease","volume":"25","author":"Wang","year":"2022","journal-title":"Chin. J. Appl. Neurol. Dis."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"10","DOI":"10.19917\/j.cnki.1005-0779.021236","article-title":"Clinical study of warming Yang and invigorating kidney moxibustion combined with acupuncture in treatment of senile dementia","volume":"37","author":"Wang","year":"2021","journal-title":"Clin. J. Acupunct. Moxib."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"335","DOI":"10.12102\/j.issn.2095-8668.2024.02.027","article-title":"Effects of aerobic exercise based on Baduanjin on cognitive function and quality of life in patients with mild to moderate Alzheimer's disease","volume":"10","author":"Wei","year":"2018","journal-title":"Evid. Based Nurs."},{"key":"ref66","first-page":"94","article-title":"Effects of walking on cognitive function and quality of life in patients with Alzheimer's disease","volume":"25","author":"Wu","year":"2015","journal-title":"Chin. J. Modern Med."},{"key":"ref67","first-page":"375","article-title":"Effects of doumai on learning and memory ability and serum APP and A\u03b2-1 in patients with Alzheimer's disease","volume":"40","author":"Xia","year":"2020","journal-title":"Chin. J. Acupunct. Moxib."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"3896","DOI":"10.13241\/j.cnki.pmb.2018.20.021","article-title":"Effects of music therapy on sleep quality, quality of life, cognitive function and agitated behavior in patients with Alzheimer's disease","volume":"18","author":"Xiao","year":"2018","journal-title":"Adv. Modern Biomed."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3969\/j.issn.1674-4721.2023.16.022","article-title":"Effect of Tiaoshen acupuncture on the treatment of Alzheimer's disease and its influence on serum superoxide dismutase level","volume":"30","author":"Xu","year":"2019","journal-title":"Chin. Contemp. Med."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.3969\/j.issn.1005-9202.2020.13.041","article-title":"Effect of tablet cognitive training on mild to moderate Alzheimer's disease","volume":"40","author":"Xu","year":"2020","journal-title":"Chin. J. Gerontol."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"824","DOI":"10.3969\/j.issn.1001-1242.2019.07.014","article-title":"Effect of aerobic exercise on cognitive function in patients with Alzheimer's disease: a meta-analysis","volume":"34","author":"Xu","year":"2019","journal-title":"Chin. J. Rehabil. Med."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"771","DOI":"10.3969\/j.issn.1001-1242.2015.08.004","article-title":"Clinical study of aerobic exercise with different training time in intervention of mild to moderate Alzheimer disease","volume":"30","author":"Yan","year":"2015","journal-title":"J. Rehabil. Med."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"126","DOI":"10.14033\/j.cnki.cfmr.2021.14.042","article-title":"Influence of motion-sensing interactive games on senile dementia patients","volume":"19","author":"Yang","year":"2019","journal-title":"J. Chin. For. Med. Res."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"485","DOI":"10.13460\/j.issn.1005-0957.2023.05.0485","article-title":"Effects of abdominal response on cognitive function and serum 5-HT, BDNF and IGF-1 in patients with mild to moderate Alzheimer's disease","volume":"5","author":"Yang","year":"2023","journal-title":"Shanghai J. Acumox"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"7","DOI":"10.12779\/dnd.2017.16.1.7","article-title":"Improvement of cognitive function after computer-based cognitive training in early stage of Alzheimer's dementia","volume":"16","author":"Yang","year":"2017","journal-title":"Dement. Neurocogn. Disord."},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.2174\/1871527315666151111123319","article-title":"The effects of aerobic exercise on cognitive function of Alzheimer's disease patients","volume":"14","author":"Yang","year":"2015","journal-title":"CNS Neurol. Disord. 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Toxicol."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3389\/fnagi.2019.00078","article-title":"Treadmill exercise decreases A\u03b2 deposition and counteracts cognitive decline in APP\/PS1 mice, possibly via hippocampal microglia modifications","volume":"11","author":"Zhang","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"6212","DOI":"10.3321\/j.issn:1673-8225.2004.28.031","article-title":"Relationship between senile plaques, neurofibrillary tangles and complement receptor type 2 in hippocampal and temporal lobe brain tissues of Alzheimer's disease patients","volume":"28","author":"Zhang","year":"2004","journal-title":"J. Clin. Rehabil."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"3236","DOI":"10.12102\/j.issn.1009-6493.2018.20.018","article-title":"Effects of home cognitive training on cognitive function of patients with mild cognitive impairment","volume":"32","author":"Zhang","year":"2018","journal-title":"Nurs. Res."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.3969\/j.issn.1002-1256.2019.19.042","article-title":"Study on the application of educational rehabilitation nursing to Alzheimer's patients with mild to moderate cognitive impairment","volume":"40","author":"Zhang","year":"2019","journal-title":"J. Qiqihar Med. Coll."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3870\/j.issn.1001-4152.2018.09.005","article-title":"Application of motion-sensing interactive games in elderly patients with dementia","volume":"33","author":"Zheng","year":"2018","journal-title":"J. Nurs. 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