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They have become a major challenge for the world's health system in the twenty-first century, with an increasing incidence year by year, complex and diverse causes, and a lack of effective therapeutic. The brain and spinal cord are composed of neurons, and activated platelets are highly similar to neurons. The occurrence and development of these diseases are often accompanied by platelet activation, suggesting that platelets play an important role in the pathological process of NDDs. This article reviews the research progress of platelets in common NDDs, and elaborates on the mechanisms of platelets' involvement in NDDs and the use as a therapeutic option for NDDs to providing new ideas for the diagnosis and treatment of NDDs.<\/jats:p>","DOI":"10.3389\/fnagi.2025.1544605","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T09:09:13Z","timestamp":1749546553000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Research progress of platelets in neurodegenerative diseases"],"prefix":"10.3389","volume":"17","author":[{"given":"Yu","family":"Lan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1016\/j.autrev.2018.07.006","article-title":"Polymerase-1 pathway activation in acute multiple sclerosis relapse","volume":"17","author":"Achiron","year":"2018","journal-title":"Autoimmunity reviews"},{"key":"B2","doi-asserted-by":"publisher","first-page":"9880","DOI":"10.1038\/s41598-022-12886-y","article-title":"Exogenous human \u03b1-Synuclein acts in vitro as a mild platelet antiaggregant inhibiting \u03b1-thrombin-induced platelet activation","volume":"12","author":"Acquasaliente","year":"2022","journal-title":"Sci. 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