{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:41:11Z","timestamp":1790095271546,"version":"4.0.1"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate whether cerebrospinal fluid (CSF) circulation markers alter in patients with probable cerebral amyloid angiopathy (pCAA) and whether they are associated with brain degeneration and cognitive impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We screened pCAA patients from the ADNI3 database according to the Boston 2.0 Criteria. Fifty-two patients with cognitive impairment (26 pCAA; 26 age-sex-matched non-pCAA) and 26 age-sex-matched cognitively normal control (NC) were included in this study. All participants underwent neurological MRI and cognitive assessments. Choroid plexus (ChP) was segmented using a deep learning-based method and its volume was extracted. Diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) was used to assess perivenous fluid mobility. AD pathological markers (A\u03b2 and tau) were assessed using positron emission tomography. Brain parenchymal damage markers included white matter hyperintensities (WMH) volume and brain atrophy ratio. All markers were compared among the three groups. Correlations among the ChP volume, DTI-ALPS index, parenchymal damage markers, and cognitive scales were analyzed in the pCAA group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The three groups exhibited significant differences in cognitive scores, AD biomarkers, and imaging markers. <jats:italic>Post hoc<\/jats:italic> analyses showed that patients with pCAA had significantly higher WMH volume, higher A\u03b2 and tau deposition, and lower DTI-ALPS compared to NC. However, no difference in ChPs volume was found among the groups. Controlling for age, sex, and vascular risk factors, partial correlation analyses showed a significant negative correlation between the DTI-ALPS and WMH volume fraction (<jats:italic>r<\/jats:italic>\u202f=\u202f\u22120.606, <jats:italic>p<\/jats:italic>\u202f=\u202f0.002). ChP volume was significantly associated with the Montreal cognitive assessment score (<jats:italic>r<\/jats:italic>\u202f=\u202f\u22120.492, <jats:italic>p<\/jats:italic>\u202f=\u202f0.028).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CSF circulation markers were associated with elevated WMH burden and cognitive impairments in probable CAA.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2025.1549072","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T05:27:27Z","timestamp":1745299647000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Relationship between cerebrospinal fluid circulation markers, brain degeneration, and cognitive impairment in cerebral amyloid angiopathy"],"prefix":"10.3389","volume":"17","author":[{"given":"Li","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingze","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ibneur.2023.12.004","article-title":"Is cerebral small vessel disease a central nervous system interstitial fluidopathy?","volume":"16","author":"Abdul Hamid","year":"2024","journal-title":"IBRO Neurosci. Rep."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e1605","DOI":"10.1212\/WNL.0000000000200142","article-title":"Cerebral microbleeds, cerebral amyloid angiopathy, and their relationships to quantitative markers of neurodegeneration","volume":"98","author":"Beaman","year":"2022","journal-title":"Neurology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e1716","DOI":"10.1212\/WNL.0000000000200136","article-title":"Cerebrovascular reactivity across the entire brain in cerebral amyloid angiopathy","volume":"98","author":"Beaudin","year":"2022","journal-title":"Neurology"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e3551","DOI":"10.1002\/nbm.3551","article-title":"Determination of detection sensitivity for cerebral microbleeds using susceptibility-weighted imaging","volume":"30","author":"Buch","year":"2017","journal-title":"NMR Biomed."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"3537","DOI":"10.1002\/alz.12970","article-title":"Pathogenesis of Alzheimer\u2019s disease: involvement of the choroid plexus","volume":"19","author":"\u010carna","year":"2023","journal-title":"Alzheimers Dement."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/S1474-4422(22)00208-3","article-title":"The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study","volume":"21","author":"Charidimou","year":"2022","journal-title":"Lancet Neurol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e2192","DOI":"10.1212\/WNL.0000000000008590","article-title":"Cortical superficial siderosis and bleeding risk in cerebral amyloid angiopathy: a meta-analysis","volume":"93","author":"Charidimou","year":"2019","journal-title":"Neurology"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1139196","DOI":"10.3389\/fnins.2023.1139196","article-title":"Subcortical volumes in cerebral amyloid angiopathy compared with Alzheimer\u2019s disease and controls","volume":"17","author":"Chen","year":"2023","journal-title":"Front. Neurosci."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/s43587-022-00181-4","article-title":"Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries","volume":"2","author":"Chen","year":"2022","journal-title":"Nat. Aging"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e079185","DOI":"10.1002\/alz.079185","article-title":"Accelerated cerebral amyloid angiopathy and vascular alterations in a mixed mouse model of Alzheimer\u2019s disease and cerebral small vessel disease","volume":"19","author":"Choi","year":"2023","journal-title":"Alzheimers Dement."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e13503","DOI":"10.1111\/acel.13503","article-title":"Effects of cerebral amyloid angiopathy on the brain vasculome","volume":"21","author":"Deng","year":"2022","journal-title":"Aging Cell"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1177\/17474930221099352","article-title":"Mediators of cognitive impairment in cerebral amyloid angiopathy","volume":"18","author":"Durrani","year":"2023","journal-title":"Int. J. Stroke"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1212\/wnl.43.9.1683","article-title":"Pathologic correlates of incidental MRI white matter signal hyperintensities","volume":"43","author":"Fazekas","year":"1993","journal-title":"Neurology"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.neuroimage.2017.08.047","article-title":"Harmonization of multi-site diffusion tensor imaging data","volume":"161","author":"Fortin","year":"2017","journal-title":"Neuroimage"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"223","DOI":"10.5853\/jos.2020.04280","article-title":"Decreased basal ganglia volume in cerebral amyloid angiopathy","volume":"23","author":"Fotiadis","year":"2021","journal-title":"J. Stroke"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/S1474-4422(16)30030-8","article-title":"Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study","volume":"15","author":"Fotiadis","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e067799","DOI":"10.1002\/alz.067799","article-title":"Alzheimer Disease candidate variants are associated with cerebral amyloid angiopathy","volume":"18","author":"Godrich","year":"2022","journal-title":"Alzheimers Dement."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"AP442","DOI":"10.1161\/str.52.suppl_1.P442","article-title":"Abstract P442: the association of amyloid and tau burden with centrum semiovale perivascular spaces in cerebral amyloid angiopathy","volume":"52","author":"Gokcal","year":"2021","journal-title":"Stroke"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41582-019-0281-2","article-title":"Cerebral amyloid angiopathy and Alzheimer disease \u2014 one peptide, two pathways","volume":"16","author":"Greenberg","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1161\/STROKEAHA.124.044293","article-title":"Cerebral amyloid Angiopathy","volume":"55","author":"Greenberg","year":"2024","journal-title":"Stroke"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13195-024-01407-w","article-title":"The relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: a study based on Alzheimer\u2019s disease continuum participants","volume":"16","author":"Hong","year":"2024","journal-title":"Alz. Res. Therapy"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"3251","DOI":"10.1002\/alz.13789","article-title":"Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer\u2019s disease","volume":"20","author":"Huang","year":"2024","journal-title":"Alzheimer\u2019s Dementia"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/alz.12366","article-title":"Prevalence of cerebral amyloid angiopathy: a systematic review and meta-analysis","volume":"18","author":"J\u00e4kel","year":"2022","journal-title":"Alzheimers Dement."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1136\/jnnp-2023-331170","article-title":"Association of choroid plexus volume with motor symptoms and dopaminergic degeneration in Parkinson\u2019s disease","volume":"94","author":"Jeong","year":"2023","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.1007\/s11064-015-1581-6","article-title":"The glymphatic system: a beginner\u2019s guide","volume":"40","author":"Jessen","year":"2015","journal-title":"Neurochem. Res."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1002\/ana.26710","article-title":"Regional glymphatic abnormality in behavioral variant frontotemporal dementia","volume":"94","author":"Jiang","year":"2023","journal-title":"Ann. 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Commun."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/S1474-4422(23)00114-X","article-title":"Progression of cerebral amyloid angiopathy: a pathophysiological framework","volume":"22","author":"Koemans","year":"2023","journal-title":"Lancet Neurol."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1126\/science.abb8739","article-title":"Glymphatic failure as a final common pathway to dementia","volume":"370","author":"Nedergaard","year":"2020","journal-title":"Science"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"267","DOI":"10.2174\/1567205020666230713151211","article-title":"Cognitive versus hemorrhagic onset in cerebral amyloid angiopathy: neuroimaging features","volume":"20","author":"Perini","year":"2023","journal-title":"Curr. Alzheimer Res."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e066555","DOI":"10.1002\/alz.066555","article-title":"Cerebral amyloid angiopathy interacts with parenchymal beta-amyloid to promote tau and cognitive decline","volume":"18","author":"Rabin","year":"2022","journal-title":"Alzheimers Dement."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s13195-021-00836-1","article-title":"Validation of amyloid PET positivity thresholds in centiloids: a multisite PET study approach","volume":"13","author":"Royse","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/s0006-8993(97)00097-8","article-title":"Human choroid plexus is an uniquely involved area of the brain in amyloidosis: a histochemical, immunohistochemical and ultrastructural study","volume":"755","author":"Sasaki","year":"1997","journal-title":"Brain Res."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1007\/s11604-017-0617-z","article-title":"Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer\u2019s disease cases","volume":"35","author":"Taoka","year":"2017","journal-title":"Jpn. J. Radiol."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00018-024-05277-1","article-title":"Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies","volume":"81","author":"van Veluw","year":"","journal-title":"Cell. Mol. Life Sci."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1093\/eurheartj\/ehae011","article-title":"A translational approach towards understanding brain waste clearance in cerebral amyloid angiopathy","volume":"45","author":"van Veluw","year":"","journal-title":"Eur. Heart J."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1016\/j.neurobiolaging.2008.08.017","article-title":"Abeta accumulation in choroid plexus is associated with mitochondrial-induced apoptosis","volume":"31","author":"Vargas","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5853\/jos.2023.01942","article-title":"Cerebral amyloid angiopathy: an undeniable small vessel disease","volume":"26","author":"Wang","year":"2024","journal-title":"J Stroke"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"737217","DOI":"10.3389\/fnhum.2021.737217","article-title":"A brief overview of the cerebrospinal fluid system and its implications for brain and spinal cord diseases","volume":"15","author":"Wichmann","year":"2021","journal-title":"Front. Hum. Neurosci."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"120524","DOI":"10.1016\/j.neuroimage.2024.120524","article-title":"Higher intracranial arterial pulsatility is associated with presumed imaging markers of the glymphatic system: an explorative study","volume":"288","author":"Xie","year":"2024","journal-title":"NeuroImage"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1177\/0271678X20904840","article-title":"Venous disruption affects white matter integrity through increased interstitial fluid in cerebral small vessel disease","volume":"41","author":"Zhang","year":"2021","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"693787","DOI":"10.3389\/fnagi.2021.693787","article-title":"The influence of demographics and vascular risk factors on Glymphatic function measured by diffusion along perivascular space","volume":"13","author":"Zhang","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"e16521","DOI":"10.1111\/ene.16521","article-title":"Glymphatic system dysfunction and risk of clinical milestones in patients with Parkinson disease","volume":"31","author":"Zhou","year":"2024","journal-title":"Eur. J. 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