{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:53:34Z","timestamp":1793757214227,"version":"4.6.1"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>The role and function of follicle-stimulating hormone in the gonads have been extremely studied. However, recent research has begun to explore the relationship between elevated follicle-stimulating hormone levels and the prevalence of extragonadal disorders, particularly in perimenopausal and postmenopausal women. These disorders include endometrial cancer, osteoporosis, obesity, and atherosclerosis. This review provides new insights into the relationship between follicle-stimulating hormone and the development of age-related diseases, with a focus on Alzheimer\u2019s disease. Follicle-stimulating hormone does not act alone in promoting Alzheimer\u2019s disease but often works in conjunction with inflammation, lipid accumulation, and vascular alterations. Furthermore, follicle-stimulating hormone synergizes with obesity, gut microbiota, autophagy, and aging, creating conditions that facilitate the onset and progression of Alzheimer\u2019s disease. This review also summarizes the therapeutic potential of FSH-blocking antibodies in treating these diseases.<\/jats:p>","DOI":"10.3389\/fnagi.2025.1578439","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T01:23:29Z","timestamp":1750037009000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["From hormones to neurodegeneration: how FSH drives Alzheimer\u2019s disease"],"prefix":"10.3389","volume":"17","author":[{"given":"Yafei","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e0235174","DOI":"10.1371\/journal.pone.0235174","article-title":"Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women","volume":"15","author":"Abildgaard","year":"2020","journal-title":"PLoS One"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1002\/alz.12638","article-title":"2022 Alzheimer's disease facts and figures","volume":"18","year":"2022","journal-title":"Alzheimers Dement."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s11011-021-00814-4","article-title":"Neurovascular dysfunction and vascular amyloid accumulation as early events in Alzheimer's disease","volume":"37","author":"Apatiga-Perez","year":"2022","journal-title":"Metab. 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