{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:10:00Z","timestamp":1793106600769,"version":"4.5.0"},"reference-count":153,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a growing global challenge, representing the most common neurodegenerative disorder and affecting millions of lives. As life expectancy continues to rise and populations expand, the number of individuals coping with the cognitive declines caused by AD is projected to double in the coming years. By 2050, we may see over 115 million people diagnosed with this devastating condition. Unfortunately, while we currently lack effective cures, there are preventative measures that can slow disease progression in symptomatic patients. Thus, research has shifted toward early detection and intervention for AD in recent years. With technological advances, we are now harnessing large datasets and more efficient, minimally invasive methods for diagnosis and treatment. This review highlights critical demographic insights, health conditions that increase the risk of developing AD, and lifestyle factors in midlife that can potentially trigger its onset. Additionally, we delve into the promising role of plant-based metabolites and their sources, which may help delay the disease\u2019s progression. The innovative multi-omics research is transforming our understanding of AD. This approach enables comprehensive data analysis from diverse cell types and biological processes, offering possible biomarkers of this disease\u2019s mechanisms. We present the latest advancements in genomics, transcriptomics, Epigenomics, proteomics, and metabolomics, including significant progress in gene editing technologies. When combined with machine learning and artificial intelligence, multi-omics analysis becomes a powerful tool for uncovering the complexities of AD pathogenesis. We also explore current trends in the application of radiomics and machine learning, emphasizing how integrating multi-omics data can transform our approach to AD research and treatment. Together, these pioneering advancements promise to develop more effective preventive and therapeutic strategies soon.<\/jats:p>","DOI":"10.3389\/fnagi.2025.1591796","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T05:35:13Z","timestamp":1753248913000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Advancements in multi-omics research to address challenges in Alzheimer\u2019s disease: a systems biology approach utilizing molecular biomarkers and innovative strategies"],"prefix":"10.3389","volume":"17","author":[{"given":"Madison","family":"Cardillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyura","family":"Katam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashanth","family":"Suravajhala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e25369","DOI":"10.1016\/j.heliyon.2024.e25369","article-title":"machine learning and deep learning-based integrated multi-omics technique for leukemia prediction.","volume":"10","author":"Abbasi","year":"2024","journal-title":"Heliyon"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1143256","DOI":"10.3389\/fnume.2023.1143256","article-title":"Radiomics insight into the neurodegenerative \u201chot\u201d brain: A narrative review from the nuclear medicine perspective.","volume":"3","author":"Aghakhanyan","year":"2023","journal-title":"Front. Nucl. Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"270","DOI":"10.4103\/1735-5362.371583","article-title":"Betaine attenuates oxidative stress and cognitive dysfunction in an amyloid \u03b2-induced rat model of Alzheimer\u2019s disease.","volume":"18","author":"Alipourfard","year":"2023","journal-title":"Res. Pharm. Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cca.2022.12.016","article-title":"Insulin resistance in Alzheimer\u2019s disease: The genetics and metabolomics links.","volume":"539","author":"Amin","year":"2023","journal-title":"Clin. Chim. Acta"},{"key":"B5","doi-asserted-by":"publisher","first-page":"3754","DOI":"10.3390\/ijms24043754","article-title":"Alzheimer\u2019s disease: An updated overview of its genetics.","volume":"24","author":"Andrade-Guerrero","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.3390\/cells13131164","article-title":"Unraveling the potential underlying mechanisms of mild behavioral impairment: Focusing on amyloid and tau pathology.","volume":"13","author":"Angelopoulou","year":"2024","journal-title":"Cells"},{"key":"B7","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/bcpt.14035","article-title":"Regulation of mitochondrial dysfunction by estrogens and estrogen receptors in Alzheimer\u2019s disease: A focused review.","volume":"135","author":"Arjmand","year":"2024","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3390\/proteomes10030026","article-title":"Proteomic discovery and validation of novel fluid biomarkers for improved patient selection and prediction of clinical outcomes in Alzheimer\u2019s disease patient cohorts.","volume":"10","author":"Awasthi","year":"2022","journal-title":"Proteomes"},{"key":"B9","doi-asserted-by":"publisher","first-page":"3517","DOI":"10.3390\/ijms21103517","article-title":"Transcriptomics in Alzheimer\u2019s disease: Aspects and challenges.","volume":"21","author":"Bagyinszky","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"4886","DOI":"10.1002\/alz.13050","article-title":"A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer\u2019s disease.","volume":"19","author":"Bai","year":"2023","journal-title":"Alzheimers Dement."},{"key":"B11","doi-asserted-by":"publisher","first-page":"210013","DOI":"10.1098\/rsob.210013","article-title":"Therapeutic potential of astaxanthin and superoxide dismutase in Alzheimer\u2019s disease.","volume":"11","author":"Balendra","year":"2021","journal-title":"Open Biol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e38542","DOI":"10.2196\/38542","article-title":"Use of Bacopa monnieri in the treatment of dementia due to Alzheimer disease: Systematic review of randomized controlled trials.","volume":"11","author":"Basheer","year":"2022","journal-title":"Int. J. Med. Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"8294","DOI":"10.1002\/alz.14249","article-title":"Comparative brain metabolomics reveals shared and distinct metabolic alterations in Alzheimer\u2019s disease and progressive supranuclear palsy.","volume":"20","author":"Batra","year":"2024","journal-title":"Alzheimers Dement."},{"key":"B14","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s13024-020-00398-0","article-title":"Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer\u2019s disease-related inhibitory circuit dysfunction in adults with Down syndrome.","volume":"15","author":"Belbin","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"B15","doi-asserted-by":"publisher","first-page":"5432","DOI":"10.3390\/jcm12165432","article-title":"Radiomics and artificial intelligence for the diagnosis and monitoring of Alzheimer\u2019s disease: A systematic review of studies in the field.","volume":"12","author":"Bevilacqua","year":"2023","journal-title":"J. Clin. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/s41582-021-00578-6","article-title":"Dissecting the complexities of Alzheimer disease with in vitro models of the human brain.","volume":"18","author":"Blanchard","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13010-021-00111-z","article-title":"Alzheimer\u2019s disease: History, ethics and medical humanities in the context of assisted suicide.","volume":"17","author":"Braun","year":"2022","journal-title":"Philos. Ethics Hum. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"5789","DOI":"10.3390\/molecules25245789","article-title":"Comprehensive review on Alzheimer\u2019s disease: Causes and treatment.","volume":"25","author":"Breijyeh","year":"2020","journal-title":"Molecules"},{"key":"B19","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s40120-024-00676-9","article-title":"Quality of life in mild cognitive impairment and mild dementia associated with Alzheimer\u2019s disease: A systematic review.","volume":"14","author":"Campbell","year":"2025","journal-title":"Neurol. Ther."},{"key":"B20","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1021\/acschemneuro.3c00587","article-title":"Characterization of hair metabolome in 5xFAD mice and patients with Alzheimer\u2019s disease using mass spectrometry-based metabolomics.","volume":"15","author":"Chang","year":"2024","journal-title":"ACS Chem. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1002\/alz.12447","article-title":"Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer\u2019s disease.","volume":"18","author":"Chatterjee","year":"2022","journal-title":"Alzheimers Dement."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.3390\/cells10061309","article-title":"Neuroprotective natural products for Alzheimer\u2019s disease.","volume":"10","author":"Chen","year":"2021","journal-title":"Cells"},{"key":"B23","doi-asserted-by":"publisher","first-page":"357","DOI":"10.3390\/metabo12040357","article-title":"Guide to metabolomics analysis: A bioinformatics workflow.","volume":"12","author":"Chen","year":"2022","journal-title":"Metabolites"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e14361","DOI":"10.1002\/alz.14361","article-title":"Integrated cerebellar radiomic-network model for predicting mild cognitive impairment in Alzheimer\u2019s disease.","volume":"21","author":"Chen","year":"2025","journal-title":"Alzheimers Dement."},{"key":"B25","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s40164-024-00572-w","article-title":"Nuclear porcupine mediates XRCC6\/Ku70 S-palmitoylation in the DNA damage response.","volume":"13","author":"Chen","year":"2024","journal-title":"Exp. Hematol. Oncol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"880","DOI":"10.3390\/cells10040880","article-title":"Advances in understanding of the role of lipid metabolism in aging.","volume":"10","author":"Chung","year":"2021","journal-title":"Cells"},{"key":"B27","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/alz.12612","article-title":"Potential role of chitinase-3-like protein 1 (CHI3L1\/YKL-40) in neurodegeneration and Alzheimer\u2019s disease.","volume":"19","author":"Connolly","year":"2023","journal-title":"Alzheimers Dement."},{"key":"B28","doi-asserted-by":"publisher","first-page":"8714","DOI":"10.3390\/ijms23158714","article-title":"Applications of CRISPR-Cas9 in Alzheimer\u2019s disease and related disorders.","volume":"23","author":"De Plano","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"26503","DOI":"10.1038\/s41598-024-78553-6","article-title":"Multimodal AI\/ML for discovering novel biomarkers and predicting disease using multi-omics profiles of patients with cardiovascular diseases.","volume":"14","author":"DeGroat","year":"2024","journal-title":"Sci. Rep."},{"key":"B30","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","article-title":"The neuropathological diagnosis of Alzheimer\u2019s disease.","volume":"14","author":"DeTure","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.3390\/ijms25021301","article-title":"Apolar extracts of St. John\u2019s wort alleviate the effects of \u03b2-amyloid toxicity in early Alzheimer\u2019s disease.","volume":"25","author":"El Menuawy","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"101391","DOI":"10.1016\/j.arr.2021.101391","article-title":"Living with the enemy: From protein-misfolding pathologies we know, to those we want to know.","volume":"70","author":"Emwas","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1016\/j.cmet.2021.10.010","article-title":"Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease.","volume":"33","author":"Erny","year":"2021","journal-title":"Cell Metab."},{"key":"B34","doi-asserted-by":"publisher","first-page":"101843","DOI":"10.1016\/j.jsps.2023.101843","article-title":"Neuroprotective effects of trigonelline in kainic acid-induced epilepsy: Behavioral, biochemical, and functional insights.","volume":"31","author":"Faizan","year":"2023","journal-title":"Saudi Pharm. J."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.3390\/ijms23031652","article-title":"Activity and function in human cells of the evolutionary conserved exonuclease polynucleotide phosphorylase.","volume":"23","author":"Falchi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e12199","DOI":"10.1002\/trc2.12199","article-title":"Supplemental thiamine as a practical, potential way to prevent Alzheimer\u2019s disease from commencing.","volume":"7","author":"Fessel","year":"2021","journal-title":"Alzheimers Dement. (NY)"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1456052","DOI":"10.3389\/fnmol.2024.1456052","article-title":"Histone post-translational modification and heterochromatin alterations in neurodegeneration: Revealing novel disease pathways and potential therapeutics.","volume":"17","author":"Fisher","year":"2024","journal-title":"Front. Mol. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.3390\/cells13151288","article-title":"The potential of metabolomics to find proper biomarkers for addressing the neuroprotective efficacy of drugs aimed at delaying parkinson\u2019s and Alzheimer\u2019s disease progression.","volume":"13","author":"Franco","year":"2024","journal-title":"Cells"},{"key":"B39","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/j.1365-2990.2010.01135.x","article-title":"Granulovacuolar degeneration (GVD) bodies of Alzheimer\u2019s disease (AD) resemble late-stage autophagic organelles.","volume":"37","author":"Funk","year":"2011","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"489","DOI":"10.3233\/JAD-240195","article-title":"Language and meaning: Asymptomatic Alzheimer\u2019s disease in the clinic and society.","volume":"99","author":"Gale","year":"2024","journal-title":"J. Alzheimers Dis."},{"key":"B41","doi-asserted-by":"publisher","first-page":"dmm045211","DOI":"10.1242\/dmm.045211","article-title":"Sex-dependent effect of APOE on Alzheimer\u2019s disease and other age-related neurodegenerative disorders.","volume":"13","author":"Gamache","year":"2020","journal-title":"Dis. Model Mech."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1007\/s10072-023-06602-5","article-title":"PSEN2 and ABCA7 variants causing early-onset preclinical pathological changes in Alzheimer\u2019s disease: A case report and literature review.","volume":"44","author":"Gan","year":"2023","journal-title":"Neurol. Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s40035-022-00279-0","article-title":"Brain-derived neurotrophic factor in Alzheimer\u2019s disease and its pharmaceutical potential.","volume":"11","author":"Gao","year":"2022","journal-title":"Transl. Neurodegener."},{"key":"B44","doi-asserted-by":"publisher","first-page":"911635","DOI":"10.3389\/fnagi.2022.911635","article-title":"Epigenetics in Alzheimer\u2019s disease.","volume":"14","author":"Gao","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1042\/CS20201033","article-title":"Vascular contributions to cognitive impairment and dementia: The emerging role of 20-HETE.","volume":"135","author":"Gonzalez-Fernandez","year":"2021","journal-title":"Clin. Sci. (Lond)"},{"key":"B46","doi-asserted-by":"publisher","first-page":"543","DOI":"10.3390\/biom11040543","article-title":"Neuroprotective herbs for the management of Alzheimer\u2019s disease.","volume":"11","author":"Gregory","year":"2021","journal-title":"Biomolecules"},{"key":"B47","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.biopsych.2021.02.968","article-title":"Sex differences in Alzheimer\u2019s disease: Insights from the multiomics landscape.","volume":"91","author":"Guo","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"B48","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s12944-019-0965-z","article-title":"Role of cholesterol and sphingolipids in brain development and neurological diseases.","volume":"18","author":"Hussain","year":"2019","journal-title":"Lipids Health Dis."},{"key":"B49","doi-asserted-by":"publisher","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised criteria for diagnosis and staging of Alzheimer\u2019s disease: Alzheimer\u2019s association workgroup.","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimers Dement."},{"key":"B50","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/proteomes9010013","article-title":"Proteomics landscape of Alzheimer\u2019s disease.","volume":"9","author":"Jain","year":"2021","journal-title":"Proteomes"},{"key":"B51","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/s13195-023-01337-z","article-title":"Blockade of adenosine A2A receptors reverses early spatial memory defects in the APP\/PS1 mouse model of Alzheimer\u2019s disease by promoting synaptic plasticity of adult-born granule cells.","volume":"15","author":"Ji","year":"2023","journal-title":"Alzheimers Res. Ther."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2620","DOI":"10.1007\/s00330-024-11158-9","article-title":"Using interpretable deep learning radiomics model to diagnose and predict progression of early AD disease spectrum: A preliminary [18F]FDG PET study.","volume":"35","author":"Jiang","year":"2024","journal-title":"Eur. Radiol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.tem.2023.06.006","article-title":"An epidemiological introduction to human metabolomic investigations.","volume":"34","author":"Joshi","year":"2023","journal-title":"Trends Endocrinol. Metab."},{"key":"B54","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/s13311-021-01152-0","article-title":"Genomics and functional genomics of Alzheimer\u2019s disease.","volume":"19","author":"Kamboh","year":"2022","journal-title":"Neurotherapeutics"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-08072-2_16","article-title":"Biosafety issue related to genome editing in plants using CRISPR-Cas9","author":"Katam","year":"2022","journal-title":"Genome editing"},{"key":"B56","doi-asserted-by":"publisher","first-page":"e48430","DOI":"10.7759\/cureus.48430","article-title":"Comprehensive review of modifiable cardiovascular risk factors and genetic influences in dementia prevention.","volume":"15","author":"Khan","year":"2023","journal-title":"Cureus"},{"key":"B57","doi-asserted-by":"publisher","first-page":"e815","DOI":"10.1212\/WNL.0000000000010005","article-title":"Serum albumin and beta-amyloid deposition in the human brain.","volume":"95","author":"Kim","year":"2020","journal-title":"Neurology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s12276-023-01148-0","article-title":"Pathological phenotypes of astrocytes in Alzheimer\u2019s disease.","volume":"56","author":"Kim","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"764","DOI":"10.2174\/1570159X21666230216094353","article-title":"Herbal therapeutics for Alzheimer\u2019s disease: Ancient indian medicine system from the modern viewpoint.","volume":"21","author":"Kushwah","year":"2023","journal-title":"Curr. Neuropharmacol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"e14476","DOI":"10.1111\/cns.14476","article-title":"NcRNAs: A synergistically antiapoptosis therapeutic tool in Alzheimer\u2019s disease.","volume":"30","author":"Li","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"B61","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s40035-022-00315-z","article-title":"A review of brain imaging biomarker genomics in Alzheimer\u2019s disease: Implementation and perspectives.","volume":"11","author":"Li","year":"2022","journal-title":"Transl. Neurodegener."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.2212.09870","article-title":"Metabolomics of aging and Alzheimer\u2019s disease: From single-omics to multi-omics.","author":"Li","year":"2022","journal-title":"arXiv [Preprint]."},{"key":"B63","doi-asserted-by":"publisher","first-page":"7397","DOI":"10.1007\/s00018-021-03986-5","article-title":"Genomics of Alzheimer\u2019s disease implicates the innate and adaptive immune systems.","volume":"78","author":"Li","year":"2021","journal-title":"Cell Mol. Life Sci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.3390\/ijms21051666","article-title":"Contributions of DNA damage to Alzheimer\u2019s disease.","volume":"21","author":"Lin","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1007\/s11064-020-03062-7","article-title":"Mulberry fruit extract alleviates cognitive impairment by promoting the clearance of amyloid-\u03b2 and inhibiting neuroinflammation in Alzheimer\u2019s disease mice.","volume":"45","author":"Liu","year":"2020","journal-title":"Neurochem. Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"e30523","DOI":"10.1016\/j.heliyon.2024.e30523","article-title":"The Intersection of cerebral cholesterol metabolism and Alzheimer\u2019s disease: Mechanisms and therapeutic prospects.","volume":"10","author":"Liu","year":"2024","journal-title":"Heliyon"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.2174\/1570159X19666210412095251","article-title":"Potential of medicinal plants as neuroprotective and therapeutic properties against Amyloid-\u03b2-Related toxicity, and glutamate-induced excitotoxicity in human neural cells.","volume":"19","author":"Lobine","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"8862025","DOI":"10.1155\/2021\/8862025","article-title":"Phytochemical analysis and cholinesterase inhibitory and antioxidant activities of enhydra fluctuans relevant in the management of Alzheimer\u2019s disease.","volume":"2021","author":"Lopa","year":"2021","journal-title":"Int. J. Food Sci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/j.neuron.2024.01.024","article-title":"Mechanisms of sex differences in Alzheimer\u2019s disease.","volume":"112","author":"Lopez-Lee","year":"2024","journal-title":"Neuron"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1406970","DOI":"10.3389\/fncel.2024.1406970","article-title":"Alzheimer\u2019s disease induced neurons bearing PSEN1 mutations exhibit reduced excitability.","volume":"18","author":"Maksour","year":"2024","journal-title":"Front. Cell Neurosci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1002\/alz.12320","article-title":"Midlife vascular risk factors and risk of incident dementia: Longitudinal cohort and mendelian randomization analyses in the UK Biobank.","volume":"17","author":"Malik","year":"2021","journal-title":"Alzheimers Dement."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1212815","DOI":"10.3389\/fendo.2023.1212815","article-title":"High preoperative blood oxaloacetate and 2-aminoadipic acid levels are associated with postoperative delayed neurocognitive recovery.","volume":"14","author":"Mao","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1002\/jbm.b.35006","article-title":"Design and evaluation of nanostructured lipid carriers loaded with Salvia officinalis extract for Alzheimer\u2019s disease treatment.","volume":"110","author":"Markova","year":"2022","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"B74","doi-asserted-by":"publisher","first-page":"119326","DOI":"10.1016\/j.bbamcr.2022.119326","article-title":"Transcriptomic and epigenomic landscapes of Alzheimer\u2019s disease evidence mitochondrial-related pathways.","volume":"1869","author":"Marmolejo-Garza","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.3390\/antiox9121224","article-title":"Proteome and Alzheimer\u2019s disease: Evidence of a Link.","volume":"9","author":"Marsillach","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1398026","DOI":"10.3389\/fnmol.2024.1398026","article-title":"Epigenetic modifications of DNA and RNA in Alzheimer\u2019s disease.","volume":"17","author":"Martinez-Feduchi","year":"2024","journal-title":"Front. Mol. Neurosci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.2174\/1570159X19666201223154009","article-title":"Recent evidence in epigenomics and proteomics biomarkers for early and minimally invasive diagnosis of Alzheimer\u2019s and Parkinson\u2019s diseases.","volume":"19","author":"Mayo","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s40035-024-00450-9","article-title":"Controversies and insights into PTBP1-related astrocyte-neuron transdifferentiation: Neuronal regeneration strategies for Parkinson\u2019s and Alzheimer\u2019s disease.","volume":"13","author":"McDowall","year":"2024","journal-title":"Transl. Neurodegener."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1101216","DOI":"10.3389\/fnagi.2023.1101216","article-title":"Pooled analysis of frontal lobe transcriptomic data identifies key mitophagy gene changes in Alzheimer\u2019s disease brain.","volume":"15","author":"Mei","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"100127","DOI":"10.1016\/j.jlr.2021.100127","article-title":"Clinical lipidomics: Realizing the potential of lipid profiling.","volume":"62","author":"Meikle","year":"2021","journal-title":"J. Lipid Res."},{"key":"B81","doi-asserted-by":"publisher","first-page":"102335","DOI":"10.1016\/j.arr.2024.102335","article-title":"Overlooked cases of mild cognitive impairment: Implications to early Alzheimer\u2019s disease.","volume":"98","author":"Mian","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.3390\/pharmaceutics15041057","article-title":"Ashwagandha (Withania somnifera)-current research on the health-promoting activities: A narrative review.","volume":"15","author":"Mikulska","year":"2023","journal-title":"Pharmaceutics"},{"key":"B83","doi-asserted-by":"publisher","first-page":"115522","DOI":"10.1016\/j.bcp.2023.115522","article-title":"Alzheimer\u2019s disease: Insights and new prospects in disease pathophysiology, biomarkers and disease-modifying drugs.","volume":"211","author":"Monteiro","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"649","DOI":"10.3233\/JAD-230729","article-title":"A community-based study of dementia in Mexican american and non-hispanic white individuals.","volume":"97","author":"Morgenstern","year":"2024","journal-title":"J. Alzheimers Dis."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.3233\/JAD-220113","article-title":"Spillover: The approval of new medications for Alzheimer\u2019s disease dementia will impact biomarker disclosure among asymptomatic research participants.","volume":"90","author":"Mozersky","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.14336\/AD.2020.0908","article-title":"Proteomic profiling of extracellular vesicles separated from plasma of former national football league players at risk for chronic traumatic encephalopathy.","volume":"12","author":"Muraoka","year":"2021","journal-title":"Aging Dis."},{"key":"B87","doi-asserted-by":"publisher","first-page":"104976","DOI":"10.1016\/j.nbd.2020.104976","article-title":"Genetic architecture of Alzheimer\u2019s disease.","volume":"143","author":"Neuner","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1211067","DOI":"10.3389\/fnagi.2023.1211067","article-title":"Regional contributions of D-serine to Alzheimer\u2019s disease pathology in male AppNL-G-F\/NL-G-F mice.","volume":"15","author":"Ni","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"B89","doi-asserted-by":"publisher","first-page":"14794","DOI":"10.3390\/ijms241914794","article-title":"Amyloid precursor protein and Alzheimer\u2019s disease.","volume":"24","author":"Orobets","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B90","doi-asserted-by":"publisher","first-page":"13954","DOI":"10.3390\/ijms232213954","article-title":"Alzheimer\u2019s disease: Treatment strategies and their limitations.","volume":"23","author":"Passeri","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.2147\/DDDT.S450739","article-title":"Network pharmacology and molecular docking identify the potential mechanism and therapeutic role of Scutellaria baicalensis in Alzheimer\u2019s disease.","volume":"18","author":"Peng","year":"2024","journal-title":"Drug Des. Dev. Ther."},{"key":"B92","doi-asserted-by":"publisher","first-page":"112155","DOI":"10.1016\/j.nut.2023.112155","article-title":"Abdominal obesity and hydration status as protective factors against mortality in older adults: A prospective study.","volume":"116","author":"Pereira","year":"2023","journal-title":"Nutrition"},{"key":"B93","doi-asserted-by":"publisher","first-page":"104052","DOI":"10.1016\/j.drudis.2024.104052","article-title":"Restoring the epigenome in Alzheimer\u2019s disease: Advancing HDAC inhibitors as therapeutic agents.","volume":"29","author":"Pereira","year":"2024","journal-title":"Drug Discov. Today"},{"key":"B94","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.3233\/JAD-210137","article-title":"Paraoxonase 1, B vitamins supplementation, and mild cognitive impairment.","volume":"81","author":"Per\u0142a-Kaj\u00e1n","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"B95","doi-asserted-by":"publisher","first-page":"734","DOI":"10.3390\/cells11040734","article-title":"Histone H3 Lysine 4 and 27 trimethylation landscape of human Alzheimer\u2019s disease.","volume":"11","author":"Persico","year":"2022","journal-title":"Cells"},{"key":"B96","doi-asserted-by":"publisher","first-page":"725","DOI":"10.3233\/JAD-200378","article-title":"Effects of citicoline as an adjunct treatment for Alzheimer\u2019s disease: A systematic review.","volume":"76","author":"Piamonte","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.15586\/alzheimersdisease.2019.ch1","article-title":"A new perspective on alzheimer\u2019s disease as a brain expression of a complex metabolic disorder","author":"Polis","year":"2019","journal-title":"Alzheimer\u2019s disease"},{"key":"B98","doi-asserted-by":"publisher","first-page":"1049890","DOI":"10.3389\/fphar.2022.1049890","article-title":"Ligusticum chuanxiong Hort as a medicinal and edible plant foods: Antioxidant, anti-aging and neuroprotective properties in Caenorhabditis elegans.","volume":"13","author":"Qin","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13148-024-01650-w","article-title":"Novel histone post-translational modifications in Alzheimer\u2019s disease: Current advances and implications.","volume":"16","author":"Qin","year":"2024","journal-title":"Clin. Epigenet."},{"key":"B100","doi-asserted-by":"publisher","first-page":"fcab261","DOI":"10.1093\/braincomms\/fcab261","article-title":"VGF as a biomarker and therapeutic target in neurodegenerative and psychiatric diseases.","volume":"3","author":"Quinn","year":"2021","journal-title":"Brain Commun."},{"key":"B101","doi-asserted-by":"publisher","first-page":"10040","DOI":"10.1093\/nar\/gkae736","article-title":"CRISPR-Cas target recognition for sensing viral and cancer biomarkers.","volume":"52","author":"Rahimi","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"B102","doi-asserted-by":"publisher","first-page":"26331055241293455","DOI":"10.1177\/26331055241293455","article-title":"The 3D genome in brain development: An exploration of molecular mechanisms and experimental methods.","volume":"19","author":"Rahman","year":"2024","journal-title":"Neurosci. Insights"},{"key":"B103","doi-asserted-by":"publisher","first-page":"561","DOI":"10.3390\/genes15050561","article-title":"Sarcopenia as a risk factor for Alzheimer\u2019s disease: Genetic and epigenetic perspectives.","volume":"15","author":"Raleigh","year":"2024","journal-title":"Genes (Basel)"},{"key":"B104","doi-asserted-by":"publisher","first-page":"937789","DOI":"10.3389\/fnmol.2022.937789","article-title":"Taurine and astrocytes: A homeostatic and neuroprotective relationship.","volume":"15","author":"Ram\u00edrez-Guerrero","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"B105","doi-asserted-by":"publisher","first-page":"12841","DOI":"10.3390\/ijms232112841","article-title":"Phosphorylated tau in Alzheimer\u2019s disease and other tauopathies.","volume":"23","author":"Rawat","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B106","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/s41386-020-00840-3","article-title":"Systems-based proteomics to resolve the biology of Alzheimer\u2019s disease beyond amyloid and tau.","volume":"46","author":"Rayaprolu","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"B107","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s11306-021-01828-w","article-title":"Challenges in LC-MS-based metabolomics for Alzheimer\u2019s disease early detection: Targeted approaches versus untargeted approaches.","volume":"17","author":"Reveglia","year":"2021","journal-title":"Metabolomics"},{"key":"B108","first-page":"13","article-title":"Therapeutic potential of Allium Sativum against the A\u03b2(1-40)-induced oxidative stress and mitochondrial dysfunction in the Wistar rats.","volume":"10","author":"Saini","year":"2021","journal-title":"Am. J. Neurodegener. Dis."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.3390\/ijms23041930","article-title":"Mechanistic insights into the polymorphic associations and cross-seeding of A\u03b2 and hIAPP in the presence of histidine tautomerism: An all-atom molecular dynamic study.","volume":"23","author":"Salimi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B110","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.semcdb.2022.05.007","article-title":"Revealing cell vulnerability in Alzheimer\u2019s disease by single-cell transcriptomics.","volume":"139","author":"Saura","year":"2023","journal-title":"Semin. Cell Dev. Biol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"2428152","DOI":"10.1080\/13510002.2024.2428152","article-title":"Inflammation and DNA methylation in Alzheimer\u2019s disease: Mechanisms of epigenetic remodelling by immune cell oxidants in the ageing brain.","volume":"29","author":"Seddon","year":"2024","journal-title":"Redox Rep."},{"key":"B112","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3390\/life12020275","article-title":"Potential applications of artificial intelligence in clinical trials for Alzheimer\u2019s disease.","volume":"12","author":"Seo","year":"2022","journal-title":"Life (Basel)"},{"key":"B113","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/S1474-4422(20)30412-9","article-title":"APOE and Alzheimer\u2019s disease: Advances in genetics, pathophysiology, and therapeutic approaches.","volume":"20","author":"Serrano-Pozo","year":"2021","journal-title":"Lancet Neurol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"fcac318","DOI":"10.1093\/braincomms\/fcac318","article-title":"Serum unsaturated phosphatidylcholines predict longitudinal basal forebrain degeneration in Alzheimer\u2019s disease.","volume":"4","author":"Shanks","year":"2022","journal-title":"Brain Commun."},{"key":"B115","doi-asserted-by":"publisher","first-page":"712545","DOI":"10.3389\/fnagi.2021.712545","article-title":"Plasma proteomic biomarkers relating to Alzheimer\u2019s disease: A meta-analysis based on our own studies.","volume":"13","author":"Shi","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"B116","doi-asserted-by":"publisher","first-page":"e778","DOI":"10.1002\/mco2.778","article-title":"Machine learning-based radiomics in neurodegenerative and cerebrovascular disease.","volume":"5","author":"Shi","year":"2024","journal-title":"MedComm (2020)"},{"key":"B117","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s13195-024-01504-w","article-title":"APP dyshomeostasis in the pathogenesis of Alzheimer\u2019s disease: Implications for current drug targets.","volume":"16","author":"Sirisi","year":"2024","journal-title":"Alzheimers Res. Ther."},{"key":"B118","doi-asserted-by":"publisher","first-page":"102011","DOI":"10.1016\/j.cdnut.2023.102011","article-title":"Creatine as a therapeutic target in Alzheimer\u2019s disease.","volume":"7","author":"Smith","year":"2023","journal-title":"Curr. Dev. Nutr."},{"key":"B119","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s40203-024-00214-3","article-title":"Computational identification of potential acetylcholinesterase (AChE) and monoamine oxidase-B inhibitors from Vitis vinifera: A case study of Alzheimer\u2019s disease (AD).","volume":"12","author":"Sofela","year":"2024","journal-title":"Silico Pharmacol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.3390\/cells11132021","article-title":"Single-Cell RNA-Sequencing: Astrocyte and microglial heterogeneity in health and disease.","volume":"11","author":"Spurgat","year":"2022","journal-title":"Cells"},{"key":"B121","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.3390\/pharmaceutics14061270","article-title":"Exploring the involvement of the amyloid precursor protein A673T mutation against amyloid pathology and Alzheimer\u2019s disease in relation to therapeutic editing tools.","volume":"14","author":"Stanciu","year":"2022","journal-title":"Pharmaceutics"},{"key":"B122","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s13195-020-00649-8","article-title":"Cathepsin D regulates cerebral A\u03b242\/40 ratios via differential degradation of A\u03b242 and A\u03b240.","volume":"12","author":"Suire","year":"2020","journal-title":"Alzheimers Res. Ther."},{"key":"B123","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.jare.2023.11.006","article-title":"Unlocking the secrets of aging: Epigenetic reader BRD4 as the target to combatting aging-related diseases.","volume":"63","author":"Sun","year":"2024","journal-title":"J. Adv. Res."},{"key":"B124","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13293-020-00310-x","article-title":"Sex differences in Alzheimer\u2019s-related Tau biomarkers and a mediating effect of testosterone.","volume":"11","author":"Sundermann","year":"2020","journal-title":"Biol. Sex Differ."},{"key":"B125","doi-asserted-by":"publisher","first-page":"4419","DOI":"10.1007\/s12035-022-02734-5","article-title":"SUMO1 modification of tau in progressive supranuclear palsy.","volume":"59","author":"Takamura","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/biomedicines13010167","article-title":"From serendipity to precision: Integrating AI, multi-omics, and human-specific models for personalized neuropsychiatric care.","volume":"13","author":"Tanaka","year":"2025","journal-title":"Biomedicines"},{"key":"B127","doi-asserted-by":"publisher","first-page":"7816","DOI":"10.1038\/s41598-023-34787-4","article-title":"Transcriptomic and glycomic analyses highlight pathway-specific glycosylation alterations unique to Alzheimer\u2019s disease.","volume":"13","author":"Tang","year":"2023","journal-title":"Sci. Rep."},{"key":"B128","doi-asserted-by":"publisher","first-page":"899175","DOI":"10.3389\/fnagi.2022.899175","article-title":"Association of circulating apolipoprotein ai levels in patients with Alzheimer\u2019s disease: A systematic review and meta-analysis.","volume":"14","author":"Tong","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"B129","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3390\/metabo13010067","article-title":"Current state and future perspectives on personalized metabolomics.","volume":"13","author":"Trifonova","year":"2023","journal-title":"Metabolites"},{"key":"B130","doi-asserted-by":"publisher","first-page":"e13209","DOI":"10.1111\/jne.13209","article-title":"Role of estrogen in women\u2019s Alzheimer\u2019s disease risk as modified by APOE.","volume":"35","author":"Valencia-Olvera","year":"2023","journal-title":"J. Neuroendocrinol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.3390\/cells11081367","article-title":"Blood-based biomarkers for Alzheimer\u2019s disease diagnosis and progression: An overview.","volume":"11","author":"Varesi","year":"2022","journal-title":"Cells"},{"key":"B132","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s12974-023-02850-6","article-title":"Alzheimer\u2019s disease-associated complement gene variants influence plasma complement protein levels.","volume":"20","author":"Veteleanu","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"B133","doi-asserted-by":"publisher","first-page":"1308500","DOI":"10.3389\/fmolb.2023.1308500","article-title":"NMR-based metabolomics in Alzheimer\u2019s disease research: A review.","volume":"10","author":"Vignoli","year":"2023","journal-title":"Front. Mol. Biosci."},{"key":"B134","doi-asserted-by":"publisher","first-page":"5970","DOI":"10.3390\/ijms25115970","article-title":"Epigenetics in Alzheimer\u2019s disease: A critical overview.","volume":"25","author":"Villa","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B135","doi-asserted-by":"publisher","first-page":"e395","DOI":"10.1212\/WNL.0000000000006852","article-title":"Brain myoinositol as a potential marker of amyloid-related pathology: A longitudinal study.","volume":"92","author":"Voevodskaya","year":"2019","journal-title":"Neurology"},{"key":"B136","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1016\/j.clnu.2024.04.039","article-title":"ESPEN guideline on nutrition and hydration in dementia - update 2024.","volume":"43","author":"Volkert","year":"2024","journal-title":"Clin. Nutr."},{"key":"B137","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.omtm.2021.03.021","article-title":"Synapsin-caveolin-1 gene therapy preserves neuronal and synaptic morphology and prevents neurodegeneration in a mouse model of AD.","volume":"21","author":"Wang","year":"2021","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"B138","doi-asserted-by":"publisher","first-page":"1200763","DOI":"10.3389\/fnins.2023.1200763","article-title":"Association between serum cystatin C level and cognition in older adults: A cross-sectional analysis.","volume":"17","author":"Wang","year":"2023","journal-title":"Front. Neurosci."},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X21992988","article-title":"Glycoside compounds from glycyrrhiza uralensis and their neuroprotective activities.","volume":"16","author":"Wei","year":"2021","journal-title":"Nat. Prod. Commun."},{"key":"B140","doi-asserted-by":"publisher","first-page":"4609","DOI":"10.1002\/alz.13042","article-title":"SCRN1: A cerebrospinal fluid biomarker correlating with tau in Alzheimer\u2019s disease.","volume":"19","author":"Weiner","year":"2023","journal-title":"Alzheimers Dement."},{"key":"B141","doi-asserted-by":"publisher","first-page":"e12219","DOI":"10.1002\/dad2.12219","article-title":"Neuropsychiatric symptoms in Brazilians with mild cognitive impairment and dementia.","volume":"13","author":"Wilson","year":"2021","journal-title":"Alzheimers Dement. (Amst)"},{"key":"B142","doi-asserted-by":"publisher","first-page":"5860","DOI":"10.1002\/alz.13390","article-title":"Artificial intelligence for biomarker discovery in Alzheimer\u2019s disease and dementia.","volume":"19","author":"Winchester","year":"2023","journal-title":"Alzheimers Dement."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1381894","DOI":"10.3389\/fonc.2024.1381894","article-title":"The deregulation of arachidonic acid metabolism in ovarian cancer.","volume":"14","author":"Xia","year":"2024","journal-title":"Front. Oncol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1016\/j.csbj.2020.08.031","article-title":"CRISPR-Cas systems: Overview, innovations and applications in human disease research and gene therapy.","volume":"18","author":"Xu","year":"2020","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"B145","doi-asserted-by":"publisher","first-page":"8417","DOI":"10.3390\/ijms24098417","article-title":"Presenilin-1 (PSEN1) mutations: Clinical phenotypes beyond Alzheimer\u2019s disease.","volume":"24","author":"Yang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B146","doi-asserted-by":"publisher","first-page":"4960","DOI":"10.3390\/ijms24054960","article-title":"Status of metabolomic measurement for insights in alzheimer\u2019s disease progression-what is missing?","volume":"24","author":"Yin","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B147","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.tins.2023.03.005","article-title":"Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer\u2019s disease.","volume":"46","author":"Young-Pearse","year":"2023","journal-title":"Trends Neurosci."},{"key":"B148","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13024-023-00636-1","article-title":"Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: Implications for preventive treatments of ischemic stroke and late-onset Alzheimer\u2019s disease.","volume":"18","author":"Yu","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"B149","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3390\/ph17010038","article-title":"Active compounds of panax ginseng in the improvement of Alzheimer\u2019s disease and application of spatial metabolomics.","volume":"17","author":"Zhang","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"key":"B150","doi-asserted-by":"publisher","first-page":"114692","DOI":"10.1016\/j.biopha.2023.114692","article-title":"Phytochemicals targeting lncRNAs: A novel direction for neuroprotection in neurological disorders.","volume":"162","author":"Zhao","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"B151","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1038\/s41593-023-01352-1","article-title":"\u03b22-Microglobulin coaggregates with A\u03b2 and contributes to amyloid pathology and cognitive deficits in Alzheimer\u2019s disease model mice.","volume":"26","author":"Zhao","year":"2023","journal-title":"Nat. Neurosci."},{"key":"B152","doi-asserted-by":"publisher","first-page":"5259","DOI":"10.3390\/ijms24065259","article-title":"Artemisia annua extract improves the cognitive deficits and reverses the pathological changes of Alzheimer\u2019s disease via regulating YAP signaling.","volume":"24","author":"Zhou","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B153","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3390\/geriatrics7020024","article-title":"The multifaceted role of neuroprotective plants in Alzheimer\u2019s disease treatment.","volume":"7","author":"Zieneldien","year":"2022","journal-title":"Geriatrics (Basel)"}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2025.1591796\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T05:35:15Z","timestamp":1753248915000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2025.1591796\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":153,"alternative-id":["10.3389\/fnagi.2025.1591796"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2025.1591796","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,23]]},"article-number":"1591796"}}