{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:16:52Z","timestamp":1793395012093,"version":"4.5.0"},"reference-count":113,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG062543"],"award-info":[{"award-number":["R01 AG062543"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21 AG077153"],"award-info":[{"award-number":["R21 AG077153"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The shift toward earlier detection in the Alzheimer's disease (AD) continuum underscores the need for more sensitive cognitive outcome assessments (COAs). Traditional COAs may lack precision in capturing cognitive dysfunction during preclinical stages. The Face-Name Associative Memory Exam (FNAME), a cross-modal task that integrates verbal and non-verbal memory, offers enhanced sensitivity and has shown associations with amyloid-\u03b2 burden across the AD continuum, even in asymptomatic older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This manuscript reports on two experiments, broadening insights into this promising COA. Experiment 1 (descriptive observational, repeated-measures design) (<jats:italic>N<\/jats:italic> = 85) evaluates the alternate form reliability of a modified FNAME (mFNAME) by serially administering eight distinct versions of the task, revealing good reliability for mFNAME metrics and the absence of significant practice effects. Experiment 2 (cross-sectional observational design) (<jats:italic>N<\/jats:italic> = 32) examines structural and functional network topology to investigate neural correlates of mFNAME performance in non-demented older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Experiment 1 demonstrated good alternate form reliability with no significant practice effect. Experiment 2 revealed significant associations between mFNAME performance and network properties like global efficiency, local efficiency, and system segregation in the default mode network (DMN) and medial temporal network (MTN). Subsequent analyses into more granular elements of the MTN and DMN revealed latent variables accounting for up to 44% of the covariance in mFNAME performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussions<\/jats:title><jats:p>These findings deepen the understanding of the FNAME's psychometric properties and the neural correlates underlying task performance, providing insights into its utility as a sensitive COA early in the continuum of AD and related dementias.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2025.1592678","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T05:31:58Z","timestamp":1753680718000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Advancing the modified face name associative memory exam in cognitive aging research: insights into connectomic correlates and task reliability"],"prefix":"10.3389","volume":"17","author":[{"given":"Yilin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Sundman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalen","family":"Hinderaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Yu-Chin Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob M.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisbeth G.","family":"Haaheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah M.","family":"Siu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Jezerc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parker","family":"Guss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-hui","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/978-1-62703-059-5_23","article-title":"Partial least squares methods: partial least squares correlation and partial least square regression","volume":"930","author":"Abdi","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0030017","article-title":"Efficiency and cost of economical brain functional networks","author":"Achard","year":"2007","journal-title":"PLoS Comput. Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"13953","DOI":"10.1038\/s41598-023-40092-x","article-title":"Functional network structure supports resilience to memory deficits in cognitively normal older adults with amyloid-beta pathology","volume":"13","author":"Adams","year":"2023","journal-title":"Sci. Rep."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1001\/archneur.65.11.1509","article-title":"Frequent amyloid deposition without significant cognitive impairment among the elderly","volume":"65","author":"Aizenstein","year":"2008","journal-title":"Arch. Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13195-020-00594-6","article-title":"A computerized version of the Short Form of the Face-Name Associative Memory Exam (FACEmemory\u00ae) for the early detection of Alzheimer's disease","volume":"12","author":"Alegret","year":"2020","journal-title":"Alzheimers. Res. Ther."},{"key":"B6","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1017\/S1355617721000084","article-title":"Validation and Normative Data of the Spanish Version of the Face Name Associative Memory Exam (S-FNAME)","volume":"28","author":"Alviarez-Schulze","year":"2022","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"B7","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.neuron.2007.10.038","article-title":"Disruption of large-scale brain systems in advanced aging","volume":"56","author":"Andrews-Hanna","year":"2007","journal-title":"Neuron"},{"key":"B8","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1198\/0003130031450","article-title":"Type I error inflation in the presence of a ceiling effect","volume":"57","author":"Austin","year":"2003","journal-title":"Am. Stat."},{"key":"B9","doi-asserted-by":"publisher","first-page":"S295","DOI":"10.1093\/ons\/opy261","article-title":"A connectomic Atlas of the human cerebrum-Chapter 7: the lateral parietal lobe","volume":"15","author":"Baker","year":"2018","journal-title":"Oper Neurosurg."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e3001275","DOI":"10.1371\/journal.pbio.3001275","article-title":"Intrinsic connectivity reveals functionally distinct cortico-hippocampal networks in the human brain","volume":"19","author":"Barnett","year":"2021","journal-title":"PLoS Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.neuroimage.2015.06.002","article-title":"Structural brain correlates of associative memory in older adults","volume":"118","author":"Becker","year":"2015","journal-title":"NeuroImage"},{"key":"B12","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.acn.2004.12.003","article-title":"Practice effects and the use of alternate forms in serial neuropsychological testing","volume":"20","author":"Beglinger","year":"2005","journal-title":"Arch. Clin. Neuropsychol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1007\/s11065-017-9361-5","article-title":"Neuropsychological measures that predict progression from mild cognitive impairment to Alzheimer's type dementia in older adults: a systematic review and meta-analysis","volume":"27","year":"2017","journal-title":"Neuropsychol. Rev."},{"key":"B14","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1076\/jcen.20.3.339.822","article-title":"Practice effects during repeated administrations of memory tests with and without alternate forms","volume":"20","author":"Benedict","year":"1998","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"292","DOI":"10.3389\/fnagi.2016.00292","article-title":"Global efficiency of structural networks mediates cognitive control in mild cognitive impairment","volume":"8","author":"Berlot","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1093\/brain\/awaa068","article-title":"Medial temporal lobe connectivity and its associations with cognition in early Alzheimer's disease","volume":"143","author":"Berron","year":"2020","journal-title":"Brain"},{"key":"B17","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3233\/JAD-140276","article-title":"Neuropsychological criteria for mild cognitive impairment improves diagnostic precision, biomarker associations, and progression rates","volume":"42","author":"Bondi","year":"2014","journal-title":"J. Alzheimers. Dis."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1196\/annals.1440.011","article-title":"The brain's default network: anatomy, function, and relevance to disease","volume":"1124","author":"Buckner","year":"2008","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3254","DOI":"10.1002\/hbm.26279","article-title":"The central role of the left inferior longitudinal fasciculus in the face-name retrieval network","volume":"44","author":"Burkhardt","year":"2023","journal-title":"Hum. Brain Mapp."},{"key":"B20","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1097\/WCO.0000000000001041","article-title":"Novel approaches to measuring neurocognitive functions in Alzheimer's disease clinical trials","volume":"35","author":"Carlson","year":"2022","journal-title":"Curr. Opin. Neurol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"12075","DOI":"10.1073\/pnas.1713308114","article-title":"Individual differences in associative memory among older adults explained by hippocampal subfield structure and function","volume":"114","author":"Carr","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B22","doi-asserted-by":"publisher","first-page":"10222","DOI":"10.1523\/JNEUROSCI.2250-06.2006","article-title":"Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis","volume":"26","author":"Celone","year":"2006","journal-title":"J. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"403","DOI":"10.3758\/BF03200930","article-title":"Feature memory and binding in young and older adults","volume":"24","author":"Chalfonte","year":"1996","journal-title":"Mem. Cognit."},{"key":"B24","doi-asserted-by":"publisher","first-page":"E4997","DOI":"10.1073\/pnas.1415122111","article-title":"Decreased segregation of brain systems across the healthy adult lifespan","volume":"111","author":"Chan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B25","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s00429-009-0218-4","article-title":"Measurement of spontaneous signal fluctuations in fMRI: adult age differences in intrinsic functional connectivity","volume":"213","author":"Chen","year":"2009","journal-title":"Brain Struct. Funct."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e2113778119","DOI":"10.1073\/pnas.2113778119","article-title":"Diffusion MRI-guided theta burst stimulation enhances memory and functional connectivity along the inferior longitudinal fasciculus in mild cognitive impairment","volume":"119","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1523\/JNEUROSCI.0949-21.2021","article-title":"Medial temporal lobe networks in Alzheimer's disease: structural and molecular vulnerabilities","volume":"42","author":"de Flores","year":"2022","journal-title":"J. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e14159","DOI":"10.1111\/psyp.14159","article-title":"The older adult brain is less modular, more integrated, and less efficient at rest: a systematic review of large-scale resting-state functional brain networks in aging","volume":"60","author":"Deery","year":"2023","journal-title":"Psychophysiology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"343","DOI":"10.2340\/16501977-0337","article-title":"How much change is true change? The minimum detectable change of the Berg Balance Scale in elderly people","volume":"41","author":"Donoghue","year":"2009","journal-title":"J. Rehabil. Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"618","DOI":"10.3233\/978-1-60750-024-7-618","article-title":"Validation of the impact of health information technology (I-HIT) scale: an international collaborative","volume":"146","author":"Dykes","year":"2009","journal-title":"Stud. Health Technol. Inform."},{"key":"B31","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1093\/arclin\/acaa107","article-title":"I know your face but can't remember your name: age-related differences in the FNAME-12NL","volume":"36","author":"Enriquez-Geppert","year":"2021","journal-title":"Arch. Clin. Neuropsychol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/s41592-018-0235-4","article-title":"fMRIPrep: a robust preprocessing pipeline for functional MRI","volume":"16","author":"Esteban","year":"2019","journal-title":"Nat. Methods"},{"key":"B33","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1093\/brain\/awab112","article-title":"Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease","volume":"144","author":"Ewers","year":"2021","journal-title":"Brain"},{"key":"B34","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/s41398-023-02420-7","article-title":"Cortical amyloid-beta burden is associated with changes in intracortical myelin in cognitively normal older adults","volume":"13","author":"Fernandez-Alvarez","year":"2023","journal-title":"Transl. Psychiatr."},{"key":"B35","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1080\/13803395.2021.1962252","article-title":"Worse associative memory recall in healthy older adults compared to young ones, a face-name study in Spain and Mexico","volume":"43","author":"Flores Vazquez","year":"2021","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"392","DOI":"10.3389\/fnins.2017.00392","article-title":"Effect of resting-state fNIRS scanning duration on functional brain connectivity and graph theory metrics of brain network","volume":"11","author":"Geng","year":"2017","journal-title":"Front. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/nature18933","article-title":"A multi-modal parcellation of human cerebral cortex","volume":"536","author":"Glasser","year":"2016","journal-title":"Nature"},{"key":"B38","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3233\/JAD-190468","article-title":"Recognition memory performance as a cognitive marker of prodromal Alzheimer's disease","volume":"72","author":"Goldstein","year":"2019","journal-title":"J. Alzheimers. Dis."},{"key":"B39","doi-asserted-by":"publisher","first-page":"100168","DOI":"10.1016\/j.ynirp.2023.100168","article-title":"Associative memory is more strongly predicted by age-related differences in the prefrontal cortex than medial temporal lobes","volume":"3","author":"Guardia","year":"2023","journal-title":"Neuroimage Rep."},{"key":"B40","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1093\/brain\/awm336","article-title":"11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment","volume":"131","author":"Jack","year":"2008","journal-title":"Brain"},{"key":"B41","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1037\/a0013008","article-title":"Recognition memory measures yield disproportionate effects of aging on learning face-name associations","volume":"23","author":"James","year":"2008","journal-title":"Psychol. Aging"},{"key":"B42","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1002\/alz.12773","article-title":"Why a clinical trial is as good as its outcome measure: a framework for the selection and use of cognitive outcome measures for clinical trials of Alzheimer's disease","volume":"19","author":"Jutten","year":"2023","journal-title":"Alzheimers. Dement."},{"key":"B43","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1212\/WNL.0b013e31822313dc","article-title":"Diffusion tensor imaging and cognitive function in older adults with no dementia","volume":"77","author":"Kantarci","year":"2011","journal-title":"Neurology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.brainres.2013.03.052","article-title":"Longitudinal white matter changes in Alzheimer's disease: a tractography-based analysis study","volume":"1515","author":"Kitamura","year":"2013","journal-title":"Brain Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.nicl.2017.01.021","article-title":"Face-name association task reveals memory networks in patients with left and right hippocampal sclerosis","volume":"14","author":"Klamer","year":"2017","journal-title":"Neuroimage Clin."},{"key":"B46","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1002\/hbm.24384","article-title":"Focal application of accelerated iTBS results in global changes in graph measures","volume":"40","author":"Klooster","year":"2019","journal-title":"Hum. Brain Mapp."},{"key":"B47","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jcm.2016.02.012","article-title":"A guideline of selecting and reporting intraclass correlation coefficients for reliability research","volume":"15","author":"Koo","year":"2016","journal-title":"J. Chiropr. Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.3389\/fpsyg.2020.02173","article-title":"Face-name associative memory performance among cognitively healthy individuals, individuals with subjective memory complaints, and patients with a diagnosis of aMCI","volume":"11","author":"Kormas","year":"2020","journal-title":"Front. Psychol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.neuroimage.2010.07.034","article-title":"Partial least squares (PLS) methods for neuroimaging: a tutorial and review","volume":"56","author":"Krishnan","year":"2011","journal-title":"NeuroImage"},{"key":"B50","doi-asserted-by":"publisher","first-page":"423","DOI":"10.3233\/JAD-170991","article-title":"The Alzheimer's disease assessment scale-cognitive subscale (ADAS-Cog): modifications and responsiveness in pre-dementia populations. a narrative review","volume":"63","author":"Kueper","year":"2018","journal-title":"J. Alzheimers. Dis."},{"key":"B51","doi-asserted-by":"publisher","first-page":"963","DOI":"10.2307\/2529876","article-title":"Random-effects models for longitudinal data","volume":"38","author":"Laird","year":"1982","journal-title":"Biometrics"},{"key":"B52","doi-asserted-by":"publisher","first-page":"6069","DOI":"10.1523\/JNEUROSCI.4286-15.2016","article-title":"Reconstructing perceived and retrieved faces from activity patterns in lateral parietal cortex","volume":"36","author":"Lee","year":"2016","journal-title":"J. Neurosci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1177\/1073191117691608","article-title":"Novel cognitive paradigms for the detection of memory impairment in preclinical Alzheimer's disease","volume":"25","author":"Loewenstein","year":"2018","journal-title":"Assessment"},{"key":"B54","doi-asserted-by":"publisher","first-page":"503235","DOI":"10.3389\/fneur.2020.503235","article-title":"Long longitudinal tract lesion contributes to the progression of Alzheimer's disease","volume":"11","author":"Luo","year":"2020","journal-title":"Front. Neurol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.bbadis.2011.08.003","article-title":"Diffusion tensor imaging of cerebral white matter integrity in cognitive aging","volume":"1822","author":"Madden","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"B56","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.1038\/s41598-018-37905-9","article-title":"Revealing the hippocampal connectome through super-resolution 1150-direction diffusion MRI","volume":"9","author":"Maller","year":"2019","journal-title":"Sci. Rep."},{"key":"B57","doi-asserted-by":"publisher","first-page":"P472","DOI":"10.1016\/j.jalz.2017.06.495","article-title":"What is the potential of Czech version of the face-name associative memory exam (CZ-FNAME-12) for assessing memory deficit?","volume":"13","author":"Mazancova","year":"2017","journal-title":"Alzheimers. Dement."},{"key":"B58","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/j.2044-8295.1987.tb02235.x","article-title":"Putting faces to names","volume":"78","author":"McWeeny","year":"1987","journal-title":"Br. J. Psychol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"4187","DOI":"10.1007\/s00429-017-1458-3","article-title":"Never forget a name: white matter connectivity predicts person memory","volume":"222","author":"Metoki","year":"2017","journal-title":"Brain Struct. Funct."},{"key":"B60","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1073\/pnas.0706818105","article-title":"Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation","volume":"105","author":"Miller","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B61","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.jalz.2016.06.2365","article-title":"Detecting cognitive changes in preclinical Alzheimer's disease: a review of its feasibility","volume":"13","author":"Mortamais","year":"2017","journal-title":"Alzheimers. Dement."},{"key":"B62","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1037\/0882-7974.19.3.541","article-title":"The associative memory deficit of older adults: further support using face-name associations","volume":"19","author":"Naveh-Benjamin","year":"2004","journal-title":"Psychol. Aging"},{"key":"B63","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1093\/brain\/awq283","article-title":"What is the role of the uncinate fasciculus? Surgical removal and proper name retrieval","volume":"134","author":"Papagno","year":"2011","journal-title":"Brain"},{"key":"B64","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1097\/JGP.0b013e318162a0a9","article-title":"Impaired medial temporal repetition suppression is related to failure of parietal deactivation in Alzheimer disease","volume":"16","author":"Pihlajamaki","year":"2008","journal-title":"Am. J. Geriatr. Psychiatr."},{"key":"B65","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.neuron.2011.09.006","article-title":"Functional network organization of the human brain","volume":"72","author":"Power","year":"2011","journal-title":"Neuron"},{"key":"B66","doi-asserted-by":"publisher","first-page":"859440","DOI":"10.3389\/fnins.2022.859440","article-title":"Improved functional organization in patients with primary insomnia after individually-targeted transcranial magnetic stimulation","volume":"16","author":"Qi","year":"2022","journal-title":"Front. Neurosci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1146\/annurev-neuro-071013-014030","article-title":"The brain's default mode network","volume":"38","author":"Raichle","year":"2015","journal-title":"Annu. Rev. Neurosci."},{"key":"B68","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/nrn3338","article-title":"Two cortical systems for memory-guided behaviour","volume":"13","author":"Ranganath","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1212\/WNL.0b013e31828c2ee5","article-title":"Disruption of cerebral networks and cognitive impairment in Alzheimer disease","volume":"80","author":"Reijmer","year":"2013","journal-title":"Neurology"},{"key":"B70","doi-asserted-by":"publisher","first-page":"2776","DOI":"10.1016\/j.neuropsychologia.2011.06.006","article-title":"Face-name associative memory performance is related to amyloid burden in normal elderly","volume":"49","author":"Rentz","year":"2011","journal-title":"Neuropsychologia"},{"key":"B71","doi-asserted-by":"publisher","first-page":"e12473","DOI":"10.1002\/dad2.12473","article-title":"Face name associative memory exam and biomarker status in the ARMADA study: advancing reliable measurement in Alzheimer's disease and cognitive aging","volume":"15","author":"Rentz","year":"2023","journal-title":"Alzheimers. Dement."},{"key":"B72","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1002\/ana.21904","article-title":"Cognition, reserve, and amyloid deposition in normal aging","volume":"67","author":"Rentz","year":"2010","journal-title":"Ann. Neurol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1097\/GME.0000000000000771","article-title":"Sex differences in episodic memory in early midlife: impact of reproductive aging","volume":"24","author":"Rentz","year":"2017","journal-title":"Menopause"},{"key":"B74","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jalz.2016.07.154","article-title":"Recommended cognitive outcomes in preclinical Alzheimer's disease: consensus statement from the European prevention of Alzheimer's Dementia project","volume":"13","author":"Ritchie","year":"2017","journal-title":"Alzheimers. Dement."},{"key":"B75","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1002\/hbm.26089","article-title":"The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation","volume":"44","author":"Rolls","year":"2023","journal-title":"Hum. Brain Mapp."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.3389\/fpsyg.2018.01464","article-title":"The face-name associative memory test as a tool for early diagnosis of Alzheimer's Disease","volume":"9","author":"Rubi\u00f1o","year":"2018","journal-title":"Front. Psychol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"147","DOI":"10.7358\/neur-2025-037-rubi","article-title":"Associative memory and memory complaints in people with first episode of depression:  use of the face-name associative memory exam (FNAME)","volume":"37","author":"Rubino","year":"2025","journal-title":"Neuropsychol. Trends."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.neuroimage.2009.10.003","article-title":"Complex network measures of brain connectivity: uses and interpretations","volume":"52","author":"Rubinov","year":"2010","journal-title":"NeuroImage"},{"key":"B79","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1016\/j.neurobiolaging.2014.04.007","article-title":"Changes in whole-brain functional networks and memory performance in aging","volume":"35","author":"Sala-Llonch","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"B80","doi-asserted-by":"publisher","first-page":"S423","DOI":"10.1093\/ons\/opy265","article-title":"A connectomic atlas of the human cerebrum-chapter 11: tractographic description of the inferior longitudinal fasciculus","volume":"15","author":"Sali","year":"2018","journal-title":"Oper Neurosurg."},{"key":"B81","doi-asserted-by":"publisher","first-page":"3828","DOI":"10.1038\/s41598-018-21644-y","article-title":"The Spanish version of face-name associative memory exam (S-FNAME) performance is related to amyloid burden in subjective cognitive decline","volume":"8","author":"Sanabria","year":"2018","journal-title":"Sci. Rep."},{"key":"B82","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3389\/fnins.2013.00032","article-title":"White matter correlates of cognitive domains in normal aging with diffusion tensor imaging","volume":"7","author":"Sasson","year":"2013","journal-title":"Front. Neurosci."},{"key":"B83","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1148\/radiol.12112361","article-title":"Disrupted topological organization in white matter structural networks in amnestic mild cognitive impairment: relationship to subtype","volume":"265","author":"Shu","year":"2012","journal-title":"Radiology"},{"key":"B84","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/nrn1178","article-title":"Prefrontal and medial temporal lobe interactions in long-term memory","volume":"4","author":"Simons","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"B85","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/s41583-021-00474-4","article-title":"The default mode network in cognition: a topographical perspective","volume":"22","author":"Smallwood","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1016\/S1053-8119(03)00391-4","article-title":"Putting names to faces: successful encoding of associative memories activates the anterior hippocampal formation","volume":"20","author":"Sperling","year":"2003","journal-title":"NeuroImage"},{"key":"B87","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.neuron.2009.07.003","article-title":"Amyloid deposition is associated with impaired default network function in older persons without dementia","volume":"63","author":"Sperling","year":"2009","journal-title":"Neuron"},{"key":"B88","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1101\/lm.40701","article-title":"Simple and associative recognition memory in the hippocampal region","volume":"8","author":"Stark","year":"2001","journal-title":"Learn. Mem."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1001\/archneurol.2009.272","article-title":"Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta deposition","volume":"66","author":"Storandt","year":"2009","journal-title":"Arch. Neurol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1162\/jocn_a_01300","article-title":"Hippocampal-targeted theta-burst stimulation enhances associative memory formation","volume":"30","author":"Tambini","year":"2018","journal-title":"J. Cogn. Neurosci."},{"key":"B91","doi-asserted-by":"publisher","first-page":"4365","DOI":"10.1523\/JNEUROSCI.2102-18.2018","article-title":"Multimodal integration and vividness in the angular gyrus during episodic encoding and retrieval","volume":"39","author":"Tibon","year":"2019","journal-title":"J. Neurosci."},{"key":"B92","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1162\/jocn.2009.21349","article-title":"Dissociable roles of the anterior temporal regions in successful encoding of memory for person identity information","volume":"22","author":"Tsukiura","year":"2010","journal-title":"J. Cogn. Neurosci."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/j.neurobiolaging.2011.01.003","article-title":"Age and amyloid-related alterations in default network habituation to stimulus repetition","volume":"33","author":"Vannini","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"B94","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1093\/cercor\/bhq051","article-title":"What goes down must come up: role of the posteromedial cortices in encoding and retrieval","volume":"21","author":"Vannini","year":"2011","journal-title":"Cereb. Cortex"},{"key":"B95","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s13195-020-00671-w","article-title":"The Latin American Spanish version of the face-name associative memory exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant Alzheimer's disease","volume":"12","author":"Vila-Castelar","year":"2020","journal-title":"Alzheimers. Res. Ther."},{"key":"B96","doi-asserted-by":"publisher","first-page":"17763","DOI":"10.1073\/pnas.1010461107","article-title":"Spatial correlation between brain aerobic glycolysis and amyloid-\u03b2 (A\u03b2) deposition","volume":"107","author":"Vlassenko","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1093\/brain\/awt094","article-title":"Dissecting the uncinate fasciculus: disorders, controversies and a hypothesis","volume":"136","author":"Von Der Heide","year":"","journal-title":"Brain"},{"key":"B98","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3389\/fnhum.2013.00017","article-title":"Anterior temporal face patches: a meta-analysis and empirical study","volume":"7","author":"Von Der Heide","year":"","journal-title":"Front. Hum. Neurosci."},{"key":"B99","doi-asserted-by":"publisher","first-page":"e21976","DOI":"10.1371\/journal.pone.0021976","article-title":"Graph theoretical analysis of functional brain networks: test-retest evaluation on short- and long-term resting-state functional MRI data","volume":"6","author":"Wang","year":"2011","journal-title":"PLoS ONE"},{"key":"B100","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1126\/science.1252900","article-title":"Targeted enhancement of cortical-hippocampal brain networks and associative memory","volume":"345","author":"Wang","year":"2014","journal-title":"Science"},{"key":"B101","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.neurobiolaging.2014.06.028","article-title":"Relationships between default-mode network connectivity, medial temporal lobe structure, and age-related memory deficits","volume":"36","author":"Ward","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"B102","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1002\/hbm.22234","article-title":"The parahippocampal gyrus links the default-mode cortical network with the medial temporal lobe memory system","volume":"35","author":"Ward","year":"2014","journal-title":"Hum. Brain Mapp."},{"key":"B103","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1080\/13803390701377829","article-title":"The nature of cognitive complaints in healthy older adults with and without objective memory decline","volume":"30","author":"Weaver Cargin","year":"2008","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/WAD.0000000000000223","article-title":"Version 3 of the Alzheimer Disease Centers' neuropsychological test battery in the uniform data set (UDS)","volume":"32","author":"Weintraub","year":"2018","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"B105","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/S0010-9452(08)70689-0","article-title":"Are faces special in Alzheimer's disease? Cognitive conceptualisation, neural correlates, and diagnostic relevance of impaired memory for faces and names","volume":"43","author":"Werheid","year":"2007","journal-title":"Cortex"},{"key":"B106","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1002\/hbm.21316","article-title":"Medial temporal contributions to successful face-name learning","volume":"33","author":"Westerberg","year":"2012","journal-title":"Hum. Brain Mapp."},{"key":"B107","doi-asserted-by":"publisher","first-page":"5553","DOI":"10.1523\/JNEUROSCI.4409-12.2013","article-title":"Alzheimer's disease neurodegenerative biomarkers are associated with decreased cognitive function but not beta-amyloid in cognitively normal older individuals","volume":"33","author":"Wirth","year":"2013","journal-title":"J. Neurosci."},{"key":"B108","doi-asserted-by":"publisher","first-page":"676618","DOI":"10.3389\/fnagi.2021.676618","article-title":"A graph theory approach to clarifying aging and disease related changes in cognitive networks","volume":"13","author":"Wright","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"J. Neurophysiol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1037\/0096-1523.12.4.466","article-title":"Face-name interference","volume":"12","author":"Young","year":"1986","journal-title":"J. Exp. Psychol. Hum. Percept. Perform."},{"key":"B111","doi-asserted-by":"publisher","first-page":"e12414","DOI":"10.1002\/dad2.12414","article-title":"Computerized cognitive practice effects in relation to amyloid and tau in preclinical Alzheimer's disease: results from a multi-site cohort","volume":"15","author":"Young","year":"2023","journal-title":"Alzheimers. Dement."},{"key":"B112","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1126\/science.1077775","article-title":"Dynamics of the hippocampus during encoding and retrieval of face-name pairs","volume":"299","author":"Zeineh","year":"2003","journal-title":"Science"},{"key":"B113","doi-asserted-by":"publisher","first-page":"1486835","DOI":"10.3389\/fpsyt.2025.1486835","article-title":"Improved brain functional network in major depressive disorder with suicidal ideation after individual target-transcranial magnetic stimulation treatment: a graph-theory analysis","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Psychiatr."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2025.1592678\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T05:32:00Z","timestamp":1753680720000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2025.1592678\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,28]]},"references-count":113,"alternative-id":["10.3389\/fnagi.2025.1592678"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2025.1592678","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,28]]},"article-number":"1592678"}}