{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:41:09Z","timestamp":1793400069489,"version":"4.5.0"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Frailty is significantly more prevalent in individuals with Parkinson\u2019s disease (PD) than in general population, yet the underlying neuropathophysiological mechanisms remain poorly understood. This study aimed to characterize the clinical features and cerebral metabolic patterns of frail PD patients using [\n                      <jats:sup>18<\/jats:sup>\n                      F]-fluorodeoxyglucose positron emission tomography (\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG PET), and to explore the potential pathophysiological mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 64 PD patients treated at Shenzhen People\u2019s Hospital underwent\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG PET\/MR imaging during June-December 2024. Age- and sex-matched healthy controls were also recruited (\n                      <jats:italic>n<\/jats:italic>\n                      = 17). For PD patients, frailty was assessed using the Fried criteria. Patient demography, cognitive performance, and clinical variables\u2014including UPDRS-III scores\u2014were compared between frail and non-frail PD patients. Regional brain metabolism, measured as\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG SUVr, was analyzed in brain regions defined by the Automated Anatomical Labeling (AAL) atlas.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the PD cohort (mean age: 66.86 \u00b1 6.97 years; 30 female), 34 were classified as non-frail (mean age: 64.29 \u00b1 6.61 years; 16 female) and 30 as frail (mean age: 69.77 \u00b1 6.17 years; 14 female). Compared to the non-frail group, frail PD patients were significantly older (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001) and exhibited more severe motor symptoms (UPDRS-III,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001; modified Hoehn &amp;amp; Yahr (Modified H&amp;amp;Y) stage,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.028), along with greater cognitive impairment (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001). Although the daily levodopa equivalent dose did not differ significantly between groups (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.076), a trend toward higher dosage was observed in the frail group.\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG PET\/MR analysis revealed significantly reduced glucose metabolism in 13 brain regions in frail PD patients compared to non-frail patients: Frontal_Mid_L (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0056), Frontal_Mid_Orb_L (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0045), Frontal_Inf_Tri_R (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0053), Occipital_Mid_L (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0035), Occipital_Inf_L (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0053), Parietal_Inf_R (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0003), Angular_L (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0015), Angular_R (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0003), Caudate_L (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0052), Caudate_R (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0019), Temporal_Mid_R (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0040), Temporal_Inf_L (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0048), and Temporal_Inf_R (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0046). Correlation analyses revealed distinct region-function associations in the cognitive domains of frail PD patients. Regression analysis indicated that hypometabolism in the Temporal_Inf_R was significantly associated with UPDRS-III scores in the frail group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Frailty in PD is associated with advanced age, greater motor severity, and possibly increased medication needs. Frail PD patients exhibit specific patterns of cerebral hypometabolism and more severe cognitive deficits. Distinct brain regions are differentially associated with specific cognitive domains. Notably, reduced metabolism in the Temporal_Inf_R is significantly related to motor symptom severity in frail PD, suggesting a key region in the pathophysiology of frailty in PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2025.1624203","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T06:53:07Z","timestamp":1769064787000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["18F-FDG PET\/MR reveals specific brain metabolic features in Parkinson\u2019s disease with frailty"],"prefix":"10.3389","volume":"17","author":[{"given":"Guoyang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, Second Clinical Medical College of Jinan University, Shenzhen People\u2019s Hospital","place":["Guangdong, China"]},{"name":"Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People\u2019s Hospital, Shenzhen","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Second Clinical Medical College of Jinan University, Shenzhen People\u2019s Hospital","place":["Guangdong, China"]},{"name":"Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People\u2019s Hospital, Shenzhen","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengju","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Second Clinical Medical College of Jinan University, Shenzhen People\u2019s Hospital","place":["Guangdong, China"]},{"name":"Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People\u2019s Hospital, Shenzhen","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"United Imaging Healthcare Group Co., Ltd.","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Sun","sequence":"additional","affiliation":[{"name":"United Imaging Healthcare Group Co., Ltd.","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[{"name":"United Imaging Healthcare Group Co., Ltd.","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangcheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Second Clinical Medical College of Jinan University, Shenzhen People\u2019s Hospital","place":["Guangdong, China"]},{"name":"Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People\u2019s Hospital, Shenzhen","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.parkreldis.2007.10.004","article-title":"Frailty in Parkinson\u2019s disease and its clinical implications.","volume":"14","author":"Ahmed","year":"2008","journal-title":"Parkinsonism Relat. 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