{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T16:31:56Z","timestamp":1793205116982,"version":"4.5.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"\n Objective<\/jats:title>\n To characterize abnormal functional connectivity in dementia with Lewy bodies (DLB) and its association with cognitive impairment using resting-state functional magnetic resonance imaging (rs-fMRI).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Sixty-eight DLB patients and 38 age-, sex-, and education-matched healthy controls underwent neuropsychological assessments (MoCA, MMSE) and rs-fMRI. Imaging analyses included seed-based functional connectivity (sFC), independent component analysis (ICA), regional homogeneity (ReHo), fractional amplitude of low-frequency fluctuations (fALFF), and graph-theoretical network metrics (small-worldness, global\/local efficiency).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n DLB patients exhibited significantly reduced FC in the default mode network (DMN) and visual network, including PCC\u2013AG (\n P<\/jats:italic>\n &lt; 0.001) and PCC\u2013mPFC (\n P<\/jats:italic>\n &lt; 0.001). ReHo and fALFF indicated decreased local neural synchronization and low-frequency activity in the posterior occipital lobe (fALFF:\n P<\/jats:italic>\n = 0.004), angular gyrus (fALFF:\n P<\/jats:italic>\n = 0.001), left temporal pole (fALFF:\n P<\/jats:italic>\n &lt; 0.001), left parietal (ReHo:\n P<\/jats:italic>\n &lt; 0.001), and posterior cerebellar lobe (ReHo:\n P<\/jats:italic>\n &lt; 0.001). Graph theory revealed impaired global network topology in DLB, with decreased small-worldness (\n P<\/jats:italic>\n &lt; 0.001) and global efficiency (\n P<\/jats:italic>\n &lt; 0.001). PCC\u2013AG connectivity positively correlated with the MoCA total score (\n r<\/jats:italic>\n = 0.53,\n P<\/jats:italic>\n &lt; 0.001), attention (\n r<\/jats:italic>\n = 0.46,\n P<\/jats:italic>\n &lt; 0.001), executive (\n r<\/jats:italic>\n = 0.41,\n P<\/jats:italic>\n &lt; 0.001), and language function (\n r<\/jats:italic>\n = 0.34,\n P<\/jats:italic>\n &lt; 0.001). Posterior occipital fALFF and left parietal ReHo showed significant positive correlations with multiple cognitive domains, including visuospatial ability (\n r<\/jats:italic>\n = 0.34,\n P<\/jats:italic>\n &lt; 0.001 for fALFF;\n r<\/jats:italic>\n = 0.42,\n P<\/jats:italic>\n &lt; 0.001 for ReHo) and memory (\n r<\/jats:italic>\n = 0.45,\n P<\/jats:italic>\n &lt; 0.001 for fALFF;\n r<\/jats:italic>\n = 0.27,\n P<\/jats:italic>\n = 0.006 for ReHo). A combined model of PCC\u2013AG connectivity, fALFF, and small-worldness predicted 42% of MoCA variance (\n R<\/jats:italic>\n 2<\/jats:sup>\n = 0.42,\n P<\/jats:italic>\n &lt; 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n DLB is characterized by DMN and visual network dysfunction, disrupted local neural activity, and impaired global network integration. These rs-fMRI metrics may serve as potential biomarkers for cognitive deficits in DLB.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fnagi.2025.1630826","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T14:19:25Z","timestamp":1763561965000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Dysfunctional default mode and visual networks underlie cognitive deficits in dementia with Lewy bodies: a resting-state fMRI study"],"prefix":"10.3389","volume":"17","author":[{"given":"Zhou","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengran","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuechang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyu","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.neuron.2010.02.005","article-title":"Functional-anatomic fractionation of the brain\u2019s default network.","volume":"65","author":"Andrews-Hanna","year":"2010","journal-title":"Neuron"},{"key":"B2","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.neurobiolaging.2017.12.023","article-title":"Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer\u2019s and Lewy body diseases: An EEG study.","volume":"65","author":"Babiloni","year":"2018","journal-title":"Neurobiol. 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