{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:58:30Z","timestamp":1793735910063,"version":"4.6.1"},"reference-count":316,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder characterized by the accumulation of amyloid-beta (A\u03b2) in the walls of cerebral vessels. It is commonly associated with cognitive decline, cerebral hemorrhage, and other neurological pathologies. Despite its prevalence and impact, there are currently no approved treatments for CAA. CAA frequently co-occurs with Alzheimer\u2019s disease (AD), but affected patients are often excluded from anti-amyloid therapies due to increased risks of cerebral edema and hemorrhage, underscoring the urgent need for alternative and safe approaches for treating individuals with CAA. Over the years, various animal models have been developed to investigate the pathophysiology of CAA and evaluate potential treatments. Recent studies have demonstrated that certain repurposed drugs, originally approved for other conditions, show promise for treating CAA. Additionally, it has been shown that positive lifestyle changes may benefit vascular health, reduce amyloid burden and neuroinflammation, and improve cognitive resilience in individuals with CAA. In this review, we summarize the current knowledge on CAA, its relationship with AD, insights from preclinical and clinical studies, and emerging evidence supporting the potential of drug repurposing and lifestyle modification in managing CAA.<\/jats:p>","DOI":"10.3389\/fnagi.2025.1632252","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:34:43Z","timestamp":1758000883000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Cerebral amyloid angiopathy: a narrative review"],"prefix":"10.3389","volume":"17","author":[{"given":"Natalia Motzko","family":"Noto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Speth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa S.","family":"Robison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e230009","DOI":"10.1148\/rg.230009","article-title":"Amyloid-related imaging abnormalities in alzheimer disease treated with anti-amyloid-\u03b2 Therapy.","volume":"43","author":"Agarwal","year":"2023","journal-title":"Radiographics"},{"key":"B2","doi-asserted-by":"publisher","first-page":"102","DOI":"10.5114\/aoms.2011.20612","article-title":"Tramiprosate in mild-to-moderate Alzheimer\u2019s disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study).","volume":"7","author":"Aisen","year":"2011","journal-title":"Arch. Med. Sci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"26331055221109254","DOI":"10.1177\/26331055221109254","article-title":"Paradoxically reduces cerebral blood flow in Alzheimer\u2019s Disease mice.","volume":"17","author":"Ali","year":"2022","journal-title":"Neurosci. Insights"},{"key":"B4","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1093\/ijnp\/pyaa046","article-title":"Serum VEGF predicts clinical improvement induced by cerebrolysin plus donepezil in patients with advanced Alzheimer\u2019s Disease.","volume":"23","author":"Alvarez","year":"2020","journal-title":"Int. J. Neuropsychopharmacol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s13195-021-00831-6","article-title":"Anticancer drugs repurposed for Alzheimer\u2019s disease: A systematic review.","volume":"13","author":"Ancidoni","year":"2021","journal-title":"Alzheimers Res. Ther"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.3233\/JAD-160674","article-title":"Intensive \u2018Brain Training\u2019 intervention fails to reduce amyloid pathologies or cognitive deficits in transgenic mouse models of Alzheimer\u2019s Disease.","volume":"55","author":"Anderson","year":"2017","journal-title":"J. Alzheimers Dis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"11134","DOI":"10.3390\/ijms241311134","article-title":"Effects of voluntary physical exercise on the neurovascular unit in a mouse model of Alzheimer\u2019s Disease.","volume":"24","author":"Andrade-Guerrero","year":"2023","journal-title":"Int. J. Mol. Sci"},{"key":"B8","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.neuro.2022.02.002","article-title":"Biological determinants impact the neurovascular toxicity of nicotine and tobacco smoke: A pharmacokinetic and pharmacodynamics perspective.","volume":"89","author":"Archie","year":"2022","journal-title":"Neurotoxicology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1097\/01.wnr.0000137183.68847.4e","article-title":"Environmental enrichment improves cognition in aged Alzheimer\u2019s transgenic mice despite stable beta-amyloid deposition.","volume":"15","author":"Arendash","year":"2004","journal-title":"Neuroreport"},{"key":"B10","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1161\/STROKEAHA.109.563932","article-title":"Effects of perindopril-based lowering of blood pressure on intracerebral hemorrhage related to amyloid angiopathy: The PROGRESS trial.","volume":"41","author":"Arima","year":"2010","journal-title":"Stroke"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.3233\/JAD-215276","article-title":"Neuropsychiatric inventory-questionnaire assessed nighttime behaviors in cognitively asymptomatic patients with pathologically confirmed Alzheimer\u2019s Disease predict more rapid cognitive deterioration.","volume":"86","author":"Atayde","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"B12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1001\/jamaneurol.2015.4078","article-title":"Validation of clinicoradiological criteria for the diagnosis of cerebral amyloid angiopathy-related inflammation.","volume":"73","author":"Auriel","year":"2016","journal-title":"JAMA Neurol"},{"key":"B13","first-page":"74","article-title":"Cerebral amyloid angiopathy: An important differential diagnosis of stroke in the elderly.","volume":"22","author":"Azmin","year":"2015","journal-title":"Malays J. Med. Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1111\/jnc.13195","article-title":"Short-term modern life-like stress exacerbates A\u03b2-pathology and synapse loss in 3xTg-AD mice.","volume":"134","author":"Baglietto-Vargas","year":"2015","journal-title":"J. Neurochem"},{"key":"B15","doi-asserted-by":"publisher","first-page":"106345","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106345","article-title":"Letter to the editor, regarding \u201cPreceding head trauma in four cases of sporadic cerebral amyloid angiopathy - case report series\u201d recently published by Oblak and colleagues.","volume":"31","author":"Banerjee","year":"2022","journal-title":"J. Stroke Cerebrovasc. Dis"},{"key":"B16","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1136\/jnnp-2016-314697","article-title":"The increasing impact of cerebral amyloid angiopathy: Essential new insights for clinical practice.","volume":"88","author":"Banerjee","year":"2017","journal-title":"J. Neurol Neurosurg. Psychiatry"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2022-328792","article-title":"Iatrogenic cerebral amyloid angiopathy: An emerging clinical phenomenon.","author":"Banerjee","year":"2022","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B18","doi-asserted-by":"publisher","first-page":"211","DOI":"10.14283\/jpad.2022.21","article-title":"Detection and management of amyloid-related imaging abnormalities in patients with Alzheimer\u2019s disease treated with anti-amyloid beta therapy.","volume":"9","author":"Barakos","year":"2022","journal-title":"J. Prev. Alzheimers Dis"},{"key":"B19","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/S1474-4422(11)70072-2","article-title":"The projected effect of risk factor reduction on Alzheimer\u2019s disease prevalence.","volume":"10","author":"Barnes","year":"2011","journal-title":"Lancet Neurol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1037\/pag0000442","article-title":"Differential effects of cognitive training modules in healthy aging and mild cognitive impairment: A comprehensive meta-analysis of randomized controlled trials.","volume":"35","author":"Basak","year":"2020","journal-title":"Psychol. Aging"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1056\/NEJMoa2304430","article-title":"Two phase 3 trials of gantenerumab in early Alzheimer\u2019s Disease.","volume":"389","author":"Bateman","year":"2023","journal-title":"N. Engl. J. Med"},{"key":"B22","doi-asserted-by":"publisher","first-page":"6027","DOI":"10.1073\/pnas.0708193105","article-title":"Role of the familial Dutch mutation E22Q in the folding and aggregation of the 15-28 fragment of the Alzheimer amyloid-beta protein.","volume":"105","author":"Baumketner","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e033464","DOI":"10.1161\/JAHA.123.033464","article-title":"Minocycline in severe cerebral amyloid angiopathy: A single-center cohort study.","volume":"13","author":"Bax","year":"2024","journal-title":"J. Am. Heart Assoc"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1111\/j.1460-9568.2004.03587.x","article-title":"Environmental enrichment in mice decreases anxiety, attenuates stress responses and enhances natural killer cell activity.","volume":"20","author":"Benaroya-Milshtein","year":"2004","journal-title":"Eur. J. Neurosci"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3988\/jcn.2011.7.1.1","article-title":"Cerebral amyloid angiopathy: A systematic review.","volume":"7","author":"Biffi","year":"2011","journal-title":"J. Clin. Neurol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1001\/jama.2015.10082","article-title":"Association between blood pressure control and risk of recurrent intracerebral hemorrhage.","volume":"314","author":"Biffi","year":"2015","journal-title":"JAMA"},{"key":"B27","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1212\/WNL.0b013e3181eee40f","article-title":"Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy.","volume":"75","author":"Biffi","year":"2010","journal-title":"Neurology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1523\/JNEUROSCI.4800-06.2007","article-title":"Learning decreases A beta*56 and tau pathology and ameliorates behavioral decline in 3xTg-AD mice.","volume":"27","author":"Billings","year":"2007","journal-title":"J. Neurosci"},{"key":"B29","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1002\/hipo.22103","article-title":"Short-term environmental enrichment, in the absence of exercise, improves memory, and increases NGF concentration, early neuronal survival, and synaptogenesis in the dentate gyrus in a time-dependent manner.","volume":"23","author":"Birch","year":"2013","journal-title":"Hippocampus"},{"key":"B30","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3389\/fnagi.2013.00026","article-title":"Brain injury, neuroinflammation and Alzheimer\u2019s disease.","volume":"5","author":"Breunig","year":"2013","journal-title":"Front. Aging Neurosci"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2025.07.012","article-title":"Transthyretin variant cerebral amyloid angiopathy fulfilling the modified Boston criteria: Retrospective data from the Bic\u00eatre hospital cohort.","author":"Brunet de Courssou","year":"2025","journal-title":"Rev. Neurol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e1911","DOI":"10.1212\/WNL.0000000000005552","article-title":"Brain pathology is related to total daily physical activity in older adults.","volume":"90","author":"Buchman","year":"2018","journal-title":"Neurology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s40478-018-0511-7","article-title":"Intravenous injection of beta-amyloid seeds promotes cerebral amyloid angiopathy (CAA).","volume":"6","author":"Burwinkel","year":"2018","journal-title":"Acta Neuropathol. Commun"},{"key":"B34","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1080\/13506129.2024.2405948","article-title":"Amyloid nomenclature 2024: Update, novel proteins, and recommendations by the International Society of Amyloidosis (ISA) Nomenclature Committee.","volume":"31","author":"Buxbaum","year":"2024","journal-title":"Amyloid"},{"key":"B35","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.neurobiolaging.2015.10.010","article-title":"The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer\u2019s disease of humans and mice.","volume":"37","author":"Cacciottolo","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"B36","doi-asserted-by":"publisher","first-page":"14436","DOI":"10.1523\/JNEUROSCI.3836-11.2011","article-title":"Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy.","volume":"31","author":"Carroll","year":"2011","journal-title":"J. Neurosci"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e2469","DOI":"10.1212\/WNL.0000000000011932","article-title":"Contribution of racial and ethnic differences in cerebral small vessel disease subtype and burden to risk of cerebral hemorrhage recurrence.","volume":"96","author":"Castello","year":"2021","journal-title":"Neurology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e754","DOI":"10.1212\/WNL.0000000000005030","article-title":"Core cerebrospinal fluid biomarker profile in cerebral amyloid angiopathy: A meta-analysis.","volume":"90","author":"Charidimou","year":"2018","journal-title":"Neurology"},{"key":"B39","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/s00234-013-1175-4","article-title":"Cerebral microbleeds: A guide to detection and clinical relevance in different disease settings.","volume":"55","author":"Charidimou","year":"2013","journal-title":"Neuroradiology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e358","DOI":"10.1212\/WNL.0000000000007818","article-title":"APOE and cortical superficial siderosis in CAA: Meta-analysis and potential mechanisms.","volume":"93","author":"Charidimou","year":"2019","journal-title":"Neurology"},{"key":"B41","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1111\/j.1747-4949.2010.00466.x","article-title":"Cerebral amyloid angiopathy in East and West.","volume":"5","author":"Chen","year":"2010","journal-title":"Int J Stroke"},{"key":"B42","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1111\/ggi.14542","article-title":"Cognitive effects of cilostazol in Alzheimer\u2019s dementia patients with peripheral arterial occlusive disease: A case-control study.","volume":"23","author":"Chien","year":"2023","journal-title":"Geriatr. Gerontol. Int"},{"key":"B43","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1097\/HJH.0000000000000086","article-title":"Angiotension receptor blockers reduce the risk of dementia.","volume":"32","author":"Chiu","year":"2014","journal-title":"J. Hypertens"},{"key":"B44","doi-asserted-by":"publisher","first-page":"117425","DOI":"10.1016\/j.jns.2021.117425","article-title":"Cerebral amyloid angiopathy and related inflammatory disorders.","volume":"424","author":"Chwalisz","year":"2021","journal-title":"J. Neurol Sci"},{"key":"B45","doi-asserted-by":"publisher","first-page":"11993","DOI":"10.1073\/pnas.91.25.11993","article-title":"Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.","volume":"91","author":"Citron","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"B46","doi-asserted-by":"publisher","first-page":"e084521","DOI":"10.1002\/alz.084521","article-title":"Single ascending dose results from an ongoing Phase 1 study of mivelsiran (ALN-APP), the first investigational RNA interference therapeutic targeting amyloid precursor protein for Alzheimer\u2019s disease.","volume":"20","author":"Cohen","year":"2024","journal-title":"Alzheimer\u2019s Dement."},{"key":"B47","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.physbeh.2015.06.008","article-title":"Effects of high-fat diet exposure on learning & memory.","volume":"152","author":"Cordner","year":"2015","journal-title":"Physiol. Behav."},{"key":"B48","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.neurobiolaging.2006.04.009","article-title":"Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms.","volume":"28","author":"Costa","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"B49","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/s0166-2236(02)02143-4","article-title":"Exercise: A behavioral intervention to enhance brain health and plasticity.","volume":"25","author":"Cotman","year":"2002","journal-title":"Trends Neurosci"},{"key":"B50","doi-asserted-by":"publisher","first-page":"120866","DOI":"10.1016\/j.jns.2023.120866","article-title":"Exploring cerebral amyloid angiopathy: Insights into pathogenesis, diagnosis, and treatment.","volume":"454","author":"Cozza","year":"2023","journal-title":"J. Neurol Sci"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1038\/s41467-025-56690-4","article-title":"Drug repurposing for Alzheimer\u2019s disease and other neurodegenerative disorders.","volume":"16","author":"Cummings","year":"2025","journal-title":"Nat. Commun"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1001\/archneurol.2011.100","article-title":"Risk factors and preventive interventions for Alzheimer disease: State of the science.","volume":"68","author":"Daviglus","year":"2011","journal-title":"Arch. Neurol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"20296","DOI":"10.1074\/jbc.M312946200","article-title":"Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch\/Iowa mutant form of amyloid beta-protein precursor.","volume":"279","author":"Davis","year":"2004","journal-title":"J. Biol. Chem"},{"key":"B54","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.1016\/j.ajpath.2018.07.030","article-title":"A novel transgenic rat model of robust cerebral microvascular amyloid with prominent vasculopathy.","volume":"188","author":"Davis","year":"2018","journal-title":"Am. J. Pathol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"100133","DOI":"10.1016\/j.cccb.2022.100133","article-title":"rTg-D: A novel transgenic rat model of cerebral amyloid angiopathy Type-2.","volume":"3","author":"Davis","year":"2022","journal-title":"Cereb. Circ. Cogn. Behav"},{"key":"B56","doi-asserted-by":"publisher","first-page":"105967","DOI":"10.1016\/j.nbd.2022.105967","article-title":"Ethanol exposure alters Alzheimer\u2019s-related pathology, behavior, and metabolism in APP\/PS1 mice.","volume":"177","author":"Day","year":"2023","journal-title":"Neurobiol. Dis"},{"key":"B57","doi-asserted-by":"publisher","first-page":"179","DOI":"10.5853\/jos.2023.04287","article-title":"Prevalence of cerebral amyloid angiopathy pathology and strictly lobar microbleeds in East-Asian Versus Western populations: A systematic review and meta-analysis.","volume":"26","author":"De Kort","year":"2024","journal-title":"J. Stroke"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1016\/j.jamda.2020.12.019","article-title":"Antihypertensive medication classes and the risk of dementia: A systematic review and network meta-analysis.","volume":"22","author":"den Brok","year":"2021","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1161\/HYPERTENSIONAHA.122.19378","article-title":"Angiotensin receptor blockers are associated with a lower risk of progression from mild cognitive impairment to dementia.","volume":"79","author":"Deng","year":"2022","journal-title":"Hypertension"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/j.jacc.2017.07.724","article-title":"Cerebral amyloid angiopathy: Diagnosis, clinical implications, and management strategies in atrial fibrillation.","volume":"70","author":"DeSimone","year":"2017","journal-title":"J. Am. Coll. Cardiol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.3233\/JAD-150070","article-title":"Recurrence of cerebral amyloid angiopathy-related inflammation: A report of two cases from the iCA\u03b2 international network.","volume":"46","author":"DiFrancesco","year":"2015","journal-title":"J. Alzheimers Dis"},{"key":"B62","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S1474-4422(19)30393-X","article-title":"Antihypertensive medications and risk for incident dementia and Alzheimer\u2019s disease: A meta-analysis of individual participant data from prospective cohort studies.","volume":"19","author":"Ding","year":"2020","journal-title":"Lancet Neurol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1326784","DOI":"10.3389\/fnins.2024.1326784","article-title":"Risk factors in developing amyloid related imaging abnormalities (ARIA) and clinical implications.","volume":"18","author":"Doran","year":"2024","journal-title":"Front. Neurosci"},{"key":"B64","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s00394-025-03651-8","article-title":"Associations of moderate alcohol intake with cerebrospinal fluid biomarkers of Alzheimer\u2019s disease: Data from the ALBION study.","volume":"64","author":"Drouka","year":"2025","journal-title":"Eur. J. Nutr"},{"key":"B65","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.jalz.2011.10.006","article-title":"Greater regional brain atrophy rate in healthy elderly subjects with a history of cigarette smoking.","volume":"8","author":"Durazzo","year":"2012","journal-title":"Alzheimers Dement"},{"key":"B66","doi-asserted-by":"publisher","first-page":"S122","DOI":"10.1016\/j.jalz.2014.04.009","article-title":"Smoking and increased Alzheimer\u2019s disease risk: A review of potential mechanisms.","volume":"10","author":"Durazzo","year":"2014","journal-title":"Alzheimers Dement."},{"key":"B67","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1055\/s-2005-867080","article-title":"Neurocognitive consequences of sleep deprivation.","volume":"25","author":"Durmer","year":"2005","journal-title":"Semin Neurol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"e29","DOI":"10.1111\/j.1468-1331.2011.03624.x","article-title":"Recurrent intracerebral haemorrhage after coitus: A case report of sporadic cerebral amyloid angiopathy in a younger patient.","volume":"19","author":"Ehling","year":"2012","journal-title":"Eur. J. Neurol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.neulet.2008.06.085","article-title":"Environmental enrichment, exercise and corticosterone affect endothelial cell proliferation in adult rat hippocampus and prefrontal cortex.","volume":"442","author":"Ekstrand","year":"2008","journal-title":"Neurosci. Lett"},{"key":"B70","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1002\/gps.1969","article-title":"Fat intake at midlife and cognitive impairment later in life: A population-based CAIDE study.","volume":"23","author":"Eskelinen","year":"2008","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"B71","doi-asserted-by":"publisher","first-page":"743","DOI":"10.3238\/arztebl.2011.0743","article-title":"Mild cognitive impairment and dementia: The importance of modifiable risk factors.","volume":"108","author":"Etgen","year":"2011","journal-title":"Dtsch Arztebl Int"},{"key":"B72","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1742-2094-4-22","article-title":"Induction of complement proteins in a mouse model for cerebral microvascular A beta deposition.","volume":"4","author":"Fan","year":"","journal-title":"J. Neuroinflammation"},{"key":"B73","doi-asserted-by":"publisher","first-page":"3057","DOI":"10.1523\/JNEUROSCI.4371-06.2007","article-title":"Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid.","volume":"27","author":"Fan","year":"","journal-title":"J. Neurosci"},{"key":"B74","doi-asserted-by":"publisher","first-page":"3111","DOI":"10.1007\/s11357-024-01488-3","article-title":"The role of the Mediterranean diet in reducing the risk of cognitive impairement, dementia, and Alzheimer\u2019s disease: A meta-analysis.","volume":"47","author":"Fekete","year":"2025","journal-title":"Geroscience"},{"key":"B75","doi-asserted-by":"publisher","first-page":"3729","DOI":"10.3390\/jcm13133729","article-title":"All GLP-1 agonists should, theoretically, cure Alzheimer\u2019s dementia but dulaglutide might be more effective than the others.","volume":"13","author":"Fessel","year":"2024","journal-title":"J. Clin. Med"},{"key":"B76","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.tins.2016.07.002","article-title":"Apolipoprotein E and sex bias in cerebrovascular aging of men and mice.","volume":"39","author":"Finch","year":"2016","journal-title":"Trends Neurosci"},{"key":"B77","doi-asserted-by":"publisher","first-page":"3443","DOI":"10.1212\/WNL.98.18_supplement.3443","article-title":"Sex differences in cerebral amyloid angiopathy: The role of monocytes\/macrophages (S2.008).","volume":"98","author":"Finger","year":"2022","journal-title":"Neurology"},{"key":"B78","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.appet.2012.12.018","article-title":"The longer-term impacts of Western diet on human cognition and the brain.","volume":"63","author":"Francis","year":"2013","journal-title":"Appetite"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1001\/jamaneurol.2014.2668","article-title":"Dementia risk after traumatic brain injury vs nonbrain trauma: The role of age and severity.","volume":"71","author":"Gardner","year":"2014","journal-title":"JAMA Neurol"},{"key":"B80","doi-asserted-by":"publisher","first-page":"3435","DOI":"10.3390\/ijms21103435","article-title":"Understanding the pathophysiology of cerebral amyloid angiopathy.","volume":"21","author":"Gatti","year":"2020","journal-title":"Int. J. Mol. Sci"},{"key":"B81","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1007\/s12603-009-0106-x","article-title":"Effect of tramiprosate in patients with mild-to-moderate Alzheimer\u2019s disease: Exploratory analyses of the MRI sub-group of the Alphase study.","volume":"13","author":"Gauthier","year":"2009","journal-title":"J. Nutr. Health Aging"},{"key":"B82","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.neurobiolaging.2006.02.015","article-title":"Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis.","volume":"28","author":"Gervais","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"B83","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1161\/HYPERTENSIONAHA.121.17595","article-title":"Blood-brain barrier crossing renin-angiotensin system drugs: Considerations for dementia and cognitive decline.","volume":"78","author":"Glodzik","year":"2021","journal-title":"Hypertension"},{"key":"B84","doi-asserted-by":"publisher","first-page":"fcae369","DOI":"10.1093\/braincomms\/fcae369","article-title":"Cerebral amyloid angiopathy impacts neurofibrillary tangle burden and cognition.","volume":"6","author":"Godrich","year":"2024","journal-title":"Brain Commun"},{"key":"B85","doi-asserted-by":"publisher","first-page":"e207977","DOI":"10.1212\/WNL.0000000000207977","article-title":"CADMUS: A novel MRI-based classification of spontaneous intracerebral hemorrhage associated with cerebral small vessel disease.","volume":"102","author":"Goeldlin","year":"2024","journal-title":"Neurology"},{"key":"B86","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1177\/23969873231193237","article-title":"Small vessel disease burden and risk of recurrent cerebrovascular events in patients with lacunar stroke and intracerebral haemorrhage attributable to deep perforator arteriolopathy.","volume":"8","author":"Goeldlin","year":"2023","journal-title":"Eur. Stroke J"},{"key":"B87","doi-asserted-by":"publisher","first-page":"e61","DOI":"10.1161\/STR.0000000000000453","article-title":"Impact of sleep disorders and disturbed sleep on brain health: A scientific statement from the American Heart Association.","volume":"55","author":"Gottesman","year":"2024","journal-title":"Stroke"},{"key":"B88","doi-asserted-by":"publisher","first-page":"e70027","DOI":"10.1002\/dad2.70027","article-title":"Input of exome sequencing in early-onset cerebral amyloid angiopathy.","volume":"16","author":"Grangeon","year":"2024","journal-title":"Alzheimers Dement."},{"key":"B89","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1016\/j.radcr.2021.05.080","article-title":"Cerebral amyloid angiopathy related inflammation: A little known but not to be underestimated disease.","volume":"16","author":"Grasso","year":"2021","journal-title":"Radiol. Case Rep"},{"key":"B90","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1161\/STROKEAHA.123.042583","article-title":"Seed to bleed: Iatrogenic cerebral amyloid angiopathy.","volume":"54","author":"Greenberg","year":"2023","journal-title":"Stroke"},{"key":"B91","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1161\/01.str.28.7.1418","article-title":"Diagnosis of cerebral amyloid angiopathy. Sensitivity and specificity of cortical biopsy.","volume":"28","author":"Greenberg","year":"1997","journal-title":"Stroke"},{"key":"B92","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41582-019-0281-2","article-title":"Cerebral amyloid angiopathy and Alzheimer disease - one peptide, two pathways.","volume":"16","author":"Greenberg","year":"2020","journal-title":"Nat. Rev. Neurol"},{"key":"B93","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1097\/01.wad.0000213845.28624.f4","article-title":"A phase 2 study of tramiprosate for cerebral amyloid angiopathy.","volume":"20","author":"Greenberg","year":"2006","journal-title":"Alzheimer Dis. Assoc. Disord"},{"key":"B94","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1111\/joim.13333","article-title":"The Mediterranean diet and health: A comprehensive overview.","volume":"290","author":"Guasch-Ferr\u00e9","year":"2021","journal-title":"J. Intern. Med"},{"key":"B95","first-page":"316","article-title":"Imaging cerebral amyloid angiopathy with susceptibility-weighted imaging.","volume":"28","author":"Haacke","year":"2007","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"4414","DOI":"10.1093\/brain\/awad188","article-title":"Amyloid-related imaging abnormalities (ARIA): Radiological, biological and clinical characteristics.","volume":"146","author":"Hampel","year":"2023","journal-title":"Brain"},{"key":"B97","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1002\/path.4468","article-title":"Prenatal high-fat diet alters the cerebrovasculature and clearance of \u03b2-amyloid in adult offspring.","volume":"235","author":"Hawkes","year":"2015","journal-title":"J. Pathol"},{"key":"B98","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1096\/fj.11-193193","article-title":"Exercise during pregnancy mitigates Alzheimer-like pathology in mouse offspring.","volume":"26","author":"Herring","year":"2012","journal-title":"FASEB J"},{"key":"B99","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/bs.irn.2019.10.017","article-title":"Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer\u2019s disease.","volume":"148","author":"Hoffman","year":"2019","journal-title":"Int. Rev. Neurobiol"},{"key":"B100","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.mcn.2014.10.006","article-title":"Vascular pathology of 20-month-old hypercholesterolemia mice in comparison to triple-transgenic and APPSwDI Alzheimer\u2019s disease mouse models.","volume":"63","author":"Hohsfield","year":"2014","journal-title":"Mol. Cell Neurosci"},{"key":"B101","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1006\/phrs.1999.0495","article-title":"Health benefits of docosahexaenoic acid (DHA).","volume":"40","author":"Horrocks","year":"1999","journal-title":"Pharmacol. Res"},{"key":"B102","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1096\/fj.09-136945","article-title":"Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer\u2019s disease-linked APPswe\/PS1DeltaE9 mice.","volume":"24","author":"Hu","year":"2010","journal-title":"FASEB J"},{"key":"B103","doi-asserted-by":"publisher","first-page":"5006","DOI":"10.1007\/s12035-017-0703-3","article-title":"Ethanol Alters APP processing and aggravates alzheimer-associated phenotypes.","volume":"55","author":"Huang","year":"2018","journal-title":"Mol. Neurobiol"},{"key":"B104","doi-asserted-by":"publisher","first-page":"e2404096","DOI":"10.1002\/advs.202404096","article-title":"Chronic stress exacerbates cerebral amyloid angiopathy through promoting neutrophil extracellular traps formation.","volume":"11","author":"Huang","year":"2024","journal-title":"Adv. Sci."},{"key":"B105","doi-asserted-by":"publisher","first-page":"4972","DOI":"10.1096\/fj.201800200R","article-title":"Cerebrovascular \u03b2-amyloid deposition and associated microhemorrhages in a Tg2576 Alzheimer mouse model are reduced with a DHA-enriched diet.","volume":"32","author":"Hur","year":"2018","journal-title":"FASEB J"},{"key":"B106","doi-asserted-by":"publisher","first-page":"255","DOI":"10.7861\/clinmedicine.14-3-255","article-title":"Cerebral amyloid angiopathy: A transient ischaemic attack mimic.","volume":"14","author":"Illsley","year":"2014","journal-title":"Clin. Med"},{"key":"B107","doi-asserted-by":"publisher","first-page":"136136","DOI":"10.1016\/j.neulet.2021.136136","article-title":"Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus.","volume":"762","author":"Inoue","year":"2021","journal-title":"Neurosci. Lett"},{"key":"B108","doi-asserted-by":"publisher","first-page":"8573","DOI":"10.1007\/s12035-019-01678-7","article-title":"Memantine, a noncompetitive N-Methyl-D-Aspartate receptor antagonist, attenuates cerebral amyloid angiopathy by increasing insulin-degrading enzyme expression.","volume":"56","author":"Inoue","year":"2019","journal-title":"Mol. Neurobiol"},{"key":"B109","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1021\/acs.biochem.4c00478","article-title":"A\u03b240 fibril assembly on human cerebral smooth muscle cells impairs cell viability.","volume":"64","author":"Irizarry","year":"2025","journal-title":"Biochemistry"},{"key":"B110","doi-asserted-by":"publisher","first-page":"611","DOI":"10.3233\/JAD-200571","article-title":"Severe obstructive sleep apnea is associated with higher brain amyloid burden: A preliminary PET imaging study.","volume":"78","author":"Jackson","year":"2020","journal-title":"J. Alzheimers Dis"},{"key":"B111","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/alz.12366","article-title":"Prevalence of cerebral amyloid angiopathy: A systematic review and meta-analysis.","volume":"18","author":"J\u00e4kel","year":"2022","journal-title":"Alzheimers Dement"},{"key":"B112","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.1042\/CS20170033","article-title":"Animal models of cerebral amyloid angiopathy.","volume":"131","author":"J\u00e4kel","year":"2017","journal-title":"Clin. Sci"},{"key":"B113","doi-asserted-by":"publisher","first-page":"5217","DOI":"10.1523\/JNEUROSCI.5080-04.2005","article-title":"Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer\u2019s disease.","volume":"25","author":"Jankowsky","year":"2005","journal-title":"J. Neurosci"},{"key":"B114","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.bbadis.2016.11.014","article-title":"Aging, microglia and cytoskeletal regulation are key factors in the pathological evolution of the APP23 mouse model for Alzheimer\u2019s disease.","volume":"1863","author":"Janssen","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis"},{"key":"B115","article-title":"Pathogenic angiogenic mechanisms in Alzheimer\u2019s Disease","author":"Jefferies","year":"2017","journal-title":"Physiologic and Pathologic Angiogenesis - Signaling Mechanisms and Targeted Therapy"},{"key":"B116","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1096\/fj.05-4265fje","article-title":"Chronic stress accelerates learning and memory impairments and increases amyloid deposition in APPV717I-CT100 transgenic mice, an Alzheimer\u2019s disease model.","volume":"20","author":"Jeong","year":"2006","journal-title":"FASEB J"},{"key":"B117","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1007\/s12640-015-9589-x","article-title":"Sex dimorphism profile of alzheimer\u2019s disease-type pathologies in an APP\/PS1 mouse model.","volume":"29","author":"Jiao","year":"2016","journal-title":"Neurotox. Res"},{"key":"B118","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/341226a0","article-title":"Amyloid beta-protein deposition in tissues other than brain in Alzheimer\u2019s disease.","volume":"341","author":"Joachim","year":"1989","journal-title":"Nature"},{"key":"B119","doi-asserted-by":"publisher","first-page":"e70238","DOI":"10.1002\/alz.70238","article-title":"Tau depletion diminishes vascular amyloid-related deficits in a mouse model of cerebral amyloid angiopathy.","volume":"21","author":"Jury-Garfe","year":"2025","journal-title":"Alzheimers Dement"},{"key":"B120","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1002\/ana.410420514","article-title":"Dietary fat intake and the risk of incident dementia in the Rotterdam Study.","volume":"42","author":"Kalmijn","year":"1997","journal-title":"Ann. Neurol"},{"key":"B121","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1212\/01.wnl.0000103860.75218.a5","article-title":"Dietary intake of fatty acids and fish in relation to cognitive performance at middle age.","volume":"62","author":"Kalmijn","year":"2004","journal-title":"Neurology"},{"key":"B122","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.3233\/JAD-170954","article-title":"Cerebral amyloid angiopathy: Similarity in African-Americans and Caucasians with Alzheimer\u2019s Disease.","volume":"62","author":"Kamara","year":"2018","journal-title":"J. Alzheimers Dis"},{"key":"B123","doi-asserted-by":"publisher","first-page":"3606","DOI":"10.1523\/JNEUROSCI.20-10-03606.2000","article-title":"Evidence for seeding of beta -amyloid by intracerebral infusion of Alzheimer brain extracts in beta -amyloid precursor protein-transgenic mice.","volume":"20","author":"Kane","year":"2000","journal-title":"J. Neurosci"},{"key":"B124","doi-asserted-by":"publisher","first-page":"e258842","DOI":"10.1001\/jamanetworkopen.2025.8842","article-title":"Cerebral amyloid angiopathy and downstream alzheimer Disease plasma biomarkers.","volume":"8","author":"Kang","year":"2025","journal-title":"JAMA Netw. Open"},{"key":"B125","doi-asserted-by":"publisher","first-page":"23989","DOI":"10.1038\/s41598-024-75202-w","article-title":"Low to moderate ethanol exposure reduces astrocyte-induced neuroinflammatory signaling and cognitive decline in presymptomatic APP\/PS1 mice.","volume":"14","author":"Kang","year":"2024","journal-title":"Sci. Rep"},{"key":"B126","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.physbeh.2010.12.003","article-title":"Western diet consumption and cognitive impairment: Links to hippocampal dysfunction and obesity.","volume":"103","author":"Kanoski","year":"2011","journal-title":"Physiol. Behav"},{"key":"B127","doi-asserted-by":"publisher","first-page":"A3021","DOI":"10.1164\/ajrccm-conference.2022.205.1_MeetingAbstracts.A3021","article-title":"Cigarette smoke increases the expression of amyloid precursor protein in pulmonary artery smooth muscle cells.","volume":"205","author":"Karoor","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1161\/STROKEAHA.122.041690","article-title":"Iatrogenic cerebral amyloid angiopathy post neurosurgery: Frequency, clinical profile, radiological features, and outcome.","volume":"54","author":"Kaushik","year":"2023","journal-title":"Stroke"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.3310\/eme08190","author":"Kehoe","year":"2021","journal-title":"Losartan to Slow the Progression of Mild-To-Moderate Alzheimer\u2019s disease Through Angiotensin Targeting: The RADAR RCT."},{"key":"B130","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/ana.10262","article-title":"Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment.","volume":"52","author":"Kempermann","year":"2002","journal-title":"Ann. Neurol"},{"key":"B131","doi-asserted-by":"publisher","first-page":"16487","DOI":"10.1038\/s41598-023-43884-3","article-title":"Association between stress-related disorders and the risk of dementia using the Korean National Sample Cohort: A matched cohort study.","volume":"13","author":"Kim","year":"2023","journal-title":"Sci. Rep"},{"key":"B132","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1007\/s11910-015-0572-y","article-title":"The inflammatory form of cerebral amyloid angiopathy or \u201cCerebral amyloid angiopathy-related inflammation\u201d (CAARI).","volume":"15","author":"Kirshner","year":"2015","journal-title":"Curr. Neurol Neurosci. Rep"},{"key":"B133","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1212\/wnl.56.12.1683","article-title":"Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study.","volume":"56","author":"Kivipelto","year":"2001","journal-title":"Neurology"},{"key":"B134","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1161\/STROKEAHA.122.040823","article-title":"Sex differences in onset and progression of cerebral amyloid angiopathy.","volume":"54","author":"Koemans","year":"2023","journal-title":"Stroke"},{"key":"B135","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1089\/neu.2015.3970","article-title":"Altered neuroinflammation and behavior after traumatic brain injury in a mouse model of Alzheimer\u2019s Disease.","volume":"33","author":"Kokiko-Cochran","year":"2016","journal-title":"J. Neurotrauma"},{"key":"B136","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.jalz.2009.03.002","article-title":"Amyloid precursor protein transgenic mouse models and Alzheimer\u2019s disease: Understanding the paradigms, limitations, and contributions.","volume":"5","author":"Kokjohn","year":"2009","journal-title":"Alzheimers Dement"},{"key":"B137","doi-asserted-by":"publisher","first-page":"111463","DOI":"10.1016\/j.isci.2024.111463","article-title":"Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer\u2019s disease.","volume":"27","author":"Koundal","year":"2024","journal-title":"iScience"},{"key":"B138","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1177\/1747493020974464","article-title":"A practical approach to the management of cerebral amyloid angiopathy.","volume":"16","author":"Kozberg","year":"2021","journal-title":"Int. J. Stroke"},{"key":"B139","doi-asserted-by":"publisher","first-page":"fcac245","DOI":"10.1093\/braincomms\/fcac245","article-title":"Blood-brain barrier leakage and perivascular inflammation in cerebral amyloid angiopathy.","volume":"4","author":"Kozberg","year":"2022","journal-title":"Brain Commun"},{"key":"B140","author":"Kuhn","year":"2025","journal-title":"Cerebral Amyloid Angiopathy."},{"key":"B141","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.3390\/nu15153356","article-title":"Mediterranean diet for primary and secondary prevention of cardiovascular disease and mortality: An updated systematic review.","volume":"15","author":"Laffond","year":"2023","journal-title":"Nutrients"},{"key":"B142","doi-asserted-by":"publisher","first-page":"70","DOI":"10.2967\/jnumed.112.109009","article-title":"Amyloid-\u03b2 imaging with Pittsburgh compound B and florbetapir: Comparing radiotracers and quantification methods.","volume":"54","author":"Landau","year":"2013","journal-title":"J. Nucl. Med"},{"key":"B143","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.exger.2008.04.002","article-title":"Alzheimer\u2019s disease, cerebrovascular dysfunction and the benefits of exercise: From vessels to neurons.","volume":"43","author":"Lange-Asschenfeldt","year":"2008","journal-title":"Exp. Gerontol"},{"key":"B144","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.cell.2005.01.015","article-title":"Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice.","volume":"120","author":"Lazarov","year":"2005","journal-title":"Cell"},{"key":"B145","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1177\/0271678X20944226","article-title":"Diffuse white matter loss in a transgenic rat model of cerebral amyloid angiopathy.","volume":"41","author":"Lee","year":"2021","journal-title":"J. Cereb. Blood Flow Metab"},{"key":"B146","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1093\/oxfordjournals.aje.a009639","article-title":"Illustration of analysis taking into account complex survey considerations: The association between wine consumption and dementia in the PAQUID study. Personnes Ages Quid.","volume":"148","author":"Lemeshow","year":"1998","journal-title":"Am. J. Epidemiol"},{"key":"B147","doi-asserted-by":"publisher","first-page":"189","DOI":"10.4067\/s0716-97602004000200003","article-title":"Risk of dementia and alcohol and wine consumption: A review of recent results.","volume":"37","author":"Letenneur","year":"2004","journal-title":"Biol. Res"},{"key":"B148","doi-asserted-by":"publisher","first-page":"b5465","DOI":"10.1136\/bmj.b5465","article-title":"Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: Prospective cohort analysis.","volume":"340","author":"Li","year":"2010","journal-title":"BMJ"},{"key":"B149","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1161\/HYPERTENSIONAHA.117.09479","article-title":"Blood pressure trajectories and the risk of intracerebral hemorrhage and cerebral infarction: A prospective study.","volume":"70","author":"Li","year":"2017","journal-title":"Hypertension"},{"key":"B150","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1007\/s00415-016-8093-4","article-title":"Traumatic brain injury and age at onset of cognitive impairment in older adults.","volume":"263","author":"Li","year":"2016","journal-title":"J. Neurol"},{"key":"B151","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1074\/jbc.M109.051664","article-title":"Estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysin.","volume":"285","author":"Liang","year":"2010","journal-title":"J. Biol. Chem"},{"key":"B152","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1161\/STROKEAHA.115.011608","article-title":"Sleep fragmentation, cerebral arteriolosclerosis, and brain infarct pathology in community-dwelling older people.","volume":"47","author":"Lim","year":"2016","journal-title":"Stroke"},{"key":"B153","doi-asserted-by":"publisher","first-page":"e003154","DOI":"10.1161\/JAHA.115.003154","article-title":"High-fat-diet intake enhances cerebral amyloid angiopathy and cognitive impairment in a mouse model of Alzheimer\u2019s Disease, independently of metabolic disorders.","volume":"5","author":"Lin","year":"2016","journal-title":"J. Am. Heart Assoc"},{"key":"B154","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s00401-017-1680-3","article-title":"Mixed pathologies including chronic traumatic encephalopathy account for dementia in retired association football (soccer) players.","volume":"133","author":"Ling","year":"2017","journal-title":"Acta Neuropathol"},{"key":"B155","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease: Risk, mechanisms and therapy.","volume":"9","author":"Liu","year":"2013","journal-title":"Nat. Rev. Neurol"},{"key":"B156","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1038\/s41598-018-20424-y","article-title":"Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function.","volume":"8","author":"Lundgaard","year":"2018","journal-title":"Sci. Rep"},{"key":"B157","doi-asserted-by":"publisher","first-page":"105378","DOI":"10.1016\/j.ebiom.2024.105378","article-title":"Association between risk of Alzheimer&#x2019;s disease and related dementias and angiotensin receptor &#x2161; blockers treatment for individuals with hypertension in high-volume claims data.","volume":"109","author":"Lundin","year":"2024","journal-title":"EBioMedicine"},{"key":"B158","doi-asserted-by":"publisher","first-page":"e14602","DOI":"10.1002\/alz.14602","article-title":"Exploring epidemiological risk factors for cerebral amyloid angiopathy: Considerations for monoclonal antibody therapy in people with Alzheimer\u2019s disease.","volume":"21","author":"Ma","year":"2025","journal-title":"Alzheimers Dement"},{"key":"B159","doi-asserted-by":"publisher","first-page":"39471","DOI":"10.1038\/srep39471","article-title":"Randomized trial on the effects of a combined physical\/cognitive training in aged MCI subjects: The Train the Brain study.","volume":"7","author":"Maffei","year":"2017","journal-title":"Sci. Rep."},{"key":"B160","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1002\/acn3.79","article-title":"Phosphodiesterase III inhibitor promotes drainage of cerebrovascular \u03b2-amyloid.","volume":"1","author":"Maki","year":"2014","journal-title":"Ann Clin Transl Neurol"},{"key":"B161","doi-asserted-by":"publisher","first-page":"12","DOI":"10.5281\/zenodo.10376125","article-title":"Recurrent intracerebral hemorrhage after exercise in a young patient presenting with sporadic cerebral amyloid angiopathy in a young patient.","volume":"9","author":"Malik","year":"2017","journal-title":"J. Vasc. Interv. Neurol."},{"key":"B162","doi-asserted-by":"publisher","first-page":"117269","DOI":"10.1016\/j.neuroimage.2020.117269","article-title":"The effects of voluntary running on cerebrovascular morphology and spatial short-term memory in a mouse model of amyloidosis.","volume":"222","author":"Maliszewska-Cyna","year":"2020","journal-title":"Neuroimage"},{"key":"B163","doi-asserted-by":"publisher","first-page":"100260","DOI":"10.1016\/j.bbih.2021.100260","article-title":"Sex differences in a murine model of Cerebral Amyloid Angiopathy.","volume":"14","author":"Maniskas","year":"2021","journal-title":"Brain Behav. Immun. Health"},{"key":"B164","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3389\/fneur.2020.00614","article-title":"Review on tramiprosate (Homotaurine) in Alzheimer\u2019s Disease and other neurocognitive disorders.","volume":"11","author":"Manzano","year":"2020","journal-title":"Front. Neurol"},{"key":"B165","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1001\/jamaneurol.2018.4519","article-title":"Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race\/Ethnicity: A Meta-analysis.","volume":"76","author":"Marini","year":"2019","journal-title":"JAMA Neurol"},{"key":"B166","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.brainresbull.2015.07.001","article-title":"Repeated cognitive stimulation alleviates memory impairments in an Alzheimer\u2019s disease mouse model.","volume":"117","author":"Martinez-Coria","year":"2015","journal-title":"Brain Res. Bull"},{"key":"B167","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1161\/01.str.19.2.205","article-title":"Autopsy study of incidence and distribution of cerebral amyloid angiopathy in Hisayama, Japan.","volume":"19","author":"Masuda","year":"1988","journal-title":"Stroke"},{"key":"B168","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1038\/s42003-023-05506-6","article-title":"Repeated multi-domain cognitive training prevents cognitive decline, anxiety and amyloid pathology found in a mouse model of Alzheimer disease.","volume":"6","author":"Mehla","year":"2023","journal-title":"Commun. Biol"},{"key":"B169","doi-asserted-by":"publisher","first-page":"e12245","DOI":"10.1002\/dad2.12245","article-title":"Relationship between objectively measured physical activity on neuropathology and cognitive outcomes in older adults: Resistance versus resilience?","volume":"13","author":"Memel","year":"2021","journal-title":"Alzheimers Dement"},{"key":"B170","doi-asserted-by":"publisher","first-page":"260","DOI":"10.5114\/pjp.2013.39334","article-title":"The development of cerebral amyloid angiopathy in cerebral vessels. A review with illustrations based upon own investigated post mortem cases.","volume":"64","author":"Mendel","year":"2013","journal-title":"Pol. J. Pathol"},{"key":"B171","doi-asserted-by":"publisher","first-page":"e41010","DOI":"10.1097\/MD.0000000000041010","article-title":"Cerebral amyloid angiopathy-related inflammation (CAA-ri): A case report.","volume":"103","author":"Meng","year":"2024","journal-title":"Medicine"},{"key":"B172","doi-asserted-by":"publisher","first-page":"7704","DOI":"10.3390\/jcm12247704","article-title":"When atrial fibrillation meets cerebral amyloid angiopathy: Current evidence and strategies.","volume":"12","author":"Merella","year":"2023","journal-title":"J. Clin. Med"},{"key":"B173","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1126\/science.1131864","article-title":"Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.","volume":"313","author":"Meyer-Luehmann","year":"2006","journal-title":"Science"},{"key":"B174","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/s0002-9440(10)62993-8","article-title":"Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein.","volume":"167","author":"Miao","year":"2005","journal-title":"Am. J. Pathol"},{"key":"B175","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1001\/archneur.60.2.194","article-title":"Dietary fats and the risk of incident Alzheimer disease.","volume":"60","author":"Morris","year":"2003","journal-title":"Arch. Neurol"},{"key":"B176","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1001\/archneur.63.8.1085","article-title":"Dietary copper and high saturated and trans fat intakes associated with cognitive decline.","volume":"63","author":"Morris","year":"2006","journal-title":"Arch. Neurol"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1101\/2025.04.23.650226","article-title":"Telmisartan and lisinopril show potential benefits in rescuing cognitive-behavioral function despite limited improvements in neuropathological outcomes in Tg-SwDI Mice.","author":"Motzko Noto","year":"2025","journal-title":"bioRxiv [Preprint]."},{"key":"B178","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00701-016-3004-0","article-title":"Cerebral amyloid angiopathy in a young man with a history of traumatic brain injury: A case report and review of the literature.","volume":"159","author":"Nakayama","year":"2017","journal-title":"Acta Neurochir"},{"key":"B179","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0303-8467(91)90004-9","article-title":"Cerebral amyloid angiopathy in Chinese: Incidence and significance.","volume":"93","author":"Ng","year":"1991","journal-title":"Clin. Neurol. Neurosurg"},{"key":"B180","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","article-title":"A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): A randomised controlled trial.","volume":"385","author":"Ngandu","year":"2015","journal-title":"Lancet"},{"key":"B181","doi-asserted-by":"publisher","first-page":"106260","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.106260","article-title":"Preceding head trauma in four cases of sporadic cerebral amyloid angiopathy - case report series.","volume":"31","author":"Oblak","year":"2022","journal-title":"J. Stroke Cerebrovasc. Dis"},{"key":"B182","doi-asserted-by":"publisher","first-page":"CD011961","DOI":"10.1002\/14651858.CD011961.pub2","article-title":"Cognitive training interventions for dementia and mild cognitive impairment in Parkinson\u2019s disease.","volume":"2","author":"Orgeta","year":"2020","journal-title":"Cochrane Database Syst. Rev"},{"key":"B183","first-page":"185","article-title":"Wine consumption and dementia in the elderly: A prospective community study in the Bordeaux area.","volume":"153","author":"Orgogozo","year":"1997","journal-title":"Rev. Neurol."},{"key":"B184","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1136\/heartjnl-2022-321930","article-title":"Primary prevention of cardiovascular disease in women with a Mediterranean diet: Systematic review and meta-analysis.","volume":"109","author":"Pant","year":"2023","journal-title":"Heart"},{"key":"B185","doi-asserted-by":"publisher","first-page":"109","DOI":"10.31887\/DCNS.2013.15.1\/dpark","article-title":"The aging mind: Neuroplasticity in response to cognitive training.","volume":"15","author":"Park","year":"2013","journal-title":"Dialogues Clin. Neurosci"},{"key":"B186","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1161\/STROKEAHA.114.005179","article-title":"Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy.","volume":"45","author":"Park","year":"2014","journal-title":"Stroke"},{"key":"B187","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1161\/01.str.26.7.1189","article-title":"Recurrence of bleeding in patients with primary intracerebral hemorrhage.","volume":"26","author":"Passero","year":"1995","journal-title":"Stroke"},{"key":"B188","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.nbd.2018.03.007","article-title":"Behavioral and SCN neurophysiological disruption in the Tg-SwDI mouse model of Alzheimer\u2019s disease.","volume":"114","author":"Paul","year":"2018","journal-title":"Neurobiol. Dis"},{"key":"B189","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1097\/WAD.0b013e3182389a9c","article-title":"The influence of chronic stress on dementia-related diagnostic change in older adults.","volume":"26","author":"Peavy","year":"2012","journal-title":"Alzheimer Dis. Assoc. Disord"},{"key":"B190","doi-asserted-by":"publisher","first-page":"112366","DOI":"10.1016\/j.bbr.2019.112366","article-title":"Prolonged isolation stress accelerates the onset of Alzheimer\u2019s disease-related pathology in 5xFAD mice despite running wheels and environmental enrichment.","volume":"379","author":"Peterman","year":"2020","journal-title":"Behav. Brain Res"},{"key":"B191","doi-asserted-by":"publisher","first-page":"1489489","DOI":"10.3389\/fnut.2024.1489489","article-title":"Enriching the Mediterranean diet could nourish the brain more effectively.","volume":"11","author":"Picone","year":"2024","journal-title":"Front. Nutr"},{"key":"B192","doi-asserted-by":"publisher","first-page":"893","DOI":"10.2165\/11203320-000000000-00000","article-title":"Cerebrolysin: A review of its use in dementia.","volume":"26","author":"Plosker","year":"2009","journal-title":"Drugs Aging"},{"key":"B193","doi-asserted-by":"publisher","first-page":"e209828","DOI":"10.1212\/WNL.0000000000209828","article-title":"CSF and plasma biomarkers in patients with iatrogenic cerebral amyloid angiopathy.","volume":"103","author":"Pollaci","year":"2024","journal-title":"Neurology"},{"key":"B194","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1146\/annurev.publhealth.24.100901.141015","article-title":"Will a healthy lifestyle help prevent Alzheimer\u2019s disease?","volume":"24","author":"Pope","year":"2003","journal-title":"Annu. Rev. Public Health"},{"key":"B195","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.3390\/ijms21072348","article-title":"Longitudinal cognitive decline in a novel rodent model of cerebral amyloid angiopathy type-1.","volume":"21","author":"Popescu","year":"2020","journal-title":"Int. J. Mol. Sci"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1101\/2025.02.19.639138","article-title":"Ketogenic diet enhances cognitive-behavioral function and hippocampal neurogenesis while attenuating amyloid pathology in Tg-SwDI Mice.","author":"Pulido-Correa","year":"2025","journal-title":"bioRxiv [Preprint]."},{"key":"B197","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3109\/13506129.2012.746937","article-title":"Cerebral amyloid angiopathy\u2013an underdiagnosed entity in younger adults with lobar intracerebral hemorrhage?","volume":"20","author":"Purrucker","year":"2013","journal-title":"Amyloid"},{"key":"B198","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1016\/j.jnutbio.2015.07.022","article-title":"Extra-virgin olive oil attenuates amyloid-\u03b2 and tau pathologies in the brains of TgSwDI mice.","volume":"26","author":"Qosa","year":"2015","journal-title":"J. Nutr. Biochem"},{"key":"B199","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1093\/brain\/awac178","article-title":"Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline.","volume":"145","author":"Rabin","year":"2022","journal-title":"Brain"},{"key":"B200","doi-asserted-by":"publisher","first-page":"777","DOI":"10.3233\/JAD-2010-091531","article-title":"Exercise plays a preventive role against Alzheimer\u2019s disease.","volume":"20","author":"Radak","year":"2010","journal-title":"J. Alzheimers Dis"},{"key":"B201","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1021\/acs.biochem.1c00781","article-title":"Insights into cerebral amyloid angiopathy type 1 and type 2 from comparisons of the fibrillar assembly and stability of the A\u03b240-Iowa and A\u03b240-Dutch Peptides.","volume":"61","author":"Rajpoot","year":"2022","journal-title":"Biochemistry"},{"key":"B202","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1590\/1980-57642015DN94000356","article-title":"Dementia resulting from traumatic brain injury.","volume":"9","author":"Ramalho","year":"2015","journal-title":"Dement. Neuropsychol"},{"key":"B203","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1001\/jamaneurol.2020.1782","article-title":"Association between immunosuppressive treatment and outcomes of cerebral amyloid angiopathy-related inflammation.","volume":"77","author":"Regenhardt","year":"2020","journal-title":"JAMA Neurol"},{"key":"B204","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1056\/NEJMoa013128","article-title":"Memantine in moderate-to-severe Alzheimer\u2019s disease.","volume":"348","author":"Reisberg","year":"2003","journal-title":"N. Engl. J. Med"},{"key":"B205","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1001\/jamaneurol.2014.681","article-title":"Clinical predictors of severe cerebral amyloid angiopathy and influence of APOE genotype in persons with pathologically verified Alzheimer disease.","volume":"71","author":"Ringman","year":"2014","journal-title":"JAMA Neurol"},{"key":"B206","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.nrl.2015.07.010","article-title":"Vascular pathology: Cause or effect in Alzheimer disease?","volume":"33","author":"Rius-P\u00e9rez","year":"2018","journal-title":"Neurologia"},{"key":"B207","doi-asserted-by":"publisher","first-page":"843","DOI":"10.3390\/ijms21030843","article-title":"Environmental enrichment: Disentangling the influence of novelty, social, and physical activity on cerebral amyloid angiopathy in a transgenic mouse model.","volume":"21","author":"Robison","year":"2020","journal-title":"Int. J. Mol. Sci"},{"key":"B208","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s12974-019-1534-0","article-title":"Long-term voluntary wheel running does not alter vascular amyloid burden but reduces neuroinflammation in the Tg-SwDI mouse model of cerebral amyloid angiopathy.","volume":"16","author":"Robison","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"B209","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s00702-004-0181-4","article-title":"Amelioration of the cerebrovascular amyloidosis in a transgenic model of Alzheimer\u2019s disease with the neurotrophic compound cerebrolysin.","volume":"112","author":"Rockenstein","year":"2005","journal-title":"J. Neural Transm"},{"key":"B210","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1007\/s00702-003-0025-7","article-title":"The neuroprotective effects of Cerebrolysin in a transgenic model of Alzheimer\u2019s disease are associated with improved behavioral performance.","volume":"110","author":"Rockenstein","year":"2003","journal-title":"J. Neural Transm"},{"key":"B211","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/jnr.20818","article-title":"Effects of Cerebrolysin on amyloid-beta deposition in a transgenic model of Alzheimer\u2019s disease.","volume":"62","author":"Rockenstein","year":"2002","journal-title":"J. Neural Transm. Suppl."},{"key":"B212","doi-asserted-by":"publisher","first-page":"115189","DOI":"10.1016\/j.expneurol.2025.115189","article-title":"Tg-SwDI transgenic mice: A suitable model for Alzheimer\u2019s disease and cerebral amyloid angiopathy basic research and preclinical studies.","volume":"387","author":"Rodriguez-Lopez","year":"2025","journal-title":"Exp. Neurol"},{"key":"B213","doi-asserted-by":"publisher","first-page":"e209719","DOI":"10.1212\/WNL.0000000000209719","article-title":"18FFlutemetamol-PET aided classification of cerebral amyloid angiopathy: A multicenter study.","volume":"103","author":"Romoli","year":"2024","journal-title":"Neurology"},{"key":"B214","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.neuroscience.2020.05.024","article-title":"Impaired amyloid beta clearance and brain microvascular dysfunction are present in the Tg-SwDI mouse model of Alzheimer\u2019s Disease.","volume":"440","author":"Rosas-Hernandez","year":"2020","journal-title":"Neuroscience"},{"key":"B215","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1042\/CS20120078","article-title":"Angiotensin II AT(1) receptor blockers as treatments for inflammatory brain disorders.","volume":"123","author":"Saavedra","year":"2012","journal-title":"Clin. Sci"},{"key":"B216","doi-asserted-by":"publisher","first-page":"k2927","DOI":"10.1136\/bmj.k2927","article-title":"Alcohol consumption and risk of dementia: 23 year follow-up of Whitehall II cohort study.","volume":"362","author":"Sabia","year":"2018","journal-title":"BMJ"},{"key":"B217","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.trci.2016.10.001","article-title":"A multicenter, randomized, placebo-controlled trial for cilostazol in patients with mild cognitive impairment: The COMCID study protocol.","volume":"2","author":"Saito","year":"2016","journal-title":"Alzheimers Dement"},{"key":"B218","doi-asserted-by":"publisher","first-page":"e2344938","DOI":"10.1001\/jamanetworkopen.2023.44938","article-title":"Efficacy and safety of cilostazol in mild cognitive impairment: A randomized clinical trial.","volume":"6","author":"Saito","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"B219","doi-asserted-by":"publisher","first-page":"643357","DOI":"10.3389\/fphar.2021.643357","article-title":"Taxifolin: A potential therapeutic agent for cerebral amyloid angiopathy.","volume":"12","author":"Saito","year":"2021","journal-title":"Front. Pharmacol"},{"key":"B220","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s40478-017-0429-5","article-title":"Taxifolin inhibits amyloid-\u03b2 oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy.","volume":"5","author":"Saito","year":"2017","journal-title":"Acta Neuropathol. Commun"},{"key":"B221","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s13244-014-0312-x","article-title":"Imaging spectrum of sporadic cerebral amyloid angiopathy: Multifaceted features of a single pathological condition.","volume":"5","author":"Sakurai","year":"2014","journal-title":"Insights Imaging"},{"key":"B222","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1001\/jamaneurol.2021.4161","article-title":"Amyloid-Related imaging abnormalities in 2 phase 3 studies evaluating aducanumab in patients with early Alzheimer Disease.","volume":"79","author":"Salloway","year":"2022","journal-title":"JAMA Neurol"},{"key":"B223","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1001\/jamaneurol.2024.3937","article-title":"Amyloid-related imaging abnormalities (ARIA) in clinical trials of gantenerumab in early Alzheimer Disease.","volume":"82","author":"Salloway","year":"2025","journal-title":"JAMA Neurol"},{"key":"B224","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1271\/bbb.120925","article-title":"Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid \u03b2 aggregation.","volume":"77","author":"Sato","year":"","journal-title":"Biosci. Biotechnol. Biochem"},{"key":"B225","doi-asserted-by":"publisher","first-page":"23212","DOI":"10.1074\/jbc.M113.464222","article-title":"Site-specific inhibitory mechanism for amyloid \u03b242 aggregation by catechol-type flavonoids targeting the Lys residues.","volume":"288","author":"Sato","year":"","journal-title":"J. Biol. Chem"},{"key":"B226","doi-asserted-by":"publisher","first-page":"26331055241288172","DOI":"10.1177\/26331055241288172","article-title":"Cerebral Proteomic Changes in the rTg-D rat model of cerebral amyloid angiopathy type-2 with cortical microhemorrhages and cognitive impairments.","volume":"19","author":"Schrader","year":"","journal-title":"Neurosci. Insights"},{"key":"B227","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1093\/jnen\/nlac057","article-title":"Distinct brain proteomic signatures in cerebral small vessel disease rat models of hypertension and cerebral amyloid angiopathy.","volume":"81","author":"Schrader","year":"","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"B228","doi-asserted-by":"publisher","first-page":"8441","DOI":"10.1038\/s41598-024-59013-7","article-title":"Longitudinal markers of cerebral amyloid angiopathy and related inflammation in rTg-DI rats.","volume":"14","author":"Schrader","year":"","journal-title":"Sci. Rep"},{"key":"B229","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1111\/jnc.15463","article-title":"Distinct brain regional proteome changes in the rTg-DI rat model of cerebral amyloid angiopathy.","volume":"159","author":"Schrader","year":"2021","journal-title":"J. Neurochem"},{"key":"B230","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.ajpath.2021.11.010","article-title":"Emergent white matter degeneration in the rTg-DI rat model of cerebral amyloid angiopathy exhibits unique proteomic changes.","volume":"192","author":"Schrader","year":"","journal-title":"Am. J. Pathol"},{"key":"B231","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/nan.12576","article-title":"Invited Review: The spectrum of age-related small vessel diseases: Potential overlap and interactions of amyloid and nonamyloid vasculopathies.","volume":"46","author":"Schreiber","year":"2020","journal-title":"Neuropathol. Appl. Neurobiol"},{"key":"B232","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s11682-014-9329-5","article-title":"Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer\u2019s disease.","volume":"9","author":"Schultz","year":"2015","journal-title":"Brain Imaging Behav"},{"key":"B233","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1212\/WNL.0000000000003001","article-title":"Cerebral amyloid angiopathy in posttransplant patients with hereditary ATTR amyloidosis.","volume":"87","author":"Sekijima","year":"2016","journal-title":"Neurology"},{"key":"B234","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/j.1749-6632.1996.tb34401.x","article-title":"The role of APP processing and trafficking pathways in the formation of amyloid beta-protein.","volume":"777","author":"Selkoe","year":"1996","journal-title":"Ann. N. Y. Acad. Sci"},{"key":"B235","doi-asserted-by":"publisher","first-page":"fcad159","DOI":"10.1093\/braincomms\/fcad159","article-title":"Cerebrospinal fluid biomarkers for cerebral amyloid angiopathy.","volume":"5","author":"Sembill","year":"2023","journal-title":"Brain Commun"},{"key":"B236","doi-asserted-by":"publisher","first-page":"113882","DOI":"10.1016\/j.bbr.2022.113882","article-title":"Assessment of sex-related neuropathology and cognitive deficits in the Tg-SwDI mouse model of Alzheimer\u2019s disease.","volume":"428","author":"Setti","year":"2022","journal-title":"Behav. Brain Res"},{"key":"B237","doi-asserted-by":"publisher","first-page":"661","DOI":"10.3174\/ajnr.A4176","article-title":"Cerebral microbleeds: Different prevalence, topography, and risk factors depending on dementia diagnosis\u2014the Karolinska Imaging Dementia Study.","volume":"36","author":"Shams","year":"2015","journal-title":"AJNR Am. J. Neuroradiol"},{"key":"B238","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1056\/NEJMra2201449","article-title":"Spontaneous intracerebral hemorrhage.","volume":"387","author":"Sheth","year":"2022","journal-title":"N. Engl. J. Med"},{"key":"B239","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/j.1749-6632.2002.tb04822.x","article-title":"Vascular changes in Iowa-type hereditary cerebral amyloid angiopathy.","volume":"977","author":"Shin","year":"2002","journal-title":"Ann. N. Y. Acad. Sci"},{"key":"B240","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s00401-016-1580-y","article-title":"Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer\u2019s disease.","volume":"132","author":"Shinohara","year":"2016","journal-title":"Acta Neuropathol"},{"key":"B241","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.neulet.2016.06.066","article-title":"Traumatic brain injury accelerates amyloid-\u03b2 deposition and impairs spatial learning in the triple-transgenic mouse model of Alzheimer\u2019s disease.","volume":"629","author":"Shishido","year":"2016","journal-title":"Neurosci. Lett"},{"key":"B242","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1001\/archneurol.2011.3747","article-title":"Dementia resulting from traumatic brain injury: What is the pathology?","volume":"69","author":"Shively","year":"2012","journal-title":"Arch. Neurol"},{"key":"B243","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.bbi.2025.03.021","article-title":"Chronic stress leads to earlier cognitive decline in an Alzheimer\u2019s mouse model: The role of neuroinflammation and TrkB.","volume":"127","author":"Shlomi-Loubaton","year":"2025","journal-title":"Brain Behav. Immun"},{"key":"B244","doi-asserted-by":"publisher","first-page":"821","DOI":"10.3390\/neurolint16040061","article-title":"Late-Life Blood Pressure and Cerebral Amyloid Angiopathy: Findings from the U.S. National Alzheimer\u2019s Coordinating Center Uniform Dataset.","volume":"16","author":"Sin","year":"2024","journal-title":"Neurol. Int"},{"key":"B245","doi-asserted-by":"publisher","first-page":"6792","DOI":"10.3390\/jcm12216792","article-title":"Anti-amyloid therapy, AD, and ARIA: Untangling the Role of CAA.","volume":"12","author":"Sin","year":"2023","journal-title":"J. Clin. Med"},{"key":"B246","doi-asserted-by":"publisher","first-page":"627","DOI":"10.3233\/ADR-220055","article-title":"Updated outlook of cerebral amyloid angiopathy and inflammatory subtypes: Pathophysiology, clinical manifestations, diagnosis and management.","volume":"6","author":"Singh","year":"2022","journal-title":"J. Alzheimers Dis. Rep"},{"key":"B247","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.3233\/JAD-210571","article-title":"Cerebral amyloid angiopathy in a mouse model of Alzheimer\u2019s disease associates with upregulated angiopoietin and downregulated hypoxia-inducible factor.","volume":"83","author":"Skaaraas","year":"2021","journal-title":"J. Alzheimers Dis"},{"key":"B248","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1212\/01.wnl.0000256368.57375.b7","article-title":"Serum cholesterol changes after midlife and late-life cognition: Twenty-one-year follow-up study.","volume":"68","author":"Solomon","year":"2007","journal-title":"Neurology"},{"key":"B249","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1159\/000231980","article-title":"Midlife serum cholesterol and increased risk of Alzheimer\u2019s and vascular dementia three decades later.","volume":"28","author":"Solomon","year":"2009","journal-title":"Dement. Geriatr. Cogn. Disord"},{"key":"B250","doi-asserted-by":"publisher","first-page":"1102809","DOI":"10.3389\/fnagi.2023.1102809","article-title":"Reconsidering the role of blood-brain barrier in Alzheimer\u2019s disease: From delivery to target.","volume":"15","author":"Sousa","year":"2023","journal-title":"Front. Aging Neurosci"},{"key":"B251","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s00401-019-02031-x","article-title":"Contact sport participation and chronic traumatic encephalopathy are associated with altered severity and distribution of cerebral amyloid angiopathy.","volume":"138","author":"Standring","year":"2019","journal-title":"Acta Neuropathol"},{"key":"B252","doi-asserted-by":"publisher","first-page":"811371","DOI":"10.3389\/fnins.2022.811371","article-title":"Impact of non-pharmacological chronic hypertension on a transgenic rat model of cerebral amyloid angiopathy.","volume":"16","author":"Stanisavljevic","year":"2022","journal-title":"Front. Neurosci"},{"key":"B253","doi-asserted-by":"publisher","first-page":"11025","DOI":"10.1073\/pnas.1206555109","article-title":"Purified and synthetic Alzheimer\u2019s amyloid beta (A\u03b2) prions.","volume":"109","author":"St\u00f6hr","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"B254","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.1111\/ene.15997","article-title":"Iatrogenic cerebral amyloid angiopathy: An illustrative case of a newly introduced disease.","volume":"30","author":"Storti","year":"2023","journal-title":"Eur. J. Neurol"},{"key":"B255","doi-asserted-by":"publisher","first-page":"e70284","DOI":"10.1111\/ene.70284","article-title":"Hippocampal subfields volume: Another hint of the continuum between CAA and AD?","volume":"32","author":"Storti","year":"2025","journal-title":"Eur. J. Neurol"},{"key":"B256","doi-asserted-by":"publisher","first-page":"2764","DOI":"10.1038\/s41598-017-03016-0","article-title":"Environmental novelty exacerbates stress hormones and A\u03b2 pathology in an Alzheimer\u2019s model.","volume":"7","author":"Stuart","year":"2017","journal-title":"Sci. Rep"},{"key":"B257","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1161\/STROKEAHA.121.036873","article-title":"Vessels Sing their ARIAs: The role of vascular amyloid in the age of aducanumab.","volume":"53","author":"Sveikata","year":"2022","journal-title":"Stroke"},{"key":"B258","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.rcl.2023.01.009","article-title":"Cerebral amyloid angiopathy.","volume":"61","author":"Szidonya","year":"2023","journal-title":"Radiol. Clin. North Am"},{"key":"B259","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1161\/HYPERTENSIONAHA.109.138586","article-title":"Angiotensin receptor blocker prevented beta-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling.","volume":"54","author":"Takeda","year":"2009","journal-title":"Hypertension"},{"key":"B260","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1002\/ibra.12098","article-title":"Basic information about memantine and its treatment of Alzheimer\u2019s disease and other clinical applications.","volume":"9","author":"Tang","year":"2023","journal-title":"Ibrain"},{"key":"B261","doi-asserted-by":"publisher","first-page":"417314","DOI":"10.4061\/2010\/417314","article-title":"Pathological hallmarks, clinical parallels, and value for drug testing in Alzheimer\u2019s Disease of the APP[V717I] London transgenic mouse model.","volume":"2010","author":"Tanghe","year":"2010","journal-title":"Int. J. Alzheimers Dis"},{"key":"B262","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrneurol.2015.119","article-title":"Clearance systems in the brain-implications for Alzheimer disease.","volume":"11","author":"Tarasoff-Conway","year":"2015","journal-title":"Nat. Rev. Neurol"},{"key":"B263","doi-asserted-by":"publisher","first-page":"773797","DOI":"10.3389\/fnagi.2021.773797","article-title":"Long-term use of metformin is associated with reduced risk of cognitive impairment with alleviation of cerebral small vessel disease burden in patients with type 2 diabetes.","volume":"13","author":"Teng","year":"2021","journal-title":"Front. Aging Neurosci"},{"key":"B264","doi-asserted-by":"publisher","first-page":"3S","DOI":"10.1177\/0898264313518133","article-title":"The ACTIVE study: Study overview and major findings.","volume":"25","author":"Tennstedt","year":"2013","journal-title":"J. Aging Health"},{"key":"B265","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1093\/jnen\/61.3.282","article-title":"Two types of sporadic cerebral amyloid angiopathy.","volume":"61","author":"Thal","year":"2002","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"B266","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0304-3940(90)90632-j","article-title":"Parenchymal preamyloid and amyloid deposits in the brains of patients with hereditary cerebral hemorrhage with amyloidosis\u2013Dutch type.","volume":"118","author":"Timmers","year":"1990","journal-title":"Neurosci. Lett"},{"key":"B267","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jphs.2016.07.001","article-title":"Cigarette smoking impairs nitric oxide-mediated cerebral blood flow increase: Implications for Alzheimer\u2019s disease.","volume":"131","author":"Toda","year":"2016","journal-title":"J. Pharmacol. Sci"},{"key":"B268","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1038\/s41380-020-0762-0","article-title":"Amyloidogenic processing of Alzheimer\u2019s disease \u03b2-amyloid precursor protein induces cellular iron retention.","volume":"25","author":"Tsatsanis","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"B269","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1093\/advances\/nmz054","article-title":"The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diets Are Associated with Less Cognitive Decline and a Lower Risk of Alzheimer\u2019s Disease-A Review.","volume":"10","author":"van den Brink","year":"2019","journal-title":"Adv. Nutr"},{"key":"B270","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in Early Alzheimer\u2019s Disease.","volume":"388","author":"van Dyck","year":"2023","journal-title":"N. Engl. J. Med"},{"key":"B271","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1212\/WNL.0000000000003486","article-title":"\u03b2-Amyloid in CSF: Biomarker for preclinical cerebral amyloid angiopathy.","volume":"88","author":"van Etten","year":"2017","journal-title":"Neurology"},{"key":"B272","doi-asserted-by":"publisher","first-page":"32860","DOI":"10.1074\/jbc.M104135200","article-title":"Pathogenic effects of D23N Iowa mutant amyloid beta -protein.","volume":"276","author":"Van Nostrand","year":"2001","journal-title":"J. Biol. Chem"},{"key":"B273","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3389\/fnagi.2015.00114","article-title":"Can insulin signaling pathways be targeted to transport A\u03b2 out of the brain?","volume":"7","author":"Vandal","year":"2015","journal-title":"Front. Aging Neurosci"},{"key":"B274","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.hest.2022.05.001","article-title":"Models of cerebral amyloid angiopathy-related intracerebral hemorrhage.","volume":"3","author":"Vargas-George","year":"2022","journal-title":"Brain Hemorrhages"},{"key":"B275","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12987-022-00380-6","article-title":"Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer\u2019s disease and type two diabetes.","volume":"19","author":"Vargas-Soria","year":"2022","journal-title":"Fluids Barriers CNS"},{"key":"B276","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/ana.21694","article-title":"Cerebrospinal fluid amyloid beta(40) is decreased in cerebral amyloid angiopathy.","volume":"66","author":"Verbeek","year":"2009","journal-title":"Ann. Neurol"},{"key":"B277","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1001\/archneurol.2009.42","article-title":"Use of antithrombotic drugs and the presence of cerebral microbleeds: The Rotterdam Scan Study.","volume":"66","author":"Vernooij","year":"2009","journal-title":"Arch. Neurol"},{"key":"B278","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s40478-023-01698-4","article-title":"Cerebrospinal fluid shotgun proteomics identifies distinct proteomic patterns in cerebral amyloid angiopathy rodent models and human patients.","volume":"12","author":"Vervuurt","year":"2024","journal-title":"Acta Neuropathol. Commun"},{"key":"B279","doi-asserted-by":"publisher","first-page":"e12804","DOI":"10.1111\/nan.12804","article-title":"Elevated expression of urokinase plasminogen activator in rodent models and patients with cerebral amyloid angiopathy.","volume":"48","author":"Vervuurt","year":"2022","journal-title":"Neuropathol. Appl. Neurobiol"},{"key":"B280","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1161\/01.str.14.6.924","article-title":"Cerebral amyloid angiopathy: Incidence and complications in the aging brain. II. The distribution of amyloid vascular changes.","volume":"14","author":"Vinters","year":"1983","journal-title":"Stroke"},{"key":"B281","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1186\/s13063-023-07371-4","article-title":"Minocycline for sporadic and hereditary cerebral amyloid angiopathy (BATMAN): Study protocol for a placebo-controlled randomized double-blind trial.","volume":"24","author":"Voigt","year":"2023","journal-title":"Trials"},{"key":"B282","doi-asserted-by":"publisher","DOI":"10.1159\/000542666","article-title":"The impact of vascular risk factors on cerebral amyloid angiopathy: A cohort study in hereditary cerebral amyloid angiopathy and a systemic review in sporadic cerebral amyloid angiopathy.","author":"Voigt","year":"2024","journal-title":"Cerebrovasc. Dis."},{"key":"B283","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1002\/ana.410300503","article-title":"Cerebral amyloid angiopathy without and with cerebral hemorrhages: A comparative histological study.","volume":"30","author":"Vonsattel","year":"1991","journal-title":"Ann. Neurol"},{"key":"B284","doi-asserted-by":"publisher","first-page":"676931","DOI":"10.3389\/fneur.2021.676931","article-title":"Cerebrovascular risk factors in possible or probable cerebral amyloid angiopathy. Modifier or Bystander?","volume":"12","author":"Wagner","year":"2021","journal-title":"Front. Neurol."},{"key":"B285","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s40478-023-01714-7","article-title":"Prevalence, distribution, and severity of cerebral amyloid angiopathy differ between Lewy body diseases and Alzheimer\u2019s disease.","volume":"12","author":"Walker","year":"2024","journal-title":"Acta Neuropathol. Commun"},{"key":"B286","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s13195-023-01308-4","article-title":"Stress, depression, and risk of dementia - a cohort study in the total population between 18 and 65 years old in Region Stockholm.","volume":"15","author":"Wallensten","year":"2023","journal-title":"Alzheimers Res. Ther"},{"key":"B287","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s12264-010-0515-1","article-title":"Regulation of \u03b2 cleavage of amyloid precursor protein.","volume":"26","author":"Wang","year":"2010","journal-title":"Neurosci. Bull"},{"key":"B288","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s13195-021-00890-9","article-title":"High-fat diet-induced atherosclerosis promotes neurodegeneration in the triple transgenic (3 \u00d7 Tg) mouse model of Alzheimer\u2019s disease associated with chronic platelet activation.","volume":"13","author":"Wang","year":"2021","journal-title":"Alzheimers Res. Ther"},{"key":"B289","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1007\/s11011-018-0207-5","article-title":"Taxifolin prevents \u03b2-amyloid-induced impairments of synaptic formation and deficits of memory via the inhibition of cytosolic phospholipase A2\/prostaglandin E2 content.","volume":"33","author":"Wang","year":"2018","journal-title":"Metab. Brain Dis"},{"key":"B290","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1136\/jnnp.58.6.699","article-title":"Hereditary cerebral haemorrhage with amyloidosis, Dutch type (HCHWA-D): Clinicopathological studies.","volume":"58","author":"Wattendorff","year":"1995","journal-title":"J. Neurol Neurosurg. Psychiatry"},{"key":"B291","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/s0002-9440(10)65616-7","article-title":"Cerebral amyloid angiopathy: Amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer\u2019s disease.","volume":"153","author":"Weller","year":"1998","journal-title":"Am. J. Pathol"},{"key":"B292","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/j.1750-3639.2008.00133.x","article-title":"Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer\u2019s disease.","volume":"18","author":"Weller","year":"2008","journal-title":"Brain Pathol"},{"key":"B293","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1080\/13506120701460923","article-title":"A primer of amyloid nomenclature.","volume":"14","author":"Westermark","year":"2007","journal-title":"Amyloid"},{"key":"B294","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1212\/01.WNL.0000149519.47454.F2","article-title":"Midlife cardiovascular risk factors and risk of dementia in late life.","volume":"64","author":"Whitmer","year":"2005","journal-title":"Neurology"},{"key":"B295","doi-asserted-by":"publisher","first-page":"87","DOI":"10.2147\/NDT.S198772","article-title":"Alcohol and dementia - what is the link? A systematic review.","volume":"16","author":"Wiegmann","year":"2020","journal-title":"Neuropsychiatr. Dis. Treat"},{"key":"B296","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1016\/s0006-291x(05)81370-1","article-title":"Peptides homologous to the amyloid protein of Alzheimer\u2019s disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.","volume":"180","author":"Wisniewski","year":"1991","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"B297","doi-asserted-by":"publisher","first-page":"e2323690","DOI":"10.1001\/jamanetworkopen.2023.23690","article-title":"Lifestyle enrichment in later life and its association with dementia risk.","volume":"6","author":"Wu","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"B298","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13024-022-00547-7","article-title":"Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.","volume":"17","author":"Xia","year":"2022","journal-title":"Mol. Neurodegener"},{"key":"B299","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.3233\/JAD-191023","article-title":"Association of hypercholesterolemia with Alzheimer\u2019s disease pathology and cerebral amyloid angiopathy.","volume":"73","author":"Xu","year":"2020","journal-title":"J. Alzheimers Dis"},{"key":"B300","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.neuroscience.2007.01.043","article-title":"Early-onset subicular microvascular amyloid and neuroinflammation correlate with behavioral deficits in vasculotropic mutant amyloid beta-protein precursor transgenic mice.","volume":"146","author":"Xu","year":"2007","journal-title":"Neuroscience"},{"key":"B301","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1196\/annals.1386.036","article-title":"Estrogen, beta-amyloid metabolism\/trafficking, and Alzheimer\u2019s disease.","volume":"1089","author":"Xu","year":"2006","journal-title":"Ann. N. Y. Acad. Sci"},{"key":"B302","doi-asserted-by":"publisher","first-page":"621","DOI":"10.3233\/JAD-130758","article-title":"Cerebral microvascular rather than parenchymal amyloid-\u03b2 protein pathology promotes early cognitive impairment in transgenic mice.","volume":"38","author":"Xu","year":"2014","journal-title":"J. Alzheimers Dis"},{"key":"B303","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1001\/archneur.59.3.378","article-title":"Serum lipoprotein levels, statin use, and cognitive function in older women.","volume":"59","author":"Yaffe","year":"2002","journal-title":"Arch. Neurol"},{"key":"B304","doi-asserted-by":"publisher","first-page":"117037","DOI":"10.1016\/j.jns.2020.117037","article-title":"Proportion of intracerebral haemorrhage due to cerebral amyloid angiopathy in the East and West: Comparison between single hospital centres in Japan and the United Kingdom.","volume":"416","author":"Yakushiji","year":"2020","journal-title":"J. Neurol Sci"},{"key":"B305","doi-asserted-by":"publisher","first-page":"17","DOI":"10.5853\/jos.2015.17.1.17","article-title":"Cerebral amyloid angiopathy: Emerging concepts.","volume":"17","author":"Yamada","year":"2015","journal-title":"J. Stroke"},{"key":"B306","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1161\/STROKEAHA.115.008582","article-title":"Minocycline reduces spontaneous hemorrhage in mouse models of cerebral amyloid angiopathy.","volume":"46","author":"Yan","year":"2015","journal-title":"Stroke"},{"key":"B307","doi-asserted-by":"publisher","first-page":"245","DOI":"10.4062\/biomolther.2012.20.3.245","article-title":"Mechanisms of Amyloid-\u03b2 peptide clearance: Potential therapeutic targets for Alzheimer\u2019s Disease.","volume":"20","author":"Yoon","year":"2012","journal-title":"Biomol. Ther"},{"key":"B308","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1016\/j.ajpath.2020.11.015","article-title":"Overlapping protein accumulation profiles of CADASIL and CAA: Is there a common mechanism driving cerebral small-vessel disease?","volume":"191","author":"Young","year":"2021","journal-title":"Am. J. Pathol"},{"key":"B309","doi-asserted-by":"publisher","first-page":"116650","DOI":"10.1016\/j.bcp.2024.116650","article-title":"KDM6B knockdown alleviates sleep deprivation-induced cerebrovascular lesions in APP\/PS1 mice by inhibiting PARP16 expression.","volume":"231","author":"Yu","year":"2025","journal-title":"Biochem. Pharmacol"},{"key":"B310","doi-asserted-by":"publisher","first-page":"e207940","DOI":"10.1212\/WNL.0000000000207940","article-title":"Sensitivity and specificity of the boston criteria version 2.0 for the diagnosis of cerebral amyloid angiopathy in a community-based sample.","volume":"102","author":"Zanon Zotin","year":"2024","journal-title":"Neurology"},{"key":"B311","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1016\/j.bbadis.2013.01.002","article-title":"Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: Implications for studying obesity-brain interactions in mice.","volume":"1832","author":"Zhang","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"B312","doi-asserted-by":"publisher","first-page":"e016766","DOI":"10.1161\/JAHA.120.016766","article-title":"Blood pressure and outcomes in patients with different etiologies of intracerebral hemorrhage: A multicenter cohort study.","volume":"9","author":"Zhang","year":"2020","journal-title":"J. Am. Heart Assoc"},{"key":"B313","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11906-023-01266-0","article-title":"Angiotensin receptor blockers and cognition: A scoping review.","volume":"26","author":"Zhou","year":"2024","journal-title":"Curr. Hypertens. Rep"},{"key":"B314","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12974-020-01755-y","article-title":"Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy.","volume":"17","author":"Zhu","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"B315","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1001\/jamaneurol.2025.0065","article-title":"Amyloid-related imaging abnormalities with donanemab in early symptomatic alzheimer disease: Secondary analysis of the TRAILBLAZER-ALZ and ALZ 2 randomized clinical trials.","volume":"82","author":"Zimmer","year":"2025","journal-title":"JAMA Neurol"},{"key":"B316","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3233\/JAD-190572","article-title":"Long-term effects of traumatic brain injury in a mouse model of Alzheimer\u2019s Disease.","volume":"72","author":"Zy\u015bk","year":"2019","journal-title":"J. Alzheimers Dis"}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2025.1632252\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:34:46Z","timestamp":1758000886000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2025.1632252\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,16]]},"references-count":316,"alternative-id":["10.3389\/fnagi.2025.1632252"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2025.1632252","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,16]]},"article-number":"1632252"}}