{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:13:31Z","timestamp":1759796011187,"version":"build-2065373602"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Fragile X-associated tremor\/ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by a premutation (PM) of the <jats:italic>FMR1<\/jats:italic> gene on the X chromosome. FXTAS is characterized by intention tremor, ataxia, and cognitive decline. Age-related cognitive-behavioral and sensorimotor (i.e., balance and gait) abnormalities are also present in PM carriers who do not develop FXTAS. Digital biomarkers of gait and balance have been proposed to be promising markers in characterizing prodromal changes in FXTAS (i.e., preFXTAS) and identifying age-related changes in the <jats:italic>FMR1<\/jats:italic> phenotype in those who do not develop FXTAS. In this mini-review, gait and balance findings in PM carriers are reviewed to highlight potential future applications. Variability measures of gait and postural sway reveal measurable impairments in individuals with FXTAS, particularly under conditions challenging sensory integration or assessing cognitive-motor interactions. However, there are limited studies quantifying these domains in <jats:italic>FMR1<\/jats:italic> PM carriers without FXTAS, and there is significant variability in the patient populations assessed (i.e., differing ages, relative lack of information in females) thus restricting conclusions about the progression of balance and gait in FXTAS and possible prodromal markers. Future research should prioritize longitudinal tracking of gait and balance in PM carriers, along with potential cognitive interactions and the characterization of sensory contributions to postural control. This mini-review aims to synthesize current findings on digital balance and gait biomarkers in FMR1 premutation carriers and to explore their potential utility for early FXTAS detection.<\/jats:p>","DOI":"10.3389\/fnagi.2025.1637819","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T05:21:55Z","timestamp":1759728115000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomarkers of balance and gait deficits in FMR1 premutation carriers: a mini-review"],"prefix":"10.3389","volume":"17","author":[{"given":"Leila C.","family":"Moore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nell","family":"Maltman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan S.","family":"Lee-Confer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan J.","family":"Kobel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1212\/01.wnl.0000269781.10417.7b","article-title":"Volumetric brain changes in females with fragile X-associated tremor\/ataxia syndrome (FXTAS)","volume":"69","author":"Adams","year":"2007","journal-title":"Neurology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1097\/MAO.0b013e31822e5bee","article-title":"The modified Romberg balance test: normative data in US adults","volume":"32","author":"Agrawal","year":"2011","journal-title":"Otol. Neurotol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1002\/ajmg.a.32211","article-title":"A quantitative assessment of tremor and ataxia in FMR1 premutation carriers using CATSYS","author":"Aguilar","year":"2008","journal-title":"Am. J. Med. Genet. A"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1136\/jmg.2007.054676","article-title":"Detection of early FXTAS motor symptoms using the CATSYS computerised neuromotor test battery","volume":"45","author":"Allen","year":"2008","journal-title":"J. Med. Genet."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/j.1749-6632.2001.tb03747.x","article-title":"Age-related changes in vestibular function: a longitudinal study","volume":"942","author":"Baloh","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1001\/archneur.55.5.649","article-title":"Static and dynamic Posturography in patients with vestibular and cerebellar lesions","volume":"55","author":"Baloh","year":"1998","journal-title":"Arch. Neurol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1111\/j.1532-5415.1995.tb07198.x","article-title":"Posturography and balance problems in older people","volume":"43","author":"Baloh","year":"1995","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1111\/gbb.12204","article-title":"Preliminary evidence of an effect of cerebellar volume on postural sway in FMR1 premutation males","volume":"14","author":"Birch","year":"2015","journal-title":"Genes Brain Behav."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1519\/JPT.0000000000000056","article-title":"Relationships between performance on assessments of executive function and fall risk screening measures in community-dwelling older adults","volume":"39","author":"Blackwood","year":"2016","journal-title":"J. Geriatr. Phys. Ther."},{"key":"ref10","first-page":"1757","article-title":"Fragile X premutation carriers: characteristic MR imaging findings of adult male patients with progressive cerebellar and cognitive dysfunction","volume":"23","author":"Brunberg","year":"2002","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.gaitpost.2017.11.024","article-title":"A systematic review of the gait characteristics associated with cerebellar Ataxia","volume":"60","author":"Buckley","year":"2018","journal-title":"Gait Posture"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2318-11-74","article-title":"Executive function predicts risk of falls in older adults without balance impairment","volume":"11","author":"Buracchio","year":"2011","journal-title":"BMC Geriatr."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/j.1399-0004.2010.01448.x","article-title":"Clinical involvement in daughters of men with fragile X-associated tremor ataxia syndrome","volume":"78","author":"Chonchaiya","year":"2010","journal-title":"Clin. Genet."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1212\/01.wnl.0000239837.57475.3a","article-title":"Molecular and imaging correlates of the fragile X-associated tremor\/ataxia syndrome","volume":"67","author":"Cohen","year":"2006","journal-title":"Neurology"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"695","DOI":"10.3389\/fneur.2018.00695","article-title":"Presence of middle cerebellar peduncle sign in FMR1 premutation carriers without tremor and ataxia","volume":"9","author":"Famula","year":"2018","journal-title":"Front. Neurol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1212\/WNL.0000000000001612","article-title":"White matter disease and cognitive impairment in FMR1 premutation carriers","volume":"84","author":"Filley","year":"2015","journal-title":"Neurology"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s12311-016-0797-6","article-title":"Fragile X-associated tremor\/ataxia syndrome (FXTAS) motor dysfunction modeled in mice","volume":"15","author":"Foote","year":"2016","journal-title":"Cerebellum"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"105711","DOI":"10.1016\/j.clinbiomech.2022.105711","article-title":"Body sway and movement strategies for control of postural stability in people with spinocerebellar ataxia type 3: a cross-sectional study","volume":"97","author":"Galv\u00e3o","year":"2022","journal-title":"Clin. Biomech."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1037\/0894-4105.22.1.48","article-title":"Cognitive profile of fragile X premutation carriers with and without fragile X-associated tremor\/ataxia syndrome","volume":"22","author":"Grigsby","year":"2008","journal-title":"Neuropsychology"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1097\/WCO.0000000000000954","article-title":"Fragile X-associated tremor\/ataxia syndrome: pathophysiology and management","volume":"34","author":"Hagerman","year":"2021","journal-title":"Curr. Opin. Neurol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.1111\/ene.14942","article-title":"Vestibular contributions to the Romberg test: testing semicircular canal and otolith function","volume":"28","author":"Halm\u00e1gyi","year":"2021","journal-title":"Eur. J. Neurol."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1093\/brain\/awq368","article-title":"A voxel-based morphometry study of grey matter loss in fragile X-associated tremor\/ataxia syndrome","volume":"134","author":"Hashimoto","year":"","journal-title":"Brain"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1002\/mds.23646","article-title":"Diffusion tensor imaging in male premutation carriers of the fragile X mental retardation gene","volume":"26","author":"Hashimoto","year":"","journal-title":"Mov. Disord."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.2522\/ptj.20150580","article-title":"Balance and gait represent independent domains of mobility in Parkinson disease","volume":"96","author":"Horak","year":"2016","journal-title":"Phys. Ther."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1093\/brain\/awl376","article-title":"Specific influences of cerebellar dysfunctions on gait","volume":"130","author":"Ilg","year":"2007","journal-title":"Brain J. Neurol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1007\/s12311-023-01625-2","article-title":"Quantitative gait and balance outcomes for Ataxia trials: consensus recommendations by the Ataxia global initiative working group on digital-motor biomarkers","volume":"23","author":"Ilg","year":"2024","journal-title":"Cerebellum"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"e1199","DOI":"10.1212\/WNL.0000000000010176","article-title":"Real-life gait assessment in degenerative cerebellar ataxia: toward ecologically valid biomarkers","volume":"95","author":"Ilg","year":"2020","journal-title":"Neurology"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1002\/mds.25558","article-title":"Gait ataxia--specific cerebellar influences and their rehabilitation","volume":"28","author":"Ilg","year":"2013","journal-title":"Mov. Disord."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1001\/jama.291.4.460","article-title":"Penetrance of the fragile X-associated tremor\/ataxia syndrome in a premutation carrier population","volume":"291","author":"Jacquemont","year":"2004","journal-title":"JAMA"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s10048-010-0270-5","article-title":"New clinical findings in the fragile X-associated tremor ataxia syndrome (FXTAS)","volume":"12","author":"Juncos","year":"2011","journal-title":"Neurogenetics"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1007\/s00415-021-10944-5","article-title":"Neural correlates of dual-task walking in people with central neurological disorders: a systematic review","volume":"269","author":"Kim","year":"2022","journal-title":"J. Neurol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.bbr.2013.07.033","article-title":"Cognitive-motor interference during postural control indicates at-risk cerebellar profiles in females with the FMR1 premutation","volume":"253","author":"Kraan","year":"2013","journal-title":"Behav. Brain Res."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"2179.e7","DOI":"10.1016\/j.neurobiolaging.2014.03.018","article-title":"Age and CGG-repeat length are associated with neuromotor impairments in at-risk females with the FMR1 premutation","volume":"35","author":"Kraan","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2825","DOI":"10.3390\/ijms26062825","article-title":"Premutation females with preFXTAS","volume":"26","author":"Liani","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"28","DOI":"10.12688\/amrcopenres.13036.1","article-title":"Symptom burden of people with progressive ataxia, and its wider impact on their friends and relatives: a cross-sectional study","volume":"3","author":"Lowit","year":"2021","journal-title":"AMRC Open Res."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1532-5415.1990.tb01588.x","article-title":"Aging and postural control: a comparison of spontaneous-and induced-sway balance tests","volume":"38","author":"Maki","year":"1990","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"M72","DOI":"10.1093\/geronj\/49.2.M72","article-title":"A prospective study of postural balance and risk of falling in an ambulatory and independent elderly population","volume":"49","author":"Maki","year":"1994","journal-title":"J. Gerontol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.rehab.2014.01.002","article-title":"The assessment and treatment of postural disorders in cerebellar ataxia: a systematic review","volume":"57","author":"Marquer","year":"2014","journal-title":"Ann. Phys. Rehabil. Med."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1152\/jn.00221.2004","article-title":"A new interpretation of spontaneous sway measures based on a simple model of human postural control","volume":"93","author":"Maurer","year":"2005","journal-title":"J. Neurophysiol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.neuroimage.2008.07.029","article-title":"Role of the prefrontal cortex in human balance control","volume":"43","author":"Mihara","year":"2008","journal-title":"NeuroImage"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.gaitpost.2017.12.031","article-title":"Psychometric properties of outcome measures evaluating decline in gait in cerebellar ataxia: a systematic review","volume":"61","author":"Milne","year":"2018","journal-title":"Gait Posture"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/ana.22165","article-title":"Gait alterations in healthy carriers of the LRRK2 G2019S mutation","volume":"69","author":"Mirelman","year":"2011","journal-title":"Ann. Neurol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1002\/cne.25463","article-title":"Characterization of fragile X mental retardation protein expression in human nociceptors and their axonal projections to the spinal dorsal horn","volume":"531","author":"Mitchell","year":"2023","journal-title":"J. Comp. Neurol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"105675","DOI":"10.1016\/j.bandc.2020.105675","article-title":"Response inhibition deficits in women with the FMR1 Premutation are associated with age and fall risk","volume":"148","author":"Moser","year":"2021","journal-title":"Brain Cogn."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"484713","DOI":"10.1155\/2011\/484713","article-title":"A quantitative assessment of tremor and Ataxia in female FMR1 Premutation carriers using CATSYS","volume":"2011","author":"Narcisa","year":"2011","journal-title":"Curr. Gerontol. Geriatr. Res."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"14006","DOI":"10.1109\/ACCESS.2023.3243178","article-title":"Technological evolution in the instrumentation of ataxia severity measurement","volume":"11","author":"Ngo","year":"2023","journal-title":"IEEE Access"},{"key":"ref9001","doi-asserted-by":"publisher","first-page":"2845","DOI":"10.1109\/EMBC44109.2020.9176289","article-title":"Decreased Theta Power Reflects Disruption in Postural Control Networks of Fragile X Premutation Carriers. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society","volume":"2020","author":"O\u2019Keeffe","year":"2020","journal-title":"Annual International Conference"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1007\/s12311-020-01199-3","article-title":"The effects of dual task cognitive interference and fast-paced walking on gait, turns, and falls in men and women with FXTAS","volume":"20","author":"O\u2019Keefe","year":"2021","journal-title":"Cerebellum"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.gaitpost.2018.09.005","article-title":"Cognitive function impacts gait, functional mobility and falls in fragile X-associated tremor\/ataxia syndrome","volume":"66","author":"O\u2019Keefe","year":"2018","journal-title":"Gait Posture"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1007\/s12311-015-0659-7","article-title":"Characterization and early detection of balance deficits in fragile X Premutation carriers with and without fragile X-associated tremor\/Ataxia syndrome (FXTAS)","volume":"14","author":"O\u2019Keefe","year":"2015","journal-title":"Cerebellum"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s12311-015-0714-4","article-title":"Gait and functional mobility deficits in fragile X-associated tremor\/ataxia syndrome","volume":"15","author":"O\u2019Keefe","year":"2016","journal-title":"Cerebellum"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12984-019-0560-6","article-title":"Complexity based measures of postural stability provide novel evidence of functional decline in fragile X premutation carriers","volume":"16","author":"O\u2019Keeffe","year":"2019","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1152\/jn.2002.88.3.1097","article-title":"Sensorimotor integration in human postural control","volume":"88","author":"Peterka","year":"2002","journal-title":"J. Neurophysiol."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1093\/cercor\/11.3.260","article-title":"The role of dorsolateral prefrontal cortex in the preparation of forthcoming actions: an fMRI study","volume":"11","author":"Pochon","year":"2001","journal-title":"Cereb. Cortex"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1109\/10.532130","article-title":"Measures of postural steadiness: differences between healthy young and elderly adults","volume":"43","author":"Prieto","year":"1996","journal-title":"I.E.E.E. Trans. Biomed. Eng."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.gaitpost.2018.04.011","article-title":"The reliability of gait variability measures for individuals with Parkinson\u2019s disease and healthy older adults \u2013 the effect of gait speed","volume":"62","author":"Rennie","year":"2018","journal-title":"Gait Posture"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3389\/fneur.2023.1308698","article-title":"Digital gait markers to potentially distinguish fragile X-associated tremor\/ataxia syndrome, Parkinson\u2019s disease, and essential tremor","volume":"14","author":"Robertson-Dick","year":"2023","journal-title":"Front. Neurol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1212\/WNL.0000000000000496","article-title":"Abnormal thalamic function in patients with vestibular migraine","volume":"82","author":"Russo","year":"2014","journal-title":"Neurology"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1007\/s00415-016-8142-z","article-title":"The interrelationship between disease severity, dynamic stability, and falls in cerebellar ataxia","volume":"263","author":"Schniepp","year":"2016","journal-title":"J. Neurol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"e808","DOI":"10.1212\/WNL.0000000000201598","article-title":"Patient-reported impact of symptoms in Friedreich Ataxia","volume":"100","author":"Seabury","year":"2023","journal-title":"Neurology"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1002\/mds.29742","article-title":"Digital measures of postural sway quantify balance deficits in spinocerebellar Ataxia","volume":"39","author":"Shah","year":"2024","journal-title":"Mov. Disord."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1352\/1944-7558-117.1.1","article-title":"Behavioral phenotype of fragile X syndrome in adolescence and adulthood","volume":"117","author":"Smith","year":"2012","journal-title":"Am. J. Intellect. Dev. Disabil."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1600018","DOI":"10.3389\/fneur.2025.1600018","article-title":"Editorial: Digital biomarkers in movement disorders","volume":"16","author":"Stephen","year":"2025","journal-title":"Front. Neurol."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ijpsycho.2018.11.006","article-title":"Monitoring multiple cortical regions during walking in young and older adults: dual-task response and comparison challenges","volume":"135","author":"Stuart","year":"2019","journal-title":"Int. J. Psychophysiol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"504","DOI":"10.3390\/jcm13020504","article-title":"Case series: vestibular migraines in fragile X Premutation carriers","volume":"13","author":"Tak","year":"2024","journal-title":"J. Clin. Med."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.3390\/s24082586","article-title":"Potential prodromal digital postural sway markers for fragile X-associated tremor\/Ataxia syndrome (FXTAS) detected via dual-tasking and sensory manipulation","volume":"24","author":"Timm","year":"2024","journal-title":"Sensors"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1002\/mds.20486","article-title":"Trunk sway in patients with spinocerebellar ataxia","volume":"20","author":"Van de Warrenburg","year":"2005","journal-title":"Mov. Disord."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.neurobiolaging.2017.03.018","article-title":"Abnormal trajectories in cerebellum and brainstem volumes in carriers of the fragile X premutation","volume":"55","author":"Wang","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s11689-018-9261-x","article-title":"Static and dynamic postural control deficits in aging fragile X mental retardation 1 (FMR1) gene premutation carriers","volume":"11","author":"Wang","year":"2019","journal-title":"J. Neurodev. Disord."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1007\/s00415-019-09386-x","article-title":"Vertigo and dizziness cause considerable more health care resource use and costs: results from the KORA FF4 study","volume":"266","author":"Wang","year":"2019","journal-title":"J. Neurol."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1866-1955-6-30","article-title":"Associated features in females with an FMR1 premutation","volume":"6","author":"Wheeler","year":"2014","journal-title":"J. Neurodev. 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