{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:02:24Z","timestamp":1790100144822,"version":"4.0.1"},"reference-count":143,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Parkinson\u2019s disease is a relatively common neurodegenerative disorder in clinical practice, and its prevalence is increasing worldwide. It not only causes patients to have movement disorders such as tremors and delayed initiation but also makes them suffer from olfactory disorders, gastrointestinal disorders, insomnia and other symptoms, which imposes a heavy burden on both patients and their families. In recent years, some scholars believe that the gut-brain axis may be the key to revealing the pathogenesis of Parkinson\u2019s disease. The changes in intestinal flora, or bacterial infections and oxidative stress, lead to abnormal aggregation of alpha-synuclein and formation of neurotoxic Lewy bodies, which are transmitted to the central nervous system via the vagus nerve, thus causing Parkinson\u2019s disease. A large number of evidence-based studies have shown that acupuncture is effective in treating motor disorders and non-motor symptoms such as constipation, neuropsychiatric symptoms, and dysphagia symptoms in Parkinson\u2019s disease, also this treatment is safe. However, its mechanism remains unclear. Acupuncture may affect the gut-brain axis and treat PD by improving intestinal flora imbalance, interfering with the expression of alpha-synuclein protecting neurological function, reducing imflammation, and influencing glial cells, etc. Therefore, the aim of this review is to elucidate the pathogenesis of PD from the perspective of neural, immune, and metabolic signaling pathways of the microbiota-gut-brain axis. In addition, this paper integrates the mechanism of acupuncture treatment with the pathogenesis of PD for the first time and to provide potential new strategies for its treatment.<\/jats:p>","DOI":"10.3389\/fnagi.2025.1640389","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T05:29:43Z","timestamp":1754544583000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Acupuncture modulates the microbiota-gut-brain axis: a new strategy for Parkinson\u2019s disease treatment"],"prefix":"10.3389","volume":"17","author":[{"given":"Zimo","family":"Zang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuye","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"102835","DOI":"10.1016\/j.autneu.2021.102835","article-title":"Vagus nerve ultrasonography in Parkinson\u2019s disease: a systematic review and meta-analysis","volume":"234","author":"Abdelnaby","year":"2021","journal-title":"Auton. Neurosci."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"593026","DOI":"10.3389\/fphys.2020.593026","article-title":"Blood-brain barrier leakage is increased in Parkinson\u2019s disease","volume":"11","author":"Al-Bachari","year":"2020","journal-title":"Front. Physiol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1016\/S1353-8020(13)70005-1","article-title":"Behavioral disorders in Parkinson\u2019s disease: the role of dopamine","volume":"20","author":"Antonelli","year":"2014","journal-title":"Park. Relat. 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Opin. Immunol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.neulet.2005.11.012","article-title":"Gastric alpha-synuclein immunoreactive inclusions in meissner\u2019s and Auerbach\u2019s plexuses in cases staged for Parkinson\u2019s disease-related brain pathology","volume":"396","author":"Braak","year":"2006","journal-title":"Neurosci. Lett."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/s0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"575481","DOI":"10.3389\/fnagi.2020.575481","article-title":"Alpha-synuclein accumulation and its phosphorylation in the enteric nervous system of patients without neurodegeneration: an explorative study","volume":"12","author":"Bu","year":"2020","journal-title":"Front. 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Sci."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1089\/acm.2016.0250","article-title":"Efficacy of combined treatment with acupuncture and bee venom acupuncture as an adjunctive treatment for Parkinson\u2019s disease","volume":"24","author":"Cho","year":"2018","journal-title":"J. Altern. Complement. Med."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"3406","DOI":"10.1039\/d2fo03825k","article-title":"Meta-analysis of randomized controlled trials of the effects of probiotics in Parkinson\u2019s disease","volume":"14","author":"Chu","year":"2023","journal-title":"Food Funct."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"101812","DOI":"10.1016\/j.arr.2022.101812","article-title":"Role of enteric glia and microbiota-gut-brain axis in Parkinson disease pathogenesis","volume":"84","author":"Claudino Dos Santos","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1038\/nrmicro2876","article-title":"The interplay between the intestinal microbiota and the brain","volume":"10","author":"Collins","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"R88","DOI":"10.1093\/hmg\/ddt398","article-title":"Sequencing the human microbiome in health and disease","volume":"22","author":"Cox","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"887407","DOI":"10.3389\/fcimb.2022.887407","article-title":"Curcumin-driven reprogramming of the gut microbiota and metabolome ameliorates motor deficits and neuroinflammation in a mouse model of Parkinson\u2019s disease","volume":"12","author":"Cui","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1038\/ctg.2015.34","article-title":"Butyrate and mucosal inflammation: new scientific evidence supports clinical observation","volume":"6","author":"Cushing","year":"2015","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/nan.12298","article-title":"Review: sporadic Parkinson\u2019s disease: development and distribution of \u03b1-synuclein pathology","volume":"42","author":"Del Tredici","year":"2016","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s12974-015-0302-z","article-title":"Electroacupuncture remediates glial dysfunction and ameliorates neurodegeneration in the astrocytic \u03b1-synuclein mutant mouse model","volume":"12","author":"Deng","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review","volume":"19","author":"Di Vincenzo","year":"2024","journal-title":"Intern. Emerg. Med."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3390\/ijms25010038","article-title":"Our mental health is determined by an intrinsic interplay between the central nervous system, enteric nerves, and gut microbiota","volume":"25","author":"Dicks","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1212\/01.wnl.0000247740.47667.03","article-title":"Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030","volume":"68","author":"Dorsey","year":"2007","journal-title":"Neurology"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.jaci.2022.07.015","article-title":"Enteric nervous system and intestinal epithelial regulation of the gut-brain axis","volume":"150","author":"Dowling","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1002\/mds.29358","article-title":"Duodenal alpha-synuclein pathology and enteric gliosis in advanced Parkinson\u2019s disease","volume":"38","author":"Emmi","year":"2023","journal-title":"Mov. 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Res."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"341","DOI":"10.2147\/JPR.S501642","article-title":"Electroacupuncture alleviates neuropathic pain and negative emotion in mice by regulating gut microbiota","volume":"18","author":"Feng","year":"2025","journal-title":"J. Pain Res."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3389\/fnagi.2019.00014","article-title":"The role of APOE4 in disrupting the homeostatic functions of astrocytes and microglia in aging and Alzheimer\u2019s disease","volume":"11","author":"Fernandez","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"ref35","first-page":"35","article-title":"The lewy body in Parkinson\u2019s disease","volume":"45","author":"Forno","year":"1987","journal-title":"Adv. Neurol."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"e28032","DOI":"10.1371\/journal.pone.0028032","article-title":"Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson\u2019s disease","volume":"6","author":"Forsyth","year":"2011","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1136\/acupmed-2015-010811","article-title":"Immediate effects of acupuncture on tongue pressure including swallowing reflex latency in Parkinson\u2019s disease","volume":"34","author":"Fukuda","year":"2016","journal-title":"J. Br. Med. Acupunct. Soc."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.neuron.2019.02.008","article-title":"Gut microbe to brain signaling: what happens in vagus \u2026","volume":"101","author":"F\u00fclling","year":"2019","journal-title":"Neuron"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1093\/advances\/nmz127","article-title":"Tryptophan metabolism: a link between the gut microbiota and brain","volume":"11","author":"Gao","year":"2020","journal-title":"Adv. Nutr."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.celrep.2019.12.078","article-title":"Probiotic bacillus subtilis protects against \u03b1-synuclein aggregation in C. elegans","volume":"30","author":"Goya","year":"2020","journal-title":"Cell Rep."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/jcbfm.2015.32","article-title":"Striatal blood-brain barrier permeability in Parkinson\u2019s disease","volume":"35","author":"Gray","year":"2015","journal-title":"J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"e30819","DOI":"10.1016\/j.heliyon.2024.e30819","article-title":"Electroacupuncture blocked motor dysfunction and gut barrier damage by modulating intestinal NLRP3 inflammasome in MPTP-induced Parkinson\u2019s disease mice","volume":"10","author":"Guo","year":"2024","journal-title":"Heliyon"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1177\/0964528421990658","article-title":"Electroacupuncture may alleviate behavioral defects via modulation of gut microbiota in a mouse model of Parkinson\u2019s disease","volume":"39","author":"Han","year":"2021","journal-title":"Acupunct. Med; J. Br. Med. Acupunct. Soc."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"6213","DOI":"10.2147\/JIR.S384949","article-title":"Vagus nerve and underlying impact on the gut microbiota-brain axis in behavior and neurodegenerative diseases","volume":"15","author":"Han","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000215875","article-title":"Levodopa: past, present, and future","volume":"62","author":"Hauser","year":"2009","journal-title":"Eur. Neurol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1159\/000518147","article-title":"Parkinson\u2019s disease and gut microbiota","volume":"77","author":"Hirayama","year":"2021","journal-title":"Ann. Nutr. Metab."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1007\/s00401-014-1343-6","article-title":"Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats","volume":"128","author":"Holmqvist","year":"2014","journal-title":"Acta Neuropathol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"7014","DOI":"10.18632\/aging.204266","article-title":"Probiotics treatment for Parkinson disease: a systematic review and meta-analysis of clinical trials","volume":"14","author":"Hong","year":"2022","journal-title":"Aging"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"111376","DOI":"10.1016\/j.exger.2021.111376","article-title":"Neuroprotective effects of short-chain fatty acids in MPTP induced mice model of Parkinson\u2019s disease","volume":"150","author":"Hou","year":"","journal-title":"Exp. Gerontol."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e26256","DOI":"10.1097\/MD.0000000000026256","article-title":"Effectiveness and safety of moxibustion for Parkinson disease: a protocol for systematic review and meta-analysis","volume":"100","author":"Hou","year":"","journal-title":"Medicine (Baltimore)"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1097\/WNR.0000000000001585","article-title":"The gut microbiota metabolite propionate ameliorates intestinal epithelial barrier dysfunction-mediated Parkinson\u2019s disease via the AKT signaling pathway","volume":"32","author":"Huang","year":"2021","journal-title":"Neuroreport"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1152\/physrev.1992.72.1.165","article-title":"Structure and function of the brain serotonin system","volume":"72","author":"Jacobs","year":"1992","journal-title":"Physiol. Rev."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1038\/s41591-019-0544-x","article-title":"A novel pathway for microbial metabolism of levodopa","volume":"25","author":"Jameson","year":"2019","journal-title":"Nat. Med."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.bbi.2020.08.015","article-title":"Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson\u2019s disease","volume":"89","author":"Jang","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1007\/s00702-015-1405-5","article-title":"Neuropathobiology of non-motor symptoms in parkinson disease","volume":"122","author":"Jellinger","year":"2015","journal-title":"J. Neural Transm."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13020-025-01104-2","article-title":"Invasive laser acupuncture targeting muscle: a novel approach to protect dopaminergic neurons and reduce neuroinflammation in a brain of Parkinson\u2019s disease model","volume":"20","author":"Jeon","year":"2025","journal-title":"Chin. Med."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"596","DOI":"10.3389\/fneur.2018.00596","article-title":"Evidence for the use of acupuncture in treating Parkinson\u2019s disease: update of information from the past 5 years, a mini review of the literature","volume":"9","author":"Jiang","year":"2018","journal-title":"Front. Neurol."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.neuron.2014.12.037","article-title":"Microbiota controls the homeostasis of glial cells in the gut lamina propria","volume":"85","author":"Kabouridis","year":"2015","journal-title":"Neuron"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"103092","DOI":"10.1016\/j.redox.2024.103092","article-title":"Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and ROS\/RNS: relevance to Parkinson\u2019s disease and therapeutic implications","volume":"71","author":"Kalyanaraman","year":"2024","journal-title":"Redox Biol."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.brainres.2006.10.089","article-title":"Acupuncture inhibits microglial activation and inflammatory events in the MPTP-induced mouse model","volume":"1131","author":"Kang","year":"2007","journal-title":"Brain Res."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.chom.2015.03.005","article-title":"Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function","volume":"17","author":"Kelly","year":"2015","journal-title":"Cell Host Microbe"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1454102","DOI":"10.3389\/fimmu.2024.1454102","article-title":"Stimulation of microneedles alleviates pathology of Parkinson\u2019s disease in mice by regulating the CD4+\/CD8+ cells from the periphery to the brain","volume":"15","author":"Kim","year":"2024","journal-title":"Front. Immunol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"789","DOI":"10.3390\/biomedicines9070789","article-title":"Vagus nerve stimulation with mild stimulation intensity exerts anti-inflammatory and neuroprotective effects in Parkinson\u2019s disease model rats","volume":"9","author":"Kin","year":"2021","journal-title":"Biomedicines"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"3581","DOI":"10.1111\/ene.15671","article-title":"Gut microbiota dysbiosis in Parkinson disease: a systematic review and pooled analysis","volume":"30","author":"Kleine Bardenhorst","year":"2023","journal-title":"Eur. J. Neurol."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3389\/fnagi.2019.00102","article-title":"Does acupuncture protect dopamine neurons in Parkinson\u2019s disease rodent model?: a systematic review and meta-analysis","volume":"11","author":"Ko","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.3390\/nu15122760","article-title":"Butyrate protects barrier integrity and suppresses immune activation in a caco-2\/PBMC co-culture model while HDAC inhibition mimics butyrate in restoring cytokine-induced barrier disruption","volume":"15","author":"Korsten","year":"2023","journal-title":"Nutrients"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"113159","DOI":"10.1016\/j.expneurol.2019.113159","article-title":"Alterations of the gut microbiota with antibiotics protects dopamine neuron loss and improve motor deficits in a pharmacological rodent model of Parkinson\u2019s disease","volume":"325","author":"Koutzoumis","year":"2020","journal-title":"Exp. 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Neurosci."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s40035-024-00430-z","article-title":"Blood-brain barrier alterations and their impact on Parkinson\u2019s disease pathogenesis and therapy","volume":"13","author":"Lau","year":"2024","journal-title":"Transl. Neurodegener."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1007\/s00726-010-0752-7","article-title":"Tryptophan metabolism, from nutrition to potential therapeutic applications","volume":"41","author":"Le Floc\u2019h","year":"2011","journal-title":"Amino Acids"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"878463","DOI":"10.3389\/fimmu.2022.878463","article-title":"The effect of acupuncture on modulating inflammatory cytokines in rodent animal models of respiratory disease: a systematic review and meta-analysis","volume":"13","author":"Lee","year":"2022","journal-title":"Front. 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