{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T20:42:03Z","timestamp":1757623323013,"version":"3.44.0"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Mild Cognitive Impairment (MCI) is a transitional stage between normal aging and dementia, frequently associated with subtle deficits in social cognition. Empathy, a core component of social cognition, encompasses both affective and cognitive dimensions and may be compromised even in prodromal phases of neurodegenerative conditions. Despite its clinical relevance, empathy in MCI remains underexplored, and standardized assessment tools are seldom used in routine diagnostics. Theory of mind is another important aspect of social cognition, and, as with empathy, it is unclear how it is affected at the MCI stage. This study aimed to investigate empathy and theory of mind abilities in individuals with MCI, excluding cases attributable to prodromal frontotemporal dementia, using two validated instruments: the Interpersonal reactivity index (IRI) and the Story-based empathy task (SET).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a case\u2013control study involving 23 individuals with MCI and 25 cognitively healthy controls. All participants completed the IRI, while a subsample (19 MCI patients) also underwent the SET. The clinical group included both amnestic and non-amnestic MCI subtypes, with heterogeneous etiologies. Group comparisons were performed on IRI subscales and SET indices to assess both self-reported empathy traits and performance-based socio-cognitive abilities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MCI group exhibited significantly lower scores in the IRI subscales of Empathic Concern and Perspective Taking compared to controls, indicating concurrent affective and cognitive empathy impairments. While no significant differences emerged in individual SET subcomponents, the MCI group showed a significantly lower global SET score, suggesting reduced integrative socio-cognitive performance. These findings should be interpreted with caution given the limited sample size and clinical heterogeneity, which make this a preliminary study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings provide preliminary evidence of early empathy-related and theory of mind alterations in MCI, supporting the inclusion of social cognition assessments in standard neuropsychological protocols. The combined use of self-report and task-based instruments may enhance early identification of socio-emotional dysfunctions and inform personalized clinical interventions. The preliminary nature of this study is mainly due to the small sample size and the heterogeneous clinical profiles, which limit generalizability but highlight the need for replication in larger cohorts.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnagi.2025.1661172","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T05:24:23Z","timestamp":1757395463000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Empathy in mild cognitive impairment: a preliminary clinical comparative study in Southern Switzerland using the interpersonal reactivity index (IRI) and the story-based empathy task (SET)"],"prefix":"10.3389","volume":"17","author":[{"given":"L.","family":"Arnaud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Morellini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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Neurodegener."},{"key":"ref2","first-page":"226","article-title":"Theory of mind abilities in neurodegenerative diseases: an update and a call to introduce mentalizing tasks in standard neuropsychological assessments","volume":"10","author":"Adenzato","year":"2013","journal-title":"Clin. Neuropsychiatry"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement."},{"key":"ref4","volume-title":"Diagnostic and statistical manual of mental disorders","year":"2022"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1017\/S1092852918001347","article-title":"State of the science on mild cognitive impairment (MCI)","volume":"24","author":"Anderson","year":"2019","journal-title":"CNS Spectr."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"4283427","DOI":"10.1155\/2018\/4283427","article-title":"Social cognition through the lens of cognitive and clinical neuroscience","volume":"2018","author":"Arioli","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"13633","DOI":"10.3390\/ijms222413633","article-title":"Investigating the Endo-lysosomal system in major neurocognitive disorders due to Alzheimer\u2019s disease, frontotemporal lobar degeneration and Lewy body disease: evidence for SORL1 as a cross-disease gene","volume":"22","author":"Benussi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/alz.12365","article-title":"Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe","volume":"18","author":"Boccardi","year":"2022","journal-title":"Alzheimers Dement."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1017\/S0033291715002573","article-title":"Meta-analysis of social cognition in attention-deficit\/hyperactivity disorder (ADHD): comparison with healthy controls and autistic spectrum disorder","volume":"46","author":"Bora","year":"2016","journal-title":"Psychol. Med."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/gps.5016","article-title":"Cognitive tests for the detection of mild cognitive impairment (MCI), the prodromal stage of dementia: meta-analysis of diagnostic accuracy studies","volume":"34","author":"Breton","year":"2019","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1093\/brain\/awu183","article-title":"Impact of brain tumour location on emotion and personality: a voxel-based lesion-symptom mapping study on mentalization processes","volume":"137","author":"Campanella","year":"2014","journal-title":"Brain"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/jnp.12431","article-title":"Understanding barriers and optimizing socio-cognitive assessment in the diagnosis of neurocognitive disorders","author":"Cerami","year":"2025","journal-title":"J. Neuropsychol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.3390\/brainsci13101356","article-title":"Theory of mind and executive functions in individuals with mild cognitive impairment or healthy aging","volume":"13","author":"Clemente","year":"2023","journal-title":"Brain Sci."},{"key":"ref14","first-page":"85","article-title":"A multidimensional approach to individual differences in empathy","volume":"10","author":"Davis","year":"1980","journal-title":"JSAS Catalog Selected Doc. Psychol."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1037\/0022-3514.44.1.113","article-title":"Measuring individual differences in empathy: evidence for a multidimensional approach","volume":"44","author":"Davis","year":"1983","journal-title":"J. Pers. Soc. Psychol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1177\/1534582304267187","article-title":"The functional architecture of human empathy","volume":"3","author":"Decety","year":"2004","journal-title":"Behav. Cogn. Neurosci. Rev."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1007\/s10072-015-2281-3","article-title":"A novel task assessing intention and emotion attribution: Italian standardization and normative data of the story-based empathy task","volume":"36","author":"Dodich","year":"2015","journal-title":"Neurol. Sci."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/B978-012088566-4\/50012-X","article-title":"Chapter 7-social cognition","volume-title":"Cognitive systems-information processing meets brain science","author":"Frith","year":"2006"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"113893","DOI":"10.1016\/j.bbr.2022.113893","article-title":"Unravelling neural correlates of empathy deficits in subjective cognitive decline, mild cognitive impairment and Alzheimer\u2019s disease","volume":"428","author":"Giacomucci","year":"2022","journal-title":"Behav. Brain Res."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1111\/jnp.12223","article-title":"Social cognition and social functioning in patients with amnestic mild cognitive impairment or Alzheimer\u2019s dementia","volume":"15","author":"Kessels","year":"2021","journal-title":"J. Neuropsychol."},{"key":"ref9001","doi-asserted-by":"publisher","first-page":"2492","DOI":"10.1016\/j.neuroimage.2010.10.014","article-title":"Meta-analytic evidence for common and distinct neural networks associated with directly experienced pain and empathy for pain","volume":"54","author":"Lamm","year":"2011","journal-title":"Neuroimage."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1002\/mds.23823","article-title":"MDS task force on mild cognitive impairment in Parkinson's disease: critical review of PD-MCI","volume":"26","author":"Litvan","year":"2011","journal-title":"Mov. Disord."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1093\/arclin\/acab100","article-title":"The reading the mind in the eyes test, Iowa gambling task and interpersonal reactivity index: normative data in an Italian population sample","volume":"37","author":"Maddaluno","year":"2022","journal-title":"Arch. Clin. Neuropsychol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1037\/0894-4105.18.3.572","article-title":"Social perception deficits after traumatic brain injury: interaction between emotion recognition, mentalizing ability, and social communication","volume":"18","author":"McDonald","year":"2004","journal-title":"Neuropsychology"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1212\/WNL.0000000000009323","article-title":"Research criteria for the diagnosis of prodromal dementia with Lewy bodies","volume":"94","author":"McKeith","year":"2020","journal-title":"Neurology"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.pscychresns.2014.10.016","article-title":"Distinct neural correlates of emotional and cognitive empathy in older adults","volume":"232","author":"Moore","year":"2015","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"994070","DOI":"10.3389\/fpsyg.2022.994070","article-title":"Theory of mind in patients with mild cognitive impairment: a systematic review","volume":"13","author":"Morellini","year":"","journal-title":"Front. Psychol."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1044385","DOI":"10.3389\/fpsyg.2022.1044385","article-title":"Emotion recognition and processing in patients with mild cognitive impairment: a systematic review","volume":"13","author":"Morellini","year":"","journal-title":"Front. Psychol."},{"key":"ref9002","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1111\/jgs.15925","article-title":"The montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005 Apr;53(4):695-9. doi: 10.1111\/j.1532-5415.2005.53221.x. Erratum in","volume":"67","author":"Nasreddine","year":"2019","journal-title":"J Am Geriatr Soc"},{"key":"ref28","first-page":"728","article-title":"Disorders of memory","volume-title":"Office practice in neurology","author":"Petersen","year":"1996"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1212\/CON.0000000000000313","article-title":"Mild cognitive impairment","volume":"22","author":"Petersen","year":"2016","journal-title":"Continuum"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1017\/S1041610297004717","article-title":"Aging, memory, and mild cognitive impairment","volume":"9","author":"Petersen","year":"1997","journal-title":"Int. Psychogeriatr."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1017\/S0140525X00076512","article-title":"Does the chimpanzee have a theory of mind?","volume":"1","author":"Premack","year":"1978","journal-title":"Behav. Brain Sci."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"117392","DOI":"10.1016\/j.socscimed.2024.117392","article-title":"Effects of executive function on age-related emotion recognition decline varied by sex","volume":"361","author":"Pua","year":"2024","journal-title":"Soc. Sci. Med."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1037\/neu0000896","article-title":"Self-assessment of empathy uncovers defective self-awareness in mild cognitive impairment","volume":"37","author":"Quaranta","year":"2023","journal-title":"Neuropsychology"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3758\/s13415-023-01146-9","article-title":"Neural correlates of empathy in mild cognitive impairment","volume":"24","author":"Quaranta","year":"2024","journal-title":"Cogn. Affect. Behav. Neurosci."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1080\/87565641.2018.1529175","article-title":"Cognitive and affective theory of mind in mild cognitive impairment and Parkinson\u2019s disease: preliminary evidence from the Italian version of the Yoni task","volume":"43","author":"Rossetto","year":"2018","journal-title":"Dev. Neuropsychol."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"415","DOI":"10.3390\/diagnostics13030415","article-title":"Transcranial magnetic stimulation improves executive functioning through modulation of social cognitive networks in patients with mild cognitive impairment: preliminary results","volume":"13","author":"Sacco","year":"","journal-title":"Diagnostics"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1162510","DOI":"10.3389\/fneur.2023.1162510","article-title":"The diagnosis and the therapy of social cognition deficits in adults affected by ADHD and MCI","volume":"14","author":"Sacco","year":"","journal-title":"Front. Neurol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1177\/1073858410379268","article-title":"The neural bases for empathy","volume":"17","author":"Shamay-Tsoory","year":"2010","journal-title":"Neuroscientist"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/B978-0-12-374176-9.00017-8","article-title":"Understanding others: brain mechanisms of theory of mind and empathy","volume-title":"Neuroeconomics: Decision making and the brain","author":"Singer","year":"2009"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1080\/13825589608256619","article-title":"Definition, course, and outcome of mild cognitive impairment","volume":"3","author":"Smith","year":"1996","journal-title":"Aging Neuropsychol. Cogn."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1080\/02699931.2013.875889","article-title":"Sex differences in the ability to recognise non-verbal displays of emotion: a meta-analysis","volume":"28","author":"Thompson","year":"2014","journal-title":"Cognit. Emot."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/nn.3085","article-title":"The neuroscience of empathy: Progress, pitfalls and promise","volume":"15","author":"Zaki","year":"2012","journal-title":"Nat. Neurosci."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2025.1661172\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T05:24:28Z","timestamp":1757395468000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2025.1661172\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,9]]},"references-count":44,"alternative-id":["10.3389\/fnagi.2025.1661172"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2025.1661172","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,9]]},"article-number":"1661172"}}