{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:37:13Z","timestamp":1787679433665,"version":"build-2784847793"},"reference-count":95,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cognitive decline advances with age, increasing the risk of dementia and Alzheimer\u2019s disease among older adults. Medium-chain triglyceride (MCT) ketogenic diets have shown potential in slowing down age-related cognitive decline; however, the exact neuroprotective roles of MCT components, specifically decanoic acid and octanoic acid, remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Swiss Albino mice were subjected to D-galactose to trigger accelerated aging, or to a combination of D-galactose and aluminium chloride to mimic Alzheimer\u2019s disease-like neurotoxicity. The animals received treated with decanoic acid, octanoic acid, or both. Cognitive function was assessed using the Morris water maze, while brain tissues were examined for oxidative stress markers, autophagy indicators, senescence activity, and amyloid-\u03b2 levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Decanoic acid significantly improved learning and memory performance, enhanced antioxidant enzyme activity (superoxide dismutase, reduced glutathione, catalase), promoted autophagy by inhibiting mTOR, reduced cellular senescence (\u03b2-galactosidase-positive cells), and decreased amyloid-\u03b2 toxicity. In contrast, octanoic acid showed no significant mechanistic effects, though it slightly improved cognitive behaviour.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study demonstrates that decanoic acid, unlike octanoic acid, exhibits significant neuroprotective effects against accelerated aging and neurotoxicity, similar to Alzheimer\u2019s disease. These findings highlight the differences in the neuroprotective mechanisms of decanoic and octanoic acids, implying that MCT-based diets should be re-evaluated as a preventive strategy for cognitive decline and neurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2025.1676926","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T06:38:10Z","timestamp":1763534290000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Decanoic acid, an MCT dietary component, alleviates cognitive impairment, cellular senescence, and promotes autophagy in accelerated aging and neurotoxic mouse models induced by chronic administration of D-galactose and D-galactose\/AlCl3"],"prefix":"10.3389","volume":"17","author":[{"given":"Shreshta","family":"Jain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Vohora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3708","DOI":"10.1002\/alz.13809","article-title":"Alzheimer's disease facts and figures","volume":"20","year":"2024","journal-title":"Alzheimers Dement."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1038\/s43587-021-00098-4","article-title":"Autophagy in healthy aging and disease","volume":"1","author":"Aman","year":"2021","journal-title":"Nat. Aging"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"17084","DOI":"10.1038\/s41598-022-20945-7","article-title":"Metformin alleviates neurocognitive impairment in aging via activation of AMPK\/BDNF\/PI3K pathway","volume":"12","author":"Ameen","year":"2022","journal-title":"Sci. Rep."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"5242","DOI":"10.1080\/10408398.2022.2153355","article-title":"Dietary restriction in senolysis and prevention and treatment of disease","volume":"64","author":"Aminzadeh-Gohari","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/S1474-4422(17)30408-8","article-title":"Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders","volume":"17","author":"Augustin","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1007\/s10522-019-09837-y","article-title":"D-galactose-induced accelerated aging model: an overview","volume":"20","author":"Azman","year":"2019","journal-title":"Biogerontology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1093\/ajcn\/36.5.950","article-title":"Medium-chain triglycerides: an update","volume":"36","author":"Bach","year":"1982","journal-title":"Am. J. Clin. Nutr."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/s41596-019-0256-1","article-title":"A toolbox for the longitudinal assessment of healthspan in aging mice","volume":"15","author":"Bellantuono","year":"2020","journal-title":"Nat. Protoc."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/s41586-019-1365-2","article-title":"From discoveries in ageing research to therapeutics for healthy ageing","volume":"571","author":"Campisi","year":"2019","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.1002\/1878-0261.13269","article-title":"Autophagy at the intersection of aging, senescence, and cancer","volume":"16","author":"Cassidy","year":"2022","journal-title":"Mol. Oncol."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1093\/nutrit\/nuac104","article-title":"Medium-chain fatty acids for the prevention or treatment of Alzheimer's disease: a systematic review and meta-analysis","volume":"81","author":"Castro","year":"2023","journal-title":"Nutr. Rev."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/brain\/awv325","article-title":"Seizure control by decanoic acid through direct AMPA receptor inhibition","volume":"139","author":"Chang","year":"2015","journal-title":"Brain"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"101828","DOI":"10.1016\/j.arr.2022.101828","article-title":"Insight into the role of adult hippocampal neurogenesis in aging and Alzheimer's disease","volume":"84","author":"Chen","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/0003-2697(70)90083-7","article-title":"Measurement of catalase activity in tissue extracts","volume":"34","author":"Cohen","year":"1970","journal-title":"Anal. Biochem."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1002\/jnr.20845","article-title":"Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-\u03b1-lipoic acid","volume":"83","author":"Cui","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/0047-6374(87)90051-0","article-title":"Distribution of superoxide dismutase, glutathione peroxidase and catalase in developing rat brain","volume":"41","author":"Del Maestro","year":"1987","journal-title":"Mech. Ageing Dev."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41580-020-00314-w","article-title":"Cellular senescence in ageing: from mechanisms to therapeutic opportunities","volume":"22","author":"Di Micco","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo","volume":"92","author":"Dimri","year":"1995","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1230467","DOI":"10.3389\/fnagi.2023.1230467","article-title":"Potential benefits of medium chain fatty acids in aging and neurodegenerative disease","volume":"15","author":"Dunn","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.jalz.2018.12.017","article-title":"A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment","volume":"15","author":"Fortier","year":"2019","journal-title":"Alzheimers Dement."},{"key":"ref22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/978-981-15-0602-4_9","article-title":"Oxidative stress and autophagy","volume-title":"Autophagy: Biology and diseases: Basic science","author":"Gao","year":"2019"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/nrm2240","article-title":"Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?","volume":"8","author":"Giorgio","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/s41392-022-01251-0","article-title":"Aging and aging-related diseases: from molecular mechanisms to interventions and treatments","volume":"7","author":"Guo","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.lfs.2015.01.016","article-title":"A high dose of short term exogenous D-galactose administration in young male rats produces symptoms simulating the natural aging process","volume":"124","author":"Haider","year":"2015","journal-title":"Life Sci."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12974-017-1026-z","article-title":"Oxidative stress predicts cognitive decline with aging in healthy adults: an observational study","volume":"15","author":"Hajjar","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1002\/jpen.2297","article-title":"Octanoic acid-rich enteral nutrition prevented lipopolysaccharide-induced acute liver injury through c-Jun N-terminal kinase-dependent autophagy","volume":"46","author":"He","year":"2022","journal-title":"JPEN J. Parenter. Enteral Nutr."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.neuro.2022.05.003","article-title":"Astragalin attenuates AlCl3\/D-galactose-induced aging-like disorders by inhibiting oxidative stress and neuroinflammation","volume":"91","author":"Hu","year":"2022","journal-title":"Neurotoxicology"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"13634","DOI":"10.1021\/acs.jafc.4c00836","article-title":"Pongamol alleviates neuroinflammation and promotes autophagy in Alzheimer\u2019s disease by regulating the Akt\/mTOR Signaling pathway","volume":"72","author":"Hu","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref30","first-page":"77","article-title":"Pathophysiology and management approaches in Alzheimer\u2019s disease","volume-title":"Drug delivery strategies in neurological disorders: Challenges and opportunities","author":"Jain","year":"2024"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"7003","DOI":"10.1038\/s41598-021-86468-9","article-title":"Octanoic acid a major component of widely consumed medium-chain triglyceride ketogenic diet is detrimental to bone","volume":"11","author":"Jain","year":"2021","journal-title":"Sci. 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Protective role of glutathione and evidence for 3, 4-bromobenzene oxide as the hepatotoxic metabolite","volume":"11","author":"Jollow","year":"1974","journal-title":"Pharmacology"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e12259","DOI":"10.1002\/trc2.12259","article-title":"Use of medium chain triglyceride (MCT) oil in subjects with Alzheimer's disease: A randomized, double-blind, placebo-controlled, crossover study, with an open-label extension","volume":"8","author":"Juby","year":"2022","journal-title":"Alzheimers Dement."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3389\/fnmol.2020.00041","article-title":"Oxidative stress in cognitive and epigenetic aging: a retrospective glance","volume":"13","author":"Kandlur","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1111\/epi.13833","article-title":"Neuronal decanoic acid oxidation is markedly lower than that of octanoic acid: A mechanistic insight into the medium-chain triglyceride ketogenic diet","volume":"58","author":"Khabbush","year":"2017","journal-title":"Epilepsia"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0003-9861(78)90479-4","article-title":"Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase","volume":"186","author":"Kono","year":"1978","journal-title":"Arch. Biochem. Biophys."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s00210-009-0442-8","article-title":"Effect of carvedilol on behavioral, mitochondrial dysfunction, and oxidative damage against d-galactose induced senescence in mice","volume":"380","author":"Kumar","year":"2009","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3389\/fmed.2020.00371","article-title":"Aging as \u201ctime-related dysfunction\u201d: A perspective","volume":"7","author":"Kyriazis","year":"2020","journal-title":"Front. Med."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"14164","DOI":"10.1073\/pnas.1009485107","article-title":"Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease","volume":"107","author":"Lipinski","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40035-024-00397-x","article-title":"The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing","volume":"13","author":"Liu","year":"2024","journal-title":"Transl. Neurodegener."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.molmed.2019.07.002","article-title":"Mitophagy and neuroprotection","volume":"26","author":"Lou","year":"2020","journal-title":"Trends Mol. Med."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"7560","DOI":"10.1039\/D2FO01246D","article-title":"\u03b3-Glutamylcysteine ameliorates d-gal-induced senescence in PC12 cells and mice via activating AMPK and SIRT1","volume":"13","author":"Lu","year":"2022","journal-title":"Food Funct."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.mad.2008.12.005","article-title":"Altered expression of Abeta metabolism-associated molecules from D-galactose\/AlCl(3) induced mouse brain","volume":"130","author":"Luo","year":"2009","journal-title":"Mech. Ageing Dev."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1016\/j.csbj.2024.05.036","article-title":"Aluminum chloride and D-galactose induced a zebrafish model of Alzheimer's disease with cognitive deficits and aging","volume":"23","author":"Luo","year":"2024","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"27(4)","DOI":"10.3390\/molecules27041210","article-title":"Amyloidosis in Alzheimer's disease: pathogeny, Etiology, and related therapeutic directions","volume":"27","author":"Ma","year":"2022","journal-title":"Molecules"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1074\/jbc.M111.294785","article-title":"Identification and mechanism of 10-carbon fatty acid as modulating ligand of peroxisome proliferator-activated receptors *","volume":"287","author":"Malapaka","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"6135","DOI":"10.1038\/s41598-021-85523-9","article-title":"The medium-chain fatty acid decanoic acid reduces oxidative stress levels in neuroblastoma cells","volume":"11","author":"Mett","year":"2021","journal-title":"Sci. Rep."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"81","DOI":"10.2165\/00002512-200421020-00002","article-title":"Role of hydrogen peroxide in the aetiology of Alzheimer\u2019s disease","volume":"21","author":"Milton","year":"2004","journal-title":"Drugs Aging"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"e04785","DOI":"10.2903\/j.efsa.2017.4785","article-title":"Re-evaluation of fatty acids (E 570) as a food additive","volume":"15","author":"Mortensen","year":"2017","journal-title":"EFSA J."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"233","DOI":"10.3233\/JAD-131436","article-title":"Coconut oil attenuates the effects of amyloid-\u03b2 on cortical neurons in vitro","volume":"39","author":"Nafar","year":"2014","journal-title":"J Alzheimer's Dis"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"3797","DOI":"10.1007\/s00213-016-4414-7","article-title":"Effect of a ketogenic meal on cognitive function in elderly adults: potential for cognitive enhancement","volume":"233","author":"Ota","year":"2016","journal-title":"Psychopharmacology"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.neulet.2018.10.048","article-title":"Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer\u2019s disease","volume":"690","author":"Ota","year":"2019","journal-title":"Neurosci. Lett."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.redox.2016.10.015","article-title":"Macroautophagy is impaired in old murine brain tissue as well as in senescent human fibroblasts","volume":"10","author":"Ott","year":"2016","journal-title":"Redox Biol."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/ptr.5358","article-title":"The mechanism of memory enhancement of acteoside (Verbascoside) in the senescent mouse model induced by a combination of d-gal and AlCl3","volume":"29","author":"Peng","year":"2015","journal-title":"Phytother. Res."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"793","DOI":"10.3390\/brainsci10110793","article-title":"Effect of treadmill exercise and trans-cinnamaldehyde against d-galactose- and Aluminum chloride-induced cognitive dysfunction in mice","volume":"10","author":"Ryu","year":"2020","journal-title":"Brain Sci."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jff.2015.08.024","article-title":"Naringin mitigate okadaic acid-induced cognitive impairment in an experimental paradigm of Alzheimer's disease","volume":"19","author":"Sachdeva","year":"2015","journal-title":"J. Funct. Foods"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1004568","DOI":"10.3389\/fphar.2022.1004568","article-title":"Neuroprotective effects of a medium chain fatty acid, decanoic acid, isolated from H. leucospilota against parkinsonism in C. elegans PD model","volume":"13","author":"Sanguanphun","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"fcab160","DOI":"10.1093\/braincomms\/fcab160","article-title":"Vita: a feasibility study of a blend of medium chain triglycerides to manage drug-resistant epilepsy","volume":"3","author":"Schoeler","year":"2021","journal-title":"Brain Commun."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.neuint.2009.02.009","article-title":"Medium-chain fatty acids accumulating in MCAD deficiency elicit lipid and protein oxidative damage and decrease non-enzymatic antioxidant defenses in rat brain","volume":"54","author":"Schuck","year":"2009","journal-title":"Neurochem. Int."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.3390\/biomedicines11092336","article-title":"Morphofunctional changes in brain and peripheral blood in adult and aged Wistar rats with AlCl3-induced neurodegeneration","volume":"11","author":"Sentyabreva","year":"2023","journal-title":"Biomedicine"},{"key":"ref65","doi-asserted-by":"crossref","DOI":"10.2139\/ssrn.4110706","volume-title":"Acute and chronic effects of intermittent ketosis established by medium-chain triglyceride supplementation on cognitive and metabolic parameters in rats","author":"Shcherbakova","year":"2022"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.exger.2017.10.029","article-title":"Role of D-galactose-induced brain aging and its potential used for therapeutic interventions","volume":"101","author":"Shwe","year":"2018","journal-title":"Exp. Gerontol."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"646924","DOI":"10.3389\/fnagi.2021.646924","article-title":"Cellular senescence in brain aging","volume":"13","author":"Sikora","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"176","DOI":"10.4161\/auto.5269","article-title":"Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila","volume":"4","author":"Simonsen","year":"2008","journal-title":"Autophagy"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"657","DOI":"10.3389\/fphys.2019.00657","article-title":"Differential metabolism of medium-chain fatty acids in differentiated human-induced pluripotent stem cell-derived astrocytes","volume":"10","author":"Sonnay","year":"2019","journal-title":"Front. Physiol."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/S1474-4422(12)70191-6","article-title":"Cognitive reserve in ageing and Alzheimer's disease","volume":"11","author":"Stern","year":"2012","journal-title":"Lancet Neurol."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.brainres.2008.06.005","article-title":"Induction of ketosis may improve mitochondrial function and decrease steady-state amyloid-\u03b2 precursor protein (APP) levels in the aged dog","volume":"1226","author":"Studzinski","year":"2008","journal-title":"Brain Res."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s11357-009-9099-y","article-title":"Alteration of a\u03b2 metabolism-related molecules in predementia induced by AlCl3 and D-galactose","volume":"31","author":"Sun","year":"2009","journal-title":"Age (Dordr.)"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"e55745","DOI":"10.7554\/eLife.55745","article-title":"Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans","volume":"9","author":"Sun","year":"2020","journal-title":"eLife"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"7108604","DOI":"10.1155\/2018\/7108604","article-title":"Matrine attenuates D-galactose-induced aging-related behavior in mice via inhibition of cellular senescence and oxidative stress","volume":"2018","author":"Sun","year":"2018","journal-title":"Oxidative Med. 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