{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:00:46Z","timestamp":1793376046119,"version":"4.5.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008343","name":"Beijing Language and Culture University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008343","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Accumulating evidence demonstrated that the cerebellum contributes to a wide range of sensorimotor and cognitive functions. However, the relationship between cerebellar function and cognitive abilities in normal aging populations remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The present cross-sectional study tested cerebellar-related cognitive changes across middle to late adulthood using the Cerebellar Cognitive Affective Syndrome (CCAS) scale and a perceptual serial reaction time (SRT) task. Participants were divided into three groups: early-middle-aged adults (\n                      <jats:italic>N<\/jats:italic>\n                      \u202f=\u202f18, 30\u201345\u202fyears), late-middle-aged adults (\n                      <jats:italic>N<\/jats:italic>\n                      \u202f=\u202f19, 46\u201357\u202fyears), and older adults (\n                      <jats:italic>N<\/jats:italic>\n                      \u202f=\u202f18, 60\u201378\u202fyears).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Although all participants were identified as cognitively healthy by the Mini-Mental State Examination (MMSE), older adults showed significant impairments in the CCAS scale, especially in semantic and phonemic fluency, category switching, digit span backward as well as cube drawing\/copy. In the perceptual SRT task, older adults responded slower than their counterparts, reflecting age-related impairments in sensorimotor integration efficiency. However, there were no age-related group differences in learning new procedural knowledge. Importantly, participants with poorer CCAS performance demonstrated slower response speed and lower accuracy in the perceptual SRT task.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The current results indicate a dissociation between general cognitive scores screened by MMSE and cerebellar-specific cognitive impairments. Furthermore, as the cerebellum plays a critical role in both sensorimotor and cognitive domains, the current study highlight the importance of incorporating screening tools which are sensitive to cerebellar functions in aging research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2025.1679443","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T06:29:00Z","timestamp":1765261740000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The cerebellar-related cognitive function is sensitive to aging: implications for early detection"],"prefix":"10.3389","volume":"17","author":[{"given":"Qianying","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruilin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"ref1","first-page":"1","article-title":"Redefining cerebellar assessment: a comprehensive review of the cerebellum\u2019s cognitive and affective roles and the efficacy of CCAS scales","volume-title":"Surgical Neurology International.","author":"Alan","year":"2024"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1017\/S0033291717003117","article-title":"Chiari 1000 registry project: assessment of surgical outcome on self-focused attention, pain, and delayed recall","volume":"48","author":"Allen","year":"2018","journal-title":"Psychol. 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