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This review summarizes the neuroimaging features and clinical implications of brain volumetric changes across distinct the clinical phases of the AD continuum [preclinical phase, subjective cognitive decline (SCD), mild cognitive impairment (MCI), and dementia phase]. Our analysis reveals a key conceptual advance: the spatiotemporal pattern of WM volume loss is not merely a consequence of GM degeneration but an active and complementary contributor to clinical decline. We identify specific, underappreciated WM tracts whose atrophy rates offer unique prognostic value beyond hippocampal volume. The primary contribution of this work is a unified model of AD neuroanatomy, which challenges the isolated view of GM and WM pathology. This refined understanding is critical for developing the next generation of biomarkers and underscores the imperative to leverage artificial intelligence for analyzing these complex, multi-tissue interactions. 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