{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T08:29:48Z","timestamp":1771921788690,"version":"3.50.1"},"reference-count":81,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rapid eye movement sleep behavior disorder (RBD) is increasingly recognized as both a prodromal marker and a significant predictor of Parkinson\u2019s disease (PD) progression. Despite a surge in related research, a comprehensive bibliometric evaluation summarizing the field\u2019s development, key contributors, and thematic evolution remains lacking. This study aimed to uncover the knowledge structure and emerging frontiers in RBD-related PD research through bibliometric analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>On September 1, 2,025, an extensive literature search was conducted in the Web of Science Core Collection and Scopus databases using standardized RBD-related PD keywords. Bibliometric analysis and knowledge mapping were performed with CiteSpace, VOSviewer, and R software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2,887 publications were identified, research output has increased steadily since 2013. Keyword co-occurrence and clustering analyses revealed three primary research directions: (1) longitudinal studies of RBD as a prodromal manifestation of synucleinopathies, (2) biomarker discovery for early diagnosis and disease monitoring, and (3) clinical interventions targeting sleep disturbances and neuroprotection. Notably, recent research trends emphasize non-motor symptoms of PD, overlapping mechanisms with Lewy body disease, and the application of advanced neuroimaging and digital sleep-monitoring technologies. Additionally, emerging keywords highlight biomarkers, gender differences, melatonin as focal points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This bibliometric analysis provides a systematic overview of the RBD-related PD research landscape. It underscores the field\u2019s shift from clinical observation to mechanistic exploration and translational application. These findings may guide future studies aimed at improving early detection and developing individualized therapeutic strategies for patients with RBD and PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2025.1744493","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:28:06Z","timestamp":1768458486000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A cross-database bibliometric analysis of rapid eye movement sleep behavior disorder in Parkinson\u2019s disease research"],"prefix":"10.3389","volume":"17","author":[{"given":"Shengjie","family":"Du","sequence":"first","affiliation":[{"name":"Department of Nursing Administration, Municipal Hospital Affiliated to Taizhou University","place":["Taizhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xijiang","family":"Tian","sequence":"additional","affiliation":[{"name":"Postgraduate School of Nursing, Sehan University","place":["Yeonggam, Republic of Korea"]},{"name":"Office of the University, Weifang University of Science and Technology","place":["Weifang, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Ren","sequence":"additional","affiliation":[{"name":"Postgraduate School of Nursing, Sehan University","place":["Yeonggam, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luya","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Nursing Administration, Municipal Hospital Affiliated to Taizhou University","place":["Taizhou, Zhejiang, China"]},{"name":"Postgraduate School of Nursing, Sehan University","place":["Yeonggam, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1002\/mds.28399","article-title":"Immunohistochemical detection of synuclein pathology in skin in idiopathic rapid eye movement sleep behavior disorder and parkinsonism","volume":"36","author":"Al-Qassabi","year":"2021","journal-title":"Mov. Disord."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and treatment of Parkinson disease a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"Neurol. Clin."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1093\/brain\/awaa365","article-title":"Dopaminergic imaging and clinical predictors for Phenoconversion of REM sleep behaviour disorder","volume":"144","author":"Arnaldi","year":"2021","journal-title":"Brain"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3390\/jpm11010051","article-title":"Cognitive and neuropsychiatric profiles in idiopathic rapid eye movement sleep behavior disorder and Parkinson's disease","volume":"11","author":"Assogna","year":"2021","journal-title":"J Pers Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e221848","DOI":"10.1148\/radiol.221848","article-title":"Altered brain Glymphatic flow at diffusion-tensor MRI in rapid eye movement sleep behavior disorder","volume":"307","author":"Bae","year":"2023","journal-title":"Radiology"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e0243454","DOI":"10.1371\/journal.pone.0243454","article-title":"REM sleep behavior in Parkinson disease: frequent, particularly with higher age","volume":"15","author":"Baumann-Vogel","year":"2020","journal-title":"PLoS One"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"73","DOI":"10.33588\/rn.7803.2023181","article-title":"Risk stratification for phenoconversion in patients with isolated REM sleep behavior disorder. A follow-up study from Turkey","volume":"78","author":"Benbir-Senel","year":"2024","journal-title":"Rev. Neurol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/s41582-021-00486-9","article-title":"Prodromal Parkinson disease subtypes \u2013 key to understanding heterogeneity","volume":"17","author":"Berg","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"S281","DOI":"10.3233\/JPD-191721","article-title":"Brain-first versus gut-first Parkinson's disease: a hypothesis","volume":"9","author":"Borghammer","year":"2019","journal-title":"J. Parkinsons Dis."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3390\/healthcare8020121","article-title":"Exploring the predictors of rapid eye movement sleep behavior disorder for Parkinson's disease patients using classifier ensemble","volume":"8","author":"Byeon","year":"2020","journal-title":"Healthcare"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/s41419-023-05672-9","article-title":"Alpha-Synuclein in Parkinson's disease and other Synucleinopathies: from overt neurodegeneration Back to early synaptic dysfunction","volume":"14","author":"Calabresi","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"101495","DOI":"10.1016\/j.smrv.2021.101495","article-title":"Structural and functional magnetic resonance imaging in isolated REM sleep behavior disorder: a systematic review of studies using neuroimaging software","volume":"59","author":"Campabadal","year":"2021","journal-title":"Sleep Med. Rev."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"zsab257","DOI":"10.1093\/sleep\/zsab257","article-title":"Video-polysomnography procedures for diagnosis of rapid eye movement sleep behavior disorder (RBD) and the identification of its prodromal stages: guidelines from the international Rbd study group","volume":"45","author":"Cesari","year":"2022","journal-title":"Sleep"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1002\/acn3.51269","article-title":"Dopamine transporter imaging predicts clinically-defined \u0391-Synucleinopathy in REM sleep behavior disorder","volume":"8","author":"Chahine","year":"2021","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/asi.20317","article-title":"CiteSpace II: detecting and visualizing emerging trends and transient patterns in scientific literature","volume":"57","author":"Chen","year":"2006","journal-title":"J. Am. Soc. Inf. Sci. Technol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1002\/asi.21309","article-title":"The structure and dynamics of cocitation clusters: a multiple-perspective cocitation analysis","volume":"61","author":"Chen","year":"2010","journal-title":"J. Am. Soc. Inf. Sci. Technol."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.neurad.2020.04.007","article-title":"Structural and functional brain alterations in patients with idiopathic rapid eye movement sleep behavior disorder","volume":"49","author":"Chen","year":"2022","journal-title":"J. Neuroradiol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e0223994","DOI":"10.1371\/journal.pone.0223994","article-title":"Visualizing a field of research: a methodology of systematic scientometric reviews","volume":"14","author":"Chen","year":"2019","journal-title":"PLoS One"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.5455\/annalsmedres.2023.09.253","article-title":"A visual and bibliometric analysis of Parkinson's disease biomarker research","volume":"30","author":"Cinpolat","year":"2023","journal-title":"Annals Med. Res."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1001\/jama.2014.3654","article-title":"Pharmacological treatment of Parkinson disease a review","volume":"311","author":"Connolly","year":"2014","journal-title":"JAMA"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41572-018-0016-5","article-title":"REM Sleep Behaviour Disorder","volume":"4","author":"Dauvilliers","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1002\/mds.29662","article-title":"Charting disease trajectories from isolated REM sleep behavior disorder to Parkinson's disease","volume":"39","author":"Di Folco","year":"2024","journal-title":"Mov. Disord."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.jbusres.2021.04.070","article-title":"How to conduct a bibliometric analysis: an overview and guidelines","volume":"133","author":"Donthu","year":"2021","journal-title":"J. Bus. Res."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.parkreldis.2021.04.007","article-title":"Consistent skin alpha-Synuclein positivity in REM sleep behavior disorder \u2013 a two center two-to-four-year follow-up study","volume":"86","author":"Doppler","year":"2021","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"108498","DOI":"10.1016\/j.pharmthera.2023.108498","article-title":"Pharmacological interventions targeting alpha-Synuclein aggregation triggered REM sleep behavior disorder and early development of Parkinson's disease","volume":"249","author":"Du","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1007\/s11192-015-1645-z","article-title":"The bibliometric analysis of scholarly production: how great is the impact?","volume":"105","author":"Ellegaard","year":"2015","journal-title":"Scientometrics"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1080\/14737175.2019.1640603","article-title":"Neuropsychological, electrophysiological, and neuroimaging biomarkers for REM behavior disorder","volume":"19","author":"Ferini-Strambi","year":"2019","journal-title":"Expert. Rev. Neurother."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.smrv.2018.09.008","article-title":"The risk of neurodegeneration in REM sleep behavior disorder: a systematic review and meta-analysis of longitudinal studies","volume":"43","author":"Galbiati","year":"2019","journal-title":"Sleep Med. Rev."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1002\/mds.28895","article-title":"Disruption of brainstem structural connectivity in REM sleep behavior disorder using 7 tesla magnetic resonance imaging","volume":"37","author":"Garc\u00eda-Gomar","year":"2022","journal-title":"Mov. Disord."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1002\/mds.28933","article-title":"Deep learning-based neuromelanin MRI changes of isolated REM sleep behavior disorder","volume":"37","author":"Gaurav","year":"2022","journal-title":"Mov. Disord."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"499","DOI":"10.2217\/bmm-2021-0646","article-title":"Synuclein-one study: skin biopsy detection of phosphorylated alpha-Synuclein for diagnosis of synucleinopathies","volume":"16","author":"Gibbons","year":"2022","journal-title":"Biomark. Med"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s00415-020-10353-0","article-title":"A critical review of the pharmacological treatment of REM sleep behavior disorder in adults: time for more and larger randomized placebo-controlled trials","volume":"269","author":"Gilat","year":"2022","journal-title":"J. Neurol."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1002\/mds.27802","article-title":"Update of the MDs research criteria for prodromal Parkinson's disease","volume":"34","author":"Heinzel","year":"2019","journal-title":"Mov. Disord."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/nrneurol.2017.157","article-title":"Idiopathic REM sleep behaviour disorder and neurodegeneration \u2013 an update","volume":"14","author":"Hogl","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"3077","DOI":"10.1093\/brain\/awaa238","article-title":"Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study","volume":"143","author":"Horsager","year":"2020","journal-title":"Brain"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"759","DOI":"10.5664\/jcsm.10424","article-title":"Management of REM Sleep Behavior Disorder: an American Academy of sleep medicine clinical practice guideline","volume":"19","author":"Howell","year":"2023","journal-title":"J. Clin. Sleep Med."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"396","DOI":"10.3390\/antiox12020396","article-title":"Neuroprotective effect of melatonin on sleep disorders associated with Parkinson's disease","volume":"12","author":"Hu","year":"2023","journal-title":"Antioxidants"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e1944","DOI":"10.1212\/WNL.0000000000207147","article-title":"Misfolded alpha-Synuclein assessment in the skin and CSF by RT-QuIC in isolated REM sleep behavior disorder","volume":"100","author":"Iranzo","year":"2023","journal-title":"Neurology"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41531-021-00242-2","article-title":"Diagnostic value of skin RT-QuIC in Parkinson's disease: a two-laboratory study","volume":"7","author":"Kuzkina","year":"2021","journal-title":"NPJ Parkinsons Dis."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/s41531-023-00519-8","article-title":"Combining skin and olfactory alpha-Synuclein seed amplification assays (SAA)-towards biomarker-driven phenotyping in synucleinopathies","volume":"9","author":"Kuzkina","year":"2023","journal-title":"NPJ Parkinsons Dis."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1177\/0312896219877678","article-title":"Conducting systematic literature reviews and bibliometric analyses","volume":"45","author":"Linnenluecke","year":"2020","journal-title":"Aust. J. Manage."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"7397","DOI":"10.3390\/jcm12237397","article-title":"REM sleep behavior disorder and cognitive functions in Parkinson's patients: a systematic review","volume":"12","author":"Marafioti","year":"2023","journal-title":"J. Clin. Med."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3233\/JPD-212571","article-title":"Brain neuroimaging of rapid eye movement sleep behavior disorder in Parkinson's disease: a systematic review","volume":"12","author":"Matzaras","year":"2022","journal-title":"J. Parkinsons Dis."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1212\/wnl.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies fourth consensus report of the DLB consortium","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Diagnosis and management of dementia with Lewy bodies \u2013 third report of the DLB consortium","volume":"65","author":"McKeith","year":"2005","journal-title":"Neurology"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"8839","DOI":"10.3390\/ijms24108839","article-title":"Oligomeric alpha-Synuclein and STX-1a from neural-derived extracellular vesicles (NDEVs) as possible biomarkers of REM sleep behavior disorder in Parkinson's disease: a preliminary cohort study","volume":"24","author":"Meloni","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/s1474-4422(21)00176-9","article-title":"Biomarkers of conversion to \u0391-Synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder","volume":"20","author":"Miglis","year":"2021","journal-title":"Lancet Neurol."},{"key":"ref51","article-title":"Software tools for conducting bibliometric analysis in science: an up-to-date review","volume":"29","author":"Moral-Mu\u00f1oz","year":"2020","journal-title":"Prof. Inferm."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1111\/psyg.12873","article-title":"Clonazepam-induced misidentification in prodromal dementia with Lewy bodies","volume":"22","author":"Morioka","year":"2022","journal-title":"Psychogeriatrics"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"13390","DOI":"10.3390\/ijms232113390","article-title":"Striatal-inoculation of \u03b1-Synuclein preformed fibrils aggravated the phenotypes of REM sleep without Atonia in A53t BAC-SNCA transgenic mice","volume":"23","author":"Okuda","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1374924","DOI":"10.3389\/fpsyg.2024.1374924","article-title":"A bibliometric analysis of speech and language impairments in Parkinson's disease based on web of science","volume":"15","author":"Pan","year":"2024","journal-title":"Front. Psychol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1212\/01.wnl.0000340980.19702.6e","article-title":"Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder","volume":"72","author":"Postuma","year":"2009","journal-title":"Neurology"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1093\/brain\/awz030","article-title":"Risk and predictors of dementia and Parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study","volume":"142","author":"Postuma","year":"2019","journal-title":"Brain"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1212\/01.wnl.0000203648.80727.5b","article-title":"Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder","volume":"66","author":"Postuma","year":"2006","journal-title":"Neurology"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"914","DOI":"10.3390\/brainsci13060914","article-title":"Parkinson's disease: a narrative review on potential molecular mechanisms of sleep disturbances, REM behavior disorder, and melatonin","volume":"13","author":"Samizadeh","year":"2023","journal-title":"Brain Sci."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.sleep.2012.10.009","article-title":"Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series","volume":"14","author":"Schenck","year":"2013","journal-title":"Sleep Med."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1212\/wnl.46.2.388","article-title":"Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder","volume":"46","author":"Schenck","year":"1996","journal-title":"Neurology"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.3233\/JPD-212749","article-title":"Management of sleep disturbances in Parkinson's disease","volume":"12","author":"Schutz","year":"2022","journal-title":"J. Parkinsons Dis."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/mds.27602","article-title":"Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review","volume":"34","author":"Seppi","year":"2019","journal-title":"Mov. Disord."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"S42","DOI":"10.1002\/mds.23884","article-title":"The movement disorder society evidence-based medicine review update: treatments for the non-motor symptoms of Parkinson's disease","volume":"26","author":"Seppi","year":"2011","journal-title":"Mov. Disord."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1443799","DOI":"10.3389\/fneur.2024.1443799","article-title":"Knowledge mapping and research trends of accidental falls in patients with Parkinson's disease from 2003 to 2023: a bibliometric analysis","volume":"15","author":"Shi","year":"2024","journal-title":"Front. Neurol."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/s41531-022-00316-9","article-title":"Neuroimaging evidence of Glymphatic system dysfunction in possible REM sleep behavior disorder and Parkinson's disease","volume":"8","author":"Si","year":"2022","journal-title":"NPJ Parkinsons Dis"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"599","DOI":"10.3390\/brainsci13040599","article-title":"Olfactory impairment is the Main predictor of higher scores at REM sleep behavior disorder (RBD) screening questionnaire in Parkinson's disease patients","volume":"13","author":"Solla","year":"2023","journal-title":"Brain Sci."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1093\/brain\/awab005","article-title":"Alpha-Synuclein seeds in olfactory mucosa of patients with isolated REM sleep behaviour disorder","volume":"144","author":"Stefani","year":"2021","journal-title":"Brain"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1002\/mds.21740","article-title":"The REM sleep behavior disorder screening questionnaire: a new diagnostic instrument","volume":"22","author":"Stiasny-Kolster","year":"2007","journal-title":"Mov. Disord."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"e30191","DOI":"10.1016\/j.heliyon.2024.e30191","article-title":"Dysphagia in Parkinson's disease: a bibliometric and visualization analysis from 2002 to 2022","volume":"10","author":"Sun","year":"2024","journal-title":"Heliyon"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.2174\/1570159X19666210517115706","article-title":"Pharmacological and non-pharmacological treatments of sleep disorders in Parkinson's disease","volume":"19","author":"Taximaimaiti","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1002\/jnr.24779","article-title":"Extra-striatal dopamine in Parkinson's disease with rapid eye movement sleep behavior disorder","volume":"99","author":"Valli","year":"2021","journal-title":"J. Neurosci. Res."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1002\/jnr.25099","article-title":"Neuroimaging of rapid eye movement sleep behavior disorder and its relation to Parkinson's disease","volume":"100","author":"Valli","year":"2022","journal-title":"J. Neurosci. Res."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: Vosviewer, a computer program for bibliometric mapping","volume":"84","author":"van Eck","year":"2010","journal-title":"Scientometrics"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.neurol.2020.06.009","article-title":"Melatonin (MEL) and its use in neurological diseases and insomnia: recommendations of the French medical and research sleep society (SFRMS)","volume":"177","author":"Vecchierini","year":"2021","journal-title":"Rev. Neurol. (Paris)"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1136\/jnnp-2021-328062","article-title":"Possible predictors of phenoconversion in isolated REM sleep behaviour disorder: a systematic review and Meta-analysis","volume":"93","author":"Wang","year":"2022","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10654-011-9581-6","article-title":"Epidemiology and etiology of Parkinson's disease: a review of the evidence","volume":"26","author":"Wirdefeldt","year":"2011","journal-title":"Eur. J. Epidemiol."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s10072-020-04769-9","article-title":"Non-motor symptoms are associated with REM sleep behavior disorder in Parkinson's disease: a systematic review and Meta-analysis","volume":"42","author":"Xie","year":"2021","journal-title":"Neurol. Sci."},{"key":"ref79","doi-asserted-by":"publisher","first-page":"709878","DOI":"10.3389\/fnagi.2021.709878","article-title":"Pharmacological interventions for REM sleep behavior disorder in Parkinson's disease: a systematic review","volume":"13","author":"Yan","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3389\/fnagi.2020.00213","article-title":"Gray matter alterations in Parkinson's disease with rapid eye movement sleep behavior disorder: a meta-analysis of voxel-based morphometry studies","volume":"12","author":"Yang","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1002\/acn3.51301","article-title":"Peripheral Synucleinopathy in Parkinson disease with Lrrk2 G2385r variants","volume":"8","author":"Yang","year":"2021","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.3233\/JPD-202243","article-title":"Predictors of conversion to \u03b1-Synucleinopathy diseases in idiopathic rapid eye movement sleep behavior disorder","volume":"10","author":"Ye","year":"2020","journal-title":"J. Parkinsons Dis."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"1388290","DOI":"10.3389\/fnagi.2024.1388290","article-title":"Mapping knowledge domain of acupuncture for Parkinson's disease: a bibliometric and visual analysis","volume":"16","author":"Zhao","year":"2024","journal-title":"Front. Aging Neurosci."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"8834950","DOI":"10.1155\/2021\/8834950","article-title":"Efficacy and safety of Pramipexole sustained release versus immediate release formulation for nocturnal symptoms in Chinese patients with advanced Parkinson's disease: a pilot study","volume":"2021","author":"Zhou","year":"2021","journal-title":"Parkinsons Dis"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1177\/1094428114562629","article-title":"Bibliometric methods in management and organization","volume":"18","author":"Zupic","year":"2015","journal-title":"Organ. Res. Methods"}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2025.1744493\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T06:55:57Z","timestamp":1771916157000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2025.1744493\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,15]]},"references-count":81,"alternative-id":["10.3389\/fnagi.2025.1744493"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2025.1744493","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,15]]},"article-number":"1744493"}}