{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T17:27:25Z","timestamp":1784395645515,"version":"3.55.0"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neuroinflammation is a core mechanism in the pathogenesis of Parkinson\u2019s disease (PD). Research on PD and neuroinflammation has been steadily increasing. This study aims to explore and analyze the current status, hotspots, and future directions of neuroinflammation-associated research in PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Data were retrieved from the Web of Science and PubMed databases. CiteSpace, VOSviewer, and the R package bibliometrix were used for data analysis and visualization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Publications on neuroinflammation in PD showed an upward trend. China had the most publications, while Norway exhibited the greatest influence. Shanghai Jiao Tong University was the most prolific institution, whereas Arizona State University demonstrated the strongest influence. The International\n                      <jats:italic>Journal of Molecular Sciences<\/jats:italic>\n                      was the most prolific journal in this field, and\n                      <jats:italic>Cell<\/jats:italic>\n                      had the strongest impact. The most productive author was Hong, Jau-Shyong, and the most influential author was Block, Michelle L. High-frequency keywords included PD, neuroinflammation, microglia, oxidative stress, alpha-synuclein, neurodegeneration, inflammation, and mouse models. Gut microbiota has become a recent focus of research.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Over the past two decades, research on neuroinflammation in PD has been continuously increasing. The research hotspots included microglia, oxidative stress,\n                      <jats:italic>\u03b1<\/jats:italic>\n                      -synuclein, brain-gut axis, and gut microbiota. This field is developing toward a multi-dimensional and in-depth exploration of mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2026.1699038","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T06:40:38Z","timestamp":1770187238000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Research trends on neuroinflammation in Parkinson\u2019s disease: an exploratory analysis"],"prefix":"10.3389","volume":"18","author":[{"given":"Yan-Jun","family":"Chen","sequence":"first","affiliation":[{"name":"The First Hospital of Hunan University of Chinese Medicine","place":["Changsha, China"]},{"name":"Graduate School of Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Rong","family":"Xie","sequence":"additional","affiliation":[{"name":"The First Clinical College of Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"National TCM Master Liu Zuyi Inheritance Studio, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Qiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"National TCM Master Liu Zuyi Inheritance Studio, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine)","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"The First Hospital of Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/nbt.1807","article-title":"Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes","volume":"29","author":"Alvarez-Erviti","year":"2011","journal-title":"Nat. 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