{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:07:25Z","timestamp":1789106845410,"version":"build-2803163510"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Postoperative cognitive dysfunction (POCD) is a common neurological complication involving the hippocampus, a brain region critical for learning and memory. Circular RNA (circRNA) plays an important role in regulating gene expression. Our objective is to predict and verify a circRNA-miRNA-mRNA network in POCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Microarray data of POCD mouse models were retrieved from the Gene Expression Omnibus (GEO) database. Differential expression analysis was used to identify differentially expressed circRNA, miRNA, and mRNA. An in silico circRNA-miRNA-mRNA network was subsequently predicted based on miRNA-mRNA pairs and miRNA-circRNA pairs obtained from public databases. From this global network, three hub subnetworks based on the competing endogenous RNA (ceRNA) hypothesis were analyzed. In hippocampal tissue of POCD mice, RT-qPCR quantified key circRNAs, miRNAs, and mRNAs, with protein levels of the corresponding mRNA confirmed by western blot. Dual-luciferase assays in HT22 cells verified interactions between mmu_circ_0001838 (mmu_circRNA_009748) and mmu-miR-337-3p, and between mmu-miR-337-3p and PLA2G12B mRNA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Analysis of publicly datasets related to POCD identified 12 genes potentially associated with programmed cell death, inflammation, immunity, and oxidative stress in POCD. According to these results, we successfully predicted a circRNA-miRNA-mRNA network, comprising 4 circRNAs, 14 miRNAs and 12 mRNAs. Furthermore, three circRNA-miRNA-mRNA subnetworks were then derived based on the ceRNA hypothesis, which included 3 circRNAs, 4 miRNAs and 8 mRNAs: mmu_circRNA_016232-mmu_miR-6912-5p-four mRNAs (GBP2, BCL3, ADGRL4, PLN), mmu_circRNA_009748-mmu_miR-362-3p\/mmu_miR-337-3p-two mRNAs (RSAD2, PLA2G12B), and mmu_circRNA_009396-mmu_miR-7030-5p-two mRNAs (SLC25A13, GPR171). The AUC value of each predicted circRNA-miRNA-mRNA path in diagnosing POCD exceeded 0.8. RT-qPCR results validated that the levels of mmu_circRNA_016232, mmu_circRNA_009748, mmu_miR-7030-5p, GBP2 mRNA, BCL3 mRNA, ADGRL4 mRNA, PLN mRNA, RSAD2 mRNA and PLA2G12B mRNA were elevated, while the levels of mmu_circRNA_009396, mmu_miR-6912-5p, mmu_miR-362-3p, mmu_miR-337-3p, SLC25A13 mRNA, and GPR171 mRNA were reduced in the hippocampal tissues of POCD mice compared to the control group. Western blot corroborated the protein-level changes for the corresponding mRNAs. Dual-luciferase assays further confirmed the direct interactions of mmu_circ_0001838 with mmu-miR-337-3p and mmu-miR-337-3p with PLA2G12B mRNA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study predicted and verified three critical circRNA-miRNA-mRNA regulatory axes, providing new insights into the molecular mechanisms underlying POCD and identifying potential biomarkers for its diagnosis and intervention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2026.1733749","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:29:12Z","timestamp":1789104552000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive analysis of circRNA-miRNA-mRNA networks to reveal potential cell death, inflammation and oxidative stress-related targets for postoperative cognitive dysfunction"],"prefix":"10.3389","volume":"18","author":[{"given":"Yajing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]},{"name":"National Clinical Research Center for Chinese Medicine","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Tianjin First Central Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]},{"name":"National Clinical Research Center for Chinese Medicine","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]},{"name":"National Clinical Research Center for Chinese Medicine","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingling","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]},{"name":"National Clinical Research Center for Chinese Medicine","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e14500","DOI":"10.1002\/alz.14500","article-title":"Hippocampal neuronal loss and cognitive decline in LATE-NC and ADNC among community-dwelling older persons","volume":"21","author":"Agrawal","year":"2025","journal-title":"Alzheimers Dement."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"13869","DOI":"10.2147\/JIR.S531241","article-title":"Downregulation of Gbp2 attenuates LPS-induced inflammation in BV2 microglia cells through inhibition of STAT1","volume":"18","author":"Bao","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"553","DOI":"10.4103\/aian.aian_175_23","article-title":"Adult onset episodic encephalopathy due to Citrin deficiency-a case report","volume":"26","author":"Baskar","year":"2023","journal-title":"Ann. Indian Acad. Neurol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e001569","DOI":"10.1136\/openhrt-2020-001569","article-title":"Does postoperative cognitive decline after coronary bypass affect quality of life?","volume":"8","author":"Blokzijl","year":"2021","journal-title":"Open Heart"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.bbi.2019.04.024","article-title":"Extracellular RNAs-TLR3 signaling contributes to cognitive decline in a mouse model of postoperative cognitive dysfunction","volume":"80","author":"Chen","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"102532","DOI":"10.1016\/j.tranon.2025.102532","article-title":"Integrated transcriptome and single-cell RNA sequencing analysis revealed the prognostic significance of GBP4 in pancreatic adenocarcinoma","volume":"61","author":"Chi","year":"2025","journal-title":"Transl. Oncol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1213\/ANE.0000000000003514","article-title":"Postoperative cognitive dysfunction and noncardiac surgery","volume":"127","author":"Evered","year":"2018","journal-title":"Anesth. Analg."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1159\/000533805","article-title":"PLA2G12B mediates arachidonic acid metabolism through activation of the NF-kappaB pathway to promote membrane nephropathy","volume":"48","author":"Fu","year":"2023","journal-title":"Kidney Blood Press. Res."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"101281","DOI":"10.1016\/j.neo.2026.101281","article-title":"Integrating single-cell and spatial transcriptomics to dissect mast-cell heterogeneity and arginine-metabolism-associated markers in BRCA","volume":"73","author":"Gao","year":"2026","journal-title":"Neoplasia"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"312","DOI":"10.5114\/fn.2024.136017","article-title":"An enriched environment promotes cognitive recovery and cerebral blood flow in aged mice under sevoflurane anaesthesia","volume":"62","author":"Gao","year":"2024","journal-title":"Folia Neuropathol."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1080\/15384101.2022.2057633","article-title":"Circular RNA CircITCH (has-circ-0001141) suppresses hepatocellular carcinoma (HCC) progression by sponging miR-184","volume":"21","author":"Guo","year":"2022","journal-title":"Cell Cycle"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1002\/jimd.12772","article-title":"Citrin deficiency-the east-side story","volume":"47","author":"Haberle","year":"2024","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"109231","DOI":"10.1016\/j.neuropharm.2022.109231","article-title":"Activation of TREM2 attenuates neuroinflammation via PI3K\/Akt signaling pathway to improve postoperative cognitive dysfunction in mice","volume":"219","author":"Han","year":"2022","journal-title":"Neuropharmacology"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4081\/ejh.2023.3766","article-title":"Dexmedetomidine attenuates neuroinflammation and microglia activation in LPS-stimulated BV2 microglia cells through targeting circ-Shank3\/miR-140-3p\/TLR4 axis","volume":"67","author":"He","year":"2023","journal-title":"Eur. J. Histochem."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e83","DOI":"10.1093\/nar\/gkae693","article-title":"Invention of circRNA promoting RNA to specifically promote circRNA production","volume":"52","author":"He","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"992869","DOI":"10.3389\/fncel.2022.992869","article-title":"Inhibition of the integrated stress response reverses oxidative stress damage-induced postoperative cognitive dysfunction","volume":"16","author":"Jiang","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e62679","DOI":"10.1371\/journal.pone.0062679","article-title":"Acetylcholinesterase inhibitors reduce neuroinflammation and -degeneration in the cortex and hippocampus of a surgery stress rat model","volume":"8","author":"Kalb","year":"2013","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.3390\/nu15102284","article-title":"Citrin deficiency: clinical and nutritional features","volume":"15","author":"Komatsu","year":"2023","journal-title":"Nutrients"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1136\/gutjnl-2024-334010","article-title":"GPR171 restrains intestinal inflammation by suppressing FABP5-mediated Th17 cell differentiation and lipid metabolism","volume":"74","author":"Kou","year":"2025","journal-title":"Gut"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e106837","DOI":"10.1371\/journal.pone.0106837","article-title":"Aging differentially affects the loss of neuronal dendritic spine, neuroinflammation and memory impairment at rats after surgery","volume":"9","author":"Le","year":"2014","journal-title":"PLoS One"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1177\/0271678X241261949","article-title":"Spatial metabolomics reveals key features of hippocampal lipid changes in rats with postoperative cognitive dysfunction","volume":"44","author":"Lei","year":"2024","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2023\/7272456","article-title":"Downregulation of Nrf2 in the Hippocampus contributes to postoperative cognitive dysfunction in aged rats by sensitizing oxidative stress and Neuroinflammation","volume":"2023","author":"Li","year":"2023","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41419-021-04464-3","article-title":"CircMTO1 suppresses hepatocellular carcinoma progression via the miR-541-5p\/ZIC1 axis by regulating Wnt\/beta-catenin signaling pathway and epithelial-to-mesenchymal transition","volume":"13","author":"Li","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"110791","DOI":"10.1016\/j.exger.2019.110791","article-title":"The potential mechanism of postoperative cognitive dysfunction in older people","volume":"130","author":"Lin","year":"2020","journal-title":"Exp. Gerontol."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"167137","DOI":"10.1016\/j.bbadis.2024.167137","article-title":"Hippocampal HDAC6 promotes POCD by regulating NLRP3-induced microglia pyroptosis via HSP90\/HSP70 in aged mice","volume":"1870","author":"Lin","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/j.1749-6632.1998.tb08254.x","article-title":"Sites of regulatory interaction between calcium ATPases and phospholamban","volume":"853","author":"Maclennan","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s12943-017-0663-2","article-title":"CircRNA: functions and properties of a novel potential biomarker for cancer","volume":"16","author":"Meng","year":"2017","journal-title":"Mol. Cancer"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1007\/s11064-017-2208-x","article-title":"Up-regulation of GBP2 is associated with neuronal apoptosis in rat brain cortex following traumatic brain injury","volume":"42","author":"Miao","year":"2017","journal-title":"Neurochem. Res."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1097\/00000542-200703000-00023","article-title":"Postoperative cognitive dysfunction after noncardiac surgery: a systematic review","volume":"106","author":"Newman","year":"2007","journal-title":"Anesthesiology"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.jhep.2025.02.007","article-title":"Developing splice-switching oligonucleotides for urea cycle disorder using an integrated diagnostic and therapeutic platform","volume":"83","author":"Ow","year":"2025","journal-title":"J. Hepatol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"e70005","DOI":"10.1002\/alz.70005","article-title":"Associations of hippocampal volumes, brain hypometabolism, and plasma NfL with amyloid, tau, and cognitive decline","volume":"21","author":"Pan","year":"2025","journal-title":"Alzheimers Dement."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"10939","DOI":"10.2147\/JIR.S535225","article-title":"Downregulated RSAD2 attenuates the apoptosis of LPS-stimulated RAW264.7 via NF-kappaB signaling pathway","volume":"18","author":"Qi","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s10549-023-06982-4","article-title":"LncRNA HOTAIR as a ceRNA is related to breast cancer risk and prognosis","volume":"200","author":"Qian","year":"2023","journal-title":"Breast Cancer Res. Treat."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s12640-022-00617-0","article-title":"CircUBE3B high expression participates in sevoflurane-induced human hippocampal neuron injury via targeting miR-326 and regulating MYD88 expression","volume":"41","author":"Qian","year":"2023","journal-title":"Neurotox. Res."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"695396","DOI":"10.3389\/fpain.2021.695396","article-title":"GPR171 agonist reduces chronic neuropathic and inflammatory pain in male, but not female mice","volume":"2","author":"Ram","year":"2021","journal-title":"Front Pain Res"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3238\/arztebl.2014.0119","article-title":"Postoperative cognitive dysfunction","volume":"111","author":"Rundshagen","year":"2014","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"752","DOI":"10.3389\/fpsyt.2018.00752","article-title":"The role of neuroinflammation in postoperative cognitive dysfunction: moving from hypothesis to treatment","volume":"9","author":"Safavynia","year":"2018","journal-title":"Front. Psych."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"11293","DOI":"10.3390\/ijms222011293","article-title":"ELTD1 activation induces an endothelial-EMT transition to a Myofibroblast phenotype","volume":"22","author":"Sheldon","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e52","DOI":"10.1002\/jex2.52","article-title":"ELTD1 is present in extracellular vesicles derived from endothelial cells as a cleaved extracellular domain which induces in vivo angiogenesis","volume":"1","author":"Sheldon","year":"2022","journal-title":"J Extracell Biol."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"377","DOI":"10.55782\/ane-2023-2464","article-title":"The protective role of circ_0016760 downregulation against sevoflurane-induced neurological impairment via modulating miR-145 expression in aged rats","volume":"83","author":"Shuai","year":"2023","journal-title":"Acta Neurobiol. Exp. (Wars)"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"439","DOI":"10.5152\/TJAR.2019.75299","article-title":"Current perspectives on postoperative cognitive dysfunction in the ageing population","volume":"47","author":"Urits","year":"2019","journal-title":"Turk J Anaesthesiol Reanim."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s13045-022-01345-w","article-title":"CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR","volume":"15","author":"Wang","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s13027-022-00470-y","article-title":"Construction and validation of prognostic signature for hepatocellular carcinoma basing on hepatitis B virus related specific genes","volume":"17","author":"Wang","year":"2022","journal-title":"Infect Agent Cancer."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1080\/08941939.2020.1771639","article-title":"CircRNA 001372 reduces inflammation in Propofol-induced Neuroinflammation and neural apoptosis through PIK3CA\/Akt\/NF-kappaB by miRNA-148b-3p","volume":"34","author":"Wang","year":"2021","journal-title":"J. Investig. Surgery"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1007\/s00018-024-05156-9","article-title":"CircAKT3 alleviates postoperative cognitive dysfunction by stabilizing the feedback cycle of miR-106a-5p\/HDAC4\/MEF2C axis in hippocampi of aged mice","volume":"81","author":"Wang","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"e70066","DOI":"10.1111\/cns.70066","article-title":"MEF2C alleviates postoperative cognitive dysfunction by repressing Ferroptosis","volume":"30","author":"Wang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"e70127","DOI":"10.1002\/jbt.70127","article-title":"circHOMER1 alleviates sevoflurane-induced hippocampal neuronal injury via targeted negative regulation of miR-217","volume":"39","author":"Wen","year":"2025","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12943-020-01215-4","article-title":"Circular RNA circCORO1C promotes laryngeal squamous cell carcinoma progression by modulating the let-7c-5p\/PBX3 axis","volume":"19","author":"Wu","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"102586","DOI":"10.1016\/j.tranon.2025.102586","article-title":"Unveiling shared PANoptosis mechanisms in LUAD and osteoarthritis via bioinformatics and machine learning","volume":"63","author":"Xiong","year":"2026","journal-title":"Transl. Oncol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"102584","DOI":"10.1016\/j.tranon.2025.102584","article-title":"Development of multiple cell death pattern features to predict prognosis and drug sensitivity in gastric adenocarcinoma","volume":"63","author":"Yang","year":"2026","journal-title":"Transl. Oncol."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"109016","DOI":"10.1016\/j.isci.2024.109016","article-title":"DExH-box helicase 9 modulates hippocampal synapses and regulates neuropathic pain","volume":"27","author":"Yang","year":"2024","journal-title":"iScience"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"140367","DOI":"10.1155\/2023\/1420367","article-title":"BCL-3 promotes intracerebral hemorrhage progression by increasing blood-brain barrier permeability, inflammation, and cell apoptosis via endoplasmic reticulum stress","volume":"2023","author":"Yin","year":"2023","journal-title":"Mediat. Inflamm."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"Cluster profiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"727805","DOI":"10.3389\/fnagi.2022.727805","article-title":"Characterization of circRNA-associated-ceRNA networks involved in the pathogenesis of postoperative cognitive dysfunction in aging mice","volume":"14","author":"Zhang","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"111615","DOI":"10.1016\/j.brainresbull.2025.111615","article-title":"HMGB1 promotes LPS-induced M1 polarization and apoptosis in microglia by mediating the expression of immune and inflammation-related genes","volume":"233","author":"Zhao","year":"2025","journal-title":"Brain Res. Bull."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"587715","DOI":"10.3389\/fnbeh.2020.587715","article-title":"Correlation between plasma CircRNA-089763 and postoperative cognitive dysfunction in elderly patients undergoing non-cardiac surgery","volume":"14","author":"Zhou","year":"2020","journal-title":"Front. Behav. Neurosci."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2026.1733749\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:29:15Z","timestamp":1789104555000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2026.1733749\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":57,"alternative-id":["10.3389\/fnagi.2026.1733749"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2026.1733749","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]},"article-number":"1733749"}}