{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:45:31Z","timestamp":1792813531615,"version":"4.5.0"},"reference-count":99,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>\n                    Multiple studies show conflicting association between APOE polymorphisms and the risk of PDD, yielding inconsistent results. To elucidate, a meta-analysis was conducted using existing articles from Web of Science, PubMed, Cochrane, Google Scholar, Embase, WanFang, and CNKI databases, including case-control studies published up to January 31, 2025. A total of 27 studies (3,115 PD controls and 1,338 PDD cases) were included, with pooled Odds Ratio (ORs) and 95% confidence intervals (CIs) calculated using CMA, Biostat, United States. To assess APOE genotypes and PDD risk, three comparisons were examined: 5 genotypes vs. \u03b53\/3, \u03b52+\/\u03b54\u202f+\u202fvs. \u03b53\/3, and \u03b54\u202f+\u202fvs. \u03b54\u2212. The \u03b53\/4 (OR\u202f=\u202f1.56, 95% CI: 1.25\u20131.95); \u03b54\u202f+\u202fvs. \u03b53\/3 (OR\u202f=\u202f1.52, 95% CI: 1.20\u20131.93) and \u03b54\u202f+\u202fvs. \u03b54\u2212 (OR\u202f=\u202f1.62, 95% CI: 1.39\u20131.90) genotypes were associated with an increased PDD risk, while \u03b52\u202f+\u202fshowed no significant effect (OR\u202f=\u202f1.21, 95% CI: 0.88\u20131.65,\n                    <jats:italic>p<\/jats:italic>\n                    \u202f=\u202f0.23). Carriers of \u03b54\u202f+\u202fhad a 1.52-fold higher risk compared to \u03b53\/3, and the \u03b54\u202f+\u202fvs. \u03b54\u202f\u2212\u202fcomparison revealed a 1.62-fold greater dementia risk in \u03b54\u202f+\u202fcarriers. Subgroup analysis by ancestral region confirmed \u03b54\u202f+\u202fas a significant risk factor for PDD across Asian, and Caucasians populations with higher susceptibility in Asian (OR\u202f=\u202f1.98, 95% CI: 1.29\u20133.05) vs. Caucasian (OR\u202f=\u202f1.48, 95% CI: 1.11\u20131.98) populations. Our findings suggest that \u03b53\/4 and \u03b54\/4 increase susceptibility to PDD, underscoring the need for further large-scale studies to validate these associations.\n                  <\/jats:p>","DOI":"10.3389\/fnagi.2026.1737073","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T05:30:00Z","timestamp":1773120600000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Meta-analysis reveals apolipoprotein \u03b54 confers higher susceptibility to Parkinson\u2019s disease dementia in Asian populations"],"prefix":"10.3389","volume":"18","author":[{"given":"Naseem","family":"Akhter","sequence":"first","affiliation":[{"name":"Department of Translational Neuroscience, Barrow Neurological Institute","place":["Phoenix, AZ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc Bao Phuong","family":"Ho","sequence":"additional","affiliation":[{"name":"Arizona State University","place":["Tempe, AZ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Nangreave","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Wofford College","place":["Spartanburg, SC, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saif","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Translational Neuroscience, Barrow Neurological Institute, SJHMC, Dignity Health","place":["Phoenix, AZ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew F.","family":"Ducruet","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Barrow Neurological Institute","place":["Phoenix, AZ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchan","family":"Bhatia","sequence":"additional","affiliation":[{"name":"School of Mathematical and Natural Sciences, Arizona State University","place":["Glendale, AZ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1002\/mds.20527","article-title":"A systematic review of prevalence studies of dementia in Parkinson's disease","volume":"20","author":"Aarsland","year":"2005","journal-title":"Movement Disord.: Official J. 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